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The map label for this gene is pyrE

Identifier: 170755064

GI number: 170755064

Start: 3514359

End: 3514934

Strand: Reverse

Name: pyrE

Synonym: CLD_1296

Alternate gene names: 170755064

Gene position: 3514934-3514359 (Counterclockwise)

Preceding gene: 170755388

Following gene: 170757055

Centisome position: 88.8

GC content: 29.86

Gene sequence:

>576_bases
ATGAGTAATATAAATGTTATAGATATATTAAAAGAATCAGATGCGTTATTAGAAGGACATTTCTTATTATCATCAGGAAG
ACATAGTAATAGATATTGTCAATGTGCAAAACTACTCCAATGCCCACAAAAAGCAGAAAAAGTTATTAGTGTAATAGCAG
AAAAGCTTAAAGAAGTAGATTTTAATATAATAGTAGGACCAGCTATGGGAGGGGTAATAGTATCCTATGAATTAGCAAGA
CAAACTAATAAACCTGGTATATTTGCAGAAAGAAAAGAAGGGGTTATGTGCATAAGAAGGGGATTTGAAATAAAAAAAGG
AGATAAAGTTATAATATCAGAAGATGTAGTAACTACAGGAAAATCTTCTTTAGAAGTAGCTAAAGTTATAGAAGAAATGG
GTGGAGAAGTAGTAGGTATAGCATGTATAGTTGATAGAAGAGCAGAGGATATAAAAACAAACTATCCAATATATAGTGCT
TGTAAATTAGAAATAGAAACTTATGAAAAAGATAACTGTGAGTTATGCAAAAAAAACATACCTTTTGTAAAACCAGGTAG
CAGAGAACAAAAATAA

Upstream 100 bases:

>100_bases
GGACTTAGAAAATTATATGAAAAAACAAGGTATTAAAAATTTAGAAGAAATAAGGGGAATTATTTAAAATAAATTTTGAA
AATATAAGGAGAAGATATAA

Downstream 100 bases:

>100_bases
ATTTTAAAATAAGAGTTGTCTCAAAATAGATTTAATTTTGGGACATTTTTTTAGTTTTAACAAATATTAAACAAAAACTT
AATTTTACTTTAATAATTAT

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase

Number of amino acids: Translated: 191; Mature: 190

Protein sequence:

>191_residues
MSNINVIDILKESDALLEGHFLLSSGRHSNRYCQCAKLLQCPQKAEKVISVIAEKLKEVDFNIIVGPAMGGVIVSYELAR
QTNKPGIFAERKEGVMCIRRGFEIKKGDKVIISEDVVTTGKSSLEVAKVIEEMGGEVVGIACIVDRRAEDIKTNYPIYSA
CKLEIETYEKDNCELCKKNIPFVKPGSREQK

Sequences:

>Translated_191_residues
MSNINVIDILKESDALLEGHFLLSSGRHSNRYCQCAKLLQCPQKAEKVISVIAEKLKEVDFNIIVGPAMGGVIVSYELAR
QTNKPGIFAERKEGVMCIRRGFEIKKGDKVIISEDVVTTGKSSLEVAKVIEEMGGEVVGIACIVDRRAEDIKTNYPIYSA
CKLEIETYEKDNCELCKKNIPFVKPGSREQK
>Mature_190_residues
SNINVIDILKESDALLEGHFLLSSGRHSNRYCQCAKLLQCPQKAEKVISVIAEKLKEVDFNIIVGPAMGGVIVSYELARQ
TNKPGIFAERKEGVMCIRRGFEIKKGDKVIISEDVVTTGKSSLEVAKVIEEMGGEVVGIACIVDRRAEDIKTNYPIYSAC
KLEIETYEKDNCELCKKNIPFVKPGSREQK

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRE_CLOB1 (A7FYI6)

Other databases:

- EMBL:   CP000726
- RefSeq:   YP_001385559.1
- ProteinModelPortal:   A7FYI6
- SMR:   A7FYI6
- STRING:   A7FYI6
- GeneID:   5394728
- GenomeReviews:   CP000726_GR
- KEGG:   cba:CLB_3272
- eggNOG:   COG0461
- HOGENOM:   HBG404341
- OMA:   FYLQSAK
- ProtClustDB:   PRK00455
- BioCyc:   CBOT441770:CLB_3272-MONOMER
- HAMAP:   MF_01208
- InterPro:   IPR023031
- InterPro:   IPR006273
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01367

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.10

Molecular weight: Translated: 21240; Mature: 21109

Theoretical pI: Translated: 7.66; Mature: 7.66

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: BINDING 118-118 BINDING 146-146

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
4.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNINVIDILKESDALLEGHFLLSSGRHSNRYCQCAKLLQCPQKAEKVISVIAEKLKEVD
CCCCCEEEEECCCCCHHCCEEEECCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHCC
FNIIVGPAMGGVIVSYELARQTNKPGIFAERKEGVMCIRRGFEIKKGDKVIISEDVVTTG
CEEEECCCCCCEEEEEHHHHCCCCCCCEEECCCCHHHHHCCCCCCCCCEEEEECCCCCCC
KSSLEVAKVIEEMGGEVVGIACIVDRRAEDIKTNYPIYSACKLEIETYEKDNCELCKKNI
CHHHHHHHHHHHHCCCEEEEEEEECCCHHHHCCCCCEEEEEEEEEEECCCCCHHHHHCCC
PFVKPGSREQK
CCCCCCCCCCC
>Mature Secondary Structure 
SNINVIDILKESDALLEGHFLLSSGRHSNRYCQCAKLLQCPQKAEKVISVIAEKLKEVD
CCCCEEEEECCCCCHHCCEEEECCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHCC
FNIIVGPAMGGVIVSYELARQTNKPGIFAERKEGVMCIRRGFEIKKGDKVIISEDVVTTG
CEEEECCCCCCEEEEEHHHHCCCCCCCEEECCCCHHHHHCCCCCCCCCEEEEECCCCCCC
KSSLEVAKVIEEMGGEVVGIACIVDRRAEDIKTNYPIYSACKLEIETYEKDNCELCKKNI
CHHHHHHHHHHHHCCCEEEEEEEECCCHHHHCCCCCEEEEEEEEEEECCCCCHHHHHCCC
PFVKPGSREQK
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA