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The map label for this gene is hemH [H]

Identifier: 17231243

GI number: 17231243

Start: 4528364

End: 4529530

Strand: Direct

Name: hemH [H]

Synonym: alr3751

Alternate gene names: 17231243

Gene position: 4528364-4529530 (Clockwise)

Preceding gene: 17231241

Following gene: 17231244

Centisome position: 70.6

GC content: 45.59

Gene sequence:

>1167_bases
ATGGGTCGTGTAGGCGTATTATTACTCAATCTCGGTGGTCCCGATAAGCTGGAGGATGTAGCTCCGTTTCTATTTAACCT
ATTCTCCGATCCGGAAATTATACGCTTACCATTCCGGTGGTTGCAGAAACCCTTGGCTTGGTTTATTGCTTCTCGACGCA
CCAAAACCTCCCAAGAGAACTATAAGCAAATTGGCGGTGGCTCCCCACTACGGAGGATTACGGAAGCCCAAGGAGAAGCC
TTAAAGGAACAGTTGCATTATTTGGGTCAAGAAGCGAATATTTATGTGGGAATGCGTTATTGGCACCCATATACGGAAGA
GGCGATCGCTCTTTTGACCCAAGATAACCTTGATAACTTGGTGATTTTGCCACTATACCCCCAATTCTCTATCAGCACTA
GTGGCTCTAGCTTCCGTCTACTAGAAAGACTTTGGCAAGAAGATCCCAAACTACAACGTCTGGAATACACAGTCATTCCT
TCTTGGTATAAAGAACCAGGTTATTTACAGGCGATGGCGGAACTCATCCGCCAAGAAATAGAGCAATTTCCTCATCCTGA
TCAGGTTCATGTGTTCTTCAGCGCTCATGGTGTACCCAAAAGCTATGTTGAAGAAGCAGGCGACCCCTATCAGCAGGAGA
TTGAGGAATGTACTGCATTAATTATGCAGACTCTCAATCGACCAAACCCTCACACTTTAGCGTACCAAAGTCGCGTCGGC
CCGGTTGAATGGCTACAACCCTATACTGAAGATGCACTCAAAGAACTAGGCGCGCAAGGTGTCAAAGATTTAGTTGTTGT
ACCTATCAGTTTCGTCTCCGAACACATCGAGACACTACAGGAAATTGATATCGAGTATCGGGAAATAGCAGAAGAAGCCG
GAATCCACAATTTCCGTCGTGTCCCTGCACCTAATACCCATCCAGTATTTATTAGAGCTTTGGCTGATTTGGTAATTGAT
GCGCTCAACAAACCCAGTTTCAAGCTTTCGCAAGCCGCCCAAATCAAGAAAATGGTCAAAATGTATCCTCCTGAGAGTTG
GGAATGGGGTATGACTTCTAGTGCGGAAGTTTGGAATGGACGGATTGCAATGCTAGGTTTCATTGCTCTAATTATCGAGT
TGGTTACAGGCCAAGGTCTACTGCACATGATTGGGCTTTTGCAGTAG

Upstream 100 bases:

>100_bases
TTGCCATTGTACTATTCCTAACTGTTAAGCTTTATATTTAATAAAGATATATTGTTAACATTAGTAAAAAATCTGAAAAG
GTTGGGGGAAAATAACTGCT

Downstream 100 bases:

>100_bases
TGAGAGAAAAGCGATGATATCCGCTAAAAGAGCGTCGCTGTAACATTTCTATCACAAAAAAATATTAATTGGAGTGATAA
ATCGGGCATTGAATTTTGAT

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 388; Mature: 387

Protein sequence:

>388_residues
MGRVGVLLLNLGGPDKLEDVAPFLFNLFSDPEIIRLPFRWLQKPLAWFIASRRTKTSQENYKQIGGGSPLRRITEAQGEA
LKEQLHYLGQEANIYVGMRYWHPYTEEAIALLTQDNLDNLVILPLYPQFSISTSGSSFRLLERLWQEDPKLQRLEYTVIP
SWYKEPGYLQAMAELIRQEIEQFPHPDQVHVFFSAHGVPKSYVEEAGDPYQQEIEECTALIMQTLNRPNPHTLAYQSRVG
PVEWLQPYTEDALKELGAQGVKDLVVVPISFVSEHIETLQEIDIEYREIAEEAGIHNFRRVPAPNTHPVFIRALADLVID
ALNKPSFKLSQAAQIKKMVKMYPPESWEWGMTSSAEVWNGRIAMLGFIALIIELVTGQGLLHMIGLLQ

Sequences:

>Translated_388_residues
MGRVGVLLLNLGGPDKLEDVAPFLFNLFSDPEIIRLPFRWLQKPLAWFIASRRTKTSQENYKQIGGGSPLRRITEAQGEA
LKEQLHYLGQEANIYVGMRYWHPYTEEAIALLTQDNLDNLVILPLYPQFSISTSGSSFRLLERLWQEDPKLQRLEYTVIP
SWYKEPGYLQAMAELIRQEIEQFPHPDQVHVFFSAHGVPKSYVEEAGDPYQQEIEECTALIMQTLNRPNPHTLAYQSRVG
PVEWLQPYTEDALKELGAQGVKDLVVVPISFVSEHIETLQEIDIEYREIAEEAGIHNFRRVPAPNTHPVFIRALADLVID
ALNKPSFKLSQAAQIKKMVKMYPPESWEWGMTSSAEVWNGRIAMLGFIALIIELVTGQGLLHMIGLLQ
>Mature_387_residues
GRVGVLLLNLGGPDKLEDVAPFLFNLFSDPEIIRLPFRWLQKPLAWFIASRRTKTSQENYKQIGGGSPLRRITEAQGEAL
KEQLHYLGQEANIYVGMRYWHPYTEEAIALLTQDNLDNLVILPLYPQFSISTSGSSFRLLERLWQEDPKLQRLEYTVIPS
WYKEPGYLQAMAELIRQEIEQFPHPDQVHVFFSAHGVPKSYVEEAGDPYQQEIEECTALIMQTLNRPNPHTLAYQSRVGP
VEWLQPYTEDALKELGAQGVKDLVVVPISFVSEHIETLQEIDIEYREIAEEAGIHNFRRVPAPNTHPVFIRALADLVIDA
LNKPSFKLSQAAQIKKMVKMYPPESWEWGMTSSAEVWNGRIAMLGFIALIIELVTGQGLLHMIGLLQ

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499021, Length=322, Percent_Identity=41.6149068322981, Blast_Score=236, Evalue=3e-62,
Organism=Homo sapiens, GI60499025, Length=322, Percent_Identity=41.6149068322981, Blast_Score=236, Evalue=4e-62,
Organism=Escherichia coli, GI1786681, Length=322, Percent_Identity=32.9192546583851, Blast_Score=134, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6324750, Length=320, Percent_Identity=36.5625, Blast_Score=196, Evalue=7e-51,
Organism=Drosophila melanogaster, GI17864156, Length=326, Percent_Identity=40.1840490797546, Blast_Score=247, Evalue=1e-65,
Organism=Drosophila melanogaster, GI24651774, Length=257, Percent_Identity=36.9649805447471, Blast_Score=175, Evalue=4e-44,
Organism=Drosophila melanogaster, GI45552018, Length=172, Percent_Identity=43.0232558139535, Blast_Score=147, Evalue=8e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 44305; Mature: 44174

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRVGVLLLNLGGPDKLEDVAPFLFNLFSDPEIIRLPFRWLQKPLAWFIASRRTKTSQEN
CCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHCCCCHHHH
YKQIGGGSPLRRITEAQGEALKEQLHYLGQEANIYVGMRYWHPYTEEAIALLTQDNLDNL
HHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHCCCCCCE
VILPLYPQFSISTSGSSFRLLERLWQEDPKLQRLEYTVIPSWYKEPGYLQAMAELIRQEI
EEEECCCCEEECCCCCHHHHHHHHHHCCCCHHHEEEEECCHHHCCCCHHHHHHHHHHHHH
EQFPHPDQVHVFFSAHGVPKSYVEEAGDPYQQEIEECTALIMQTLNRPNPHTLAYQSRVG
HHCCCCCEEEEEEEECCCCHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCC
PVEWLQPYTEDALKELGAQGVKDLVVVPISFVSEHIETLQEIDIEYREIAEEAGIHNFRR
CHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCC
VPAPNTHPVFIRALADLVIDALNKPSFKLSQAAQIKKMVKMYPPESWEWGMTSSAEVWNG
CCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCC
RIAMLGFIALIIELVTGQGLLHMIGLLQ
HHHHHHHHHHHHHHHHCCCHHHHHHHCC
>Mature Secondary Structure 
GRVGVLLLNLGGPDKLEDVAPFLFNLFSDPEIIRLPFRWLQKPLAWFIASRRTKTSQEN
CCEEEEEEECCCCCHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHCCCCHHHH
YKQIGGGSPLRRITEAQGEALKEQLHYLGQEANIYVGMRYWHPYTEEAIALLTQDNLDNL
HHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHCCCCCCE
VILPLYPQFSISTSGSSFRLLERLWQEDPKLQRLEYTVIPSWYKEPGYLQAMAELIRQEI
EEEECCCCEEECCCCCHHHHHHHHHHCCCCHHHEEEEECCHHHCCCCHHHHHHHHHHHHH
EQFPHPDQVHVFFSAHGVPKSYVEEAGDPYQQEIEECTALIMQTLNRPNPHTLAYQSRVG
HHCCCCCEEEEEEEECCCCHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCC
PVEWLQPYTEDALKELGAQGVKDLVVVPISFVSEHIETLQEIDIEYREIAEEAGIHNFRR
CHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCC
VPAPNTHPVFIRALADLVIDALNKPSFKLSQAAQIKKMVKMYPPESWEWGMTSSAEVWNG
CCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCC
RIAMLGFIALIIELVTGQGLLHMIGLLQ
HHHHHHHHHHHHHHHHCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA