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The map label for this gene is lysC [H]

Identifier: 17231136

GI number: 17231136

Start: 4396589

End: 4398409

Strand: Direct

Name: lysC [H]

Synonym: alr3644

Alternate gene names: 17231136

Gene position: 4396589-4398409 (Clockwise)

Preceding gene: 17231133

Following gene: 17231137

Centisome position: 68.55

GC content: 47.83

Gene sequence:

>1821_bases
ATGGCGCTTATAGTTCAGAAGTTTGGTGGTTCATCTGTCGGTTCAGTAGAACGTATTCAAGCAGTGGCACAGCGTGTCTA
CAAAACAGTGAAAGCAGGAAATTCACTGGTTGTAGTGGTTTCTGCAATGGGCAAAACCACCGATGGACTCGTCAAACTAG
CTAATGAAATTTCTCGCAATCCTAATCGTCGGGAAATGGATATGTTACTGTCCACAGGGGAACAAGTCACCATTGCTCTA
CTCAGTATGGCATTGCAAGAACTTGGACAACCAGCGATTTCCATGACTGGCGCTCAAGTAGGAATTGTGACAGAAGCTGA
ACACACCCGCGCCAGAATTTTACACATCGAAACTGAACGAGTAGAAGGCCATATTAAGGAAGGTAAGGTAGTGGTAGTAG
CTGGTTTTCAAGGGATATCCAGCAACGGCTCACTAGAAATCACCACTCTAGGGCGCGGTGGTTCCGATACATCAGCCGTG
GCTTTAGCAGCAGCATTACAGGCGGATTTCTGTGAAATTTATACAGATGTGCCAGGAATTTTAACTACAGACCCCCGCAT
AGTGCCTGAAGCCCAGTTAATGGGTGAAATCACCTGTAATGAAATGCTGGAGTTGGCAAGTTTAGGGGCAAAAGTGTTAC
ATCCCCGTGCGGTGGAAATTGCCCGTAACTATGGGATGCCTTTGGTAGTCAAATCTAGCTGGACAGATGATCCTGGTACG
TGGGTAACTACACCAAAACCCCAAGGGCGATCGCTCATCAATTTAGAACTAGCCCGGCCAGTGGATGATGTAGAACTTGA
TACAGACCAAGCTAAAGTCGCTCTGTTACGCGTACCCGATAAACCAGGAGTAGCAGCAAAATTATTTGGGGAAATTTCCC
GTCAAAAAGTAGACGTAGATTTAATTATTCAATCAATCCATGAAGGTAACAGTAACGACATCGCCTTTACTGTCACCACA
CCTATATTAAAACGAGCAGAAGCCGTAGCCGCCGCGATTGCCCCATCCCTCCGCAGTCCATCTCATCCCAAATCAGACGA
GGCTGAGGTGATGGTAGAACAAAACATTGCCAAAGTCAGTATTGCTGGTGCAGGGATGATCGGCCGTCCTGGGGTAGCTG
CCCAAATGTTCGCCACCTTAGCCGAAGCCGGGGTAAACATTCAAATGATTTCCACCAGCGAAGTCAAAGTTAGTTGTGTT
ATTGATGCCCAAGACGGCGATCGCGCTATCATTGCCCTCCGCAAAGCCTTTGAAATCGAAACCCCTCTCCACTCACAACT
CCCCACGCCCTCTTCCCTCTCCACTCACAACTCCCCTCCCGTTCGCGGTGTCGCCTTAGACTTAAACCAAGCCCGGCTGG
CTATTCGTCAAGTCCCAGACCGTCCAGGGATGGCGGCGCAGTTGTTTGGTATTCTCTCCCAGCACAATATCAGCGTAGAC
ATGATCATTCAGTCTCAACGTTGTCGCATTGTTGATGGTGTTCCCCGTCGGGATATTGCTTTTACAGTCCCCCGCATGGA
TGGGGAAACTGCCCAAAAATTGCTCTGTCAAGTAGCCCCAGAGTTGGGTTGGGGTGATGTGGTTTTGGATAGTGCGATCG
CTAAAGTTAGTATTGTCGGTGCGGGGATGGTAGGTCAACCAGGTGTAGCCGCCAAAATGTTTGAAGCATTAGCTAAACAC
CAAATCAACATTCAAATGATTGCCACCTCCGAAATTAAAATTAGCTGTGTTGTCTCTCAAGAACAAGGTGTACAAGCTTT
ACAAGTTATTCACACTGCTTTTGAGTTAGCAGGTACCGAGAAATTTGTTGTACCTGCGTAG

Upstream 100 bases:

>100_bases
CTGCACGATGTTTAGTACACTAGATTACTAACAAGCCTTCAAGCCTTCCTAGCACGGCGGAAGTATTGAAACAAGTAGGC
AACTTGGTTAGATAAAAGTT

Downstream 100 bases:

>100_bases
TTGCTGAGTTTGGGCTAATTTAACTCATGATTTTAACGATAGAAAGGTTGATTTATAGTTAAACTATGCCCAAGTTAGAC
ATCATCCACAACTCGGTAAA

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 606; Mature: 605

Protein sequence:

>606_residues
MALIVQKFGGSSVGSVERIQAVAQRVYKTVKAGNSLVVVVSAMGKTTDGLVKLANEISRNPNRREMDMLLSTGEQVTIAL
LSMALQELGQPAISMTGAQVGIVTEAEHTRARILHIETERVEGHIKEGKVVVVAGFQGISSNGSLEITTLGRGGSDTSAV
ALAAALQADFCEIYTDVPGILTTDPRIVPEAQLMGEITCNEMLELASLGAKVLHPRAVEIARNYGMPLVVKSSWTDDPGT
WVTTPKPQGRSLINLELARPVDDVELDTDQAKVALLRVPDKPGVAAKLFGEISRQKVDVDLIIQSIHEGNSNDIAFTVTT
PILKRAEAVAAAIAPSLRSPSHPKSDEAEVMVEQNIAKVSIAGAGMIGRPGVAAQMFATLAEAGVNIQMISTSEVKVSCV
IDAQDGDRAIIALRKAFEIETPLHSQLPTPSSLSTHNSPPVRGVALDLNQARLAIRQVPDRPGMAAQLFGILSQHNISVD
MIIQSQRCRIVDGVPRRDIAFTVPRMDGETAQKLLCQVAPELGWGDVVLDSAIAKVSIVGAGMVGQPGVAAKMFEALAKH
QINIQMIATSEIKISCVVSQEQGVQALQVIHTAFELAGTEKFVVPA

Sequences:

>Translated_606_residues
MALIVQKFGGSSVGSVERIQAVAQRVYKTVKAGNSLVVVVSAMGKTTDGLVKLANEISRNPNRREMDMLLSTGEQVTIAL
LSMALQELGQPAISMTGAQVGIVTEAEHTRARILHIETERVEGHIKEGKVVVVAGFQGISSNGSLEITTLGRGGSDTSAV
ALAAALQADFCEIYTDVPGILTTDPRIVPEAQLMGEITCNEMLELASLGAKVLHPRAVEIARNYGMPLVVKSSWTDDPGT
WVTTPKPQGRSLINLELARPVDDVELDTDQAKVALLRVPDKPGVAAKLFGEISRQKVDVDLIIQSIHEGNSNDIAFTVTT
PILKRAEAVAAAIAPSLRSPSHPKSDEAEVMVEQNIAKVSIAGAGMIGRPGVAAQMFATLAEAGVNIQMISTSEVKVSCV
IDAQDGDRAIIALRKAFEIETPLHSQLPTPSSLSTHNSPPVRGVALDLNQARLAIRQVPDRPGMAAQLFGILSQHNISVD
MIIQSQRCRIVDGVPRRDIAFTVPRMDGETAQKLLCQVAPELGWGDVVLDSAIAKVSIVGAGMVGQPGVAAKMFEALAKH
QINIQMIATSEIKISCVVSQEQGVQALQVIHTAFELAGTEKFVVPA
>Mature_605_residues
ALIVQKFGGSSVGSVERIQAVAQRVYKTVKAGNSLVVVVSAMGKTTDGLVKLANEISRNPNRREMDMLLSTGEQVTIALL
SMALQELGQPAISMTGAQVGIVTEAEHTRARILHIETERVEGHIKEGKVVVVAGFQGISSNGSLEITTLGRGGSDTSAVA
LAAALQADFCEIYTDVPGILTTDPRIVPEAQLMGEITCNEMLELASLGAKVLHPRAVEIARNYGMPLVVKSSWTDDPGTW
VTTPKPQGRSLINLELARPVDDVELDTDQAKVALLRVPDKPGVAAKLFGEISRQKVDVDLIIQSIHEGNSNDIAFTVTTP
ILKRAEAVAAAIAPSLRSPSHPKSDEAEVMVEQNIAKVSIAGAGMIGRPGVAAQMFATLAEAGVNIQMISTSEVKVSCVI
DAQDGDRAIIALRKAFEIETPLHSQLPTPSSLSTHNSPPVRGVALDLNQARLAIRQVPDRPGMAAQLFGILSQHNISVDM
IIQSQRCRIVDGVPRRDIAFTVPRMDGETAQKLLCQVAPELGWGDVVLDSAIAKVSIVGAGMVGQPGVAAKMFEALAKHQ
INIQMIATSEIKISCVVSQEQGVQALQVIHTAFELAGTEKFVVPA

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=359, Percent_Identity=31.1977715877437, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1790455, Length=295, Percent_Identity=31.1864406779661, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1790376, Length=113, Percent_Identity=38.9380530973451, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6320893, Length=305, Percent_Identity=29.5081967213115, Blast_Score=102, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 64383; Mature: 64252

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALIVQKFGGSSVGSVERIQAVAQRVYKTVKAGNSLVVVVSAMGKTTDGLVKLANEISRN
CEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHCC
PNRREMDMLLSTGEQVTIALLSMALQELGQPAISMTGAQVGIVTEAEHTRARILHIETER
CCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEECCCEEEEEECCCCCEEEEEEEEEHH
VEGHIKEGKVVVVAGFQGISSNGSLEITTLGRGGSDTSAVALAAALQADFCEIYTDVPGI
HCCEECCCCEEEEEECCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
LTTDPRIVPEAQLMGEITCNEMLELASLGAKVLHPRAVEIARNYGMPLVVKSSWTDDPGT
EECCCCCCCCHHHHHCCCHHHHHHHHHCCHHHCCCHHHHHHHHCCCCEEEECCCCCCCCC
WVTTPKPQGRSLINLELARPVDDVELDTDQAKVALLRVPDKPGVAAKLFGEISRQKVDVD
EEECCCCCCCCEEEEEECCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCHH
LIIQSIHEGNSNDIAFTVTTPILKRAEAVAAAIAPSLRSPSHPKSDEAEVMVEQNIAKVS
HHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHEEEECCCEEEE
IAGAGMIGRPGVAAQMFATLAEAGVNIQMISTSEVKVSCVIDAQDGDRAIIALRKAFEIE
EECCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCEEEEEEEECCCCCEEEEEEEHHHCCC
TPLHSQLPTPSSLSTHNSPPVRGVALDLNQARLAIRQVPDRPGMAAQLFGILSQHNISVD
CCHHHCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEE
MIIQSQRCRIVDGVPRRDIAFTVPRMDGETAQKLLCQVAPELGWGDVVLDSAIAKVSIVG
EEEECCCCEEECCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHEEEEEE
AGMVGQPGVAAKMFEALAKHQINIQMIATSEIKISCVVSQEQGVQALQVIHTAFELAGTE
CCCCCCCCHHHHHHHHHHHCCEEEEEEEECCEEEEEEEECCCCHHHHHHHHHHHHHCCCC
KFVVPA
EEECCC
>Mature Secondary Structure 
ALIVQKFGGSSVGSVERIQAVAQRVYKTVKAGNSLVVVVSAMGKTTDGLVKLANEISRN
EEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHCC
PNRREMDMLLSTGEQVTIALLSMALQELGQPAISMTGAQVGIVTEAEHTRARILHIETER
CCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEECCCEEEEEECCCCCEEEEEEEEEHH
VEGHIKEGKVVVVAGFQGISSNGSLEITTLGRGGSDTSAVALAAALQADFCEIYTDVPGI
HCCEECCCCEEEEEECCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
LTTDPRIVPEAQLMGEITCNEMLELASLGAKVLHPRAVEIARNYGMPLVVKSSWTDDPGT
EECCCCCCCCHHHHHCCCHHHHHHHHHCCHHHCCCHHHHHHHHCCCCEEEECCCCCCCCC
WVTTPKPQGRSLINLELARPVDDVELDTDQAKVALLRVPDKPGVAAKLFGEISRQKVDVD
EEECCCCCCCCEEEEEECCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCHH
LIIQSIHEGNSNDIAFTVTTPILKRAEAVAAAIAPSLRSPSHPKSDEAEVMVEQNIAKVS
HHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHEEEECCCEEEE
IAGAGMIGRPGVAAQMFATLAEAGVNIQMISTSEVKVSCVIDAQDGDRAIIALRKAFEIE
EECCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCEEEEEEEECCCCCEEEEEEEHHHCCC
TPLHSQLPTPSSLSTHNSPPVRGVALDLNQARLAIRQVPDRPGMAAQLFGILSQHNISVD
CCHHHCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEE
MIIQSQRCRIVDGVPRRDIAFTVPRMDGETAQKLLCQVAPELGWGDVVLDSAIAKVSIVG
EEEECCCCEEECCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHEEEEEE
AGMVGQPGVAAKMFEALAKHQINIQMIATSEIKISCVVSQEQGVQALQVIHTAFELAGTE
CCCCCCCCHHHHHHHHHHHCCEEEEEEEECCEEEEEEEECCCCHHHHHHHHHHHHHCCCC
KFVVPA
EEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]