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The map label for this gene is 17231404

Identifier: 17231404

GI number: 17231404

Start: 4716186

End: 4717070

Strand: Direct

Name: 17231404

Synonym: alr3912

Alternate gene names: NA

Gene position: 4716186-4717070 (Clockwise)

Preceding gene: 17231403

Following gene: 17231407

Centisome position: 73.53

GC content: 35.82

Gene sequence:

>885_bases
ATGAACAAAATCAATCGTGTTGCTATTGTTGGTGGTACTCATGGGAATGAATTTACAGGCGCATTCCTGGTTAAAAAATT
TCAGCAGTTTCCAGAGGTAATCCAAAAACCTAGCTTTGAAACGTTAACAATACTGGGTAATCCCAAAGCTTTCGAGGCTG
GTAAGCGCTATATAGAAAAAGATTTAAACCGTTGCTTTTTAACCGAAAGTTTGCAAAATACAAATCTTTCTAGTTATGAA
GACATCAGGGCAAAACAAATAGCCGGAGTTTTAGGAGCAGAGAATAAACCCAACGTAGATGTAGTTATTGATTTACACAG
TACAACTGCAAATATGGGATTGAGTATTATTTTAGGTAACCAAGATCCATTTTTATTAAAGCTATGTGCTTATTTAAGTG
ACATCAACCCTTTAGTAAAGGTTTGCTATACTATCCCCGAAAAGGGTAGTAATTTTCTGCGCTCTCTTAATAAACTGGGT
TTTGTGATTGAGGTAGGGGCTGTAGCTCAAGGTGTATTAAATGCTGAATTATTCCAAAAAACTGAACAATTAATATATAC
GATTTTGGATTATTTAGAACAATATAATCGAGGCAATATTCCAAAAATAAATAATCTACTAGCTCTGTATAAATTTACGG
GTACTGTTGATTACCCCAGAAATGAAAATGGTGACATTCAAGGGATGATTCATCCAGACATTCAATTTCGAGATTATGAA
CCTCTAAATCCTGGCGACCCTTTATTCTTAACCTTAGATGGTAAGGCGATCGCCTACGAAGGTACATCAACAGTTTACCC
CATATTTATCAACGAAGCCGCTTATTACGAGAAAGGAATTGCTATGCTGTTCACTGAAAAGCAACTCATAAATCCGTCAT
CTTGA

Upstream 100 bases:

>100_bases
GCTTTGTTCAACCCGCCTGCGCGGGTTTTGTCCGGATGGCTGGGATCTCTATCTACAGATGGACTTCTAAGTCTAAAATC
CAAAATGATATAACCTGTCT

Downstream 100 bases:

>100_bases
ATTACTTAATGAATTGCTTTTTTTAATAATTGGGGAATCAAAGAAGGACGTTCTGCAACAGGAACTTCGGCGGCTTCAAA
AGCTGTAATTTTACTTTGAG

Product: aspartoacylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MNKINRVAIVGGTHGNEFTGAFLVKKFQQFPEVIQKPSFETLTILGNPKAFEAGKRYIEKDLNRCFLTESLQNTNLSSYE
DIRAKQIAGVLGAENKPNVDVVIDLHSTTANMGLSIILGNQDPFLLKLCAYLSDINPLVKVCYTIPEKGSNFLRSLNKLG
FVIEVGAVAQGVLNAELFQKTEQLIYTILDYLEQYNRGNIPKINNLLALYKFTGTVDYPRNENGDIQGMIHPDIQFRDYE
PLNPGDPLFLTLDGKAIAYEGTSTVYPIFINEAAYYEKGIAMLFTEKQLINPSS

Sequences:

>Translated_294_residues
MNKINRVAIVGGTHGNEFTGAFLVKKFQQFPEVIQKPSFETLTILGNPKAFEAGKRYIEKDLNRCFLTESLQNTNLSSYE
DIRAKQIAGVLGAENKPNVDVVIDLHSTTANMGLSIILGNQDPFLLKLCAYLSDINPLVKVCYTIPEKGSNFLRSLNKLG
FVIEVGAVAQGVLNAELFQKTEQLIYTILDYLEQYNRGNIPKINNLLALYKFTGTVDYPRNENGDIQGMIHPDIQFRDYE
PLNPGDPLFLTLDGKAIAYEGTSTVYPIFINEAAYYEKGIAMLFTEKQLINPSS
>Mature_294_residues
MNKINRVAIVGGTHGNEFTGAFLVKKFQQFPEVIQKPSFETLTILGNPKAFEAGKRYIEKDLNRCFLTESLQNTNLSSYE
DIRAKQIAGVLGAENKPNVDVVIDLHSTTANMGLSIILGNQDPFLLKLCAYLSDINPLVKVCYTIPEKGSNFLRSLNKLG
FVIEVGAVAQGVLNAELFQKTEQLIYTILDYLEQYNRGNIPKINNLLALYKFTGTVDYPRNENGDIQGMIHPDIQFRDYE
PLNPGDPLFLTLDGKAIAYEGTSTVYPIFINEAAYYEKGIAMLFTEKQLINPSS

Specific function: Unknown

COG id: COG2988

COG function: function code E; Succinylglutamate desuccinylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AspA/AstE family. Aspartoacylase subfamily

Homologues:

Organism=Homo sapiens, GI18087825, Length=292, Percent_Identity=40.4109589041096, Blast_Score=224, Evalue=9e-59,
Organism=Homo sapiens, GI4557335, Length=299, Percent_Identity=41.4715719063545, Blast_Score=218, Evalue=7e-57,
Organism=Homo sapiens, GI189339202, Length=299, Percent_Identity=41.4715719063545, Blast_Score=218, Evalue=7e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ASPA_NOSS1 (Q8YQC1)

Other databases:

- EMBL:   BA000019
- PIR:   AI2294
- RefSeq:   NP_487952.1
- ProteinModelPortal:   Q8YQC1
- SMR:   Q8YQC1
- STRING:   Q8YQC1
- GeneID:   1107510
- GenomeReviews:   BA000019_GR
- KEGG:   ana:alr3912
- NMPDR:   fig|103690.1.peg.4219
- eggNOG:   COG2988
- HOGENOM:   HBG635125
- OMA:   DFLIQMF
- ProtClustDB:   PRK02259
- BioCyc:   NSP103690:ALR3912-MONOMER
- HAMAP:   MF_00704
- InterPro:   IPR016708
- InterPro:   IPR007036
- PIRSF:   PIRSF018001

Pfam domain/function: PF04952 AstE_AspA

EC number: =3.5.1.15

Molecular weight: Translated: 32846; Mature: 32846

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: NA

Important sites: BINDING 56-56 BINDING 164-164 BINDING 275-275

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKINRVAIVGGTHGNEFTGAFLVKKFQQFPEVIQKPSFETLTILGNPKAFEAGKRYIEK
CCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHH
DLNRCFLTESLQNTNLSSYEDIRAKQIAGVLGAENKPNVDVVIDLHSTTANMGLSIILGN
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCEEEEECC
QDPFLLKLCAYLSDINPLVKVCYTIPEKGSNFLRSLNKLGFVIEVGAVAQGVLNAELFQK
CCHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHCCEEEEECHHHHHHHHHHHHHH
TEQLIYTILDYLEQYNRGNIPKINNLLALYKFTGTVDYPRNENGDIQGMIHPDIQFRDYE
HHHHHHHHHHHHHHHCCCCCCCHHHEEEEEEECCEECCCCCCCCCEEEEECCCCEECCCC
PLNPGDPLFLTLDGKAIAYEGTSTVYPIFINEAAYYEKGIAMLFTEKQLINPSS
CCCCCCCEEEEECCCEEEECCCCEEEEEEECCHHHHHCCEEEEEECHHHCCCCC
>Mature Secondary Structure
MNKINRVAIVGGTHGNEFTGAFLVKKFQQFPEVIQKPSFETLTILGNPKAFEAGKRYIEK
CCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHH
DLNRCFLTESLQNTNLSSYEDIRAKQIAGVLGAENKPNVDVVIDLHSTTANMGLSIILGN
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCEEEEECC
QDPFLLKLCAYLSDINPLVKVCYTIPEKGSNFLRSLNKLGFVIEVGAVAQGVLNAELFQK
CCHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHCCEEEEECHHHHHHHHHHHHHH
TEQLIYTILDYLEQYNRGNIPKINNLLALYKFTGTVDYPRNENGDIQGMIHPDIQFRDYE
HHHHHHHHHHHHHHHCCCCCCCHHHEEEEEEECCEECCCCCCCCCEEEEECCCCEECCCC
PLNPGDPLFLTLDGKAIAYEGTSTVYPIFINEAAYYEKGIAMLFTEKQLINPSS
CCCCCCCEEEEECCCEEEECCCCEEEEEEECCHHHHHCCEEEEEECHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11759840