Click here to switch to the map view.

The map label for this gene is czcD [H]

Identifier: 17230337

GI number: 17230337

Start: 3465886

End: 3466731

Strand: Reverse

Name: czcD [H]

Synonym: all2845

Alternate gene names: 17230337

Gene position: 3466731-3465886 (Counterclockwise)

Preceding gene: 17230338

Following gene: 17230336

Centisome position: 54.05

GC content: 43.62

Gene sequence:

>846_bases
ATGCAGGAATGTACAAATGTTCAGGTATCGAAAATGATGCTTTCAGCACCACAGCATCTGGTGGGTGGCTCGGTATCCGA
GATAACTCCCAATCGTGACCTGAGTTTAGATTCAATGCACACAAGCCAGGTTAAGCAAAATATCCGGGCGCTGTGGACTG
CACTAGTATTACTCAGTGTCTTTTTTTGCATAGAACTTAGTGCAGGAATCTGGAGCCACAGTCTGTCCCTGTTAGCAGAT
GCAGAACACATTCTTTCAGATGTAGCAGCATTAGGCTTGGCACTAATTGCCTCTTGGCTATCTCAATCAATATCCCAGCG
AACTATATTTGGGCGCTACAAATTAGAAGTTTTAGCAGCCTTAATCAACGGTATTAGTTTAGCTTGTATTGCTTGTTGGA
TAGTGAGAGAAGCCTTAGTACGCTTGCAATCTCCAACCACAGAGATTCTGGGTGTACCGATGTTAACAACTGCATTAATA
GGTGTGGGAGTTAACAGTTTTAATGCTCTGTGTCTACACAAATGTAGCCATAAAGACCTCAATATTAGAGGTGCATTGCT
GCATCTGATAGCAGATTTAGCCAGTTCTGTTGGCGCAGTGTTAGCAGCGATCGCTATTATCTGGCTGAACTGGACTTGGG
CTGATGGTGTGATCAGCTTGGTTGTAGCAATGTTAATAGCTAGTTTTGCCGCTTATTTGTTGATTCAAAGCGTGCAGTGT
CTACGGGGTCAAATAGCCGATATTAGCGATATTGCCTGTATGTGTCCTCCACAATCAGAAGTTTGTGTAGACCGTCAGCA
GGCAGAAAAACTATTGTTTCCTACCTTGGAGGAACTTGTGCAATGA

Upstream 100 bases:

>100_bases
AGCAAATGATAACCATTCTTGTAGAACCCAGTCTCAGACTGAATTTTACTTAATATTAAACCTTAATTATAAAATCATTA
ACCTTAGGGCTGATACATTA

Downstream 100 bases:

>100_bases
TTTCCTTACTCAAACGTCATAAACGTTTTTTAGCTTGGTTTGTGTCTGGTTTAGTGGCAGTAATTTTCCTGTCCTGGGGA
ATTTCCGAAAAACAACCAGC

Product: cation-efflux system membrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MQECTNVQVSKMMLSAPQHLVGGSVSEITPNRDLSLDSMHTSQVKQNIRALWTALVLLSVFFCIELSAGIWSHSLSLLAD
AEHILSDVAALGLALIASWLSQSISQRTIFGRYKLEVLAALINGISLACIACWIVREALVRLQSPTTEILGVPMLTTALI
GVGVNSFNALCLHKCSHKDLNIRGALLHLIADLASSVGAVLAAIAIIWLNWTWADGVISLVVAMLIASFAAYLLIQSVQC
LRGQIADISDIACMCPPQSEVCVDRQQAEKLLFPTLEELVQ

Sequences:

>Translated_281_residues
MQECTNVQVSKMMLSAPQHLVGGSVSEITPNRDLSLDSMHTSQVKQNIRALWTALVLLSVFFCIELSAGIWSHSLSLLAD
AEHILSDVAALGLALIASWLSQSISQRTIFGRYKLEVLAALINGISLACIACWIVREALVRLQSPTTEILGVPMLTTALI
GVGVNSFNALCLHKCSHKDLNIRGALLHLIADLASSVGAVLAAIAIIWLNWTWADGVISLVVAMLIASFAAYLLIQSVQC
LRGQIADISDIACMCPPQSEVCVDRQQAEKLLFPTLEELVQ
>Mature_281_residues
MQECTNVQVSKMMLSAPQHLVGGSVSEITPNRDLSLDSMHTSQVKQNIRALWTALVLLSVFFCIELSAGIWSHSLSLLAD
AEHILSDVAALGLALIASWLSQSISQRTIFGRYKLEVLAALINGISLACIACWIVREALVRLQSPTTEILGVPMLTTALI
GVGVNSFNALCLHKCSHKDLNIRGALLHLIADLASSVGAVLAAIAIIWLNWTWADGVISLVVAMLIASFAAYLLIQSVQC
LRGQIADISDIACMCPPQSEVCVDRQQAEKLLFPTLEELVQ

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI52352805, Length=191, Percent_Identity=29.3193717277487, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI21359890, Length=219, Percent_Identity=30.1369863013699, Blast_Score=85, Evalue=6e-17,
Organism=Homo sapiens, GI21361112, Length=222, Percent_Identity=29.2792792792793, Blast_Score=75, Evalue=9e-14,
Organism=Escherichia coli, GI1786966, Length=222, Percent_Identity=38.7387387387387, Blast_Score=90, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17555794, Length=209, Percent_Identity=30.1435406698565, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17555796, Length=224, Percent_Identity=28.5714285714286, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI32564488, Length=220, Percent_Identity=30.9090909090909, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI193210990, Length=237, Percent_Identity=27.0042194092827, Blast_Score=74, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6320411, Length=180, Percent_Identity=31.1111111111111, Blast_Score=73, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 30356; Mature: 30356

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
3.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQECTNVQVSKMMLSAPQHLVGGSVSEITPNRDLSLDSMHTSQVKQNIRALWTALVLLSV
CCCCHHHHHHHHHHHCCHHHHCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
FFCIELSAGIWSHSLSLLADAEHILSDVAALGLALIASWLSQSISQRTIFGRYKLEVLAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LINGISLACIACWIVREALVRLQSPTTEILGVPMLTTALIGVGVNSFNALCLHKCSHKDL
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCC
NIRGALLHLIADLASSVGAVLAAIAIIWLNWTWADGVISLVVAMLIASFAAYLLIQSVQC
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRGQIADISDIACMCPPQSEVCVDRQQAEKLLFPTLEELVQ
HHHCCCCHHHHHHCCCCCHHHHHCHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MQECTNVQVSKMMLSAPQHLVGGSVSEITPNRDLSLDSMHTSQVKQNIRALWTALVLLSV
CCCCHHHHHHHHHHHCCHHHHCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
FFCIELSAGIWSHSLSLLADAEHILSDVAALGLALIASWLSQSISQRTIFGRYKLEVLAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LINGISLACIACWIVREALVRLQSPTTEILGVPMLTTALIGVGVNSFNALCLHKCSHKDL
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCC
NIRGALLHLIADLASSVGAVLAAIAIIWLNWTWADGVISLVVAMLIASFAAYLLIQSVQC
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRGQIADISDIACMCPPQSEVCVDRQQAEKLLFPTLEELVQ
HHHCCCCHHHHHHCCCCCHHHHHCHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA