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The map label for this gene is ptrB [H]

Identifier: 17231403

GI number: 17231403

Start: 4713981

End: 4716047

Strand: Direct

Name: ptrB [H]

Synonym: alr3911

Alternate gene names: 17231403

Gene position: 4713981-4716047 (Clockwise)

Preceding gene: 17231402

Following gene: 17231404

Centisome position: 73.5

GC content: 37.4

Gene sequence:

>2067_bases
ATGATGAATAAGGACAAGATTTCGCAAAATCAAATCACGCCACCCATTGCCGATAAACAGCCCCAAGTTTTAGAATTGCA
TGGCGATCGCCGAGTAGATAATTACTTTTGGATGCGCGATATAGATAACCCAAAAGTAGTTGCATATCTAGAAGCAGAAA
ATTCATATACAAAAGTCATGATGCAGCACACAGAAACGCTGCAAAAAACTCTTTATAATGAAATGCTCTCACGAATCAAA
GAAACTGATTTATCCGTACCTTACCGCAAGGATAATTATTATTATTACTCTCGAACAGAAGCAGGCAAAGACTATAGAAT
TCATTGCCGAAAAGAAGGCGATTTAGATGCTCCAGAAGAAGTCATTTTAGACGAAAATGAATTAGCCGCCGGACATGATT
TTTTTGAATTAGGAATATTTGCTATTAGCCCCAATCATCAGATACTAGCTTATTCCTATGACACCAGTGGTTCGGAGCAA
TATACGCTTTTATTTCTTGACTTAACGACCCGTGAGTTATATCCAGAAACTATTGCTGATACTTATTTTTCTTTTTGTTG
GTGTAACGATAATCAAACATCATTTTATACAAAAATTGATGCAGCAAATCGCCCTTACCAGCTTTTTAAGCACACTTTAG
GAACGCCACCTACAAAAGATGAATTAATCTACCACGAGCCAGATCATGCTTATGCTTTATATGTAGGGAAAACCCGCAGT
CAAGCATATATATTGATGACTTTGCAAAGCAGCATCACTACAGAAGTTCACTATTTAGATGCCAACAATCCTGAGAGTAA
TTTTCAGATAATTTATCCACGAGAACCTGGAGTAGAATATGACGTTGAGCATCATAGTGATTACTTTTATATAGTCACAA
ATGAAGCTGCTACAAACTTTAAATTAGTAAAAACTCCATTAACTATGCCATCCAAGGAGAATTGGCAAACTGTTATTCCC
CACCGTGAAGATGTGCTGTTATCTGGAGTGAGCCTGTTTATTAATCACTTAGTCATCTATGAAAGAAAAGATGGACTACA
AACTGCTAGAGTGCAAAATATATCTACAGGTAGTGAAAGTAATATTATTTTCCCAGAACCAACTTATCAATTTTATGAAG
GGAATAACCCCGAATTTAATACTAATATTTTGCGGTTTAATTACACTTCTTTAATTACACCGCCATCTGTATTTGATTAT
GATATGGAAACCCACGAACAGGAGTTAAAAAAACAGACAGAAGTTCTGGGGGACTATGACAAAAATCAATATCAGAGTGA
GTGGTTACTTGCTACTGCTGAAGATGGTACGCAAATTCCCATATCAATTATTTACAAAAAAGTTACTAAAAAAGATGGGA
AAAATCCTTTACTAATGACAGGTTATGGAGCCTATGGTGCATCTTACCCGGCATCTTTCTCATCAGCTAGACTAGCATTG
CTAGACCGAGGAGTAGTGTTTGCTATTGCCCACATTCGTGGTGGTGAAGAAATGGGGCGTAAATGGTATGAAGATGGCAA
ATTTTTGCAGAAAAAGAACACCTTTACAGATTTTATCGCCTGTGCTGAGTATTTAATCAAAGAAGGTTGGACAACAAGCG
ATCGCCTAGCTATTACAGGCGGTAGCGCAGGTGGTTTATTGATGGGAGCGGTGATTAATTTGCGTCCCAAATTGTTTAAA
GTTGTAGTTGCCGATGTACCTTTCGTAGATGTAGTGACAACAATTTTAGATACATCTTTGCCCTTATCAGCAATGGAGTG
GGAAGAATGGGGTAATCCTAATGATCAAATCTACTATGAGTATATGAAATCTTACTCACCCTATGATAATGTCGAAGCCA
AAGATTATCCCCATTTGTTAATTACTGCTGGCTTAAATGATTCTCGCGTTAAATATTGGGAACCAGCCAAATGGACAGCT
AAATTGCGAGAACTTAAAACAGATCATCATGTTCTGTTGTTAAAAACTAATATGGATGCTGGTCATAGTGGCGCATCTGG
ACGTTATGAAAGCCTACGGGAACTTGCTTTTGAGTATGCTTTTATTTTGGATCGTTTAGGGTTGTAG

Upstream 100 bases:

>100_bases
ATTGGCTTATGTAGTTTAAGAAGAAAATCTCATCGGAAAATCGGAATTACTAGCTCATCTTAAGTGGCTATTTGCTGGAT
CTAGAGTACAGGTTGCATAT

Downstream 100 bases:

>100_bases
ATAAGAAGTTTACGCAGGTGGACTAACAAAAAAATCAAGCTTTGTTCAACCCGCCTGCGCGGGTTTTGTCCGGATGGCTG
GGATCTCTATCTACAGATGG

Product: protease II

Products: NA

Alternate protein names: Oligopeptidase B; Protease II [H]

Number of amino acids: Translated: 688; Mature: 688

Protein sequence:

>688_residues
MMNKDKISQNQITPPIADKQPQVLELHGDRRVDNYFWMRDIDNPKVVAYLEAENSYTKVMMQHTETLQKTLYNEMLSRIK
ETDLSVPYRKDNYYYYSRTEAGKDYRIHCRKEGDLDAPEEVILDENELAAGHDFFELGIFAISPNHQILAYSYDTSGSEQ
YTLLFLDLTTRELYPETIADTYFSFCWCNDNQTSFYTKIDAANRPYQLFKHTLGTPPTKDELIYHEPDHAYALYVGKTRS
QAYILMTLQSSITTEVHYLDANNPESNFQIIYPREPGVEYDVEHHSDYFYIVTNEAATNFKLVKTPLTMPSKENWQTVIP
HREDVLLSGVSLFINHLVIYERKDGLQTARVQNISTGSESNIIFPEPTYQFYEGNNPEFNTNILRFNYTSLITPPSVFDY
DMETHEQELKKQTEVLGDYDKNQYQSEWLLATAEDGTQIPISIIYKKVTKKDGKNPLLMTGYGAYGASYPASFSSARLAL
LDRGVVFAIAHIRGGEEMGRKWYEDGKFLQKKNTFTDFIACAEYLIKEGWTTSDRLAITGGSAGGLLMGAVINLRPKLFK
VVVADVPFVDVVTTILDTSLPLSAMEWEEWGNPNDQIYYEYMKSYSPYDNVEAKDYPHLLITAGLNDSRVKYWEPAKWTA
KLRELKTDHHVLLLKTNMDAGHSGASGRYESLRELAFEYAFILDRLGL

Sequences:

>Translated_688_residues
MMNKDKISQNQITPPIADKQPQVLELHGDRRVDNYFWMRDIDNPKVVAYLEAENSYTKVMMQHTETLQKTLYNEMLSRIK
ETDLSVPYRKDNYYYYSRTEAGKDYRIHCRKEGDLDAPEEVILDENELAAGHDFFELGIFAISPNHQILAYSYDTSGSEQ
YTLLFLDLTTRELYPETIADTYFSFCWCNDNQTSFYTKIDAANRPYQLFKHTLGTPPTKDELIYHEPDHAYALYVGKTRS
QAYILMTLQSSITTEVHYLDANNPESNFQIIYPREPGVEYDVEHHSDYFYIVTNEAATNFKLVKTPLTMPSKENWQTVIP
HREDVLLSGVSLFINHLVIYERKDGLQTARVQNISTGSESNIIFPEPTYQFYEGNNPEFNTNILRFNYTSLITPPSVFDY
DMETHEQELKKQTEVLGDYDKNQYQSEWLLATAEDGTQIPISIIYKKVTKKDGKNPLLMTGYGAYGASYPASFSSARLAL
LDRGVVFAIAHIRGGEEMGRKWYEDGKFLQKKNTFTDFIACAEYLIKEGWTTSDRLAITGGSAGGLLMGAVINLRPKLFK
VVVADVPFVDVVTTILDTSLPLSAMEWEEWGNPNDQIYYEYMKSYSPYDNVEAKDYPHLLITAGLNDSRVKYWEPAKWTA
KLRELKTDHHVLLLKTNMDAGHSGASGRYESLRELAFEYAFILDRLGL
>Mature_688_residues
MMNKDKISQNQITPPIADKQPQVLELHGDRRVDNYFWMRDIDNPKVVAYLEAENSYTKVMMQHTETLQKTLYNEMLSRIK
ETDLSVPYRKDNYYYYSRTEAGKDYRIHCRKEGDLDAPEEVILDENELAAGHDFFELGIFAISPNHQILAYSYDTSGSEQ
YTLLFLDLTTRELYPETIADTYFSFCWCNDNQTSFYTKIDAANRPYQLFKHTLGTPPTKDELIYHEPDHAYALYVGKTRS
QAYILMTLQSSITTEVHYLDANNPESNFQIIYPREPGVEYDVEHHSDYFYIVTNEAATNFKLVKTPLTMPSKENWQTVIP
HREDVLLSGVSLFINHLVIYERKDGLQTARVQNISTGSESNIIFPEPTYQFYEGNNPEFNTNILRFNYTSLITPPSVFDY
DMETHEQELKKQTEVLGDYDKNQYQSEWLLATAEDGTQIPISIIYKKVTKKDGKNPLLMTGYGAYGASYPASFSSARLAL
LDRGVVFAIAHIRGGEEMGRKWYEDGKFLQKKNTFTDFIACAEYLIKEGWTTSDRLAITGGSAGGLLMGAVINLRPKLFK
VVVADVPFVDVVTTILDTSLPLSAMEWEEWGNPNDQIYYEYMKSYSPYDNVEAKDYPHLLITAGLNDSRVKYWEPAKWTA
KLRELKTDHHVLLLKTNMDAGHSGASGRYESLRELAFEYAFILDRLGL

Specific function: Cleaves peptide bonds on the C-terminal side of lysyl and argininyl residues [H]

COG id: COG1770

COG function: function code E; Protease II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9A family [H]

Homologues:

Organism=Homo sapiens, GI41349456, Length=704, Percent_Identity=27.4147727272727, Blast_Score=243, Evalue=6e-64,
Organism=Homo sapiens, GI284172420, Length=543, Percent_Identity=30.0184162062615, Blast_Score=231, Evalue=2e-60,
Organism=Homo sapiens, GI284172413, Length=543, Percent_Identity=30.0184162062615, Blast_Score=231, Evalue=2e-60,
Organism=Homo sapiens, GI70778815, Length=543, Percent_Identity=30.0184162062615, Blast_Score=231, Evalue=2e-60,
Organism=Homo sapiens, GI284172438, Length=543, Percent_Identity=30.0184162062615, Blast_Score=230, Evalue=3e-60,
Organism=Homo sapiens, GI284172431, Length=543, Percent_Identity=30.0184162062615, Blast_Score=230, Evalue=3e-60,
Organism=Homo sapiens, GI108860686, Length=273, Percent_Identity=36.6300366300366, Blast_Score=165, Evalue=1e-40,
Organism=Homo sapiens, GI108860692, Length=221, Percent_Identity=38.4615384615385, Blast_Score=159, Evalue=8e-39,
Organism=Escherichia coli, GI1788150, Length=674, Percent_Identity=45.8456973293769, Blast_Score=610, Evalue=1e-176,
Organism=Drosophila melanogaster, GI24583414, Length=700, Percent_Identity=27.1428571428571, Blast_Score=225, Evalue=9e-59,
Organism=Drosophila melanogaster, GI221510989, Length=703, Percent_Identity=25.8890469416785, Blast_Score=218, Evalue=8e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002471
- InterPro:   IPR001375
- InterPro:   IPR002470
- InterPro:   IPR004106 [H]

Pfam domain/function: PF00326 Peptidase_S9; PF02897 Peptidase_S9_N [H]

EC number: =3.4.21.83 [H]

Molecular weight: Translated: 79186; Mature: 79186

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMNKDKISQNQITPPIADKQPQVLELHGDRRVDNYFWMRDIDNPKVVAYLEAENSYTKVM
CCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCEEEEEECCCCEEEEEEECCCCHHHHH
MQHTETLQKTLYNEMLSRIKETDLSVPYRKDNYYYYSRTEAGKDYRIHCRKEGDLDAPEE
HHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCEEEEEECCCCCCEEEEEECCCCCCCCHH
VILDENELAAGHDFFELGIFAISPNHQILAYSYDTSGSEQYTLLFLDLTTRELYPETIAD
HEECCCCCCCCCCEEEEEEEEECCCCEEEEEEECCCCCCEEEEEEEEECCHHHCHHHHHH
TYFSFCWCNDNQTSFYTKIDAANRPYQLFKHTLGTPPTKDELIYHEPDHAYALYVGKTRS
CEEEEEEECCCCCEEEEEECCCCCCHHHHHHHCCCCCCCCCEEEECCCCEEEEEEECCCC
QAYILMTLQSSITTEVHYLDANNPESNFQIIYPREPGVEYDVEHHSDYFYIVTNEAATNF
CEEEEEEECCCCCEEEEEEECCCCCCCEEEEECCCCCCEEEECCCCCEEEEEECCCCCCE
KLVKTPLTMPSKENWQTVIPHREDVLLSGVSLFINHLVIYERKDGLQTARVQNISTGSES
EEEECCCCCCCCCCCEEECCCCHHHHHHHHHHHHHEEEEEECCCCCCHHHEEECCCCCCC
NIIFPEPTYQFYEGNNPEFNTNILRFNYTSLITPPSVFDYDMETHEQELKKQTEVLGDYD
CEECCCCCEEEECCCCCCCCCEEEEEECHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCC
KNQYQSEWLLATAEDGTQIPISIIYKKVTKKDGKNPLLMTGYGAYGASYPASFSSARLAL
CCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCEEEE
LDRGVVFAIAHIRGGEEMGRKWYEDGKFLQKKNTFTDFIACAEYLIKEGWTTSDRLAITG
ECCCEEEEEEEECCCHHHHHHHHHCCCEEHHCCCHHHHHHHHHHHHHCCCCCCCEEEEEC
GSAGGLLMGAVINLRPKLFKVVVADVPFVDVVTTILDTSLPLSAMEWEEWGNPNDQIYYE
CCCCCHHHHHHHHCCHHHEEEECCCCCHHHHHHHHHCCCCCCCHHHHHHCCCCCCHHHHH
YMKSYSPYDNVEAKDYPHLLITAGLNDSRVKYWEPAKWTAKLRELKTDHHVLLLKTNMDA
HHHCCCCCCCCCCCCCCEEEEEECCCCCCEEEECCCHHHHHHHHCCCCCEEEEEEECCCC
GHSGASGRYESLRELAFEYAFILDRLGL
CCCCCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MMNKDKISQNQITPPIADKQPQVLELHGDRRVDNYFWMRDIDNPKVVAYLEAENSYTKVM
CCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCEEEEEECCCCEEEEEEECCCCHHHHH
MQHTETLQKTLYNEMLSRIKETDLSVPYRKDNYYYYSRTEAGKDYRIHCRKEGDLDAPEE
HHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCEEEEEECCCCCCEEEEEECCCCCCCCHH
VILDENELAAGHDFFELGIFAISPNHQILAYSYDTSGSEQYTLLFLDLTTRELYPETIAD
HEECCCCCCCCCCEEEEEEEEECCCCEEEEEEECCCCCCEEEEEEEEECCHHHCHHHHHH
TYFSFCWCNDNQTSFYTKIDAANRPYQLFKHTLGTPPTKDELIYHEPDHAYALYVGKTRS
CEEEEEEECCCCCEEEEEECCCCCCHHHHHHHCCCCCCCCCEEEECCCCEEEEEEECCCC
QAYILMTLQSSITTEVHYLDANNPESNFQIIYPREPGVEYDVEHHSDYFYIVTNEAATNF
CEEEEEEECCCCCEEEEEEECCCCCCCEEEEECCCCCCEEEECCCCCEEEEEECCCCCCE
KLVKTPLTMPSKENWQTVIPHREDVLLSGVSLFINHLVIYERKDGLQTARVQNISTGSES
EEEECCCCCCCCCCCEEECCCCHHHHHHHHHHHHHEEEEEECCCCCCHHHEEECCCCCCC
NIIFPEPTYQFYEGNNPEFNTNILRFNYTSLITPPSVFDYDMETHEQELKKQTEVLGDYD
CEECCCCCEEEECCCCCCCCCEEEEEECHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCC
KNQYQSEWLLATAEDGTQIPISIIYKKVTKKDGKNPLLMTGYGAYGASYPASFSSARLAL
CCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCEEEE
LDRGVVFAIAHIRGGEEMGRKWYEDGKFLQKKNTFTDFIACAEYLIKEGWTTSDRLAITG
ECCCEEEEEEEECCCHHHHHHHHHCCCEEHHCCCHHHHHHHHHHHHHCCCCCCCEEEEEC
GSAGGLLMGAVINLRPKLFKVVVADVPFVDVVTTILDTSLPLSAMEWEEWGNPNDQIYYE
CCCCCHHHHHHHHCCHHHEEEECCCCCHHHHHHHHHCCCCCCCHHHHHHCCCCCCHHHHH
YMKSYSPYDNVEAKDYPHLLITAGLNDSRVKYWEPAKWTAKLRELKTDHHVLLLKTNMDA
HHHCCCCCCCCCCCCCCEEEEEECCCCCCEEEECCCHHHHHHHHCCCCCEEEEEEECCCC
GHSGASGRYESLRELAFEYAFILDRLGL
CCCCCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1769955; 9097040; 9278503 [H]