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The map label for this gene is mtaD [H]

Identifier: 17231241

GI number: 17231241

Start: 4526069

End: 4527469

Strand: Direct

Name: mtaD [H]

Synonym: alr3749

Alternate gene names: 17231241

Gene position: 4526069-4527469 (Clockwise)

Preceding gene: 17231234

Following gene: 17231243

Centisome position: 70.57

GC content: 43.33

Gene sequence:

>1401_bases
GTGAGTTTCACTATCCAAAATGTTCTACTGGCTACTGATGACGGTTACACCACTGCCGATGTTCAGGTTGTAGGTGATAA
AATCGCCGCTATTGCCCCCAATTTAGATGTTATCGGTACTGCCATTGACGGTAAACATAAGCTTTTATTACCTGGTTTTG
TCAATGCTCATACCCACTCATCGGAAATGTGGCAAAGAGGCTTAATCTCTATTTTTCCTTTAGAGTTATGGCTGGCGGAA
CTGTATGATTTTGCGCCTTTGGATACGGAGAAGGTCTATCTCAGCGCCTTGGGTACGGCGGTAGAAACTTTACTGTCTGG
GGGAACGAGTGTAGTAGATCATCTGGTATTAATTCCTGGGCAAGAGTTGGAAACTATCGCCAGTGCAGTCCGCGCTTATC
AAGAAGTGGGGATTCGGGCTTTTATCGCCCCCCTCATTCAAGACCAATCCCTCTCCGCCGGGCTACCTGCTGGGGAATCT
ACCCAGACCCATGAGCCTTTTTTCCGTTCCACTGCTGCCACTTTAGACTTGATTGAGGAGGCGGTGAAACAGTTTCATCA
TCCAGATGCAGGTGTGAGTATTTTAGTTGCCCCTACGGGGATACAGTTGTGTACAGATGCTTTATTCACAGGTTGTATTG
AATTAAGCGATCGCTATAATTTATGTCGTCACTCTCACTTATTAGAAACCAAAGCCCAAGAAAAACTCGCCCAAGAGAAA
TACGGTTGTAGTGCTGTTACCCATTTGCAACGCATTGGTTATTTAGGCGATCGCACTTCTTTAGCTCATTGTGTGTGGTT
AAATGATGCTGATATCGATATCCTTGCACAAACCCAATCGACAGTCGTTCACAATCCTTTAAGTAATTTACGTTTAGGGA
GTGGAATTGCCCCAATTTTAAAATATCGTCAAGCCGGAGTAAATGTAACTTTTGGTTGTGATGGTGCTTCTAGTAATGAC
TCGCAAGATTTGTTAGAAGCTATTAAAATTGGGTCTATTTTGCATAACGTCACCGACTTTGATTATCGCTCTTGGATTTC
CCCCAGACAAGCAGTAGAAATGGCATCTTTGGGCGCTGCCAAGGGACTAAATCTGGTGGATCAACTCGGTTCAATTACCG
TTGGCAAAAAAGCCGATTTAATACTTTATGATCTGACTAATTTATCATTGGTTCCCCGTACAGATCCCATTGGTTTATTA
GTTTTAGGTCGTCCTACAAACGTTGTCGATAGTGCTTGGGTAAATGGTCAGCCAATCATCACAAATGGTCAAGTAAATAC
AATTGACGTTGAGAAATTGCGAGCAGAATTATTCCACCTCAGTGAATGGGCTACTAATCGCCAATCTCAAACAGTGGAAA
AATTCGAGCTTCATTACCGCACAGTCATGGGTTTAACTTAG

Upstream 100 bases:

>100_bases
CGTAAAGACTGATCCATAAAATTGCATCACCCAACATAATTACTATTTTGTACCTTGAAATCATATTGAGCGTTTAATTA
CTTAATTAAGGTTAAAATCC

Downstream 100 bases:

>100_bases
GATCACACAGAAGTGTAGAGAGCTATTTACACATAAGTATAGTGGCACAGATACTTTCAACAGTAAAAAAATATAGGTTG
GGTGGAGCGTAGCGCAACCC

Product: hypothetical protein

Products: NA

Alternate protein names: MTA/SAH deaminase [H]

Number of amino acids: Translated: 466; Mature: 465

Protein sequence:

>466_residues
MSFTIQNVLLATDDGYTTADVQVVGDKIAAIAPNLDVIGTAIDGKHKLLLPGFVNAHTHSSEMWQRGLISIFPLELWLAE
LYDFAPLDTEKVYLSALGTAVETLLSGGTSVVDHLVLIPGQELETIASAVRAYQEVGIRAFIAPLIQDQSLSAGLPAGES
TQTHEPFFRSTAATLDLIEEAVKQFHHPDAGVSILVAPTGIQLCTDALFTGCIELSDRYNLCRHSHLLETKAQEKLAQEK
YGCSAVTHLQRIGYLGDRTSLAHCVWLNDADIDILAQTQSTVVHNPLSNLRLGSGIAPILKYRQAGVNVTFGCDGASSND
SQDLLEAIKIGSILHNVTDFDYRSWISPRQAVEMASLGAAKGLNLVDQLGSITVGKKADLILYDLTNLSLVPRTDPIGLL
VLGRPTNVVDSAWVNGQPIITNGQVNTIDVEKLRAELFHLSEWATNRQSQTVEKFELHYRTVMGLT

Sequences:

>Translated_466_residues
MSFTIQNVLLATDDGYTTADVQVVGDKIAAIAPNLDVIGTAIDGKHKLLLPGFVNAHTHSSEMWQRGLISIFPLELWLAE
LYDFAPLDTEKVYLSALGTAVETLLSGGTSVVDHLVLIPGQELETIASAVRAYQEVGIRAFIAPLIQDQSLSAGLPAGES
TQTHEPFFRSTAATLDLIEEAVKQFHHPDAGVSILVAPTGIQLCTDALFTGCIELSDRYNLCRHSHLLETKAQEKLAQEK
YGCSAVTHLQRIGYLGDRTSLAHCVWLNDADIDILAQTQSTVVHNPLSNLRLGSGIAPILKYRQAGVNVTFGCDGASSND
SQDLLEAIKIGSILHNVTDFDYRSWISPRQAVEMASLGAAKGLNLVDQLGSITVGKKADLILYDLTNLSLVPRTDPIGLL
VLGRPTNVVDSAWVNGQPIITNGQVNTIDVEKLRAELFHLSEWATNRQSQTVEKFELHYRTVMGLT
>Mature_465_residues
SFTIQNVLLATDDGYTTADVQVVGDKIAAIAPNLDVIGTAIDGKHKLLLPGFVNAHTHSSEMWQRGLISIFPLELWLAEL
YDFAPLDTEKVYLSALGTAVETLLSGGTSVVDHLVLIPGQELETIASAVRAYQEVGIRAFIAPLIQDQSLSAGLPAGEST
QTHEPFFRSTAATLDLIEEAVKQFHHPDAGVSILVAPTGIQLCTDALFTGCIELSDRYNLCRHSHLLETKAQEKLAQEKY
GCSAVTHLQRIGYLGDRTSLAHCVWLNDADIDILAQTQSTVVHNPLSNLRLGSGIAPILKYRQAGVNVTFGCDGASSNDS
QDLLEAIKIGSILHNVTDFDYRSWISPRQAVEMASLGAAKGLNLVDQLGSITVGKKADLILYDLTNLSLVPRTDPIGLLV
LGRPTNVVDSAWVNGQPIITNGQVNTIDVEKLRAELFHLSEWATNRQSQTVEKFELHYRTVMGLT

Specific function: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine [H]

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MTA/SAH deaminase family [H]

Homologues:

Organism=Homo sapiens, GI4758426, Length=348, Percent_Identity=23.5632183908046, Blast_Score=80, Evalue=4e-15,
Organism=Escherichia coli, GI1789249, Length=388, Percent_Identity=25.7731958762887, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI87082177, Length=436, Percent_Identity=24.0825688073394, Blast_Score=77, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6319963, Length=359, Percent_Identity=25.0696378830084, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24643849, Length=360, Percent_Identity=26.9444444444444, Blast_Score=101, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.4.28 [H]

Molecular weight: Translated: 50598; Mature: 50467

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFTIQNVLLATDDGYTTADVQVVGDKIAAIAPNLDVIGTAIDGKHKLLLPGFVNAHTHS
CCEEEEEEEEEECCCCEEEEEEEECCHHHHCCCCCCEEEEEECCCCEEEECCCCCCCCCH
SEMWQRGLISIFPLELWLAELYDFAPLDTEKVYLSALGTAVETLLSGGTSVVDHLVLIPG
HHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHEEECCC
QELETIASAVRAYQEVGIRAFIAPLIQDQSLSAGLPAGESTQTHEPFFRSTAATLDLIEE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
AVKQFHHPDAGVSILVAPTGIQLCTDALFTGCIELSDRYNLCRHSHLLETKAQEKLAQEK
HHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YGCSAVTHLQRIGYLGDRTSLAHCVWLNDADIDILAQTQSTVVHNPLSNLRLGSGIAPIL
CCHHHHHHHHHHCCCCCCCCEEEEEEECCCCCEEEECCCHHHHHCCHHHCCCCCCHHHHH
KYRQAGVNVTFGCDGASSNDSQDLLEAIKIGSILHNVTDFDYRSWISPRQAVEMASLGAA
HHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHCCC
KGLNLVDQLGSITVGKKADLILYDLTNLSLVPRTDPIGLLVLGRPTNVVDSAWVNGQPII
CCCHHHHHHCCEECCCCCCEEEEEECCCEEECCCCCCEEEEECCCCCCHHCCCCCCCCEE
TNGQVNTIDVEKLRAELFHLSEWATNRQSQTVEKFELHYRTVMGLT
ECCCCCEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SFTIQNVLLATDDGYTTADVQVVGDKIAAIAPNLDVIGTAIDGKHKLLLPGFVNAHTHS
CEEEEEEEEEECCCCEEEEEEEECCHHHHCCCCCCEEEEEECCCCEEEECCCCCCCCCH
SEMWQRGLISIFPLELWLAELYDFAPLDTEKVYLSALGTAVETLLSGGTSVVDHLVLIPG
HHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHEEECCC
QELETIASAVRAYQEVGIRAFIAPLIQDQSLSAGLPAGESTQTHEPFFRSTAATLDLIEE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
AVKQFHHPDAGVSILVAPTGIQLCTDALFTGCIELSDRYNLCRHSHLLETKAQEKLAQEK
HHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YGCSAVTHLQRIGYLGDRTSLAHCVWLNDADIDILAQTQSTVVHNPLSNLRLGSGIAPIL
CCHHHHHHHHHHCCCCCCCCEEEEEEECCCCCEEEECCCHHHHHCCHHHCCCCCCHHHHH
KYRQAGVNVTFGCDGASSNDSQDLLEAIKIGSILHNVTDFDYRSWISPRQAVEMASLGAA
HHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHCCC
KGLNLVDQLGSITVGKKADLILYDLTNLSLVPRTDPIGLLVLGRPTNVVDSAWVNGQPII
CCCHHHHHHCCEECCCCCCEEEEEECCCEEECCCCCCEEEEECCCCCCHHCCCCCCCCEE
TNGQVNTIDVEKLRAELFHLSEWATNRQSQTVEKFELHYRTVMGLT
ECCCCCEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]