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The map label for this gene is hbd

Identifier: 170755442

GI number: 170755442

Start: 3478442

End: 3479272

Strand: Reverse

Name: hbd

Synonym: CLD_1330

Alternate gene names: 170755442

Gene position: 3479272-3478442 (Counterclockwise)

Preceding gene: 170756239

Following gene: 170754683

Centisome position: 87.9

GC content: 30.32

Gene sequence:

>831_bases
ATGAAAGTATTTATTTTAGGTGGCGGAACAATGGGAGCAGGCATCGTTGAAGTTTTTGCTAAATCTGGCCATGAAGTTGT
TTTAAAAAGATTCGTTGGTAAGGGAATGGATAAAATAATAAAAAGCTTTGATAAGCAAGTTAAAAAAGGAAGAATGACAG
AAGAAGAAAAAAATGATTGCATAAATAGAATAACAGTTACAACAGATATGGATTTAGCCAAAGATGCTGATCTAGTTGTT
GAAGCATCTAAAGAAGACATGGAAATGAAAAAGGATATATTTAGTCAATTGGATAAGATTTGTAAACTAGAAACTATATT
TGCAACAAATACATCTTCTTTATCAATAACGACAATTGCTAGTAGCACAAATAGACCAGATAAAGTAATAGGAATGCATT
TCTTTAATCCAGCTCCTGTAATGAAATTAATAGAAGTAATAAAAGGTATAGCGACTTCAGAAGAAACTAAAAACACTGTA
ATTGAAATATCAAAGAAATTAGGAAAAGAACCAGTAGAAGTAGAGGAAGCGCCAGGATTTGTAGTTAATAGAATGCTTAT
ACCTATGATAAATGAAGCTATTGGTATATATGCAGAAGGAATTGCTACTGTTGAAGATATAGATTTAGCTATGAAATTAG
GAGCTAATCATCCTATTGGACCATTAGCTTTAGCAGATTTAATTGGTAATGATGTATGTTTGGCTATAATGGATGTATTA
CACTCTGAATTTGGGGATTCAAAATATAGACCTCATCCATTATTAATAAAAATGGTTAGAGGAAATTTATTAGGAAGAAA
AACAGGAAAAGGATTTTATGAATATAAATAA

Upstream 100 bases:

>100_bases
TGTTTTGCAACAGAAGACCAAAAAGAAGGAATGGAAGCTTTTTTAGAAAAAAGAAAACCAAATTTTATTAATAAATATTA
AATTTTAAGGGGGCATAAAA

Downstream 100 bases:

>100_bases
TAATTAAATTTGGGGGTATGGAAAATGAAAAATGTTGTTATTGCTAGTGCTGTAAGAACACCTATAGGAAAATTTGGAGG
AACATTAAAAAGTGTTTCAG

Product: 3-hydroxybutyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 276; Mature: 276

Protein sequence:

>276_residues
MKVFILGGGTMGAGIVEVFAKSGHEVVLKRFVGKGMDKIIKSFDKQVKKGRMTEEEKNDCINRITVTTDMDLAKDADLVV
EASKEDMEMKKDIFSQLDKICKLETIFATNTSSLSITTIASSTNRPDKVIGMHFFNPAPVMKLIEVIKGIATSEETKNTV
IEISKKLGKEPVEVEEAPGFVVNRMLIPMINEAIGIYAEGIATVEDIDLAMKLGANHPIGPLALADLIGNDVCLAIMDVL
HSEFGDSKYRPHPLLIKMVRGNLLGRKTGKGFYEYK

Sequences:

>Translated_276_residues
MKVFILGGGTMGAGIVEVFAKSGHEVVLKRFVGKGMDKIIKSFDKQVKKGRMTEEEKNDCINRITVTTDMDLAKDADLVV
EASKEDMEMKKDIFSQLDKICKLETIFATNTSSLSITTIASSTNRPDKVIGMHFFNPAPVMKLIEVIKGIATSEETKNTV
IEISKKLGKEPVEVEEAPGFVVNRMLIPMINEAIGIYAEGIATVEDIDLAMKLGANHPIGPLALADLIGNDVCLAIMDVL
HSEFGDSKYRPHPLLIKMVRGNLLGRKTGKGFYEYK
>Mature_276_residues
MKVFILGGGTMGAGIVEVFAKSGHEVVLKRFVGKGMDKIIKSFDKQVKKGRMTEEEKNDCINRITVTTDMDLAKDADLVV
EASKEDMEMKKDIFSQLDKICKLETIFATNTSSLSITTIASSTNRPDKVIGMHFFNPAPVMKLIEVIKGIATSEETKNTV
IEISKKLGKEPVEVEEAPGFVVNRMLIPMINEAIGIYAEGIATVEDIDLAMKLGANHPIGPLALADLIGNDVCLAIMDVL
HSEFGDSKYRPHPLLIKMVRGNLLGRKTGKGFYEYK

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=285, Percent_Identity=44.9122807017544, Blast_Score=235, Evalue=4e-62,
Organism=Homo sapiens, GI296179427, Length=302, Percent_Identity=42.3841059602649, Blast_Score=223, Evalue=1e-58,
Organism=Homo sapiens, GI20127408, Length=277, Percent_Identity=36.101083032491, Blast_Score=171, Evalue=9e-43,
Organism=Homo sapiens, GI68989263, Length=291, Percent_Identity=36.0824742268041, Blast_Score=145, Evalue=4e-35,
Organism=Homo sapiens, GI261878539, Length=291, Percent_Identity=36.0824742268041, Blast_Score=145, Evalue=5e-35,
Organism=Homo sapiens, GI115430219, Length=233, Percent_Identity=29.6137339055794, Blast_Score=92, Evalue=7e-19,
Organism=Escherichia coli, GI1787661, Length=279, Percent_Identity=40.8602150537634, Blast_Score=231, Evalue=4e-62,
Organism=Escherichia coli, GI1788682, Length=260, Percent_Identity=37.3076923076923, Blast_Score=169, Evalue=2e-43,
Organism=Escherichia coli, GI1790281, Length=262, Percent_Identity=32.4427480916031, Blast_Score=137, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17553560, Length=284, Percent_Identity=42.2535211267606, Blast_Score=222, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI17549919, Length=285, Percent_Identity=38.2456140350877, Blast_Score=205, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI17563036, Length=291, Percent_Identity=36.426116838488, Blast_Score=191, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI25144276, Length=279, Percent_Identity=37.2759856630824, Blast_Score=167, Evalue=7e-42,
Organism=Caenorhabditis elegans, GI17508953, Length=279, Percent_Identity=37.2759856630824, Blast_Score=167, Evalue=8e-42,
Organism=Caenorhabditis elegans, GI17508951, Length=279, Percent_Identity=37.2759856630824, Blast_Score=166, Evalue=9e-42,
Organism=Caenorhabditis elegans, GI17558304, Length=282, Percent_Identity=35.8156028368794, Blast_Score=162, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI71985923, Length=279, Percent_Identity=35.84229390681, Blast_Score=157, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI71985930, Length=276, Percent_Identity=34.0579710144928, Blast_Score=144, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI115533614, Length=191, Percent_Identity=25.6544502617801, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI193203623, Length=191, Percent_Identity=25.6544502617801, Blast_Score=78, Evalue=6e-15,
Organism=Drosophila melanogaster, GI19921000, Length=279, Percent_Identity=34.4086021505376, Blast_Score=160, Evalue=9e-40,
Organism=Drosophila melanogaster, GI24583077, Length=279, Percent_Identity=34.4086021505376, Blast_Score=160, Evalue=1e-39,
Organism=Drosophila melanogaster, GI24583079, Length=279, Percent_Identity=34.4086021505376, Blast_Score=160, Evalue=1e-39,
Organism=Drosophila melanogaster, GI45549573, Length=239, Percent_Identity=27.6150627615063, Blast_Score=91, Evalue=8e-19,
Organism=Drosophila melanogaster, GI20129993, Length=238, Percent_Identity=26.0504201680672, Blast_Score=87, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 30322; Mature: 30322

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00067 3HCDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVFILGGGTMGAGIVEVFAKSGHEVVLKRFVGKGMDKIIKSFDKQVKKGRMTEEEKNDC
CEEEEEECCCHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHH
INRITVTTDMDLAKDADLVVEASKEDMEMKKDIFSQLDKICKLETIFATNTSSLSITTIA
HHEEEEEECCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEEEEE
SSTNRPDKVIGMHFFNPAPVMKLIEVIKGIATSEETKNTVIEISKKLGKEPVEVEEAPGF
CCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCH
VVNRMLIPMINEAIGIYAEGIATVEDIDLAMKLGANHPIGPLALADLIGNDVCLAIMDVL
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHCCHHHHHHHHHH
HSEFGDSKYRPHPLLIKMVRGNLLGRKTGKGFYEYK
HHHCCCCCCCCCHHHHHHHHCCHHCCCCCCCCCCCC
>Mature Secondary Structure
MKVFILGGGTMGAGIVEVFAKSGHEVVLKRFVGKGMDKIIKSFDKQVKKGRMTEEEKNDC
CEEEEEECCCHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHH
INRITVTTDMDLAKDADLVVEASKEDMEMKKDIFSQLDKICKLETIFATNTSSLSITTIA
HHEEEEEECCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEEEEE
SSTNRPDKVIGMHFFNPAPVMKLIEVIKGIATSEETKNTVIEISKKLGKEPVEVEEAPGF
CCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCH
VVNRMLIPMINEAIGIYAEGIATVEDIDLAMKLGANHPIGPLALADLIGNDVCLAIMDVL
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHCCHHHHHHHHHH
HSEFGDSKYRPHPLLIKMVRGNLLGRKTGKGFYEYK
HHHCCCCCCCCCHHHHHHHHCCHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA