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The map label for this gene is guaA [H]

Identifier: 17230338

GI number: 17230338

Start: 3467094

End: 3468716

Strand: Reverse

Name: guaA [H]

Synonym: all2846

Alternate gene names: 17230338

Gene position: 3468716-3467094 (Counterclockwise)

Preceding gene: 17230339

Following gene: 17230337

Centisome position: 54.08

GC content: 46.52

Gene sequence:

>1623_bases
ATGAATACAGCGGTGACTCTACTAACCGAACAAGCCCCTCAACCAATAGAAGAGTTTGGGCAGCTTGAGCGTCAAATCAT
TATCATATTAGACTTCGGCTCTCAGTATTCAGAACTGATTGCCCGACGCATCCGCGAGACTCAAGTATACTCTGAAGTTT
TGTCTTATCGCACCCCTGCTGAACATTTACGCCAACTCAATCCCAAGGGAATTATTCTTTCTGGTGGCCCCAGTTCAGTT
TATAGCGATCGCGCTCCCCATTGTGACCCAGAAATCTGGAATTTGGGAGTCCCCATTTTGGGTGTCTGCTACGGAATGCA
GCTGATGGTCAACCAACTCGGTGGCGAAGTAGCCAAAGCTGACCGGGGTGAGTATGGGAAAGCATCATTACACATTGATG
ATCCCACCGATTTACTGACCAACGTTGAAGATGGCACAACAATGTGGATGAGTCATGGTGATTCAGTCACAAAAATGCCC
CCAGGGTTTGAAGTGTTGGCACATACAGATAATACTCCCTGTGCTGCTGTTGCTGACCACGAGAAAAAGCTTTATGGCGT
GCAGTTCCATCCAGAAGTAGTCCATTCCGTTGGTGGTTTGGCATTAATTCGCAACTTTGTTTATCACATTTGTGAGTGTG
AACCCACCTGGACGACGGCTGCTTTTGTGGAAGAAGCTATTCGGGAAGTCCGGGCTAAAGTTGGTGACAAGCGAGTACTA
TTGGCGCTTTCGGGAGGAGTCGATTCTTCTACCCTGGCTTTCTTGATGCACAAAGCCATCGGCGACCAATTGACTTGTGT
ATTTATCGACCAAGGCTTTATGCGGAAGTATGAGCCAGAAAGGTTGGTGAAACTATTTCAGGAGCAGTTTCATATCCCTG
TTGAATATGTTAACGCCCGCGATCGCTTCTTAGATATCATGTCAGGTGTGACAGACCCAGAAGAAAAACGTCGTCGCATT
GGACATGAATTCATCCAGGTATTTGAAGAAACATCTAAAAATCTGGGCCCCTTTGACTATCTAGCACAAGGGACTCTTTA
CCCAGATGTCATTGAATCGGCTGATACCAATGTTGACCCCCAAACTGGGGAACGGGTAGCGGTAAAAATCAAAAGCCATC
ACAACGTTGGCGGCTTACCCAAAGACTTGAGATTTAAACTAGTTGAACCCCTGCGGAAACTGTTTAAAGATGAAGTCCGT
AAAGTAGGGCGGTCTGTTGGTTTACCAGAAGAGATTGTTCAACGCCAGCCATTTCCTGGCCCTGGTTTAGCTATTCGGAT
TTTGGGTGAAGTCACCGCCGACAGATTGAACATTCTCCGCGATGCTGATTTGATTGTGCGCCAAGAAATTAACCAACGCG
GTTTATACAATGAATATTGGCAAGCATTCGCAGTTTTACTACCTATCCGCAGTGTGGGCGTAATGGGTGATCAACGCACC
TATGCTTATCCTATCGTCTTACGCATTGTCAAGAGCGAAGATGGCATGACAGCAGATTGGGCGCGTGTACCTTACGATGT
TTTAGAAGCAATTTCTAACCGCATTGTCAACGAAGTTAAAGGCGTTAACCGCGTGGTGTTTGATATTACTTCCAAGCCAC
CCGGAACCATTGAGTGGGAATAA

Upstream 100 bases:

>100_bases
GATTAACTCACCATTTATCAGTCTAAACAAGCTGAAAAATGGTGTTTATGTTCAGAACCCAAAATAACCATCTACTACCA
GACTCACACTTTCGCCATTT

Downstream 100 bases:

>100_bases
TAGCAATTTTAGAGTATTAGGTAGGGTGGGCAATGCCCACCTTATTTTTTGAGATTCCGGCTGATTCTGGCGATATAGCT
GGGGACTGGGGACTAGGGAC

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 540; Mature: 540

Protein sequence:

>540_residues
MNTAVTLLTEQAPQPIEEFGQLERQIIIILDFGSQYSELIARRIRETQVYSEVLSYRTPAEHLRQLNPKGIILSGGPSSV
YSDRAPHCDPEIWNLGVPILGVCYGMQLMVNQLGGEVAKADRGEYGKASLHIDDPTDLLTNVEDGTTMWMSHGDSVTKMP
PGFEVLAHTDNTPCAAVADHEKKLYGVQFHPEVVHSVGGLALIRNFVYHICECEPTWTTAAFVEEAIREVRAKVGDKRVL
LALSGGVDSSTLAFLMHKAIGDQLTCVFIDQGFMRKYEPERLVKLFQEQFHIPVEYVNARDRFLDIMSGVTDPEEKRRRI
GHEFIQVFEETSKNLGPFDYLAQGTLYPDVIESADTNVDPQTGERVAVKIKSHHNVGGLPKDLRFKLVEPLRKLFKDEVR
KVGRSVGLPEEIVQRQPFPGPGLAIRILGEVTADRLNILRDADLIVRQEINQRGLYNEYWQAFAVLLPIRSVGVMGDQRT
YAYPIVLRIVKSEDGMTADWARVPYDVLEAISNRIVNEVKGVNRVVFDITSKPPGTIEWE

Sequences:

>Translated_540_residues
MNTAVTLLTEQAPQPIEEFGQLERQIIIILDFGSQYSELIARRIRETQVYSEVLSYRTPAEHLRQLNPKGIILSGGPSSV
YSDRAPHCDPEIWNLGVPILGVCYGMQLMVNQLGGEVAKADRGEYGKASLHIDDPTDLLTNVEDGTTMWMSHGDSVTKMP
PGFEVLAHTDNTPCAAVADHEKKLYGVQFHPEVVHSVGGLALIRNFVYHICECEPTWTTAAFVEEAIREVRAKVGDKRVL
LALSGGVDSSTLAFLMHKAIGDQLTCVFIDQGFMRKYEPERLVKLFQEQFHIPVEYVNARDRFLDIMSGVTDPEEKRRRI
GHEFIQVFEETSKNLGPFDYLAQGTLYPDVIESADTNVDPQTGERVAVKIKSHHNVGGLPKDLRFKLVEPLRKLFKDEVR
KVGRSVGLPEEIVQRQPFPGPGLAIRILGEVTADRLNILRDADLIVRQEINQRGLYNEYWQAFAVLLPIRSVGVMGDQRT
YAYPIVLRIVKSEDGMTADWARVPYDVLEAISNRIVNEVKGVNRVVFDITSKPPGTIEWE
>Mature_540_residues
MNTAVTLLTEQAPQPIEEFGQLERQIIIILDFGSQYSELIARRIRETQVYSEVLSYRTPAEHLRQLNPKGIILSGGPSSV
YSDRAPHCDPEIWNLGVPILGVCYGMQLMVNQLGGEVAKADRGEYGKASLHIDDPTDLLTNVEDGTTMWMSHGDSVTKMP
PGFEVLAHTDNTPCAAVADHEKKLYGVQFHPEVVHSVGGLALIRNFVYHICECEPTWTTAAFVEEAIREVRAKVGDKRVL
LALSGGVDSSTLAFLMHKAIGDQLTCVFIDQGFMRKYEPERLVKLFQEQFHIPVEYVNARDRFLDIMSGVTDPEEKRRRI
GHEFIQVFEETSKNLGPFDYLAQGTLYPDVIESADTNVDPQTGERVAVKIKSHHNVGGLPKDLRFKLVEPLRKLFKDEVR
KVGRSVGLPEEIVQRQPFPGPGLAIRILGEVTADRLNILRDADLIVRQEINQRGLYNEYWQAFAVLLPIRSVGVMGDQRT
YAYPIVLRIVKSEDGMTADWARVPYDVLEAISNRIVNEVKGVNRVVFDITSKPPGTIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=552, Percent_Identity=37.5, Blast_Score=325, Evalue=9e-89,
Organism=Escherichia coli, GI1788854, Length=528, Percent_Identity=49.0530303030303, Blast_Score=540, Evalue=1e-155,
Organism=Caenorhabditis elegans, GI133901714, Length=599, Percent_Identity=36.3939899833055, Blast_Score=325, Evalue=5e-89,
Organism=Caenorhabditis elegans, GI71992717, Length=599, Percent_Identity=36.3939899833055, Blast_Score=325, Evalue=5e-89,
Organism=Caenorhabditis elegans, GI71992710, Length=599, Percent_Identity=36.5609348914858, Blast_Score=324, Evalue=8e-89,
Organism=Saccharomyces cerevisiae, GI6323873, Length=521, Percent_Identity=48.5604606525912, Blast_Score=501, Evalue=1e-142,
Organism=Saccharomyces cerevisiae, GI6322638, Length=163, Percent_Identity=31.2883435582822, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI281365319, Length=552, Percent_Identity=36.9565217391304, Blast_Score=323, Evalue=2e-88,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR001962
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00733 Asn_synthase; PF00117 GATase; PF00958 GMP_synt_C [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 60703; Mature: 60703

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTAVTLLTEQAPQPIEEFGQLERQIIIILDFGSQYSELIARRIRETQVYSEVLSYRTPA
CCCEEEEEECCCCCHHHHHHCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCH
EHLRQLNPKGIILSGGPSSVYSDRAPHCDPEIWNLGVPILGVCYGMQLMVNQLGGEVAKA
HHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHCCHHHHC
DRGEYGKASLHIDDPTDLLTNVEDGTTMWMSHGDSVTKMPPGFEVLAHTDNTPCAAVADH
CCCCCCCEEEEECCHHHHHCCCCCCCEEEEECCCCCCCCCCCCEEEEECCCCCCCCCCCC
EKKLYGVQFHPEVVHSVGGLALIRNFVYHICECEPTWTTAAFVEEAIREVRAKVGDKRVL
CHHEEEEEECHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCEEE
LALSGGVDSSTLAFLMHKAIGDQLTCVFIDQGFMRKYEPERLVKLFQEQFHIPVEYVNAR
EEEECCCCHHHHHHHHHHHHCCCEEEEEECCHHHHCCCHHHHHHHHHHHCCCCHHHHCHH
DRFLDIMSGVTDPEEKRRRIGHEFIQVFEETSKNLGPFDYLAQGTLYPDVIESADTNVDP
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCHHHHHHCCCCCCC
QTGERVAVKIKSHHNVGGLPKDLRFKLVEPLRKLFKDEVRKVGRSVGLPEEIVQRQPFPG
CCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCC
PGLAIRILGEVTADRLNILRDADLIVRQEINQRGLYNEYWQAFAVLLPIRSVGVMGDQRT
CCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCC
YAYPIVLRIVKSEDGMTADWARVPYDVLEAISNRIVNEVKGVNRVVFDITSKPPGTIEWE
CCEEEEEEEEECCCCCCCHHHHCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MNTAVTLLTEQAPQPIEEFGQLERQIIIILDFGSQYSELIARRIRETQVYSEVLSYRTPA
CCCEEEEEECCCCCHHHHHHCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCH
EHLRQLNPKGIILSGGPSSVYSDRAPHCDPEIWNLGVPILGVCYGMQLMVNQLGGEVAKA
HHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHCCHHHHC
DRGEYGKASLHIDDPTDLLTNVEDGTTMWMSHGDSVTKMPPGFEVLAHTDNTPCAAVADH
CCCCCCCEEEEECCHHHHHCCCCCCCEEEEECCCCCCCCCCCCEEEEECCCCCCCCCCCC
EKKLYGVQFHPEVVHSVGGLALIRNFVYHICECEPTWTTAAFVEEAIREVRAKVGDKRVL
CHHEEEEEECHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCEEE
LALSGGVDSSTLAFLMHKAIGDQLTCVFIDQGFMRKYEPERLVKLFQEQFHIPVEYVNAR
EEEECCCCHHHHHHHHHHHHCCCEEEEEECCHHHHCCCHHHHHHHHHHHCCCCHHHHCHH
DRFLDIMSGVTDPEEKRRRIGHEFIQVFEETSKNLGPFDYLAQGTLYPDVIESADTNVDP
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCHHHHHHCCCCCCC
QTGERVAVKIKSHHNVGGLPKDLRFKLVEPLRKLFKDEVRKVGRSVGLPEEIVQRQPFPG
CCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCC
PGLAIRILGEVTADRLNILRDADLIVRQEINQRGLYNEYWQAFAVLLPIRSVGVMGDQRT
CCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCC
YAYPIVLRIVKSEDGMTADWARVPYDVLEAISNRIVNEVKGVNRVVFDITSKPPGTIEWE
CCEEEEEEEEECCCCCCCHHHHCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA