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The map label for this gene is cusR [H]

Identifier: 17227568

GI number: 17227568

Start: 75965

End: 76639

Strand: Direct

Name: cusR [H]

Synonym: alr0072

Alternate gene names: 17227568

Gene position: 75965-76639 (Clockwise)

Preceding gene: 17227565

Following gene: 17227569

Centisome position: 1.18

GC content: 45.33

Gene sequence:

>675_bases
ATGCGGATATTACTAGTGGAAGATGATTATGAACAATTAGAGCCATTACAAGGTATCTTATCGGAAGCTGGCTATATTGT
AGATACGGCGGAAGACGGAGAAATAGCCGAGTGGTTGATTTCCCAAAAGGATTATGACCTATTGATTTTAGATTGGATGC
TACCCACAATAAGCGGATTAAGTTTGTGTCGCCAGTATCGTTGTTCGGGCAAAACTGCACCTATATTGATGCTAACAGCT
AGAGACACCACACCAGACAAAGTGATGGGTTTAGATGCTGGTGCAGATGATTATCTCGTCAAACCCGCAGACTTAGTGGA
ACTGTTGGCGCGGGTTCGTGCTTTAGCAAGGCGAGTCCCTAATTGGCAAGGAGACAGCTTGCGCGTTGCAGACTTACAAT
TGCATCTAGCATATTTAACCGTAGAACGAGAGCAAATTAAGGTCGAGCTATCTCCCCGCGAAGCACGATTACTCGAATAT
CTCATGCGTCACCCCAATCAGGTTTTAACTCGCAGCCAGATAGAAGAAGCCCTGTGGGAGTGGGGAATGGAACCAGAAAG
CAATGCTTTAACTGTACTGGTACGCAAGCTGCGACACCGTTTGCAGCAAGTAGATGCAGCAGAGTGGATTAGAACGGTTT
ATGGTATGGGTTATCGCCTAAATCCACAATATTAA

Upstream 100 bases:

>100_bases
TGGTCGAACAAATCAAAATATAAAATTGAGATAGTAATGATGATAGAAAAACACTTATCTTTATTAAAAAGCATCTAACA
ATCCCATCCCCAAAAATATT

Downstream 100 bases:

>100_bases
ATATTGTCAATCAATGGGATAATTGCGTAAAAGATAGGGACTGGGAATTGGGAACTAGGTAAAACCAGATAACATAACTA
ATACCCATTACCTATTACCC

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MRILLVEDDYEQLEPLQGILSEAGYIVDTAEDGEIAEWLISQKDYDLLILDWMLPTISGLSLCRQYRCSGKTAPILMLTA
RDTTPDKVMGLDAGADDYLVKPADLVELLARVRALARRVPNWQGDSLRVADLQLHLAYLTVEREQIKVELSPREARLLEY
LMRHPNQVLTRSQIEEALWEWGMEPESNALTVLVRKLRHRLQQVDAAEWIRTVYGMGYRLNPQY

Sequences:

>Translated_224_residues
MRILLVEDDYEQLEPLQGILSEAGYIVDTAEDGEIAEWLISQKDYDLLILDWMLPTISGLSLCRQYRCSGKTAPILMLTA
RDTTPDKVMGLDAGADDYLVKPADLVELLARVRALARRVPNWQGDSLRVADLQLHLAYLTVEREQIKVELSPREARLLEY
LMRHPNQVLTRSQIEEALWEWGMEPESNALTVLVRKLRHRLQQVDAAEWIRTVYGMGYRLNPQY
>Mature_224_residues
MRILLVEDDYEQLEPLQGILSEAGYIVDTAEDGEIAEWLISQKDYDLLILDWMLPTISGLSLCRQYRCSGKTAPILMLTA
RDTTPDKVMGLDAGADDYLVKPADLVELLARVRALARRVPNWQGDSLRVADLQLHLAYLTVEREQIKVELSPREARLLEY
LMRHPNQVLTRSQIEEALWEWGMEPESNALTVLVRKLRHRLQQVDAAEWIRTVYGMGYRLNPQY

Specific function: Member of the two-component regulatory system CusS/CusR. Activates the expression of cusCFBA in response to increasing levels of copper ions, and probably silver ions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=221, Percent_Identity=42.0814479638009, Blast_Score=165, Evalue=2e-42,
Organism=Escherichia coli, GI1789402, Length=223, Percent_Identity=39.4618834080717, Blast_Score=146, Evalue=1e-36,
Organism=Escherichia coli, GI87082012, Length=220, Percent_Identity=36.8181818181818, Blast_Score=144, Evalue=5e-36,
Organism=Escherichia coli, GI1790552, Length=220, Percent_Identity=39.0909090909091, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI1786599, Length=226, Percent_Identity=33.6283185840708, Blast_Score=124, Evalue=6e-30,
Organism=Escherichia coli, GI1787375, Length=220, Percent_Identity=35.9090909090909, Blast_Score=120, Evalue=9e-29,
Organism=Escherichia coli, GI1789809, Length=229, Percent_Identity=31.4410480349345, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1790860, Length=219, Percent_Identity=32.8767123287671, Blast_Score=107, Evalue=6e-25,
Organism=Escherichia coli, GI1787229, Length=226, Percent_Identity=31.858407079646, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1788394, Length=226, Percent_Identity=32.7433628318584, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1790863, Length=230, Percent_Identity=30.4347826086957, Blast_Score=103, Evalue=9e-24,
Organism=Escherichia coli, GI1786911, Length=221, Percent_Identity=34.3891402714932, Blast_Score=98, Evalue=4e-22,
Organism=Escherichia coli, GI2367329, Length=226, Percent_Identity=34.070796460177, Blast_Score=96, Evalue=1e-21,
Organism=Escherichia coli, GI145693140, Length=236, Percent_Identity=27.5423728813559, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788521, Length=106, Percent_Identity=36.7924528301887, Blast_Score=61, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25807; Mature: 25807

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILLVEDDYEQLEPLQGILSEAGYIVDTAEDGEIAEWLISQKDYDLLILDWMLPTISGL
CEEEEEECCHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHCCCCCCEEEHHHHHHHHHHH
SLCRQYRCSGKTAPILMLTARDTTPDKVMGLDAGADDYLVKPADLVELLARVRALARRVP
HHHHHHHCCCCCCCEEEEEECCCCCHHEEECCCCCCCCEECCHHHHHHHHHHHHHHHHCC
NWQGDSLRVADLQLHLAYLTVEREQIKVELSPREARLLEYLMRHPNQVLTRSQIEEALWE
CCCCCCEEEEHHEEEEHHEEEEHHHEEEEECCHHHHHHHHHHHCCHHHHHHHHHHHHHHH
WGMEPESNALTVLVRKLRHRLQQVDAAEWIRTVYGMGYRLNPQY
CCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCEEECCCC
>Mature Secondary Structure
MRILLVEDDYEQLEPLQGILSEAGYIVDTAEDGEIAEWLISQKDYDLLILDWMLPTISGL
CEEEEEECCHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHCCCCCCEEEHHHHHHHHHHH
SLCRQYRCSGKTAPILMLTARDTTPDKVMGLDAGADDYLVKPADLVELLARVRALARRVP
HHHHHHHCCCCCCCEEEEEECCCCCHHEEECCCCCCCCEECCHHHHHHHHHHHHHHHHCC
NWQGDSLRVADLQLHLAYLTVEREQIKVELSPREARLLEYLMRHPNQVLTRSQIEEALWE
CCCCCCEEEEHHEEEEHHEEEEHHHEEEEECCHHHHHHHHHHHCCHHHHHHHHHHHHHHH
WGMEPESNALTVLVRKLRHRLQQVDAAEWIRTVYGMGYRLNPQY
CCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]