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The map label for this gene is glmU [H]

Identifier: 17231413

GI number: 17231413

Start: 4728513

End: 4729868

Strand: Direct

Name: glmU [H]

Synonym: alr3921

Alternate gene names: 17231413

Gene position: 4728513-4729868 (Clockwise)

Preceding gene: 17231412

Following gene: 17231417

Centisome position: 73.72

GC content: 46.09

Gene sequence:

>1356_bases
ATGGTAGTCGTAGCAATACTAGCAGCAGGACGCGGCACAAGAATGAAATCGGACTTACCCAAAGTTTTACATTCTTTGGG
TGGGCGATCGCTAGTTGAAAGAGTTATTGACAGTGTAGAACCGCTTTCACCTTCACGGCGACTCGTCATTGTCGGTTATC
AGGCTGAACAAGTTAAAACAGGTCTCCAGTCTCCTAATCTGGAGTTTGTGGAGCAAACTGTGCAGTTAGGAACAGGTCAC
GCTATCCAACAATTGCTCCCCCACCTTGAGGGTTACAGAGGGGATTTGCTAGTACTCAATGGTGATGTGCCACTGTTACG
CACTCAAACCTTAGAACAGCTATTACAAACTCACCAAACAAATCAGAACGCCGCTACTATCCTGACATCCCACCTACCTA
ACCCCAAAGGCTACGGACGAGTTTTTTGTAACGGTAACAATATTGTGCAGCAAATTGTTGAGGACAAAGATTGTTCTCCA
GCCCAGAGGCAAAATCACCGGATTAATGCCGGGATTTATTGCTTCCGTTGGGAAAATTTAGCGCAAGTTCTACCCCATCT
GGAAGCAAACAACGCTCAAAAGGAATATTACCTGACAGACGCTGTTACTCAAGTTGGTCAGGTGATGGCAGTAGATGTAG
AAGATTATCAAGAAATTTTGGGGATTAACGATCGCCTGCAATTAGCTACAGCCTACGAAATTTTGCAGAGGCGAGTCAAA
GAACAATGGATGATGGCTGGTGTCACTCTGATAGACCCTAATAGCATCACAATTGATGACACTGTAGAATTACAGCCTGA
TGTGATTATTGAACCCCAAACGCACCTCCGGGGCAGTACTGTGATCCAATCCGGGAGCCGCATCGGGCCGGGAAGTTTAA
TTGAAAATAGCCAGTTGGGTGCAAATGTCACAGTCCACTATTCTGTGGTGACAGATAGTACCATCCAAGATGGCACTAAA
ATTGGCCCTTATGCCCATTTGCGCGGTCATGCTCAAGTCGGTGCTAATTGCCGTATCGGTAATTTTGTCGAGTTGAAAAA
TACAGAATTAGGCGATCGCACCAACGTAGCGCACTTATCATATTTGGGTGATGCTACTGCGGGAACACAGGTAAATATTG
GTGCAGGGACAATTACTGCCAATTATGACGGCGTGAAAAAGCATCGCACAAAAATAGGCGATCGCACTAAAACAGGTTCT
AATAGTGTCTTGGTTGCCCCTGTAACCTTGGGTGATGATGTCTATGTAGCAGCTGGTTCAACTGTCACCGAAGATGTACC
CAATGATTCCTTAGTAATTGCCCGGACTCGTCAGGTGATAAAACTGGGATGGCGGAGGAAGAGCGGGGAATCGTGA

Upstream 100 bases:

>100_bases
TCCCTAGTCCCCATGCTCCCTCATTAGCTGGTATGATTTGAGCCTAAATCTCAAAGTACCAAGCGCAAAAGCGCTATTTA
TTGAAAGCTAATAGCTAATT

Downstream 100 bases:

>100_bases
GCAGGGAGCAGGGAGCAGGGAGCAGGGGGAGAAATTACTTCAGGATTTTCGCCCAGTCCCCAGTCCCCAATCCCTAACTG
ACTTAAAGATTTTCGCCCAG

Product: bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MVVVAILAAGRGTRMKSDLPKVLHSLGGRSLVERVIDSVEPLSPSRRLVIVGYQAEQVKTGLQSPNLEFVEQTVQLGTGH
AIQQLLPHLEGYRGDLLVLNGDVPLLRTQTLEQLLQTHQTNQNAATILTSHLPNPKGYGRVFCNGNNIVQQIVEDKDCSP
AQRQNHRINAGIYCFRWENLAQVLPHLEANNAQKEYYLTDAVTQVGQVMAVDVEDYQEILGINDRLQLATAYEILQRRVK
EQWMMAGVTLIDPNSITIDDTVELQPDVIIEPQTHLRGSTVIQSGSRIGPGSLIENSQLGANVTVHYSVVTDSTIQDGTK
IGPYAHLRGHAQVGANCRIGNFVELKNTELGDRTNVAHLSYLGDATAGTQVNIGAGTITANYDGVKKHRTKIGDRTKTGS
NSVLVAPVTLGDDVYVAAGSTVTEDVPNDSLVIARTRQVIKLGWRRKSGES

Sequences:

>Translated_451_residues
MVVVAILAAGRGTRMKSDLPKVLHSLGGRSLVERVIDSVEPLSPSRRLVIVGYQAEQVKTGLQSPNLEFVEQTVQLGTGH
AIQQLLPHLEGYRGDLLVLNGDVPLLRTQTLEQLLQTHQTNQNAATILTSHLPNPKGYGRVFCNGNNIVQQIVEDKDCSP
AQRQNHRINAGIYCFRWENLAQVLPHLEANNAQKEYYLTDAVTQVGQVMAVDVEDYQEILGINDRLQLATAYEILQRRVK
EQWMMAGVTLIDPNSITIDDTVELQPDVIIEPQTHLRGSTVIQSGSRIGPGSLIENSQLGANVTVHYSVVTDSTIQDGTK
IGPYAHLRGHAQVGANCRIGNFVELKNTELGDRTNVAHLSYLGDATAGTQVNIGAGTITANYDGVKKHRTKIGDRTKTGS
NSVLVAPVTLGDDVYVAAGSTVTEDVPNDSLVIARTRQVIKLGWRRKSGES
>Mature_451_residues
MVVVAILAAGRGTRMKSDLPKVLHSLGGRSLVERVIDSVEPLSPSRRLVIVGYQAEQVKTGLQSPNLEFVEQTVQLGTGH
AIQQLLPHLEGYRGDLLVLNGDVPLLRTQTLEQLLQTHQTNQNAATILTSHLPNPKGYGRVFCNGNNIVQQIVEDKDCSP
AQRQNHRINAGIYCFRWENLAQVLPHLEANNAQKEYYLTDAVTQVGQVMAVDVEDYQEILGINDRLQLATAYEILQRRVK
EQWMMAGVTLIDPNSITIDDTVELQPDVIIEPQTHLRGSTVIQSGSRIGPGSLIENSQLGANVTVHYSVVTDSTIQDGTK
IGPYAHLRGHAQVGANCRIGNFVELKNTELGDRTNVAHLSYLGDATAGTQVNIGAGTITANYDGVKKHRTKIGDRTKTGS
NSVLVAPVTLGDDVYVAAGSTVTEDVPNDSLVIARTRQVIKLGWRRKSGES

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc [H]

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Escherichia coli, GI1790168, Length=448, Percent_Identity=41.7410714285714, Blast_Score=322, Evalue=3e-89,
Organism=Saccharomyces cerevisiae, GI6320148, Length=352, Percent_Identity=23.2954545454545, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21355443, Length=320, Percent_Identity=24.6875, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24644084, Length=320, Percent_Identity=24.6875, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005882
- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 49192; Mature: 49192

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVVVAILAAGRGTRMKSDLPKVLHSLGGRSLVERVIDSVEPLSPSRRLVIVGYQAEQVKT
CEEEEEEECCCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCEEEEEECCHHHHHH
GLQSPNLEFVEQTVQLGTGHAIQQLLPHLEGYRGDLLVLNGDVPLLRTQTLEQLLQTHQT
CCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEECCCCCEEHHHHHHHHHHHHCC
NQNAATILTSHLPNPKGYGRVFCNGNNIVQQIVEDKDCSPAQRQNHRINAGIYCFRWENL
CCCHHEEEECCCCCCCCCEEEEECCCHHHHHHHCCCCCCCHHHCCCCCCCCEEEEEHHHH
AQVLPHLEANNAQKEYYLTDAVTQVGQVMAVDVEDYQEILGINDRLQLATAYEILQRRVK
HHHHCCCCCCCCCCEEEEHHHHHHCCCEEEEEHHHHHHHHCCCCHHHHHHHHHHHHHHHH
EQWMMAGVTLIDPNSITIDDTVELQPDVIIEPQTHLRGSTVIQSGSRIGPGSLIENSQLG
HHHHHCCEEEECCCCEEECCEEECCCCEEECCCCCCCCCHHCCCCCCCCCCCCCCCCCCC
ANVTVHYSVVTDSTIQDGTKIGPYAHLRGHAQVGANCRIGNFVELKNTELGDRTNVAHLS
CEEEEEEEEEECCCCCCCCCCCCCCEECCCCCCCCCCCCCCEEEECCCCCCCCCCEEEEE
YLGDATAGTQVNIGAGTITANYDGVKKHRTKIGDRTKTGSNSVLVAPVTLGDDVYVAAGS
ECCCCCCCCEEEECCCEEEECCCCHHHHHHHCCCCCCCCCCCEEEEEEEECCCEEEEECC
TVTEDVPNDSLVIARTRQVIKLGWRRKSGES
EEECCCCCCCEEEEEHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MVVVAILAAGRGTRMKSDLPKVLHSLGGRSLVERVIDSVEPLSPSRRLVIVGYQAEQVKT
CEEEEEEECCCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCEEEEEECCHHHHHH
GLQSPNLEFVEQTVQLGTGHAIQQLLPHLEGYRGDLLVLNGDVPLLRTQTLEQLLQTHQT
CCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEECCCCCEEHHHHHHHHHHHHCC
NQNAATILTSHLPNPKGYGRVFCNGNNIVQQIVEDKDCSPAQRQNHRINAGIYCFRWENL
CCCHHEEEECCCCCCCCCEEEEECCCHHHHHHHCCCCCCCHHHCCCCCCCCEEEEEHHHH
AQVLPHLEANNAQKEYYLTDAVTQVGQVMAVDVEDYQEILGINDRLQLATAYEILQRRVK
HHHHCCCCCCCCCCEEEEHHHHHHCCCEEEEEHHHHHHHHCCCCHHHHHHHHHHHHHHHH
EQWMMAGVTLIDPNSITIDDTVELQPDVIIEPQTHLRGSTVIQSGSRIGPGSLIENSQLG
HHHHHCCEEEECCCCEEECCEEECCCCEEECCCCCCCCCHHCCCCCCCCCCCCCCCCCCC
ANVTVHYSVVTDSTIQDGTKIGPYAHLRGHAQVGANCRIGNFVELKNTELGDRTNVAHLS
CEEEEEEEEEECCCCCCCCCCCCCCEECCCCCCCCCCCCCCEEEECCCCCCCCCCEEEEE
YLGDATAGTQVNIGAGTITANYDGVKKHRTKIGDRTKTGSNSVLVAPVTLGDDVYVAAGS
ECCCCCCCCEEEECCCEEEECCCCHHHHHHHCCCCCCCCCCCEEEEEEEECCCEEEEECC
TVTEDVPNDSLVIARTRQVIKLGWRRKSGES
EEECCCCCCCEEEEEHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA