Click here to switch to the map view.

The map label for this gene is proC

Identifier: 170755914

GI number: 170755914

Start: 3455946

End: 3456752

Strand: Reverse

Name: proC

Synonym: CLD_1349

Alternate gene names: 170755914

Gene position: 3456752-3455946 (Counterclockwise)

Preceding gene: 170754495

Following gene: 170755063

Centisome position: 87.33

GC content: 32.47

Gene sequence:

>807_bases
ATGAATAAAGTAATTGGATTTATTGGTGCTGGAAATATGGGACAAGCAATGGTTGGAGGAATAGTTAATTCAAAATTAGT
TGCTCCAAAAAATATTATATTATCAGATTTGAATGAAAAGGCATTAGAATCTGCTAAAGAAAAATTTGGGGTTAGAGTAA
CAACAAATAGCAATGAATTAGCTAAAGAAGTAGATATATTAGTTTTATCTGTAAAACCAAATTTATATCCAATAGTTATA
AAAGGTATAAAAGATAGTGTTAAAAAAGAAGTTATAGTAGTTACTATTGCAGCTGGTAAAGCATTAGAAGATACTGAAAC
TATGTTTGGAAAAAGAATAAAAATAGTTAGAGTAATGCCTAACACTCCTGCATTAGTTGGAGAAGGTATGGCTGCTATAT
GTCCTAACGATTTGGTTTCTAAAGAGGAAGCTGAAGAAGTTATAAGTATCTTTGAAAGCTTTGGAAAAGCAGAAATAGTG
GAAGAGAAATTGATGGATGCAGTAACTGTAGTAAGTGGTTCATCTCCAGCTTATGTGTATATGTTTATAGAAGCTATGGC
AGATGCAGCTGTGCTAGAAGGTATGCCAAGAGATAAGGCTTATAAATTTGCAGCACAAGCTGTATTAGGATCAGCAAAAA
TGGTTCTAGAAACAGGAATGCATCCAGGTGCATTAAAAGATATGGTTTGTTCACCAGGCGGAACTACAATTGAGGCAGTA
GCAACTCTTGAAAAAAATGGTTTTAGAAATGCAATTATAGAAGCTATGAGAGATTGTGCAATAAAATCTAAAGAAATGTC
TAAATAA

Upstream 100 bases:

>100_bases
ATATATTATTGTAAAGAAAAATAAAAGCTAGGAGAAGGAACTAAGATTTATAATTTAAGTCTTTCTCCTAGTAACAAATT
TTTATTAGGAGGAAAGCTAC

Downstream 100 bases:

>100_bases
TACAGTTAACATTTCTTCGTTATCCTATCTTTTAAAGATAGGATAACGAAAAAATATAAAACAAATTACCAAGTTATAGA
AACAATAATCAGAATATTGC

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 268; Mature: 268

Protein sequence:

>268_residues
MNKVIGFIGAGNMGQAMVGGIVNSKLVAPKNIILSDLNEKALESAKEKFGVRVTTNSNELAKEVDILVLSVKPNLYPIVI
KGIKDSVKKEVIVVTIAAGKALEDTETMFGKRIKIVRVMPNTPALVGEGMAAICPNDLVSKEEAEEVISIFESFGKAEIV
EEKLMDAVTVVSGSSPAYVYMFIEAMADAAVLEGMPRDKAYKFAAQAVLGSAKMVLETGMHPGALKDMVCSPGGTTIEAV
ATLEKNGFRNAIIEAMRDCAIKSKEMSK

Sequences:

>Translated_268_residues
MNKVIGFIGAGNMGQAMVGGIVNSKLVAPKNIILSDLNEKALESAKEKFGVRVTTNSNELAKEVDILVLSVKPNLYPIVI
KGIKDSVKKEVIVVTIAAGKALEDTETMFGKRIKIVRVMPNTPALVGEGMAAICPNDLVSKEEAEEVISIFESFGKAEIV
EEKLMDAVTVVSGSSPAYVYMFIEAMADAAVLEGMPRDKAYKFAAQAVLGSAKMVLETGMHPGALKDMVCSPGGTTIEAV
ATLEKNGFRNAIIEAMRDCAIKSKEMSK
>Mature_268_residues
MNKVIGFIGAGNMGQAMVGGIVNSKLVAPKNIILSDLNEKALESAKEKFGVRVTTNSNELAKEVDILVLSVKPNLYPIVI
KGIKDSVKKEVIVVTIAAGKALEDTETMFGKRIKIVRVMPNTPALVGEGMAAICPNDLVSKEEAEEVISIFESFGKAEIV
EEKLMDAVTVVSGSSPAYVYMFIEAMADAAVLEGMPRDKAYKFAAQAVLGSAKMVLETGMHPGALKDMVCSPGGTTIEAV
ATLEKNGFRNAIIEAMRDCAIKSKEMSK

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI21361454, Length=267, Percent_Identity=38.9513108614232, Blast_Score=183, Evalue=1e-46,
Organism=Homo sapiens, GI24797097, Length=266, Percent_Identity=37.593984962406, Blast_Score=181, Evalue=9e-46,
Organism=Homo sapiens, GI24797095, Length=266, Percent_Identity=37.593984962406, Blast_Score=180, Evalue=1e-45,
Organism=Homo sapiens, GI198041662, Length=266, Percent_Identity=34.2105263157895, Blast_Score=174, Evalue=9e-44,
Organism=Escherichia coli, GI1786585, Length=268, Percent_Identity=54.1044776119403, Blast_Score=288, Evalue=3e-79,
Organism=Caenorhabditis elegans, GI17569021, Length=262, Percent_Identity=38.5496183206107, Blast_Score=175, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17540664, Length=278, Percent_Identity=37.0503597122302, Blast_Score=168, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6320861, Length=279, Percent_Identity=31.5412186379928, Blast_Score=123, Evalue=3e-29,
Organism=Drosophila melanogaster, GI21358587, Length=265, Percent_Identity=36.6037735849057, Blast_Score=183, Evalue=9e-47,
Organism=Drosophila melanogaster, GI24648116, Length=280, Percent_Identity=38.2142857142857, Blast_Score=177, Evalue=7e-45,
Organism=Drosophila melanogaster, GI24647700, Length=169, Percent_Identity=42.0118343195266, Blast_Score=146, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 28574; Mature: 28574

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
5.6 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKVIGFIGAGNMGQAMVGGIVNSKLVAPKNIILSDLNEKALESAKEKFGVRVTTNSNEL
CCCEEEEEECCCCCHHHHHHHHCCCCCCCHHHHHHCCCHHHHHHHHHHCCEEEECCCHHH
AKEVDILVLSVKPNLYPIVIKGIKDSVKKEVIVVTIAAGKALEDTETMFGKRIKIVRVMP
HHEEEEEEEEECCCEEEEEEECCHHHCCCEEEEEEEECCCCCHHHHHHHCCEEEEEEECC
NTPALVGEGMAAICPNDLVSKEEAEEVISIFESFGKAEIVEEKLMDAVTVVSGSSPAYVY
CCCCHHHCCCCEECCHHHCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHEECCCCCEEEE
MFIEAMADAAVLEGMPRDKAYKFAAQAVLGSAKMVLETGMHPGALKDMVCSPGGTTIEAV
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCEEHHH
ATLEKNGFRNAIIEAMRDCAIKSKEMSK
HHHHHCCHHHHHHHHHHHHHHCHHCCCC
>Mature Secondary Structure
MNKVIGFIGAGNMGQAMVGGIVNSKLVAPKNIILSDLNEKALESAKEKFGVRVTTNSNEL
CCCEEEEEECCCCCHHHHHHHHCCCCCCCHHHHHHCCCHHHHHHHHHHCCEEEECCCHHH
AKEVDILVLSVKPNLYPIVIKGIKDSVKKEVIVVTIAAGKALEDTETMFGKRIKIVRVMP
HHEEEEEEEEECCCEEEEEEECCHHHCCCEEEEEEEECCCCCHHHHHHHCCEEEEEEECC
NTPALVGEGMAAICPNDLVSKEEAEEVISIFESFGKAEIVEEKLMDAVTVVSGSSPAYVY
CCCCHHHCCCCEECCHHHCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHEECCCCCEEEE
MFIEAMADAAVLEGMPRDKAYKFAAQAVLGSAKMVLETGMHPGALKDMVCSPGGTTIEAV
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCEEHHH
ATLEKNGFRNAIIEAMRDCAIKSKEMSK
HHHHHCCHHHHHHHHHHHHHHCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6296787; 9278503 [H]