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The map label for this gene is purM

Identifier: 170756492

GI number: 170756492

Start: 3112928

End: 3113923

Strand: Reverse

Name: purM

Synonym: CLD_1665

Alternate gene names: 170756492

Gene position: 3113923-3112928 (Counterclockwise)

Preceding gene: 170755843

Following gene: 170757645

Centisome position: 78.67

GC content: 30.12

Gene sequence:

>996_bases
ATGGTATCTTACAAAGAAGCTGGGGTTAACATAGAGGAAGGTTACAAATCTGTAGATCTTATAAAAAAACATGCTTCCAA
AACTTTTACAAAGGGAGTATTAAATAATTTAGGAAGTTTTGCAGGAATGTTTGAACTTCCTAAATATAAAAATCCTGTAT
TAGTATCAGGTACAGATGGAGTTGGAACTAAATTAGATATAGCCTTTAGAATGAAAAAATATAATACAGTAGGAATAGAT
TGTGTAGCTATGTGTGTAAATGATATATTATGCCATGGTGCTAAACCGTTATTTTTCTTAGATTATATAGCTTGCGGGAA
ATTGGAATCAGAGATTGCAGCTCAGCTTGTAGAAGGGGTTAGTAATGGTTGTATCCAAAGTGAATGTGCTCTAATAGGTG
GAGAAACAGCAGAAATGCCAGGCTTTTATAGAGATGGGGAATATGATATAGCTGGTTTTGCTGTAGGTATAGCAGAAAAA
GATGAAATAATAGATGGAAGTAAAATAGAAGATGGGGATATATTAATAGGTATAGCATCTTCAGGACCTCATAGCAACGG
ATATTCTCTTATAAGAAAATTAGTAGAAGATTTACATAAAGATTTTGAAGGAAATAAAATAGGAAATACTCTTTTAACTC
CTACAAAAATATATGTAAAACCTGTAATGAAACTTTTAGAAAAATATAATATAAAAGGTATGGCTCATGTAACTGGAGGA
GGTTTTTATGAAAATATTCCTAGAATGTTTAAAGAGGATTTTACAGCAGTTATAAATAAAAAATCTTATCCATTACCAAA
TATATTTAGCCATTTAATGAGTTTAGGGATAGAAGAAGATCATATGTACAATACTTTTAATATGGGGATTGGTTTTGTAT
TATGTGTAAATGAAAAAGATGGGGAAAATATAATAAAAGACCTGATAGAAATGGGAGAAAAGGGTTATAAAATAGGATAT
GTTAAAAAAGGAGATAAGTCTGTTGAACTAATTTAA

Upstream 100 bases:

>100_bases
ATTTAATCGATTATTTTTTCATGATCCTAAAGTTAAAATAACTTAATATAGTTTTTTTATTGGTAGAATAACTAATAATT
TAAAGAAGGGAATGTTATTC

Downstream 100 bases:

>100_bases
AAAATAGTGCTAAAGGATTTATAATAATAATTAGTTTATAGGTTAGAGCTTTAAAATAATTAATTAGGGAATTAATTATT
TATAGAATATACATGAAAAA

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 331; Mature: 331

Protein sequence:

>331_residues
MVSYKEAGVNIEEGYKSVDLIKKHASKTFTKGVLNNLGSFAGMFELPKYKNPVLVSGTDGVGTKLDIAFRMKKYNTVGID
CVAMCVNDILCHGAKPLFFLDYIACGKLESEIAAQLVEGVSNGCIQSECALIGGETAEMPGFYRDGEYDIAGFAVGIAEK
DEIIDGSKIEDGDILIGIASSGPHSNGYSLIRKLVEDLHKDFEGNKIGNTLLTPTKIYVKPVMKLLEKYNIKGMAHVTGG
GFYENIPRMFKEDFTAVINKKSYPLPNIFSHLMSLGIEEDHMYNTFNMGIGFVLCVNEKDGENIIKDLIEMGEKGYKIGY
VKKGDKSVELI

Sequences:

>Translated_331_residues
MVSYKEAGVNIEEGYKSVDLIKKHASKTFTKGVLNNLGSFAGMFELPKYKNPVLVSGTDGVGTKLDIAFRMKKYNTVGID
CVAMCVNDILCHGAKPLFFLDYIACGKLESEIAAQLVEGVSNGCIQSECALIGGETAEMPGFYRDGEYDIAGFAVGIAEK
DEIIDGSKIEDGDILIGIASSGPHSNGYSLIRKLVEDLHKDFEGNKIGNTLLTPTKIYVKPVMKLLEKYNIKGMAHVTGG
GFYENIPRMFKEDFTAVINKKSYPLPNIFSHLMSLGIEEDHMYNTFNMGIGFVLCVNEKDGENIIKDLIEMGEKGYKIGY
VKKGDKSVELI
>Mature_331_residues
MVSYKEAGVNIEEGYKSVDLIKKHASKTFTKGVLNNLGSFAGMFELPKYKNPVLVSGTDGVGTKLDIAFRMKKYNTVGID
CVAMCVNDILCHGAKPLFFLDYIACGKLESEIAAQLVEGVSNGCIQSECALIGGETAEMPGFYRDGEYDIAGFAVGIAEK
DEIIDGSKIEDGDILIGIASSGPHSNGYSLIRKLVEDLHKDFEGNKIGNTLLTPTKIYVKPVMKLLEKYNIKGMAHVTGG
GFYENIPRMFKEDFTAVINKKSYPLPNIFSHLMSLGIEEDHMYNTFNMGIGFVLCVNEKDGENIIKDLIEMGEKGYKIGY
VKKGDKSVELI

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=332, Percent_Identity=44.8795180722892, Blast_Score=289, Evalue=2e-78,
Organism=Homo sapiens, GI209869995, Length=332, Percent_Identity=44.8795180722892, Blast_Score=289, Evalue=2e-78,
Organism=Homo sapiens, GI209869993, Length=332, Percent_Identity=44.8795180722892, Blast_Score=289, Evalue=2e-78,
Organism=Escherichia coli, GI1788845, Length=337, Percent_Identity=48.3679525222552, Blast_Score=340, Evalue=1e-94,
Organism=Caenorhabditis elegans, GI17567511, Length=337, Percent_Identity=41.5430267062315, Blast_Score=243, Evalue=1e-64,
Organism=Saccharomyces cerevisiae, GI6321203, Length=339, Percent_Identity=40.7079646017699, Blast_Score=267, Evalue=2e-72,
Organism=Drosophila melanogaster, GI24582400, Length=270, Percent_Identity=43.7037037037037, Blast_Score=227, Evalue=7e-60,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 36310; Mature: 36310

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSYKEAGVNIEEGYKSVDLIKKHASKTFTKGVLNNLGSFAGMFELPKYKNPVLVSGTDG
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCC
VGTKLDIAFRMKKYNTVGIDCVAMCVNDILCHGAKPLFFLDYIACGKLESEIAAQLVEGV
CCCEEEEEEEEECCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHH
SNGCIQSECALIGGETAEMPGFYRDGEYDIAGFAVGIAEKDEIIDGSKIEDGDILIGIAS
HCCCHHHHHHEECCCHHHCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCEEEEEEC
SGPHSNGYSLIRKLVEDLHKDFEGNKIGNTLLTPTKIYVKPVMKLLEKYNIKGMAHVTGG
CCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCC
GFYENIPRMFKEDFTAVINKKSYPLPNIFSHLMSLGIEEDHMYNTFNMGIGFVLCVNEKD
CHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHCEEEEECCCEEEEEECCCC
GENIIKDLIEMGEKGYKIGYVKKGDKSVELI
CHHHHHHHHHHCCCCCEEEEEECCCCCEECC
>Mature Secondary Structure
MVSYKEAGVNIEEGYKSVDLIKKHASKTFTKGVLNNLGSFAGMFELPKYKNPVLVSGTDG
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCC
VGTKLDIAFRMKKYNTVGIDCVAMCVNDILCHGAKPLFFLDYIACGKLESEIAAQLVEGV
CCCEEEEEEEEECCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHH
SNGCIQSECALIGGETAEMPGFYRDGEYDIAGFAVGIAEKDEIIDGSKIEDGDILIGIAS
HCCCHHHHHHEECCCHHHCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCEEEEEEC
SGPHSNGYSLIRKLVEDLHKDFEGNKIGNTLLTPTKIYVKPVMKLLEKYNIKGMAHVTGG
CCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCC
GFYENIPRMFKEDFTAVINKKSYPLPNIFSHLMSLGIEEDHMYNTFNMGIGFVLCVNEKD
CHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHCEEEEECCCEEEEEECCCC
GENIIKDLIEMGEKGYKIGYVKKGDKSVELI
CHHHHHHHHHHCCCCCEEEEEECCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA