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The map label for this gene is pyrC [H]

Identifier: 170751691

GI number: 170751691

Start: 5629389

End: 5630468

Strand: Direct

Name: pyrC [H]

Synonym: Mrad2831_5321

Alternate gene names: 170751691

Gene position: 5629389-5630468 (Clockwise)

Preceding gene: 170751690

Following gene: 170751692

Centisome position: 92.62

GC content: 71.85

Gene sequence:

>1080_bases
ATGGGCGTCGCCGAGCTGTTCCCCGCCGAGCGCCAGGAGGCGAACCCGGTCGACCGGATCACGATCCGCCGGCCGGACGA
CTGGCACATCCACCTGCGCGACGGCGCCATGCTGAAGGCGGTGCTGCCCTACACGGCGGCGCAGTTCGCCCGGGGCATCA
TCATGCCGAACCTCGTGCCGCCGGTGACCACGGTCGCGGCCGCGCAGGCCTATCGCGAGCGCATCCTGGCGGCCCTGCCC
GAGGGCCAGGACTTCACGCCGCTGATGACCTGCTACCTGCGGGACGACACCGACCCGGACGAGATCGAGCGCGGCTTCGG
GGAGAAGGTCTGGGTCGCCGCCAAGCTCTACCCGGCGGGCGCGACCACGAACTCGCACGCGGGCGTCACCGACCTCAATG
GCATCGCGCCCGTGCTGGAGCGGATGGAGCGGATCGGCATGCCGCTCCTGATCCACGGCGAGGCGACCGACCCGGAGATC
GACATCTTCGACCGCGAGGCCGCCTTCATGGAGGGCAGCCTGATCCCGCTCCTCGGCCGCCATCAGGGGCTGAAGGTCAC
CGTGGAGCACGCCACCACCGCGGAGATCCTCGACGTGGTCCGCGAGCACCGGAGCCGGTGCGCGGCGACGATCACGCCGC
ACCACCTCGTGATCAACCGGACGCACATCTTCCAGGGTGGCCTGCGCCCGCACCTGTACTGCCTGCCGGTGGCCAAGCGC
GAGCGGCACCGGCTCGCCCTGCGCCGGGCCGCGACCTCCGGCGAGGCCTGCTTCTATCTCGGCACCGACACGGCCCCGCA
TGTCCGCGGCGCCAAGGAGGCGTCCTGCGGCTGCGCCGGCGTGTTCTGCGGCCCGAGCGCGCTCCAGACCTACGTGCAGG
TCTTCGACGAGGAGGGGGCGCTGGACAAGTTCGAGGCTTTCGCGTCGCTCAACGGCGCCCGCTTCCACGGTCTGGAGCCG
AATGCCGGGACCGTCACCCTGGAGCGCCGGGAGAGCCGCATCGCCGAGGCCGTCGCGGTCGACGACACGGCGGTGGTGGT
GTTCCGCGGCGAGGAGACGCTGCCCTGGTCGGTGGCGTGA

Upstream 100 bases:

>100_bases
ACCCTGGCGGAGGTCGAGCGCTTCCTCAACGCCCCGGCGGAGTGGTCGGCGGCCCACGGCGGCATCTCCGCCTTCGGCCA
GGCCTGAGGAGAGGATCGCG

Downstream 100 bases:

>100_bases
CCGCCTAGGCTGGGACCGCGCACCGTCATCGCGGGCGCGGCGAGGCGACCCCGGGCAGCGCGAGATCGGTGACCGTCGGG
CGACATGGGGTTGCTTCGCC

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 359; Mature: 358

Protein sequence:

>359_residues
MGVAELFPAERQEANPVDRITIRRPDDWHIHLRDGAMLKAVLPYTAAQFARGIIMPNLVPPVTTVAAAQAYRERILAALP
EGQDFTPLMTCYLRDDTDPDEIERGFGEKVWVAAKLYPAGATTNSHAGVTDLNGIAPVLERMERIGMPLLIHGEATDPEI
DIFDREAAFMEGSLIPLLGRHQGLKVTVEHATTAEILDVVREHRSRCAATITPHHLVINRTHIFQGGLRPHLYCLPVAKR
ERHRLALRRAATSGEACFYLGTDTAPHVRGAKEASCGCAGVFCGPSALQTYVQVFDEEGALDKFEAFASLNGARFHGLEP
NAGTVTLERRESRIAEAVAVDDTAVVVFRGEETLPWSVA

Sequences:

>Translated_359_residues
MGVAELFPAERQEANPVDRITIRRPDDWHIHLRDGAMLKAVLPYTAAQFARGIIMPNLVPPVTTVAAAQAYRERILAALP
EGQDFTPLMTCYLRDDTDPDEIERGFGEKVWVAAKLYPAGATTNSHAGVTDLNGIAPVLERMERIGMPLLIHGEATDPEI
DIFDREAAFMEGSLIPLLGRHQGLKVTVEHATTAEILDVVREHRSRCAATITPHHLVINRTHIFQGGLRPHLYCLPVAKR
ERHRLALRRAATSGEACFYLGTDTAPHVRGAKEASCGCAGVFCGPSALQTYVQVFDEEGALDKFEAFASLNGARFHGLEP
NAGTVTLERRESRIAEAVAVDDTAVVVFRGEETLPWSVA
>Mature_358_residues
GVAELFPAERQEANPVDRITIRRPDDWHIHLRDGAMLKAVLPYTAAQFARGIIMPNLVPPVTTVAAAQAYRERILAALPE
GQDFTPLMTCYLRDDTDPDEIERGFGEKVWVAAKLYPAGATTNSHAGVTDLNGIAPVLERMERIGMPLLIHGEATDPEID
IFDREAAFMEGSLIPLLGRHQGLKVTVEHATTAEILDVVREHRSRCAATITPHHLVINRTHIFQGGLRPHLYCLPVAKRE
RHRLALRRAATSGEACFYLGTDTAPHVRGAKEASCGCAGVFCGPSALQTYVQVFDEEGALDKFEAFASLNGARFHGLEPN
AGTVTLERRESRIAEAVAVDDTAVVVFRGEETLPWSVA

Specific function: Pyrimidine biosynthesis; third step. [C]

COG id: COG0418

COG function: function code F; Dihydroorotase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 1 subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787301, Length=343, Percent_Identity=58.600583090379, Blast_Score=417, Evalue=1e-118,
Organism=Saccharomyces cerevisiae, GI6323452, Length=355, Percent_Identity=31.5492957746479, Blast_Score=160, Evalue=2e-40,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004721
- InterPro:   IPR002195 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 39341; Mature: 39210

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS00482 DIHYDROOROTASE_1 ; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVAELFPAERQEANPVDRITIRRPDDWHIHLRDGAMLKAVLPYTAAQFARGIIMPNLVP
CCHHHCCCCCCCCCCCCCEEEEECCCCCEEEEECCCEEHHHHHHHHHHHHCCCCCCCCCC
PVTTVAAAQAYRERILAALPEGQDFTPLMTCYLRDDTDPDEIERGFGEKVWVAAKLYPAG
CHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCHHHHHHCCCCEEEEEEEEEECC
ATTNSHAGVTDLNGIAPVLERMERIGMPLLIHGEATDPEIDIFDREAAFMEGSLIPLLGR
CCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCEEEECCHHHHHCCCCCEECCC
HQGLKVTVEHATTAEILDVVREHRSRCAATITPHHLVINRTHIFQGGLRPHLYCLPVAKR
CCCCEEEEECCCHHHHHHHHHHHHHHCEEECCCCEEEEEEEEEECCCCCCEEEEEECCHH
ERHRLALRRAATSGEACFYLGTDTAPHVRGAKEASCGCAGVFCGPSALQTYVQVFDEEGA
HHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHHHCCCCC
LDKFEAFASLNGARFHGLEPNAGTVTLERRESRIAEAVAVDDTAVVVFRGEETLPWSVA
HHHHHHHHHCCCCEEECCCCCCCEEEEHHHHHHHHHHEEECCEEEEEEECCCCCCCCCC
>Mature Secondary Structure 
GVAELFPAERQEANPVDRITIRRPDDWHIHLRDGAMLKAVLPYTAAQFARGIIMPNLVP
CHHHCCCCCCCCCCCCCEEEEECCCCCEEEEECCCEEHHHHHHHHHHHHCCCCCCCCCC
PVTTVAAAQAYRERILAALPEGQDFTPLMTCYLRDDTDPDEIERGFGEKVWVAAKLYPAG
CHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCHHHHHHCCCCEEEEEEEEEECC
ATTNSHAGVTDLNGIAPVLERMERIGMPLLIHGEATDPEIDIFDREAAFMEGSLIPLLGR
CCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCEEEECCHHHHHCCCCCEECCC
HQGLKVTVEHATTAEILDVVREHRSRCAATITPHHLVINRTHIFQGGLRPHLYCLPVAKR
CCCCEEEEECCCHHHHHHHHHHHHHHCEEECCCCEEEEEEEEEECCCCCCEEEEEECCHH
ERHRLALRRAATSGEACFYLGTDTAPHVRGAKEASCGCAGVFCGPSALQTYVQVFDEEGA
HHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHHHCCCCC
LDKFEAFASLNGARFHGLEPNAGTVTLERRESRIAEAVAVDDTAVVVFRGEETLPWSVA
HHHHHHHHHCCCCEEECCCCCCCEEEEHHHHHHHHHHEEECCEEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA