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The map label for this gene is menB [H]

Identifier: 172087717

GI number: 172087717

Start: 1878192

End: 1879073

Strand: Reverse

Name: menB [H]

Synonym: VF_1669

Alternate gene names: 172087717

Gene position: 1879073-1878192 (Counterclockwise)

Preceding gene: 59712277

Following gene: 59712274

Centisome position: 64.85

GC content: 45.35

Gene sequence:

>882_bases
ATGGACATAAATCCCATGGCAAGAACTGTTGGCATTTCAGAAGAAGAACTTTACGCTCCAGTAGATTGGACAGATTGCAC
TGCGCAATACGAAGACATTCAGTACCACAAATCAGCAGATGGTATCGCAAAGATTACGATTGCTCGTCCACAAGTGCGTA
ACGCATTTCGTCCGGGCACAGTAAAAGAGATGATCGATGCGTTAGCGGATGCACGTTACGATGAAAAAGTAGGTGTGATC
ATTTTAACTGGTTTAGGTGAAGACGCATTCTGTTCAGGTGGCGACCAGAAGATCCGTGGCGATTACGGCGGTTACCGTGA
TGACAGTGGTACACACCACTTAAACGTATTGGATTTCCAACGTCAAATCCGTACTTGTCCAAAACCAGTGATTGCTGCAG
TAGCAGGTTACGCTGTTGGTGGTGGTCATGTTCTTCATATGATGTGTGATTTAACCATTGCTGCTGAAAATGCACAGTTT
GGTCAAACAGGTCCTAAAGTAGGTTCTTTTGACGGTGGTTGGGGTGCTTCTTACATGGCTCGCATCGTTGGTCAGAAGAA
AGCTCGTGAAATCTGGTTCCTTTGCCGTTTCTACGATGCTCAAGAAGCGTTGGATATGGGTTTAGTAAACACGGTTGTTC
CTGTTGCTGATCTAGAAAAAGAAACGGTTCGTTGGTGTCGTGAAACACTACAACACAGCCCAATGGCATTACGTTGTCTA
AAAGCGGCGTTAAATGCTGATTGTGATGGCCAAGCAGGTCTTCAAGAGTTAGCGGGTAACGCAACAATGATGTTCTACAT
GACAGAAGAAGGTCAAGAGGGTCGTAACGCGTTTAACGAAAAACGTCGTCCAGACTTCGATAAGTTCCCTCGTAACCCAT
AA

Upstream 100 bases:

>100_bases
AAAGTCAATTAACGTATCAAATCATTGCTCAGGCAGGGCATAACGCTCATGTGGAACAGCCCGAACGCTTTACACATGTA
CTTAATACATTCTTACAACA

Downstream 100 bases:

>100_bases
TTCGCTGTTACAGATTCAATTAAGTATTAGAGGCTCCTTTGAGTCTCTTTTTTCTTTTATTGGTTGGAGTAAGAGATGAA
AACAGCCAAGATCTATCAAT

Product: naphthoate synthase

Products: NA

Alternate protein names: DHNA-CoA synthase [H]

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MDINPMARTVGISEEELYAPVDWTDCTAQYEDIQYHKSADGIAKITIARPQVRNAFRPGTVKEMIDALADARYDEKVGVI
ILTGLGEDAFCSGGDQKIRGDYGGYRDDSGTHHLNVLDFQRQIRTCPKPVIAAVAGYAVGGGHVLHMMCDLTIAAENAQF
GQTGPKVGSFDGGWGASYMARIVGQKKAREIWFLCRFYDAQEALDMGLVNTVVPVADLEKETVRWCRETLQHSPMALRCL
KAALNADCDGQAGLQELAGNATMMFYMTEEGQEGRNAFNEKRRPDFDKFPRNP

Sequences:

>Translated_293_residues
MDINPMARTVGISEEELYAPVDWTDCTAQYEDIQYHKSADGIAKITIARPQVRNAFRPGTVKEMIDALADARYDEKVGVI
ILTGLGEDAFCSGGDQKIRGDYGGYRDDSGTHHLNVLDFQRQIRTCPKPVIAAVAGYAVGGGHVLHMMCDLTIAAENAQF
GQTGPKVGSFDGGWGASYMARIVGQKKAREIWFLCRFYDAQEALDMGLVNTVVPVADLEKETVRWCRETLQHSPMALRCL
KAALNADCDGQAGLQELAGNATMMFYMTEEGQEGRNAFNEKRRPDFDKFPRNP
>Mature_293_residues
MDINPMARTVGISEEELYAPVDWTDCTAQYEDIQYHKSADGIAKITIARPQVRNAFRPGTVKEMIDALADARYDEKVGVI
ILTGLGEDAFCSGGDQKIRGDYGGYRDDSGTHHLNVLDFQRQIRTCPKPVIAAVAGYAVGGGHVLHMMCDLTIAAENAQF
GQTGPKVGSFDGGWGASYMARIVGQKKAREIWFLCRFYDAQEALDMGLVNTVVPVADLEKETVRWCRETLQHSPMALRCL
KAALNADCDGQAGLQELAGNATMMFYMTEEGQEGRNAFNEKRRPDFDKFPRNP

Specific function: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) [H]

COG id: COG0447

COG function: function code H; Dihydroxynaphthoic acid synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=264, Percent_Identity=33.7121212121212, Blast_Score=121, Evalue=7e-28,
Organism=Homo sapiens, GI31542718, Length=253, Percent_Identity=33.201581027668, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI4502327, Length=253, Percent_Identity=30.4347826086957, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI45643119, Length=209, Percent_Identity=30.1435406698565, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI260275230, Length=209, Percent_Identity=30.1435406698565, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI260274832, Length=209, Percent_Identity=30.1435406698565, Blast_Score=78, Evalue=8e-15,
Organism=Homo sapiens, GI25453481, Length=251, Percent_Identity=25.0996015936255, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI51538573, Length=251, Percent_Identity=25.0996015936255, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI4757966, Length=251, Percent_Identity=25.0996015936255, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI51538581, Length=251, Percent_Identity=25.0996015936255, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI4757968, Length=251, Percent_Identity=25.4980079681275, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI49355787, Length=251, Percent_Identity=25.4980079681275, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI68989263, Length=214, Percent_Identity=28.5046728971963, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI70995211, Length=238, Percent_Identity=27.7310924369748, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1788597, Length=280, Percent_Identity=85.7142857142857, Blast_Score=513, Evalue=1e-147,
Organism=Escherichia coli, GI1787659, Length=245, Percent_Identity=32.2448979591837, Blast_Score=110, Evalue=9e-26,
Organism=Escherichia coli, GI87082183, Length=237, Percent_Identity=29.535864978903, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI221142681, Length=257, Percent_Identity=29.9610894941634, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1787660, Length=256, Percent_Identity=28.515625, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17554946, Length=249, Percent_Identity=33.3333333333333, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI25145438, Length=252, Percent_Identity=34.1269841269841, Blast_Score=114, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI17540714, Length=207, Percent_Identity=30.9178743961353, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17535521, Length=255, Percent_Identity=27.4509803921569, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17560910, Length=203, Percent_Identity=29.5566502463054, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17534483, Length=223, Percent_Identity=28.2511210762332, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI20129971, Length=262, Percent_Identity=35.1145038167939, Blast_Score=123, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24653477, Length=262, Percent_Identity=35.1145038167939, Blast_Score=123, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24653139, Length=255, Percent_Identity=30.1960784313725, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI21357171, Length=180, Percent_Identity=32.2222222222222, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24654903, Length=190, Percent_Identity=30.5263157894737, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24650670, Length=174, Percent_Identity=29.8850574712644, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376
- InterPro:   IPR010198 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.1.3.36 [H]

Molecular weight: Translated: 32384; Mature: 32384

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS00018 EF_HAND_1 ; PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDINPMARTVGISEEELYAPVDWTDCTAQYEDIQYHKSADGIAKITIARPQVRNAFRPGT
CCCCCCHHHCCCCHHHEECCCCCCCCHHHHHHHHHHCCCCCEEEEEEECHHHHHCCCCCH
VKEMIDALADARYDEKVGVIILTGLGEDAFCSGGDQKIRGDYGGYRDDSGTHHLNVLDFQ
HHHHHHHHHCCCCCCCCCEEEEECCCCCHHCCCCCCEECCCCCCCCCCCCCEEEEHHHHH
RQIRTCPKPVIAAVAGYAVGGGHVLHMMCDLTIAAENAQFGQTGPKVGSFDGGWGASYMA
HHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCCHHHHHH
RIVGQKKAREIWFLCRFYDAQEALDMGLVNTVVPVADLEKETVRWCRETLQHSPMALRCL
HHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCHHHCCHHHHHHHHHHHHCCCHHHHHH
KAALNADCDGQAGLQELAGNATMMFYMTEEGQEGRNAFNEKRRPDFDKFPRNP
HHHHCCCCCCCHHHHHHCCCCEEEEEECCCCCCHHHHHHHHCCCCHHCCCCCC
>Mature Secondary Structure
MDINPMARTVGISEEELYAPVDWTDCTAQYEDIQYHKSADGIAKITIARPQVRNAFRPGT
CCCCCCHHHCCCCHHHEECCCCCCCCHHHHHHHHHHCCCCCEEEEEEECHHHHHCCCCCH
VKEMIDALADARYDEKVGVIILTGLGEDAFCSGGDQKIRGDYGGYRDDSGTHHLNVLDFQ
HHHHHHHHHCCCCCCCCCEEEEECCCCCHHCCCCCCEECCCCCCCCCCCCCEEEEHHHHH
RQIRTCPKPVIAAVAGYAVGGGHVLHMMCDLTIAAENAQFGQTGPKVGSFDGGWGASYMA
HHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCCHHHHHH
RIVGQKKAREIWFLCRFYDAQEALDMGLVNTVVPVADLEKETVRWCRETLQHSPMALRCL
HHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCHHHCCHHHHHHHHHHHHCCCHHHHHH
KAALNADCDGQAGLQELAGNATMMFYMTEEGQEGRNAFNEKRRPDFDKFPRNP
HHHHCCCCCCCHHHHHHCCCCEEEEEECCCCCCHHHHHHHHCCCCHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]