Click here to switch to the map view.

The map label for this gene is pyrD

Identifier: 170755388

GI number: 170755388

Start: 3514968

End: 3515864

Strand: Reverse

Name: pyrD

Synonym: CLD_1295

Alternate gene names: 170755388

Gene position: 3515864-3514968 (Counterclockwise)

Preceding gene: 170756240

Following gene: 170755064

Centisome position: 88.82

GC content: 31.66

Gene sequence:

>897_bases
ATGCTTCAAGTAAATTTATGTGGTAAGATCTTTAAAAATCCTATTATAGCTGCATCAGGAACTTTTGGATTTGGAGAAGA
ATATGGGGAATTTTATGATGTTTCTAAATTAGGAGGAATTTCAAGTAAAGGATTGACCTTAAATCCTAAAGACGGAAATA
ATGGAATAAGAATTCATGAAACTAGTTCCGGTATAATGAACAGTGTAGGACTTCAGAATCCAGGAGTAGATAAATTTATA
AAAGAAGAGTTACCTAAAATGCAAAAAATGGATACAGTAACCATTGCAAATGTTGGTGGAGGATGTATAGAAGATTATAT
TGAAGTCATAGAGAAATTAAATAAAACAGATGTAGATATGATAGAGCTAAATATATCCTGTCCCAATGTAAAGCATGGAG
GTATGGCCTTTGGAATAAAGTCAGAAATAGCTTATGAAGTAGTAAAAGAAGTTAAAGAAATATGTCAAAAGCCACTTATG
GTAAAGCTATCTCCCAATGCAGAAGATATAGTAGATATGGCTATAAAATGTGAGAAAGCAGGAGCAGATGCAATTTCATT
AGTAAATACATTTAAGGCTATGGCTATAGATATAAAGAGAAAAACTCCTGTATTTGAAAATATAACTGCAGGTTTATCAG
GCCCATGCATTAAGCCTATGGCATTGAGAATGGTATATGAAGTGTGTAAGCAGGTGGAAATACCGGTTATAGGTATAGGA
GGAATATGTAATTATAAAGATGTAATAGAATTTATTATGGCGGGGGCCACAGCAGTACAAATAGGAACAACTAATTTTAT
GAATCCATATTCAGCTGTAGATATAATAGAGGACTTAGAAAATTATATGAAAAAACAAGGTATTAAAAATTTAGAAGAAA
TAAGGGGAATTATTTAA

Upstream 100 bases:

>100_bases
GTCTTGTGTGTACTTGTAAAACTAAATTTGGTAATAAAAGAACTTGCAAGGATGGTCCCGTATTTAAAGGAGAGGACATT
CTTTTGAAAGGAGATATATA

Downstream 100 bases:

>100_bases
AATAAATTTTGAAAATATAAGGAGAAGATATAAATGAGTAATATAAATGTTATAGATATATTAAAAGAATCAGATGCGTT
ATTAGAAGGACATTTCTTAT

Product: dihydroorotate dehydrogenase 1B

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 298; Mature: 298

Protein sequence:

>298_residues
MLQVNLCGKIFKNPIIAASGTFGFGEEYGEFYDVSKLGGISSKGLTLNPKDGNNGIRIHETSSGIMNSVGLQNPGVDKFI
KEELPKMQKMDTVTIANVGGGCIEDYIEVIEKLNKTDVDMIELNISCPNVKHGGMAFGIKSEIAYEVVKEVKEICQKPLM
VKLSPNAEDIVDMAIKCEKAGADAISLVNTFKAMAIDIKRKTPVFENITAGLSGPCIKPMALRMVYEVCKQVEIPVIGIG
GICNYKDVIEFIMAGATAVQIGTTNFMNPYSAVDIIEDLENYMKKQGIKNLEEIRGII

Sequences:

>Translated_298_residues
MLQVNLCGKIFKNPIIAASGTFGFGEEYGEFYDVSKLGGISSKGLTLNPKDGNNGIRIHETSSGIMNSVGLQNPGVDKFI
KEELPKMQKMDTVTIANVGGGCIEDYIEVIEKLNKTDVDMIELNISCPNVKHGGMAFGIKSEIAYEVVKEVKEICQKPLM
VKLSPNAEDIVDMAIKCEKAGADAISLVNTFKAMAIDIKRKTPVFENITAGLSGPCIKPMALRMVYEVCKQVEIPVIGIG
GICNYKDVIEFIMAGATAVQIGTTNFMNPYSAVDIIEDLENYMKKQGIKNLEEIRGII
>Mature_298_residues
MLQVNLCGKIFKNPIIAASGTFGFGEEYGEFYDVSKLGGISSKGLTLNPKDGNNGIRIHETSSGIMNSVGLQNPGVDKFI
KEELPKMQKMDTVTIANVGGGCIEDYIEVIEKLNKTDVDMIELNISCPNVKHGGMAFGIKSEIAYEVVKEVKEICQKPLM
VKLSPNAEDIVDMAIKCEKAGADAISLVNTFKAMAIDIKRKTPVFENITAGLSGPCIKPMALRMVYEVCKQVEIPVIGIG
GICNYKDVIEFIMAGATAVQIGTTNFMNPYSAVDIIEDLENYMKKQGIKNLEEIRGII

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI119943098, Length=211, Percent_Identity=26.5402843601896, Blast_Score=88, Evalue=8e-18,
Organism=Homo sapiens, GI45006951, Length=312, Percent_Identity=25.3205128205128, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI87082059, Length=319, Percent_Identity=27.8996865203762, Blast_Score=114, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI71984108, Length=185, Percent_Identity=27.5675675675676, Blast_Score=83, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6322633, Length=307, Percent_Identity=27.6872964169381, Blast_Score=98, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24640763, Length=175, Percent_Identity=32.5714285714286, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI18858217, Length=175, Percent_Identity=32.5714285714286, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI281361352, Length=318, Percent_Identity=26.1006289308176, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17137316, Length=318, Percent_Identity=26.1006289308176, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.3.1 [H]

Molecular weight: Translated: 32442; Mature: 32442

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
7.4 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
7.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQVNLCGKIFKNPIIAASGTFGFGEEYGEFYDVSKLGGISSKGLTLNPKDGNNGIRIHE
CEEECCHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCEECCCCCCCCEEEEE
TSSGIMNSVGLQNPGVDKFIKEELPKMQKMDTVTIANVGGGCIEDYIEVIEKLNKTDVDM
CCCHHHHHCCCCCCCHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHCCCCCCEE
IELNISCPNVKHGGMAFGIKSEIAYEVVKEVKEICQKPLMVKLSPNAEDIVDMAIKCEKA
EEEEECCCCCCCCCEEECHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHC
GADAISLVNTFKAMAIDIKRKTPVFENITAGLSGPCIKPMALRMVYEVCKQVEIPVIGIG
CCHHHHHHHHHHHHHEECCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEC
GICNYKDVIEFIMAGATAVQIGTTNFMNPYSAVDIIEDLENYMKKQGIKNLEEIRGII
CCCCHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCC
>Mature Secondary Structure
MLQVNLCGKIFKNPIIAASGTFGFGEEYGEFYDVSKLGGISSKGLTLNPKDGNNGIRIHE
CEEECCHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCEECCCCCCCCEEEEE
TSSGIMNSVGLQNPGVDKFIKEELPKMQKMDTVTIANVGGGCIEDYIEVIEKLNKTDVDM
CCCHHHHHCCCCCCCHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHCCCCCCEE
IELNISCPNVKHGGMAFGIKSEIAYEVVKEVKEICQKPLMVKLSPNAEDIVDMAIKCEKA
EEEEECCCCCCCCCEEECHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHC
GADAISLVNTFKAMAIDIKRKTPVFENITAGLSGPCIKPMALRMVYEVCKQVEIPVIGIG
CCHHHHHHHHHHHHHEECCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEC
GICNYKDVIEFIMAGATAVQIGTTNFMNPYSAVDIIEDLENYMKKQGIKNLEEIRGII
CCCCHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA