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The map label for this gene is fabL [H]

Identifier: 17231389

GI number: 17231389

Start: 4700541

End: 4701365

Strand: Direct

Name: fabL [H]

Synonym: alr3897

Alternate gene names: 17231389

Gene position: 4700541-4701365 (Clockwise)

Preceding gene: 17231388

Following gene: 17231392

Centisome position: 73.29

GC content: 46.91

Gene sequence:

>825_bases
ATGTCGCTTAACGGTAAACACGCATTAGTTACCGGAGGCTCACGCGGTATCGGTAGAGCAATCACATTAAAACTAGCCGA
ACAAGGGGTGAAAGTAGCTATCCACTACCACAAAAATGATGAAGCGGCGAACAATACCCTAGTACAAATACGAGAACAAG
GTGGAGACGGCTTTATCGTGCAAGCCGATGTTTTACAGCCTCAAGATATTAATCGGATGTTTAGTCAGGTTAAGGATAAA
TTTGGCAGTCTAGATATCTTTGTCAATTGTGCCAGACCAGACTTAGCAACTTTCTACAGTTCTCCCATGAAGATGACATT
AGACCACTGGCGTGCGGCTATGGATTCTCAAGCGCAGGCCTTCCTATTGGGAACTCAACAAGCCGCCAATCTGATGCGAG
ATGGAGGCAGAATCATCGCCATCACCTATTCACCAAGTGGGCGTACTGGTAGCTGGCAGCCTTGGATGGCAATGGGAACG
GCTAAAGCTGCTTTAGAATCGCTTTGTCGCTATTTTGCCGTTGCCCTTGGTTCCCGTGGTATTACTGTTAATGGAATTAG
CCCTGGAGTTATCTTTGGTGAACCAAACCCCTTGGAAGGAGGAGTCTTGCGTTCTTTACCAACAGCAGCACAGGAAGCCA
CTCAAAATTGGCATGAGAGTGGATGGACACCCATGAGACGGGTGGGAACTCCAGATGATATTGCTAATGCAGCTATGCTC
TTATGTATGCAGGAAGCTAGCTTTATTACAGGTCAAATCATTCATGTGGACGGTGGTGCTTCCATTATGGACTCGATGTG
TCCTCTGGAAATTCAGCAGGGATAG

Upstream 100 bases:

>100_bases
TGCTTAACAGAAAATTTAAGGTATTATCATCGCCAGGAAATCATATTAGCCTCTATTACGTACTAGATTGAAATTATTGT
CATGTACATGAGGTTTTGAG

Downstream 100 bases:

>100_bases
GACTGGGAATTGGTGATAAACTCCCGAATTTCTCCAGCTACAAGCCCAACACAGGATTCTGGTAAGTTACTTTCAGCATG
AGCAATGATCTTTAACTCTG

Product: hypothetical protein

Products: NA

Alternate protein names: Enoyl-acyl carrier protein reductase III; NADPH-dependent enoyl-ACP reductase [H]

Number of amino acids: Translated: 274; Mature: 273

Protein sequence:

>274_residues
MSLNGKHALVTGGSRGIGRAITLKLAEQGVKVAIHYHKNDEAANNTLVQIREQGGDGFIVQADVLQPQDINRMFSQVKDK
FGSLDIFVNCARPDLATFYSSPMKMTLDHWRAAMDSQAQAFLLGTQQAANLMRDGGRIIAITYSPSGRTGSWQPWMAMGT
AKAALESLCRYFAVALGSRGITVNGISPGVIFGEPNPLEGGVLRSLPTAAQEATQNWHESGWTPMRRVGTPDDIANAAML
LCMQEASFITGQIIHVDGGASIMDSMCPLEIQQG

Sequences:

>Translated_274_residues
MSLNGKHALVTGGSRGIGRAITLKLAEQGVKVAIHYHKNDEAANNTLVQIREQGGDGFIVQADVLQPQDINRMFSQVKDK
FGSLDIFVNCARPDLATFYSSPMKMTLDHWRAAMDSQAQAFLLGTQQAANLMRDGGRIIAITYSPSGRTGSWQPWMAMGT
AKAALESLCRYFAVALGSRGITVNGISPGVIFGEPNPLEGGVLRSLPTAAQEATQNWHESGWTPMRRVGTPDDIANAAML
LCMQEASFITGQIIHVDGGASIMDSMCPLEIQQG
>Mature_273_residues
SLNGKHALVTGGSRGIGRAITLKLAEQGVKVAIHYHKNDEAANNTLVQIREQGGDGFIVQADVLQPQDINRMFSQVKDKF
GSLDIFVNCARPDLATFYSSPMKMTLDHWRAAMDSQAQAFLLGTQQAANLMRDGGRIIAITYSPSGRTGSWQPWMAMGTA
KAALESLCRYFAVALGSRGITVNGISPGVIFGEPNPLEGGVLRSLPTAAQEATQNWHESGWTPMRRVGTPDDIANAAMLL
CMQEASFITGQIIHVDGGASIMDSMCPLEIQQG

Specific function: 7-Alpha-Dehydroxylation Of Cholic Acid, Yielding Deoxycholic Acid And Lithocholic Acid, Respectively. Highest Affinity With Taurochenodeoxycholic Acid. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI32483357, Length=268, Percent_Identity=29.4776119402985, Blast_Score=88, Evalue=9e-18,
Organism=Homo sapiens, GI19923817, Length=271, Percent_Identity=25.830258302583, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI10190704, Length=264, Percent_Identity=28.4090909090909, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI4503301, Length=270, Percent_Identity=28.5185185185185, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1787905, Length=259, Percent_Identity=32.046332046332, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI2367175, Length=257, Percent_Identity=29.1828793774319, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1787335, Length=266, Percent_Identity=32.3308270676692, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1787545, Length=276, Percent_Identity=27.8985507246377, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1788459, Length=260, Percent_Identity=28.8461538461538, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1789378, Length=267, Percent_Identity=28.8389513108614, Blast_Score=85, Evalue=4e-18,
Organism=Escherichia coli, GI87082160, Length=265, Percent_Identity=27.1698113207547, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI2367365, Length=258, Percent_Identity=29.8449612403101, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI87082100, Length=268, Percent_Identity=27.2388059701493, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1789057, Length=259, Percent_Identity=27.7992277992278, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17560220, Length=279, Percent_Identity=30.4659498207885, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17560676, Length=263, Percent_Identity=27.3764258555133, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI193204405, Length=278, Percent_Identity=31.294964028777, Blast_Score=87, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17562906, Length=279, Percent_Identity=30.4659498207885, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17560332, Length=268, Percent_Identity=29.4776119402985, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17562990, Length=276, Percent_Identity=30.0724637681159, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17538480, Length=272, Percent_Identity=27.2058823529412, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17560150, Length=272, Percent_Identity=28.3088235294118, Blast_Score=84, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17562908, Length=279, Percent_Identity=30.8243727598566, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17559104, Length=276, Percent_Identity=29.3478260869565, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17563726, Length=269, Percent_Identity=28.996282527881, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17551412, Length=271, Percent_Identity=27.3062730627306, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17555706, Length=259, Percent_Identity=27.7992277992278, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI72000259, Length=282, Percent_Identity=25.886524822695, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17562904, Length=273, Percent_Identity=26.7399267399267, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17536025, Length=271, Percent_Identity=28.0442804428044, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17544670, Length=271, Percent_Identity=25.830258302583, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17531453, Length=277, Percent_Identity=28.5198555956679, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17562910, Length=275, Percent_Identity=26.5454545454545, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17561402, Length=260, Percent_Identity=25.3846153846154, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17538486, Length=274, Percent_Identity=26.2773722627737, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17536651, Length=265, Percent_Identity=25.6603773584906, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17555612, Length=210, Percent_Identity=31.4285714285714, Blast_Score=67, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17561272, Length=266, Percent_Identity=29.6992481203008, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17565030, Length=270, Percent_Identity=25.9259259259259, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI23397609, Length=262, Percent_Identity=28.6259541984733, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21355319, Length=259, Percent_Identity=27.4131274131274, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24644339, Length=272, Percent_Identity=27.2058823529412, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI21357041, Length=270, Percent_Identity=28.8888888888889, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI17737361, Length=268, Percent_Identity=26.4925373134328, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI28571526, Length=270, Percent_Identity=26.6666666666667, Blast_Score=71, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24644337, Length=271, Percent_Identity=25.830258302583, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.3.1.10 [H]

Molecular weight: Translated: 29494; Mature: 29363

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLNGKHALVTGGSRGIGRAITLKLAEQGVKVAIHYHKNDEAANNTLVQIREQGGDGFIV
CCCCCCEEEEECCCCCCCCEEEEEEECCCEEEEEEEECCCCCCCCEEEEEEECCCCEEEE
QADVLQPQDINRMFSQVKDKFGSLDIFVNCARPDLATFYSSPMKMTLDHWRAAMDSQAQA
EECCCCCHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHCCCHHHHHHHHHHHHCCCCEE
FLLGTQQAANLMRDGGRIIAITYSPSGRTGSWQPWMAMGTAKAALESLCRYFAVALGSRG
EEEECHHHHHHHHCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
ITVNGISPGVIFGEPNPLEGGVLRSLPTAAQEATQNWHESGWTPMRRVGTPDDIANAAML
EEEECCCCCEEECCCCCCCCCHHHHCCHHHHHHHHHHHHCCCCCHHHCCCCHHHHHHHHH
LCMQEASFITGQIIHVDGGASIMDSMCPLEIQQG
HHHHHCCCCEEEEEEECCCHHHHHCCCCEEECCC
>Mature Secondary Structure 
SLNGKHALVTGGSRGIGRAITLKLAEQGVKVAIHYHKNDEAANNTLVQIREQGGDGFIV
CCCCCEEEEECCCCCCCCEEEEEEECCCEEEEEEEECCCCCCCCEEEEEEECCCCEEEE
QADVLQPQDINRMFSQVKDKFGSLDIFVNCARPDLATFYSSPMKMTLDHWRAAMDSQAQA
EECCCCCHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHCCCHHHHHHHHHHHHCCCCEE
FLLGTQQAANLMRDGGRIIAITYSPSGRTGSWQPWMAMGTAKAALESLCRYFAVALGSRG
EEEECHHHHHHHHCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
ITVNGISPGVIFGEPNPLEGGVLRSLPTAAQEATQNWHESGWTPMRRVGTPDDIANAAML
EEEECCCCCEEECCCCCCCCCHHHHCCHHHHHHHHHHHHCCCCCHHHCCCCHHHHHHHHH
LCMQEASFITGQIIHVDGGASIMDSMCPLEIQQG
HHHHHCCCCEEEEEEECCCHHHHHCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8946165; 9202460; 9384377 [H]