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The map label for this gene is Dml [H]

Identifier: 17229355

GI number: 17229355

Start: 2225862

End: 2226725

Strand: Reverse

Name: Dml [H]

Synonym: all1863

Alternate gene names: 17229355

Gene position: 2226725-2225862 (Counterclockwise)

Preceding gene: 17229356

Following gene: 17229354

Centisome position: 34.72

GC content: 45.6

Gene sequence:

>864_bases
ATGTCTTCTAGCCACAAACTGCGGCAGTTACTTGCAAATCCTGAAATTATTGTAATTCCTGGTATCTACGATTGCCTGAG
TGCCAAACTGGCTGAAAATATTGGTTTTGATGTGGTGGCTACCAGTGGTTTTGGTATTGCTGCATCTACTTTGGGTTTGC
CAGATTACGGTTTTCTTACAGCTACAGAAGCGCTTTATAGTGTGGGGCGTATTGCTCAGTCCGTGAGTGTTCCTCTCATT
GCCGATTTAGATACTGGCTATGGCAATGCTTTAAATGTGATGCGGACTATCAAGGATGCTGTGCAGTTGGGTGTGGCGGG
CGTATTGTTAGAAGACCAAGAATGGCCGAAAAAGTGCGGACATTTTGAAGGGAAGCGAGTTATACCCACATCTGAACACG
CTGGCAAAATTCGTGCAGCAGTAGAGGCGCGGGGTGATAGTGGTTTAGTCATTATTGCGCGTACCGATGCCCGTGGCCCA
CTGGGTTTAGAGGAAGCGATCGCCCGTGGTCATGCTTACATTGAGGCAGGCGCAGATATACTATTTGTGGAAGCTCCCCA
GTCTGTGGCAGAATTAAAGGCGATCGCCTCAGCTTTCCCTCACACACCCCTAGTAGCCAATATTGTTGAAGGCGGCAAAA
CTCCCCCACTATCTGCATCAGAACTACAAGATTTAGGCTTTAAAATCGTGTTTTTCCCCCTTACTGGTTTATTGGCAGTA
ACGCAAACTTTAACAGCTTGCTTAAGTCATATTAAAGAACAGGGAAGCACAGCTAATTTTACTGACATAGTGAACTTTCA
AGATTTTCAAGCCCTTGTCGGCGTTCCCCAATTTCTGCAAATGGAACAAAAGTTTAAATCGTAA

Upstream 100 bases:

>100_bases
TATATGGCGTACAGTCCTCTTTAATTACGAATTACGAACTACAAATTACGAATTATTCCCTTGTTGTATCCTCAAACTGT
TGCGTAATTTGTATTTTTAT

Downstream 100 bases:

>100_bases
GTCAAATAATTCTCATTTCCCGACTATGGCAAGATTAGCTAGGATCAGCATCTTGCCTTTGTGTTCAATTAACCTGCCAT
CTCAAAAGATTACCTTGAGT

Product: carboxyphosphonoenolpyruvate phosphonomutase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 287; Mature: 286

Protein sequence:

>287_residues
MSSSHKLRQLLANPEIIVIPGIYDCLSAKLAENIGFDVVATSGFGIAASTLGLPDYGFLTATEALYSVGRIAQSVSVPLI
ADLDTGYGNALNVMRTIKDAVQLGVAGVLLEDQEWPKKCGHFEGKRVIPTSEHAGKIRAAVEARGDSGLVIIARTDARGP
LGLEEAIARGHAYIEAGADILFVEAPQSVAELKAIASAFPHTPLVANIVEGGKTPPLSASELQDLGFKIVFFPLTGLLAV
TQTLTACLSHIKEQGSTANFTDIVNFQDFQALVGVPQFLQMEQKFKS

Sequences:

>Translated_287_residues
MSSSHKLRQLLANPEIIVIPGIYDCLSAKLAENIGFDVVATSGFGIAASTLGLPDYGFLTATEALYSVGRIAQSVSVPLI
ADLDTGYGNALNVMRTIKDAVQLGVAGVLLEDQEWPKKCGHFEGKRVIPTSEHAGKIRAAVEARGDSGLVIIARTDARGP
LGLEEAIARGHAYIEAGADILFVEAPQSVAELKAIASAFPHTPLVANIVEGGKTPPLSASELQDLGFKIVFFPLTGLLAV
TQTLTACLSHIKEQGSTANFTDIVNFQDFQALVGVPQFLQMEQKFKS
>Mature_286_residues
SSSHKLRQLLANPEIIVIPGIYDCLSAKLAENIGFDVVATSGFGIAASTLGLPDYGFLTATEALYSVGRIAQSVSVPLIA
DLDTGYGNALNVMRTIKDAVQLGVAGVLLEDQEWPKKCGHFEGKRVIPTSEHAGKIRAAVEARGDSGLVIIARTDARGPL
GLEEAIARGHAYIEAGADILFVEAPQSVAELKAIASAFPHTPLVANIVEGGKTPPLSASELQDLGFKIVFFPLTGLLAVT
QTLTACLSHIKEQGSTANFTDIVNFQDFQALVGVPQFLQMEQKFKS

Specific function: Catalyzes the formation of proponate and pyruvate from (2R,3S)-2,3-dimethylmalate. Has no activity toward dimethylmaleate, malate, citramalate, isocitrate and citrate [H]

COG id: COG2513

COG function: function code G; PEP phosphonomutase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate lyase/PEP mutase superfamily [H]

Homologues:

Organism=Escherichia coli, GI1786525, Length=282, Percent_Identity=35.4609929078014, Blast_Score=172, Evalue=2e-44,
Organism=Escherichia coli, GI1790445, Length=205, Percent_Identity=30.2439024390244, Blast_Score=72, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI71982926, Length=135, Percent_Identity=38.5185185185185, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17561814, Length=135, Percent_Identity=38.5185185185185, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320908, Length=103, Percent_Identity=35.9223300970874, Blast_Score=62, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000918
- InterPro:   IPR018523
- InterPro:   IPR015813 [H]

Pfam domain/function: PF00463 ICL [H]

EC number: =4.1.3.32 [H]

Molecular weight: Translated: 30415; Mature: 30284

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSSHKLRQLLANPEIIVIPGIYDCLSAKLAENIGFDVVATSGFGIAASTLGLPDYGFLT
CCCHHHHHHHHCCCCEEEECCHHHHHHHHHHHHCCCEEEEECCCCHHHHHCCCCCCCHHH
ATEALYSVGRIAQSVSVPLIADLDTGYGNALNVMRTIKDAVQLGVAGVLLEDQEWPKKCG
HHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHEEECCCHHHHHCC
HFEGKRVIPTSEHAGKIRAAVEARGDSGLVIIARTDARGPLGLEEAIARGHAYIEAGADI
CCCCCCCCCCCCCCCHHHHEEEECCCCCEEEEEECCCCCCCCHHHHHHCCCCEEECCCCE
LFVEAPQSVAELKAIASAFPHTPLVANIVEGGKTPPLSASELQDLGFKIVFFPLTGLLAV
EEEECCHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCHHHHHHCCCEEEEHHHHHHHHH
TQTLTACLSHIKEQGSTANFTDIVNFQDFQALVGVPQFLQMEQKFKS
HHHHHHHHHHHHHCCCCCCHHCCCCHHHHHHHHCCHHHHHHHHHHCC
>Mature Secondary Structure 
SSSHKLRQLLANPEIIVIPGIYDCLSAKLAENIGFDVVATSGFGIAASTLGLPDYGFLT
CCHHHHHHHHCCCCEEEECCHHHHHHHHHHHHCCCEEEEECCCCHHHHHCCCCCCCHHH
ATEALYSVGRIAQSVSVPLIADLDTGYGNALNVMRTIKDAVQLGVAGVLLEDQEWPKKCG
HHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHEEECCCHHHHHCC
HFEGKRVIPTSEHAGKIRAAVEARGDSGLVIIARTDARGPLGLEEAIARGHAYIEAGADI
CCCCCCCCCCCCCCCHHHHEEEECCCCCEEEEEECCCCCCCCHHHHHHCCCCEEECCCCE
LFVEAPQSVAELKAIASAFPHTPLVANIVEGGKTPPLSASELQDLGFKIVFFPLTGLLAV
EEEECCHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCHHHHHHCCCEEEEHHHHHHHHH
TQTLTACLSHIKEQGSTANFTDIVNFQDFQALVGVPQFLQMEQKFKS
HHHHHHHHHHHHHCCCCCCHHCCCCHHHHHHHHCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA