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The map label for this gene is adh

Identifier: 170754746

GI number: 170754746

Start: 3149997

End: 3151058

Strand: Reverse

Name: adh

Synonym: CLD_1638

Alternate gene names: 170754746

Gene position: 3151058-3149997 (Counterclockwise)

Preceding gene: 170755775

Following gene: 170757744

Centisome position: 79.61

GC content: 36.63

Gene sequence:

>1062_bases
ATGAAAGGTTTTGCAATGTTAAGTATCAATAAATTAGGATGGATTGAAAAAGAAAATCCCAAAGCGGGTCCTTATGATGC
AATAGTACGTCCTTTGGCTATATCACCCTGTACATCAGATATACACACTGTGTTTGAGGGAGCTCTAGGTGATAGACATA
ATATGATATTAGGACACGAATCCGTAGGTGAGGTTATTGAAATTGGCAGCGAAGTTAAAGATTTTAAACCTGGTGATAAA
GTTATTGTGCCTGCAATAACTCCTGATTGGAGATCCTTAGAAGTTCAAGCCGGATTTCATCAACACTCAAATGGTATGTT
AGCAGGTTGGAAATTTTCAAATTTTAAAGACGGAGTGTTTGCAGAATTATTTCATGTAAATGATGCGGATATGAATCTTG
CAATTTTACCTGATAATATATCCTTAGAAAGTGCCGTTATGATAACAGATATGATGACTACAGGATTTCATGGAGCAGAA
CTAGCAGATATACAATTAGGATCAAGTGTTGTAGTAATTGGAATAGGCGCTGTTGGGTTAATGGCTATAGCAGGTGCTAA
ATTGCGAGGGGCTGGTAGAATTATAGGTGTAGGAAGTAGACCGATTTGTGTTGAAGCTGCAAAATTTTATGGGGCATCAG
ATATTGTAAACTATAAAAATGGAGATATAGTTAAGCAGGTTTTAGAATTGACTAATGGAAAAGGTGTTAATCGTGTCATT
ATGGCTGGAGGTGGAGCTGATACTTTGGCACAAGCAGTGGCAATGGTTAAACCTGGAGGGGTAATTTCAAATGTTAACTA
TCATGGAACAGGTGAAATACTTCCGATACCTCGTGTAGAATGGGGATGTGGAATGGCTCATAAGAGTATTAAAGGAGGTC
TTTGTCCTGGGGGACGTCTTAGAATGGAAATGCTTGCAGACCTTGTAAAGTATAAGCGTGTTGATTTAAGTAAATTAGTT
ACTCATGTATTTGAAGGCTATGATAATATAGAAAAAGCTCTACTGTTAATGAAAGATAAACCAAAGGATTTAATTAAACC
GGTAGTAATATTAAACAAATAA

Upstream 100 bases:

>100_bases
AACCTATAGATAAGAAGAAATCCTTCGGCATGTTAATTGCTAAATAAAAGTATATAAACATATTAATATTTAAAAATTAT
ACTTAGGAGGGAATTATATT

Downstream 100 bases:

>100_bases
AATTTAAATATGTTTTAAAATAAAATTTGGTTAATTTGAAAATTAAAATAAATCTATAATATCTTACAGTGTAATAAATT
TTTTTATTGCACTATTTTTT

Product: NADP-dependent alcohol dehydrogenase

Products: NA

Alternate protein names: CbADH [H]

Number of amino acids: Translated: 353; Mature: 353

Protein sequence:

>353_residues
MKGFAMLSINKLGWIEKENPKAGPYDAIVRPLAISPCTSDIHTVFEGALGDRHNMILGHESVGEVIEIGSEVKDFKPGDK
VIVPAITPDWRSLEVQAGFHQHSNGMLAGWKFSNFKDGVFAELFHVNDADMNLAILPDNISLESAVMITDMMTTGFHGAE
LADIQLGSSVVVIGIGAVGLMAIAGAKLRGAGRIIGVGSRPICVEAAKFYGASDIVNYKNGDIVKQVLELTNGKGVNRVI
MAGGGADTLAQAVAMVKPGGVISNVNYHGTGEILPIPRVEWGCGMAHKSIKGGLCPGGRLRMEMLADLVKYKRVDLSKLV
THVFEGYDNIEKALLLMKDKPKDLIKPVVILNK

Sequences:

>Translated_353_residues
MKGFAMLSINKLGWIEKENPKAGPYDAIVRPLAISPCTSDIHTVFEGALGDRHNMILGHESVGEVIEIGSEVKDFKPGDK
VIVPAITPDWRSLEVQAGFHQHSNGMLAGWKFSNFKDGVFAELFHVNDADMNLAILPDNISLESAVMITDMMTTGFHGAE
LADIQLGSSVVVIGIGAVGLMAIAGAKLRGAGRIIGVGSRPICVEAAKFYGASDIVNYKNGDIVKQVLELTNGKGVNRVI
MAGGGADTLAQAVAMVKPGGVISNVNYHGTGEILPIPRVEWGCGMAHKSIKGGLCPGGRLRMEMLADLVKYKRVDLSKLV
THVFEGYDNIEKALLLMKDKPKDLIKPVVILNK
>Mature_353_residues
MKGFAMLSINKLGWIEKENPKAGPYDAIVRPLAISPCTSDIHTVFEGALGDRHNMILGHESVGEVIEIGSEVKDFKPGDK
VIVPAITPDWRSLEVQAGFHQHSNGMLAGWKFSNFKDGVFAELFHVNDADMNLAILPDNISLESAVMITDMMTTGFHGAE
LADIQLGSSVVVIGIGAVGLMAIAGAKLRGAGRIIGVGSRPICVEAAKFYGASDIVNYKNGDIVKQVLELTNGKGVNRVI
MAGGGADTLAQAVAMVKPGGVISNVNYHGTGEILPIPRVEWGCGMAHKSIKGGLCPGGRLRMEMLADLVKYKRVDLSKLV
THVFEGYDNIEKALLLMKDKPKDLIKPVVILNK

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI71565152, Length=353, Percent_Identity=28.8951841359773, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI156627571, Length=342, Percent_Identity=26.6081871345029, Blast_Score=89, Evalue=9e-18,
Organism=Homo sapiens, GI71743840, Length=348, Percent_Identity=28.448275862069, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI262073058, Length=348, Percent_Identity=28.448275862069, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI1786825, Length=280, Percent_Identity=30.3571428571429, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1788073, Length=343, Percent_Identity=25.3644314868805, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI87082125, Length=319, Percent_Identity=26.9592476489028, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1788407, Length=304, Percent_Identity=26.3157894736842, Blast_Score=72, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17562878, Length=225, Percent_Identity=28.8888888888889, Blast_Score=85, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6323099, Length=353, Percent_Identity=28.0453257790368, Blast_Score=92, Evalue=9e-20,
Organism=Saccharomyces cerevisiae, GI6322619, Length=306, Percent_Identity=29.0849673202614, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6319955, Length=306, Percent_Identity=29.0849673202614, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6320033, Length=244, Percent_Identity=28.2786885245902, Blast_Score=74, Evalue=5e-14,
Organism=Drosophila melanogaster, GI17137530, Length=194, Percent_Identity=27.319587628866, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17737895, Length=269, Percent_Identity=29.368029739777, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17737897, Length=190, Percent_Identity=26.3157894736842, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.2 [H]

Molecular weight: Translated: 37794; Mature: 37794

Theoretical pI: Translated: 7.33; Mature: 7.33

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGFAMLSINKLGWIEKENPKAGPYDAIVRPLAISPCTSDIHTVFEGALGDRHNMILGHE
CCCEEEEEECCCCCEECCCCCCCCHHHHHCCEECCCCCHHHHHHHHHHCCCCCCEEECCH
SVGEVIEIGSEVKDFKPGDKVIVPAITPDWRSLEVQAGFHQHSNGMLAGWKFSNFKDGVF
HHHHHHHHCCHHHCCCCCCCEEEEECCCCCCEEEEEECCEECCCCEEEEEECCCCCCCCE
AELFHVNDADMNLAILPDNISLESAVMITDMMTTGFHGAELADIQLGSSVVVIGIGAVGL
EEEEECCCCCCEEEEECCCCCCCCEEEEEHHHHCCCCCCEEEEEEECCEEEEEEHHHHHH
MAIAGAKLRGAGRIIGVGSRPICVEAAKFYGASDIVNYKNGDIVKQVLELTNGKGVNRVI
HHHHCCCCCCCCEEEEECCCCEEEEHHHHCCCHHEEECCCCHHHHHHHHHHCCCCCCEEE
MAGGGADTLAQAVAMVKPGGVISNVNYHGTGEILPIPRVEWGCGMAHKSIKGGLCPGGRL
EECCCHHHHHHHHHHCCCCCEEECCCCCCCCCEEECCCCCCCCCCHHHHCCCCCCCCCCH
RMEMLADLVKYKRVDLSKLVTHVFEGYDNIEKALLLMKDKPKDLIKPVVILNK
HHHHHHHHHHHHHCCHHHHHHHHHHCHHHHHHHHHEECCCCHHHHCCEEEECC
>Mature Secondary Structure
MKGFAMLSINKLGWIEKENPKAGPYDAIVRPLAISPCTSDIHTVFEGALGDRHNMILGHE
CCCEEEEEECCCCCEECCCCCCCCHHHHHCCEECCCCCHHHHHHHHHHCCCCCCEEECCH
SVGEVIEIGSEVKDFKPGDKVIVPAITPDWRSLEVQAGFHQHSNGMLAGWKFSNFKDGVF
HHHHHHHHCCHHHCCCCCCCEEEEECCCCCCEEEEEECCEECCCCEEEEEECCCCCCCCE
AELFHVNDADMNLAILPDNISLESAVMITDMMTTGFHGAELADIQLGSSVVVIGIGAVGL
EEEEECCCCCCEEEEECCCCCCCCEEEEEHHHHCCCCCCEEEEEEECCEEEEEEHHHHHH
MAIAGAKLRGAGRIIGVGSRPICVEAAKFYGASDIVNYKNGDIVKQVLELTNGKGVNRVI
HHHHCCCCCCCCEEEEECCCCEEEEHHHHCCCHHEEECCCCHHHHHHHHHHCCCCCCEEE
MAGGGADTLAQAVAMVKPGGVISNVNYHGTGEILPIPRVEWGCGMAHKSIKGGLCPGGRL
EECCCHHHHHHHHHHCCCCCEEECCCCCCCCCEEECCCCCCCCCCHHHHCCCCCCCCCCH
RMEMLADLVKYKRVDLSKLVTHVFEGYDNIEKALLLMKDKPKDLIKPVVILNK
HHHHHHHHHHHHHCCHHHHHHHHHHCHHHHHHHHHEECCCCHHHHCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8349550; 9836873; 12381840 [H]