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The map label for this gene is thiD [H]

Identifier: 17231032

GI number: 17231032

Start: 4265400

End: 4266245

Strand: Reverse

Name: thiD [H]

Synonym: all3540

Alternate gene names: 17231032

Gene position: 4266245-4265400 (Counterclockwise)

Preceding gene: 17231033

Following gene: 17231030

Centisome position: 66.52

GC content: 45.98

Gene sequence:

>846_bases
ATGAATGCTGAAACAATATCCAGGGTTCCTGTTGCATTAACCATTGCCGGTTCCGATAGCGGCGGTGGTGCGGGAATTCA
AGCTGATTTACGCACCTTTGCCTTTCATTGTGTCCACGGTACTAGCGCTATAACCTGCGTCACGGCACAAAATACCTTGG
GAGTAGCCAGATTTGATGCTATGGCACCGGAGGCAGTTGCAGCCCAAATACAAGCCGTTGTAGAGGATATTGGTGTACAG
GCGGCGAAAACGGGAATGTTACTCAATCAAGCAATTATCGCTACTGTTGCCCAGCAAGTGCAAGCTTTAGGAATAAACAA
CTTAGTAGTTGACCCGGTAATGGTTTCACGGACTGGGGCGCAATTAATTGATGATGATGCTATCAAGACCCTACGCCAGC
AACTAATCCCTCTGGCGGCGATAATTACACCCAACAGGTATGAAGCCCAGATTTTAAGTGGTCTATCGATAAATACCCTA
GATGATATGAGGGCAGCAACTCAAGTAATTCACCGCAATTTAAAAGCAAAAGCTGTGTTAGTCAAGGGTGGAGGGATGCA
GGGAAATGCCCGTGGTGTGGATATTTGGTTTGATGGACAACATCTAGAAACTCTGACAACCAAGCAGGTAGATACCAAAA
ATACTCACGGTACTGGTTGTACTTTATCAGCTGCGATCGCCTCCAATCTAGCCAAAGGTCAAAATTTACACCAAGCTGTA
ACCCAAGCAAAGGAATATGTCACTACTGCACTTACTTACTCCCTCAATATTGGGCAAGGGCAAGGGCCAGTAGGACATTT
CTTTCCGTTGTTACAAAATGATGGGTGTAGGGGTTTAGGGGTTTAG

Upstream 100 bases:

>100_bases
TTATCTTACGGTTATACCCCAAACTAGACCCCAAAACCCTCAACCAAACCCTTTGGCAGCAGTAGCCAAGCAACTACCAT
CACGTCAGTAATCCGCGCTT

Downstream 100 bases:

>100_bases
GGGTATAGGGAGTAAATTTCATCCCCAGTCCCCAATCCCCAATCCCCAATCCCCACTCATTTCACACAGGACTAATAGAC
AGTGTTTTCACTCTTTGAGT

Product: phosphomethylpyrimidine kinase

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MNAETISRVPVALTIAGSDSGGGAGIQADLRTFAFHCVHGTSAITCVTAQNTLGVARFDAMAPEAVAAQIQAVVEDIGVQ
AAKTGMLLNQAIIATVAQQVQALGINNLVVDPVMVSRTGAQLIDDDAIKTLRQQLIPLAAIITPNRYEAQILSGLSINTL
DDMRAATQVIHRNLKAKAVLVKGGGMQGNARGVDIWFDGQHLETLTTKQVDTKNTHGTGCTLSAAIASNLAKGQNLHQAV
TQAKEYVTTALTYSLNIGQGQGPVGHFFPLLQNDGCRGLGV

Sequences:

>Translated_281_residues
MNAETISRVPVALTIAGSDSGGGAGIQADLRTFAFHCVHGTSAITCVTAQNTLGVARFDAMAPEAVAAQIQAVVEDIGVQ
AAKTGMLLNQAIIATVAQQVQALGINNLVVDPVMVSRTGAQLIDDDAIKTLRQQLIPLAAIITPNRYEAQILSGLSINTL
DDMRAATQVIHRNLKAKAVLVKGGGMQGNARGVDIWFDGQHLETLTTKQVDTKNTHGTGCTLSAAIASNLAKGQNLHQAV
TQAKEYVTTALTYSLNIGQGQGPVGHFFPLLQNDGCRGLGV
>Mature_281_residues
MNAETISRVPVALTIAGSDSGGGAGIQADLRTFAFHCVHGTSAITCVTAQNTLGVARFDAMAPEAVAAQIQAVVEDIGVQ
AAKTGMLLNQAIIATVAQQVQALGINNLVVDPVMVSRTGAQLIDDDAIKTLRQQLIPLAAIITPNRYEAQILSGLSINTL
DDMRAATQVIHRNLKAKAVLVKGGGMQGNARGVDIWFDGQHLETLTTKQVDTKNTHGTGCTLSAAIASNLAKGQNLHQAV
TQAKEYVTTALTYSLNIGQGQGPVGHFFPLLQNDGCRGLGV

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=265, Percent_Identity=41.1320754716981, Blast_Score=174, Evalue=5e-45,
Organism=Saccharomyces cerevisiae, GI6325378, Length=275, Percent_Identity=31.6363636363636, Blast_Score=132, Evalue=5e-32,
Organism=Saccharomyces cerevisiae, GI6324517, Length=276, Percent_Identity=34.0579710144928, Blast_Score=122, Evalue=5e-29,
Organism=Saccharomyces cerevisiae, GI6324997, Length=276, Percent_Identity=34.0579710144928, Blast_Score=121, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 29344; Mature: 29344

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAETISRVPVALTIAGSDSGGGAGIQADLRTFAFHCVHGTSAITCVTAQNTLGVARFDA
CCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHEECCCCEEEEEEECCCCCHHHHHH
MAPEAVAAQIQAVVEDIGVQAAKTGMLLNQAIIATVAQQVQALGINNLVVDPVMVSRTGA
CCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCEEECCCCC
QLIDDDAIKTLRQQLIPLAAIITPNRYEAQILSGLSINTLDDMRAATQVIHRNLKAKAVL
HHHCHHHHHHHHHHHCCCCEEECCCCHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEEE
VKGGGMQGNARGVDIWFDGQHLETLTTKQVDTKNTHGTGCTLSAAIASNLAKGQNLHQAV
EECCCCCCCCCEEEEEECCCCHHHHHHCCCCCCCCCCCCCEEHHHHHHHHHCCCHHHHHH
TQAKEYVTTALTYSLNIGQGQGPVGHFFPLLQNDGCRGLGV
HHHHHHHHHHEEEEEECCCCCCCHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MNAETISRVPVALTIAGSDSGGGAGIQADLRTFAFHCVHGTSAITCVTAQNTLGVARFDA
CCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHEECCCCEEEEEEECCCCCHHHHHH
MAPEAVAAQIQAVVEDIGVQAAKTGMLLNQAIIATVAQQVQALGINNLVVDPVMVSRTGA
CCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCEEECCCCC
QLIDDDAIKTLRQQLIPLAAIITPNRYEAQILSGLSINTLDDMRAATQVIHRNLKAKAVL
HHHCHHHHHHHHHHHCCCCEEECCCCHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEEE
VKGGGMQGNARGVDIWFDGQHLETLTTKQVDTKNTHGTGCTLSAAIASNLAKGQNLHQAV
EECCCCCCCCCEEEEEECCCCHHHHHHCCCCCCCCCCCCCEEHHHHHHHHHCCCHHHHHH
TQAKEYVTTALTYSLNIGQGQGPVGHFFPLLQNDGCRGLGV
HHHHHHHHHHEEEEEECCCCCCCHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA