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The map label for this gene is hisB

Identifier: 17227569

GI number: 17227569

Start: 76760

End: 77551

Strand: Direct

Name: hisB

Synonym: alr0073

Alternate gene names: NA

Gene position: 76760-77551 (Clockwise)

Preceding gene: 17227568

Following gene: 17227570

Centisome position: 1.2

GC content: 43.06

Gene sequence:

>792_bases
ATGACTACAAAAGCGATCGCTGTATTTGATATAGATGGAGTTATCCGCGATGTTGGTGGTTCCTATCGTCGAGCCTTAGC
AGACACGGTAGAGTATTTTACAAACAACGCCTATCGTCCCACCTCTTTAGAAATTGACGAACTCAAATCCGAAGGTATTT
GGAATAACGATTGGGAAGCGTCTCAAGAATTAATCTCCCGTTACCTTGCGGAGCAAGGAACACCCCGTGAACAATTGCAG
CTAAACTACAACACTATAGTTGCCTTTTTTCAATCCCGTTACCGTGGCCCAGACCCAGATAATTGGACGGGATATATCTG
TGATGAACCGTTATTATTACAACCAAGTTATTTAGAAGAACTTACACAAGCGGGTATTGCTTGGGGATTTTTTAGTGGTG
CTACTCGTGGTTCTGCTAACTATGTTTTAAAACAACGTTTGGGTTTACAGTCTCCTGTACTCATTGCAATGGAAGATGCG
CCAGGTAAACCAGACCCCACAGGTCTTTTTGCAACTATTAACCAGTTAGAGGATGGGCTAGAGGAAAAATCAGTAGTTCT
CTATGTCGGAGACACGGTAGCAGATATGTACACAGTCAGCAAGGCTAGAGAACTCAAACCTCACCGTACTTGGATTGGAG
TAGGTATCTTACCTCCTCATGTCCAAGAAACAGCAGCCCGTCGAGAAGCTTATGCACAAACACTAGTAACAGCCGGTGCA
GCAGTAGTTTTGAGTAATGTTGAACAGTTAAATCCAGCGCAAATACAAGATTTATTACAGCAATTGTGTTGA

Upstream 100 bases:

>100_bases
AATTGCGTAAAAGATAGGGACTGGGAATTGGGAACTAGGTAAAACCAGATAACATAACTAATACCCATTACCTATTACCC
ATTACCCATGAACAGTTTTG

Downstream 100 bases:

>100_bases
CCGGAAAAGGCAAGGGGAAAGGGAGCAGGGAGGCTCACAAGTATAGGTTTTTAAAAAATTACCAAATCTAGAGGCTAGAT
TTACATAATTAGCAACTGGG

Product: imidazoleglycerol-phosphate dehydratase

Products: 3-(imidazol-4-yl)-2-oxopropyl phosphate; H2O

Alternate protein names: HAD Family Hydrolase; HAD Superfamily Hydrolase; HAD Superfamily Phosphatase; HAD Superfamily Hydrolase TIGR

Number of amino acids: Translated: 263; Mature: 262

Protein sequence:

>263_residues
MTTKAIAVFDIDGVIRDVGGSYRRALADTVEYFTNNAYRPTSLEIDELKSEGIWNNDWEASQELISRYLAEQGTPREQLQ
LNYNTIVAFFQSRYRGPDPDNWTGYICDEPLLLQPSYLEELTQAGIAWGFFSGATRGSANYVLKQRLGLQSPVLIAMEDA
PGKPDPTGLFATINQLEDGLEEKSVVLYVGDTVADMYTVSKARELKPHRTWIGVGILPPHVQETAARREAYAQTLVTAGA
AVVLSNVEQLNPAQIQDLLQQLC

Sequences:

>Translated_263_residues
MTTKAIAVFDIDGVIRDVGGSYRRALADTVEYFTNNAYRPTSLEIDELKSEGIWNNDWEASQELISRYLAEQGTPREQLQ
LNYNTIVAFFQSRYRGPDPDNWTGYICDEPLLLQPSYLEELTQAGIAWGFFSGATRGSANYVLKQRLGLQSPVLIAMEDA
PGKPDPTGLFATINQLEDGLEEKSVVLYVGDTVADMYTVSKARELKPHRTWIGVGILPPHVQETAARREAYAQTLVTAGA
AVVLSNVEQLNPAQIQDLLQQLC
>Mature_262_residues
TTKAIAVFDIDGVIRDVGGSYRRALADTVEYFTNNAYRPTSLEIDELKSEGIWNNDWEASQELISRYLAEQGTPREQLQL
NYNTIVAFFQSRYRGPDPDNWTGYICDEPLLLQPSYLEELTQAGIAWGFFSGATRGSANYVLKQRLGLQSPVLIAMEDAP
GKPDPTGLFATINQLEDGLEEKSVVLYVGDTVADMYTVSKARELKPHRTWIGVGILPPHVQETAARREAYAQTLVTAGAA
VVLSNVEQLNPAQIQDLLQQLC

Specific function: Unknown

COG id: COG0546

COG function: function code R; Predicted phosphatases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 4.2.1.19

Molecular weight: Translated: 29218; Mature: 29087

Theoretical pI: Translated: 4.34; Mature: 4.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTKAIAVFDIDGVIRDVGGSYRRALADTVEYFTNNAYRPTSLEIDELKSEGIWNNDWEA
CCCCEEEEEEHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCCCHHH
SQELISRYLAEQGTPREQLQLNYNTIVAFFQSRYRGPDPDNWTGYICDEPLLLQPSYLEE
HHHHHHHHHHHCCCCHHHEEECHHHHHHHHHHHCCCCCCCCCCEEEECCCEEECCHHHHH
LTQAGIAWGFFSGATRGSANYVLKQRLGLQSPVLIAMEDAPGKPDPTGLFATINQLEDGL
HHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCC
EEKSVVLYVGDTVADMYTVSKARELKPHRTWIGVGILPPHVQETAARREAYAQTLVTAGA
CCCEEEEEECCHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
AVVLSNVEQLNPAQIQDLLQQLC
HHHHHHHHHCCHHHHHHHHHHHC
>Mature Secondary Structure 
TTKAIAVFDIDGVIRDVGGSYRRALADTVEYFTNNAYRPTSLEIDELKSEGIWNNDWEA
CCCEEEEEEHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCCCHHH
SQELISRYLAEQGTPREQLQLNYNTIVAFFQSRYRGPDPDNWTGYICDEPLLLQPSYLEE
HHHHHHHHHHHCCCCHHHEEECHHHHHHHHHHHCCCCCCCCCCEEEECCCEEECCHHHHH
LTQAGIAWGFFSGATRGSANYVLKQRLGLQSPVLIAMEDAPGKPDPTGLFATINQLEDGL
HHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCC
EEKSVVLYVGDTVADMYTVSKARELKPHRTWIGVGILPPHVQETAARREAYAQTLVTAGA
CCCEEEEEECCHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
AVVLSNVEQLNPAQIQDLLQQLC
HHHHHHHHHCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate

Specific reaction: D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA