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The map label for this gene is pdp

Identifier: 170754547

GI number: 170754547

Start: 1986128

End: 1987432

Strand: Reverse

Name: pdp

Synonym: CLD_2777

Alternate gene names: 170754547

Gene position: 1987432-1986128 (Counterclockwise)

Preceding gene: 170756883

Following gene: 170754794

Centisome position: 50.21

GC content: 30.73

Gene sequence:

>1305_bases
ATGAGAATGTATGATTTGATCCTAAAGAAAAGAAATGGCGGAGAGTTAAGTAAAGAAGAAATAGATTATTTTATTTTAGA
ATATATTAATGGTAATGTCCCAGATTATCAAGCTTCAGCTCTTTTAATGGCTATATACTTTCAAAAAATGAAAAGAAGAG
AAACTGTAGATTTGACTATGGCTATGGTTAACTCTGGAGATATATTGGATTTATCAAAAATACAGGGTATAAAAGTTGAT
AAACATAGTACTGGTGGAGTTGGGGATACTACTACCTTAGTTTTGGCGCCTATGGTAGCAGCCTTAGGTATACCTGTAGC
TAAAATGTCTGGTAGAGGTTTAGGTCATACTGGTGGAACTATAGATAAATTAGAATCTTTTAAAGGTTTTTCAGTAAATA
TGACAGAGGATAAATTTATAAATAACGTTAACAATATTAAAATAGCTGTAGGAGCTCAAACAGCAGATTTAGCTCCAGCG
GATAAAAAATTATATGCATTAAGAGATGTTACTGCTACAGTAGACAATATTTCTTTAATAGCTTCTAGTATAATGAGCAA
AAAAATAGCTGCAGGAGCTAATGCCATAGTTCTAGATGTGAAGGTAGGAGAAGGAGCCTTTATGAAAACTCCGGAAACTG
CAAAAGAACTAGCAGAAGAAATGGTTAATATAGGGAAAAGTGTAGGCAGAAATACTGTAGCTATATTATCAGATATGGAT
CAACCATTAGGTCACTCTATAGGGAACGCTTTAGAAGTAAAAGAAGCTATAGATACACTAAAAGGCAAAGGTCCTAAGGA
TTTATTAGAACTATGCTTAACTTTAGGAAGTAATATGGTTATTTTAGCACAAAAAGCAAATACTATAGAGGAAGCAAGAG
AAATGCTTTTAGATACTATAGAAAAAGGATTAGCTATAGAAAAATTAAAAGAATTTGTTAAATCTCAGGGCGGAGATGAT
ACTTTAATAGACAATACAGAAAAATTACCAAAGGCAGAATATATAATTCCTGTAATTTGTGATAGAAATGGATATATAAA
TAAAATTCATGCCCAAAATATAGGAATAATAGCATCAGAGCTAGGAGCCGGAAGGGTTACAAAGGATAGTATTATAGATT
TAGCAGTAGGTATAGTTTTAAATAAGAAAAGATCAGATAAAATTAAAAAAGGAGATATAATAGCTTACATTCATGCTAAT
GATAAAATAAAAGGAGAAAAGGCTGCAAAAGATATATTAAATAATTATGTTATAGAAGAAGAGTTAAAAGAAGAATTACC
TTTAATATATGATACAGTAAAATAG

Upstream 100 bases:

>100_bases
ATTTCGCTAACAAGTCATAAATGTGTATACATTAAAACTAGATCTATTTGGAGGCAATCCTTATATTATATAATAATTGC
TTTGTAGGGAGGAATAAATT

Downstream 100 bases:

>100_bases
CATAGTTAAAGCATTCATAAAAGCATATTTAATTTTTAAAGTAGGTTTAAATTAAAGCTATAATTATAAAAAGTTATAAT
CATACAAGCATAGAGGAGGA

Product: pyrimidine-nucleoside phosphorylase

Products: NA

Alternate protein names: PYNP [H]

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MRMYDLILKKRNGGELSKEEIDYFILEYINGNVPDYQASALLMAIYFQKMKRRETVDLTMAMVNSGDILDLSKIQGIKVD
KHSTGGVGDTTTLVLAPMVAALGIPVAKMSGRGLGHTGGTIDKLESFKGFSVNMTEDKFINNVNNIKIAVGAQTADLAPA
DKKLYALRDVTATVDNISLIASSIMSKKIAAGANAIVLDVKVGEGAFMKTPETAKELAEEMVNIGKSVGRNTVAILSDMD
QPLGHSIGNALEVKEAIDTLKGKGPKDLLELCLTLGSNMVILAQKANTIEEAREMLLDTIEKGLAIEKLKEFVKSQGGDD
TLIDNTEKLPKAEYIIPVICDRNGYINKIHAQNIGIIASELGAGRVTKDSIIDLAVGIVLNKKRSDKIKKGDIIAYIHAN
DKIKGEKAAKDILNNYVIEEELKEELPLIYDTVK

Sequences:

>Translated_434_residues
MRMYDLILKKRNGGELSKEEIDYFILEYINGNVPDYQASALLMAIYFQKMKRRETVDLTMAMVNSGDILDLSKIQGIKVD
KHSTGGVGDTTTLVLAPMVAALGIPVAKMSGRGLGHTGGTIDKLESFKGFSVNMTEDKFINNVNNIKIAVGAQTADLAPA
DKKLYALRDVTATVDNISLIASSIMSKKIAAGANAIVLDVKVGEGAFMKTPETAKELAEEMVNIGKSVGRNTVAILSDMD
QPLGHSIGNALEVKEAIDTLKGKGPKDLLELCLTLGSNMVILAQKANTIEEAREMLLDTIEKGLAIEKLKEFVKSQGGDD
TLIDNTEKLPKAEYIIPVICDRNGYINKIHAQNIGIIASELGAGRVTKDSIIDLAVGIVLNKKRSDKIKKGDIIAYIHAN
DKIKGEKAAKDILNNYVIEEELKEELPLIYDTVK
>Mature_434_residues
MRMYDLILKKRNGGELSKEEIDYFILEYINGNVPDYQASALLMAIYFQKMKRRETVDLTMAMVNSGDILDLSKIQGIKVD
KHSTGGVGDTTTLVLAPMVAALGIPVAKMSGRGLGHTGGTIDKLESFKGFSVNMTEDKFINNVNNIKIAVGAQTADLAPA
DKKLYALRDVTATVDNISLIASSIMSKKIAAGANAIVLDVKVGEGAFMKTPETAKELAEEMVNIGKSVGRNTVAILSDMD
QPLGHSIGNALEVKEAIDTLKGKGPKDLLELCLTLGSNMVILAQKANTIEEAREMLLDTIEKGLAIEKLKEFVKSQGGDD
TLIDNTEKLPKAEYIIPVICDRNGYINKIHAQNIGIIASELGAGRVTKDSIIDLAVGIVLNKKRSDKIKKGDIIAYIHAN
DKIKGEKAAKDILNNYVIEEELKEELPLIYDTVK

Specific function: The Enzymes Which Catalyze The Reversible Phosphorolysis Of Pyrimidine Nucleosides Are Involved In The Degradation Of These Compounds And In Their Utilization As Carbon And Energy Sources, Or In The Rescue Of Pyrimidine Bases For Nucleotide Synthesis. [C

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI166158925, Length=407, Percent_Identity=38.0835380835381, Blast_Score=270, Evalue=2e-72,
Organism=Homo sapiens, GI4503445, Length=407, Percent_Identity=38.0835380835381, Blast_Score=270, Evalue=2e-72,
Organism=Homo sapiens, GI166158922, Length=407, Percent_Identity=38.0835380835381, Blast_Score=270, Evalue=2e-72,
Organism=Escherichia coli, GI1790842, Length=431, Percent_Identity=40.8352668213457, Blast_Score=305, Evalue=4e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR018090
- InterPro:   IPR000053
- InterPro:   IPR017872 [H]

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C [H]

EC number: =2.4.2.2 [H]

Molecular weight: Translated: 47105; Mature: 47105

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRMYDLILKKRNGGELSKEEIDYFILEYINGNVPDYQASALLMAIYFQKMKRRETVDLTM
CCHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHEEEE
AMVNSGDILDLSKIQGIKVDKHSTGGVGDTTTLVLAPMVAALGIPVAKMSGRGLGHTGGT
EEECCCCEEEHHHCCCEEECCCCCCCCCCHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCC
IDKLESFKGFSVNMTEDKFINNVNNIKIAVGAQTADLAPADKKLYALRDVTATVDNISLI
HHHHHHCCCCEEECCHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHH
ASSIMSKKIAAGANAIVLDVKVGEGAFMKTPETAKELAEEMVNIGKSVGRNTVAILSDMD
HHHHHHHHHHCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEHHHHCC
QPLGHSIGNALEVKEAIDTLKGKGPKDLLELCLTLGSNMVILAQKANTIEEAREMLLDTI
HHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHH
EKGLAIEKLKEFVKSQGGDDTLIDNTEKLPKAEYIIPVICDRNGYINKIHAQNIGIIASE
HHCHHHHHHHHHHHCCCCCCCCCCCCHHCCCCCEEEEEEECCCCCEEEEECCCCCEEECC
LGAGRVTKDSIIDLAVGIVLNKKRSDKIKKGDIIAYIHANDKIKGEKAAKDILNNYVIEE
CCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHH
ELKEELPLIYDTVK
HHHHCCCCCEECCC
>Mature Secondary Structure
MRMYDLILKKRNGGELSKEEIDYFILEYINGNVPDYQASALLMAIYFQKMKRRETVDLTM
CCHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHEEEE
AMVNSGDILDLSKIQGIKVDKHSTGGVGDTTTLVLAPMVAALGIPVAKMSGRGLGHTGGT
EEECCCCEEEHHHCCCEEECCCCCCCCCCHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCC
IDKLESFKGFSVNMTEDKFINNVNNIKIAVGAQTADLAPADKKLYALRDVTATVDNISLI
HHHHHHCCCCEEECCHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHH
ASSIMSKKIAAGANAIVLDVKVGEGAFMKTPETAKELAEEMVNIGKSVGRNTVAILSDMD
HHHHHHHHHHCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEHHHHCC
QPLGHSIGNALEVKEAIDTLKGKGPKDLLELCLTLGSNMVILAQKANTIEEAREMLLDTI
HHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHH
EKGLAIEKLKEFVKSQGGDDTLIDNTEKLPKAEYIIPVICDRNGYINKIHAQNIGIIASE
HHCHHHHHHHHHHHCCCCCCCCCCCCHHCCCCCEEEEEEECCCCCEEEEECCCCCEEECC
LGAGRVTKDSIIDLAVGIVLNKKRSDKIKKGDIIAYIHANDKIKGEKAAKDILNNYVIEE
CCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHH
ELKEELPLIYDTVK
HHHHCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA