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The map label for this gene is purL

Identifier: 17231144

GI number: 17231144

Start: 4406022

End: 4408370

Strand: Reverse

Name: purL

Synonym: all3652

Alternate gene names: 17231144

Gene position: 4408370-4406022 (Counterclockwise)

Preceding gene: 17231145

Following gene: 17231143

Centisome position: 68.73

GC content: 47.0

Gene sequence:

>2349_bases
ATGACTGCCACATCTCCCTTTTCCCCTCAAGAAATTGCTGCTGAAGGCATCAAACCAGAAGAATACGCAGAAATTGTCCG
AAGATTAGGCCGTCATCCCAATAAAGCTGAACTGGGAATGTTTGGGGTGATGTGGTCAGAACATTGTTGCTACAAAAATT
CTCGCCCCCTACTCAAACAGTTTCCCACCACAGGCCCCCGCATTCTGGTAGGCCCAGGGGAAAATGCTGGGGTTGTGGAT
TTAGGTGAAGGATTGCAACTGGCATTTAAGATTGAATCTCACAACCACCCTTCAGCAGTTGAACCCTTTCAAGGCGCTGC
CACTGGTGTGGGGGGTATTCTCAGAGATATTTTTACAATGGGTGCGCGTCCCATTGCTTTGTTAAATTCTTTACGTTTTG
GTTCCTTAGAAGACCCCAAAACCCAAAGATTATTTTCTGGCGTAGTTGCTGGAATTTCCCACTATGGTAACTGTGTCGGT
GTTCCTACTGTCGGTGGTGAAGTTTATTTTGATCCCGCCTATTCAGGAAATCCCCTAGTAAATGTCATGGCTTTGGGATT
AATGGAAACACCAGAAATTGTCAAATCTGGAGCTGCTGGTATCGGTAATCCTGTATTGTACGTGGGTTCCACTACGGGAC
GGGATGGTATGGGAGGGGCGAGTTTTGCCAGTGCGGAATTAAGTGATGAGTCAATCGATGACCGTCCGGCTGTGCAGGTG
GGTGATCCTTTTTTGGAAAAATCATTAATTGAAGCTTGTTTAGAAGCATTTAAAACAGGTGCAGTGGTCGCGGCTCAAGA
TATGGGTGCGGCGGGAATTACCTGTTCTACTTCCGAGATGGCGGCTAAAGGTGGGGTAGGGATTGAGTTAGATTTGGATA
AAATTCCTGTGCGGGAAACACGGATGGTTCCTTATGAATATTTACTATCAGAATCTCAAGAACGAATGTTATTTGTTGCT
CATCAAGGACGAGAGCAAGAATTAATCGATATATTCCACCGTTGGGGACTACAGGCGGTTGTTGCCGGTACAGTGATTGC
CGAACCTATTGTCAGAATTTTCTTTCAAGGTGCAATTGCTGCGGAAATTCCGGCTGATGCTTTAGCAGAGAATACCCCAC
TTTACGAGCGTGAGTTATTGGCAGAACCCCCAGAATATGCTCGTCTAGCTTGGGAATGGTCATCTGAAGCCTTACCTACT
GGTACAACTGCGGGTATTGAGATTCAAGGAAATCTGCACAGTTGGCAGGATATTTTGTTAACTTTGCTCAATACTCCCAC
GATCGCCTCGAAAAATTGGGTGTATCGTCAATATGACCACCAGGTGCAGAATAATACGGTTTTCCTCCCTGGTGGTGCAG
ATGCGGCAGTTGTGCGCTTACGTCCCCTAGAAGGGCAGGGGAGCAGAGGAGCAGGGGAGCAGGGGGGAGTTAATAGCCTC
AGTGGTGTTGCGGCTACGGTGGATTGCAATCCTCGGTATGTTTACCTTGATCCCTATGAGGGAGCTAAGGCAGTGGTAGC
AGAAGCAGCCCGGAATCTTAGCTGTGTGGGGGCAGAACCTTTGGCGGTGACAGATAACTTAAATTTTGGCAGTCCAGAAA
AACCCATTGGTTATTGGCAATTGTCGGAGGCTTGTCGGGGTTTGGCGGAAGGTTGTCGAGAATTGGCAACCCCGGTCACT
GGTGGGAATGTCTCTCTATATAACGAAACCTTTGACACTCAAGGCAACCCCCAACCAATTTACCCAACTCCAGTTGTGGG
GATGGTGGGGTTGATTGCTGATTTAACCAAAATTTGCGGTCAAGGTTGGCAAGGTGTAGGTGATGTGATTTACCTTTTAG
GCGCATCTATTACCACTTTAGGCGCATCTGAATATTTAGCGACTATTCACAACACTGTAGCAGGCAGACCCCCACGGGTA
GATTTTGATTTAGAACGCCGTGTACAAAAAGTTTGTCGTGAAGGGATTCATGCAGGTTCGGTACGTTCAGCTCATGATTG
TGCTGAGGGGGGTTTAGCCGTGGCGCTGGCAGAATCTTGTCTTGCTGGCAACCTGGGGGCAGAAATTCACCTAGAAGTTT
CTCCTACTCAGTTACAACGCCTGGATGAGGTGCTGTTTGGTGAGGGTGGAGCCAGAATTTTAGTATCTGTAGTATCAACA
CAGCAAGCAACTTGGGAATCCTATTTACAGGAACATCTAGGACAAAATTGGCAAAAATTAGGCATAGTTGGAAATACCGA
TACAGATCTGGCGGTTTTAACTACTGATAATCAAACCTTAATCCGCGTTAGCATCGAAGAAATGAACGATCGCTATCAAA
ATGCGATCGCTAGAAGGTTAGCCCTGTGA

Upstream 100 bases:

>100_bases
CTCAGCAGCAAAAACTTATCCAGTAAAACAACTAACAACTGACACGCATAGCGCACTAAATCGATACAATAATGCTCTGT
CCTGTTGGTGCATTATTTCC

Downstream 100 bases:

>100_bases
AGAAGTAGATAGTAGGGGGCGTAATTAACAGCCCCTAACTAGTCACAACTAACCAATGACTACTGACAAATGACAAATTC
CTCAAATCAATAGCATCTTT

Product: phosphoribosylformylglycinamidine synthase II

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase II; FGAM synthase II

Number of amino acids: Translated: 782; Mature: 781

Protein sequence:

>782_residues
MTATSPFSPQEIAAEGIKPEEYAEIVRRLGRHPNKAELGMFGVMWSEHCCYKNSRPLLKQFPTTGPRILVGPGENAGVVD
LGEGLQLAFKIESHNHPSAVEPFQGAATGVGGILRDIFTMGARPIALLNSLRFGSLEDPKTQRLFSGVVAGISHYGNCVG
VPTVGGEVYFDPAYSGNPLVNVMALGLMETPEIVKSGAAGIGNPVLYVGSTTGRDGMGGASFASAELSDESIDDRPAVQV
GDPFLEKSLIEACLEAFKTGAVVAAQDMGAAGITCSTSEMAAKGGVGIELDLDKIPVRETRMVPYEYLLSESQERMLFVA
HQGREQELIDIFHRWGLQAVVAGTVIAEPIVRIFFQGAIAAEIPADALAENTPLYERELLAEPPEYARLAWEWSSEALPT
GTTAGIEIQGNLHSWQDILLTLLNTPTIASKNWVYRQYDHQVQNNTVFLPGGADAAVVRLRPLEGQGSRGAGEQGGVNSL
SGVAATVDCNPRYVYLDPYEGAKAVVAEAARNLSCVGAEPLAVTDNLNFGSPEKPIGYWQLSEACRGLAEGCRELATPVT
GGNVSLYNETFDTQGNPQPIYPTPVVGMVGLIADLTKICGQGWQGVGDVIYLLGASITTLGASEYLATIHNTVAGRPPRV
DFDLERRVQKVCREGIHAGSVRSAHDCAEGGLAVALAESCLAGNLGAEIHLEVSPTQLQRLDEVLFGEGGARILVSVVST
QQATWESYLQEHLGQNWQKLGIVGNTDTDLAVLTTDNQTLIRVSIEEMNDRYQNAIARRLAL

Sequences:

>Translated_782_residues
MTATSPFSPQEIAAEGIKPEEYAEIVRRLGRHPNKAELGMFGVMWSEHCCYKNSRPLLKQFPTTGPRILVGPGENAGVVD
LGEGLQLAFKIESHNHPSAVEPFQGAATGVGGILRDIFTMGARPIALLNSLRFGSLEDPKTQRLFSGVVAGISHYGNCVG
VPTVGGEVYFDPAYSGNPLVNVMALGLMETPEIVKSGAAGIGNPVLYVGSTTGRDGMGGASFASAELSDESIDDRPAVQV
GDPFLEKSLIEACLEAFKTGAVVAAQDMGAAGITCSTSEMAAKGGVGIELDLDKIPVRETRMVPYEYLLSESQERMLFVA
HQGREQELIDIFHRWGLQAVVAGTVIAEPIVRIFFQGAIAAEIPADALAENTPLYERELLAEPPEYARLAWEWSSEALPT
GTTAGIEIQGNLHSWQDILLTLLNTPTIASKNWVYRQYDHQVQNNTVFLPGGADAAVVRLRPLEGQGSRGAGEQGGVNSL
SGVAATVDCNPRYVYLDPYEGAKAVVAEAARNLSCVGAEPLAVTDNLNFGSPEKPIGYWQLSEACRGLAEGCRELATPVT
GGNVSLYNETFDTQGNPQPIYPTPVVGMVGLIADLTKICGQGWQGVGDVIYLLGASITTLGASEYLATIHNTVAGRPPRV
DFDLERRVQKVCREGIHAGSVRSAHDCAEGGLAVALAESCLAGNLGAEIHLEVSPTQLQRLDEVLFGEGGARILVSVVST
QQATWESYLQEHLGQNWQKLGIVGNTDTDLAVLTTDNQTLIRVSIEEMNDRYQNAIARRLAL
>Mature_781_residues
TATSPFSPQEIAAEGIKPEEYAEIVRRLGRHPNKAELGMFGVMWSEHCCYKNSRPLLKQFPTTGPRILVGPGENAGVVDL
GEGLQLAFKIESHNHPSAVEPFQGAATGVGGILRDIFTMGARPIALLNSLRFGSLEDPKTQRLFSGVVAGISHYGNCVGV
PTVGGEVYFDPAYSGNPLVNVMALGLMETPEIVKSGAAGIGNPVLYVGSTTGRDGMGGASFASAELSDESIDDRPAVQVG
DPFLEKSLIEACLEAFKTGAVVAAQDMGAAGITCSTSEMAAKGGVGIELDLDKIPVRETRMVPYEYLLSESQERMLFVAH
QGREQELIDIFHRWGLQAVVAGTVIAEPIVRIFFQGAIAAEIPADALAENTPLYERELLAEPPEYARLAWEWSSEALPTG
TTAGIEIQGNLHSWQDILLTLLNTPTIASKNWVYRQYDHQVQNNTVFLPGGADAAVVRLRPLEGQGSRGAGEQGGVNSLS
GVAATVDCNPRYVYLDPYEGAKAVVAEAARNLSCVGAEPLAVTDNLNFGSPEKPIGYWQLSEACRGLAEGCRELATPVTG
GNVSLYNETFDTQGNPQPIYPTPVVGMVGLIADLTKICGQGWQGVGDVIYLLGASITTLGASEYLATIHNTVAGRPPRVD
FDLERRVQKVCREGIHAGSVRSAHDCAEGGLAVALAESCLAGNLGAEIHLEVSPTQLQRLDEVLFGEGGARILVSVVSTQ
QATWESYLQEHLGQNWQKLGIVGNTDTDLAVLTTDNQTLIRVSIEEMNDRYQNAIARRLAL

Specific function: Unknown

COG id: COG0046

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGAMS family

Homologues:

Organism=Escherichia coli, GI48994899, Length=789, Percent_Identity=24.0811153358682, Blast_Score=118, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17553022, Length=708, Percent_Identity=24.4350282485876, Blast_Score=96, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6321498, Length=805, Percent_Identity=23.4782608695652, Blast_Score=100, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24582111, Length=690, Percent_Identity=24.0579710144928, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24582109, Length=690, Percent_Identity=24.0579710144928, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17137292, Length=690, Percent_Identity=24.0579710144928, Blast_Score=92, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURL_NOSS1 (Q8YR06)

Other databases:

- EMBL:   BA000019
- PIR:   AE2262
- RefSeq:   NP_487692.1
- ProteinModelPortal:   Q8YR06
- STRING:   Q8YR06
- GeneID:   1107250
- GenomeReviews:   BA000019_GR
- KEGG:   ana:all3652
- NMPDR:   fig|103690.1.peg.3959
- eggNOG:   COG0046
- HOGENOM:   HBG311214
- OMA:   YGNSFGV
- ProtClustDB:   PRK01213
- BioCyc:   NSP103690:ALL3652-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00420
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR010074
- InterPro:   IPR016188
- TIGRFAMs:   TIGR01736

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.5.3

Molecular weight: Translated: 83581; Mature: 83450

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTATSPFSPQEIAAEGIKPEEYAEIVRRLGRHPNKAELGMFGVMWSEHCCYKNSRPLLKQ
CCCCCCCCHHHHHHCCCCHHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHCCCCCCCHHHH
FPTTGPRILVGPGENAGVVDLGEGLQLAFKIESHNHPSAVEPFQGAATGVGGILRDIFTM
CCCCCCEEEECCCCCCCEEECCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHC
GARPIALLNSLRFGSLEDPKTQRLFSGVVAGISHYGNCVGVPTVGGEVYFDPAYSGNPLV
CCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCEEECCCCCCEEEECCCCCCCCHH
NVMALGLMETPEIVKSGAAGIGNPVLYVGSTTGRDGMGGASFASAELSDESIDDRPAVQV
HHHHHCCCCCHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCEEC
GDPFLEKSLIEACLEAFKTGAVVAAQDMGAAGITCSTSEMAAKGGVGIELDLDKIPVRET
CCHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCEECCHHHHHCCCCEEEEECCCCCCCHH
RMVPYEYLLSESQERMLFVAHQGREQELIDIFHRWGLQAVVAGTVIAEPIVRIFFQGAIA
CCCCHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCHH
AEIPADALAENTPLYERELLAEPPEYARLAWEWSSEALPTGTTAGIEIQGNLHSWQDILL
HCCCHHHHHCCCCCHHHHHHCCCCHHHEEEEECCCCCCCCCCCCCEEEECCCHHHHHHHH
TLLNTPTIASKNWVYRQYDHQVQNNTVFLPGGADAAVVRLRPLEGQGSRGAGEQGGVNSL
HHHCCCCCCCCCCEEHHHHHHCCCCEEEEECCCCEEEEEEEECCCCCCCCCCCCCCCCCC
SGVAATVDCNPRYVYLDPYEGAKAVVAEAARNLSCVGAEPLAVTDNLNFGSPEKPIGYWQ
CCEEEEEECCCEEEEECCCCCHHHHHHHHHHCCEECCCCCEEEECCCCCCCCCCCCCHHH
LSEACRGLAEGCRELATPVTGGNVSLYNETFDTQGNPQPIYPTPVVGMVGLIADLTKICG
HHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHC
QGWQGVGDVIYLLGASITTLGASEYLATIHNTVAGRPPRVDFDLERRVQKVCREGIHAGS
CCCCCHHHHHHHHHCHHHHCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCC
VRSAHDCAEGGLAVALAESCLAGNLGAEIHLEVSPTQLQRLDEVLFGEGGARILVSVVST
CCCHHHHHCCCCHHHHHHHHHCCCCCCEEEEEECHHHHHHHHHHHHCCCCCEEEEEHHHH
QQATWESYLQEHLGQNWQKLGIVGNTDTDLAVLTTDNQTLIRVSIEEMNDRYQNAIARRL
HHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEECCCEEEEEEHHHHHHHHHHHHHHHH
AL
CC
>Mature Secondary Structure 
TATSPFSPQEIAAEGIKPEEYAEIVRRLGRHPNKAELGMFGVMWSEHCCYKNSRPLLKQ
CCCCCCCHHHHHHCCCCHHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHCCCCCCCHHHH
FPTTGPRILVGPGENAGVVDLGEGLQLAFKIESHNHPSAVEPFQGAATGVGGILRDIFTM
CCCCCCEEEECCCCCCCEEECCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHC
GARPIALLNSLRFGSLEDPKTQRLFSGVVAGISHYGNCVGVPTVGGEVYFDPAYSGNPLV
CCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCEEECCCCCCEEEECCCCCCCCHH
NVMALGLMETPEIVKSGAAGIGNPVLYVGSTTGRDGMGGASFASAELSDESIDDRPAVQV
HHHHHCCCCCHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCEEC
GDPFLEKSLIEACLEAFKTGAVVAAQDMGAAGITCSTSEMAAKGGVGIELDLDKIPVRET
CCHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCEECCHHHHHCCCCEEEEECCCCCCCHH
RMVPYEYLLSESQERMLFVAHQGREQELIDIFHRWGLQAVVAGTVIAEPIVRIFFQGAIA
CCCCHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCHH
AEIPADALAENTPLYERELLAEPPEYARLAWEWSSEALPTGTTAGIEIQGNLHSWQDILL
HCCCHHHHHCCCCCHHHHHHCCCCHHHEEEEECCCCCCCCCCCCCEEEECCCHHHHHHHH
TLLNTPTIASKNWVYRQYDHQVQNNTVFLPGGADAAVVRLRPLEGQGSRGAGEQGGVNSL
HHHCCCCCCCCCCEEHHHHHHCCCCEEEEECCCCEEEEEEEECCCCCCCCCCCCCCCCCC
SGVAATVDCNPRYVYLDPYEGAKAVVAEAARNLSCVGAEPLAVTDNLNFGSPEKPIGYWQ
CCEEEEEECCCEEEEECCCCCHHHHHHHHHHCCEECCCCCEEEECCCCCCCCCCCCCHHH
LSEACRGLAEGCRELATPVTGGNVSLYNETFDTQGNPQPIYPTPVVGMVGLIADLTKICG
HHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHC
QGWQGVGDVIYLLGASITTLGASEYLATIHNTVAGRPPRVDFDLERRVQKVCREGIHAGS
CCCCCHHHHHHHHHCHHHHCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCC
VRSAHDCAEGGLAVALAESCLAGNLGAEIHLEVSPTQLQRLDEVLFGEGGARILVSVVST
CCCHHHHHCCCCHHHHHHHHHCCCCCCEEEEEECHHHHHHHHHHHHCCCCCEEEEEHHHH
QQATWESYLQEHLGQNWQKLGIVGNTDTDLAVLTTDNQTLIRVSIEEMNDRYQNAIARRL
HHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEECCCEEEEEEHHHHHHHHHHHHHHHH
AL
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11759840