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The map label for this gene is uppS2

Identifier: 17230924

GI number: 17230924

Start: 4139777

End: 4140553

Strand: Reverse

Name: uppS2

Synonym: all3432

Alternate gene names: 17230924

Gene position: 4140553-4139777 (Counterclockwise)

Preceding gene: 17230925

Following gene: 17230912

Centisome position: 64.56

GC content: 45.17

Gene sequence:

>777_bases
GTGAACTTTCCCCCAATCCACCCATCAACACCAAAAATGACCCCCCCAGACTTAGATCCCCAAAAAATCCCCCAACACAT
AGCCGTCATCATGGATGGTAACGGCAGATGGGCAACTAGCCGAGGATTACCACGCATAGCCGGACATCGCCAAGGCGCAA
GAACACTCAAAGAACTCTTGCGCTGCTGTAAAGATTGGGGAATCAAAGCCCTCACCGCCTACGCCTTCTCTACGGAAAAT
TGGCAGCGTCCCATCGAAGAAGTAGATTTTCTGATGCTTTTATTTGAGCGATTACTGCGCCGGGAATTATCGCAAATGCA
CCGAGAAGGAGTGAGAATTTCCTTTATTGGCGATTTGACAGCATTACCCAAGTCACTACAAACGGAAATGGAACGCTCCA
TGACAGAGACATTAAATAATCAAGCAATTCACTTTACTGTTGCAGTCAACTATGGCAGTCGCAACGAAATTACTAGAGCC
TGTCGTCAAGTAGCGGAACTGGTGCAACAAGGCAAACTCAGTGCTGATGCAGTAAACGAAGGTATTGTAGAACAACATCT
TTACACAACAGATACTCAACCACCAGATTTATTGATTCGGACTAGCGGAGAGATGCGATTGAGTAACTTTCTGTTGTGGC
AGATGGCATATACAGAGATGTATTTCACAGATATTCTGTGGCCTGATTTTGACAGAGAAGCATTTCATCAGGCTTTGTTG
AGTTACCAAAAACGCGATCGCCGTTTTGGTCAAGTTAAAGCTTTAATCTCAGCCTAA

Upstream 100 bases:

>100_bases
CCAAACCATGCGCCGCCTGTGGACATGGCACAACACCCTTAACCCAAAATATCTCAACAATCTACTAAGTAGTTAATAAC
CCCTCTATACTCTCCTCTGC

Downstream 100 bases:

>100_bases
TATATCACCCACGGCAGGGCATAGACCCACTGTAGGCGATCGCGATTGATGAATACAATTGCTGCAACAACTTACTCAGG
CAGATTAATCGCCGGATTGC

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase 2; Di-trans,poly-cis-decaprenylcistransferase 2; Undecaprenyl diphosphate synthase 2; UDS 2

Number of amino acids: Translated: 258; Mature: 258

Protein sequence:

>258_residues
MNFPPIHPSTPKMTPPDLDPQKIPQHIAVIMDGNGRWATSRGLPRIAGHRQGARTLKELLRCCKDWGIKALTAYAFSTEN
WQRPIEEVDFLMLLFERLLRRELSQMHREGVRISFIGDLTALPKSLQTEMERSMTETLNNQAIHFTVAVNYGSRNEITRA
CRQVAELVQQGKLSADAVNEGIVEQHLYTTDTQPPDLLIRTSGEMRLSNFLLWQMAYTEMYFTDILWPDFDREAFHQALL
SYQKRDRRFGQVKALISA

Sequences:

>Translated_258_residues
MNFPPIHPSTPKMTPPDLDPQKIPQHIAVIMDGNGRWATSRGLPRIAGHRQGARTLKELLRCCKDWGIKALTAYAFSTEN
WQRPIEEVDFLMLLFERLLRRELSQMHREGVRISFIGDLTALPKSLQTEMERSMTETLNNQAIHFTVAVNYGSRNEITRA
CRQVAELVQQGKLSADAVNEGIVEQHLYTTDTQPPDLLIRTSGEMRLSNFLLWQMAYTEMYFTDILWPDFDREAFHQALL
SYQKRDRRFGQVKALISA
>Mature_258_residues
MNFPPIHPSTPKMTPPDLDPQKIPQHIAVIMDGNGRWATSRGLPRIAGHRQGARTLKELLRCCKDWGIKALTAYAFSTEN
WQRPIEEVDFLMLLFERLLRRELSQMHREGVRISFIGDLTALPKSLQTEMERSMTETLNNQAIHFTVAVNYGSRNEITRA
CRQVAELVQQGKLSADAVNEGIVEQHLYTTDTQPPDLLIRTSGEMRLSNFLLWQMAYTEMYFTDILWPDFDREAFHQALL
SYQKRDRRFGQVKALISA

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family

Homologues:

Organism=Homo sapiens, GI45580738, Length=225, Percent_Identity=41.7777777777778, Blast_Score=171, Evalue=8e-43,
Organism=Homo sapiens, GI45580742, Length=225, Percent_Identity=41.7777777777778, Blast_Score=171, Evalue=8e-43,
Organism=Escherichia coli, GI1786371, Length=231, Percent_Identity=46.7532467532467, Blast_Score=230, Evalue=6e-62,
Organism=Caenorhabditis elegans, GI71993029, Length=226, Percent_Identity=38.0530973451327, Blast_Score=154, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6319474, Length=239, Percent_Identity=35.5648535564854, Blast_Score=128, Evalue=9e-31,
Organism=Saccharomyces cerevisiae, GI6323748, Length=228, Percent_Identity=34.6491228070175, Blast_Score=117, Evalue=1e-27,
Organism=Drosophila melanogaster, GI18857969, Length=231, Percent_Identity=40.6926406926407, Blast_Score=173, Evalue=1e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UPPS2_NOSS1 (Q8YRL4)

Other databases:

- EMBL:   BA000019
- PIR:   AI2234
- RefSeq:   NP_487472.1
- ProteinModelPortal:   Q8YRL4
- SMR:   Q8YRL4
- STRING:   Q8YRL4
- GeneID:   1107030
- GenomeReviews:   BA000019_GR
- KEGG:   ana:all3432
- NMPDR:   fig|103690.1.peg.3739
- eggNOG:   COG0020
- HOGENOM:   HBG627837
- OMA:   ACMERGV
- PhylomeDB:   Q8YRL4
- ProtClustDB:   PRK14832
- BioCyc:   NSP103690:ALL3432-MONOMER
- HAMAP:   MF_01139
- InterPro:   IPR001441
- InterPro:   IPR018520
- Gene3D:   G3DSA:3.40.1180.10
- PANTHER:   PTHR10291
- TIGRFAMs:   TIGR00055

Pfam domain/function: PF01255 Prenyltransf; SSF64005 UPP_synth

EC number: =2.5.1.31

Molecular weight: Translated: 29748; Mature: 29748

Theoretical pI: Translated: 8.10; Mature: 8.10

Prosite motif: PS01066 UPP_SYNTHASE

Important sites: ACT_SITE 32-32

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFPPIHPSTPKMTPPDLDPQKIPQHIAVIMDGNGRWATSRGLPRIAGHRQGARTLKELL
CCCCCCCCCCCCCCCCCCCHHHHHHHEEEEECCCCCEECCCCCCHHHCCCHHHHHHHHHH
RCCKDWGIKALTAYAFSTENWQRPIEEVDFLMLLFERLLRRELSQMHREGVRISFIGDLT
HHHHHCCHHHHHHHHHCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHH
ALPKSLQTEMERSMTETLNNQAIHFTVAVNYGSRNEITRACRQVAELVQQGKLSADAVNE
HHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCHHHHHH
GIVEQHLYTTDTQPPDLLIRTSGEMRLSNFLLWQMAYTEMYFTDILWPDFDREAFHQALL
HHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
SYQKRDRRFGQVKALISA
HHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNFPPIHPSTPKMTPPDLDPQKIPQHIAVIMDGNGRWATSRGLPRIAGHRQGARTLKELL
CCCCCCCCCCCCCCCCCCCHHHHHHHEEEEECCCCCEECCCCCCHHHCCCHHHHHHHHHH
RCCKDWGIKALTAYAFSTENWQRPIEEVDFLMLLFERLLRRELSQMHREGVRISFIGDLT
HHHHHCCHHHHHHHHHCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHH
ALPKSLQTEMERSMTETLNNQAIHFTVAVNYGSRNEITRACRQVAELVQQGKLSADAVNE
HHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCHHHHHH
GIVEQHLYTTDTQPPDLLIRTSGEMRLSNFLLWQMAYTEMYFTDILWPDFDREAFHQALL
HHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
SYQKRDRRFGQVKALISA
HHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11759840