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The map label for this gene is btuR [C]

Identifier: 17229883

GI number: 17229883

Start: 2874586

End: 2875722

Strand: Reverse

Name: btuR [C]

Synonym: all2391

Alternate gene names: 17229883

Gene position: 2875722-2874586 (Counterclockwise)

Preceding gene: 17229887

Following gene: 17229882

Centisome position: 44.84

GC content: 45.29

Gene sequence:

>1137_bases
ATGACAAGGAACGGCATCGGTATCCGCACAGCACAAGTGCGTTCAGAACGGCTTACTGGCCAAATTCATGTATATGATGG
TGTCGGTAAAGGTAAGTCACAAGCAGCGTTGGGTGTAGTTTTACGCTCCATAGGCTTAGGAATAAACGCACCGAACAATT
CCAATCGTGTACTGCTACTACGCTTTTTAAAAGGGCCAGAACGAGATTATGACGAAGACGGAGCGATCGCTGCTTTACAG
CGTGGATTCCCCCATTTAATTGACCAAGTACGCACCGGGAGAGCAGAATTTTTTGGCCCAGAAGAAATCACAACTTTTGA
CCGTAGTGAAGCGGGACGGGGTTGGGATGTCGCCAAAGGCGCGATCGCTTCTGGTTTATATTCTGTTGTTGTCTTAGATG
AAATTAACCCAGTTCTCGATTTAGGGTTACTTTCGGTAGATGAGGTAGTGGGGACATTAAAATCAAAACCCCAAGAGTTA
GAAATTATTGCCACAGGAAGAGGTGCGCCACAAAAATTACTTGACATTGCGGATTTACACTCAGAAATGAAACCCTTACA
CCACCCCAAAGCCACAGAACTTTTGATGACGGGGATTGAAATTTATACTGGTGCAGGTAAAGGTAAATCTACCAGTGCTT
TAGGTAAGGCATTACAAGCAATTGGCAGAGGTATCAACCATCCAGGGTCAACGCGGGTATTAATTATGCAGTGGCTCAAA
GGTGGTAGCGGCTATACAGAAGATGCAGCGATCTCAGCCTTGCGGCAATCATACCCTGAGGTGGTAGATCATCAACGCTG
TGGTCGAGATGCGATCGTTTGGCGCAATTCTCGACAAGAATTAGACTACGTAGAAGCAGAACGGGGTTGGGAAATAGCTA
AAGTTGCGATCGCCTCTGGACTATACAAAACCATCATCCTTGATGAACTCAATCCCACTGTTGATTTGGAACTACTCCCG
GTAGAACCAATTGTCCAAGCTTTACTTCGTAAACCCCGCGACACCGAAATCATCATTACTGGACGTTGCCAAAATCAACC
TGCTTACTTTGACCTAGCCAGTATTCACTCCGAAGTTTACTGCCACAAACATTATGCTAATCAAGGTGTAGAACTAAAAA
GGGGCGTAGATTTTTAA

Upstream 100 bases:

>100_bases
CTGTTGAGAACGGGTGTAAGGGTGTAAGGTTTTGAATTTAGAGCGTAGCGACCTAACCTCCGGTAAGATAGGAAACTGCC
ACGTTACAGCTTTTCAACAG

Downstream 100 bases:

>100_bases
ATTAGTCATTAGTTCTTCCTCCTGCTGTCTTGCCTCTCCCCAATCCCAGCAACATAAGTTGAAAATTTGATAAAAAACTT
TAAAATAAGGGTTTGGGGAG

Product: hypothetical protein

Products: Adenosylcobalamin; Phosphate; Diphosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 378; Mature: 377

Protein sequence:

>378_residues
MTRNGIGIRTAQVRSERLTGQIHVYDGVGKGKSQAALGVVLRSIGLGINAPNNSNRVLLLRFLKGPERDYDEDGAIAALQ
RGFPHLIDQVRTGRAEFFGPEEITTFDRSEAGRGWDVAKGAIASGLYSVVVLDEINPVLDLGLLSVDEVVGTLKSKPQEL
EIIATGRGAPQKLLDIADLHSEMKPLHHPKATELLMTGIEIYTGAGKGKSTSALGKALQAIGRGINHPGSTRVLIMQWLK
GGSGYTEDAAISALRQSYPEVVDHQRCGRDAIVWRNSRQELDYVEAERGWEIAKVAIASGLYKTIILDELNPTVDLELLP
VEPIVQALLRKPRDTEIIITGRCQNQPAYFDLASIHSEVYCHKHYANQGVELKRGVDF

Sequences:

>Translated_378_residues
MTRNGIGIRTAQVRSERLTGQIHVYDGVGKGKSQAALGVVLRSIGLGINAPNNSNRVLLLRFLKGPERDYDEDGAIAALQ
RGFPHLIDQVRTGRAEFFGPEEITTFDRSEAGRGWDVAKGAIASGLYSVVVLDEINPVLDLGLLSVDEVVGTLKSKPQEL
EIIATGRGAPQKLLDIADLHSEMKPLHHPKATELLMTGIEIYTGAGKGKSTSALGKALQAIGRGINHPGSTRVLIMQWLK
GGSGYTEDAAISALRQSYPEVVDHQRCGRDAIVWRNSRQELDYVEAERGWEIAKVAIASGLYKTIILDELNPTVDLELLP
VEPIVQALLRKPRDTEIIITGRCQNQPAYFDLASIHSEVYCHKHYANQGVELKRGVDF
>Mature_377_residues
TRNGIGIRTAQVRSERLTGQIHVYDGVGKGKSQAALGVVLRSIGLGINAPNNSNRVLLLRFLKGPERDYDEDGAIAALQR
GFPHLIDQVRTGRAEFFGPEEITTFDRSEAGRGWDVAKGAIASGLYSVVVLDEINPVLDLGLLSVDEVVGTLKSKPQELE
IIATGRGAPQKLLDIADLHSEMKPLHHPKATELLMTGIEIYTGAGKGKSTSALGKALQAIGRGINHPGSTRVLIMQWLKG
GSGYTEDAAISALRQSYPEVVDHQRCGRDAIVWRNSRQELDYVEAERGWEIAKVAIASGLYKTIILDELNPTVDLELLPV
EPIVQALLRKPRDTEIIITGRCQNQPAYFDLASIHSEVYCHKHYANQGVELKRGVDF

Specific function: Required For Both De Novo Synthesis Of The Corrin Ring For The Assimilation Of Exogenous Corrinoids. Participates In The Adenosylation Of A Variety Of Incomplete And Complete Corrinoids (By Similarity). [C]

COG id: COG2109

COG function: function code H; ATP:corrinoid adenosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1787525, Length=181, Percent_Identity=32.0441988950276, Blast_Score=81, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y2391_NOSS1 (P46080)

Other databases:

- EMBL:   BA000019
- EMBL:   U09240
- EMBL:   S76266
- PIR:   AH2104
- RefSeq:   NP_486431.1
- ProteinModelPortal:   P46080
- STRING:   P46080
- GeneID:   1105988
- GenomeReviews:   BA000019_GR
- KEGG:   ana:all2391
- NMPDR:   fig|103690.1.peg.2698
- eggNOG:   COG2109
- HOGENOM:   HBG287056
- OMA:   ADLHSEM
- PhylomeDB:   P46080
- ProtClustDB:   PRK07413
- BioCyc:   NSP103690:ALL2391-MONOMER
- InterPro:   IPR003724

Pfam domain/function: PF02572 CobA_CobO_BtuR

EC number: 2.5.1.17 [C]

Molecular weight: Translated: 41341; Mature: 41210

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRNGIGIRTAQVRSERLTGQIHVYDGVGKGKSQAALGVVLRSIGLGINAPNNSNRVLLL
CCCCCCCEEHHHHHHHHCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEE
RFLKGPERDYDEDGAIAALQRGFPHLIDQVRTGRAEFFGPEEITTFDRSEAGRGWDVAKG
EECCCCCCCCCCCCHHHHHHCCCHHHHHHHHCCCHHCCCCHHHCCCCCCCCCCCCHHHHH
AIASGLYSVVVLDEINPVLDLGLLSVDEVVGTLKSKPQELEIIATGRGAPQKLLDIADLH
HHHHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHH
SEMKPLHHPKATELLMTGIEIYTGAGKGKSTSALGKALQAIGRGINHPGSTRVLIMQWLK
HHHHHCCCCHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHC
GGSGYTEDAAISALRQSYPEVVDHQRCGRDAIVWRNSRQELDYVEAERGWEIAKVAIASG
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCHHCCHHHHHCCCHHHHHHHHHH
LYKTIILDELNPTVDLELLPVEPIVQALLRKPRDTEIIITGRCQNQPAYFDLASIHSEVY
HHHHHEECCCCCCEEEEEECHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEHHHHHHHHH
CHKHYANQGVELKRGVDF
HHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
TRNGIGIRTAQVRSERLTGQIHVYDGVGKGKSQAALGVVLRSIGLGINAPNNSNRVLLL
CCCCCCEEHHHHHHHHCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEE
RFLKGPERDYDEDGAIAALQRGFPHLIDQVRTGRAEFFGPEEITTFDRSEAGRGWDVAKG
EECCCCCCCCCCCCHHHHHHCCCHHHHHHHHCCCHHCCCCHHHCCCCCCCCCCCCHHHHH
AIASGLYSVVVLDEINPVLDLGLLSVDEVVGTLKSKPQELEIIATGRGAPQKLLDIADLH
HHHHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHH
SEMKPLHHPKATELLMTGIEIYTGAGKGKSTSALGKALQAIGRGINHPGSTRVLIMQWLK
HHHHHCCCCHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHC
GGSGYTEDAAISALRQSYPEVVDHQRCGRDAIVWRNSRQELDYVEAERGWEIAKVAIASG
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCHHCCHHHHHCCCHHHHHHHHHH
LYKTIILDELNPTVDLELLPVEPIVQALLRKPRDTEIIITGRCQNQPAYFDLASIHSEVY
HHHHHEECCCCCCEEEEEECHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEHHHHHHHHH
CHKHYANQGVELKRGVDF
HHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; Cob(I)alamin; H2O [C]

Specific reaction: ATP + Cob(I)alamin + H2O <==> Adenosylcobalamin + Phosphate + Diphosphate [C]

General reaction: Adenosyl group transfer [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11759840; 7883709