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The map label for this gene is edd [H]

Identifier: 170749828

GI number: 170749828

Start: 3641057

End: 3642883

Strand: Direct

Name: edd [H]

Synonym: Mrad2831_3428

Alternate gene names: 170749828

Gene position: 3641057-3642883 (Clockwise)

Preceding gene: 170749827

Following gene: 170749829

Centisome position: 59.91

GC content: 72.52

Gene sequence:

>1827_bases
ATGACCGAGCTTCATCCCGAGGTCGCGGCGGTCACCGAGCGCGTCGTGGCGCGCTCCCGCGAGACCCGGCGCGCCTATCT
CGACCTGATCGCCCGCGAGCGCGAGGCGGGGGTCCGGCGCGGCAAGCTCGCCTGCGGCAACCTCGCCCACGGCTTCGCGG
CCTCCGGCGAGGACAAGGCGGCGATCCGCGACGAGCGGACGGTGATGAACATCGGCATCGTCACCGCCTACAACGACATG
CTCTCGGCCCATCAGCCCTACGGGCGCTACCCGGAGCAGATCAAGCTGTTCGCCCGGGAGCGCGGCGCCACCGCGCAGGT
CGCGGGCGGTACGCCGGCCATGTGCGACGGCGTCACCCAGGGCCAGAGCGGCATGGAGCTGTCGCTGTTCTCCCGGGACA
CGATCGCGCTCTCCACCGCGGTGGCGCTGAGCCACGGCATGTTCGACGGGGCGGCGCTCCTCGGCATCTGCGACAAGATC
GTGCCGGGCCTGCTCATCGGGGCGCTCCGCTTCGGCCACCTGCCGACGATCCTGATCCCGGCCGGTCCCATGCCCTCGGG
CCTCGCCAACAAGGAGAAGCAGCGGATCCGCCAGCTCTACGCCGAGGGCAAGGTCGGCCGGGCGGAACTGCTCGAATCCG
AGTCCGCCTCCTACCACGCGGCCGGGACCTGCACGTTCTACGGCACCGCCAACTCCAACCAGATGATGATGGACATGATG
GGCCTGCACATGCCGGGCGCGTCCTTCATCAATCCGGGCACCAAGCTGCGCCAGGCCGTGACCCGGGCGGCGATCCACCG
CCTCACCGAGATCGGCGGCGCCGGCAACGACTACCGCCCCCTCGGCCTCTGCGTCGACGAGAAGGCGATCGTCAACGCCG
CGGTCGGCCTCCTCGCCACGGGCGGCTCGACCAACCACGCGATCCACCTGCCGGCCATCGCGCGCGCCGCCGGCATCGTG
ATCGACTGGGAGGATATCGACCGGCTCTCCAGCGCCGTGCCGCTGATCGCCCGCGTCTACCCGAACGGCGCCGGCGACGT
GAACCACTTCCACGCCGCGGGCGGCATGAGCTTCGTGATGGCGGCGCTGCTCGACGCGGGCCTCCTGCACGACGACATCC
TGACCGTGGCGGGCCAGTCGCTGCGCGACCACGCCCGCGACCCGAAACTCGACGGCGAGGATCTGGTCTTCGAGGACGCG
GTGCCGGAGAGCCTGGACGACACGATGCTGCGCCGGCCGGGCAACCCGTTCCAGCCCGACGGCGGCATGCGGCTCGTGAA
GGGCAATCTCGGCCGGGCGACGTTCAAGACCAGCGCCGTCGAGGAGCACCGCCGCACCATCGAGGCCCCGGCCCGGGTCT
TCTCCGACCAGGACGAGGTGCTGAAGGCGTTCAAGGCCGGGGAGCTGGAGCGCGACGTCGTGGTCGTGGTCCGGTTCCAG
GGCCCGAAGGCGAACGGCATGCCCGAGCTGCACAAGCTGACCCCGCCGCTGGGCGTGCTGCAGGACCGCGGCCACCGGGT
CGCCCTGGTGACCGACGGGCGCATGTCGGGGGCGTCGGGCAAGGTGCCGGCCGCCATCCACCTGAGCCCCGAGGCGCTCG
GCGGCGGCCCGATCGGGCGGATCCGCGACGGCGACATCGTCCGCCTCAGCGCCGCCGACGGGCTGCTGCAGGTTCTGGTC
GACGACGCGGAATTCGCGGCGCGCCCCGAGGCCGAGGCGCCGGAGGCCGCGCAGGGCACCGGGCGGGAGCTGTTCGCGTT
CATGCGCCAGGGGGCCGACACGGCGGAGCGGGGCGCCTCGGCGATGCTCGCCGCCGCCGGCCTCTGA

Upstream 100 bases:

>100_bases
ACCCCCTTAGATACCGGCCACCGACGACGCGGCCGCGCGGCCGATCCCGACTCGCGGCCCCGGCCGCGCGCCCGTCGGCA
CCGAGCCTGGAGGAACGAGC

Downstream 100 bases:

>100_bases
AACCGAGAGGGAGTTGCCGACCATGAACGATCTGACCAGCATCGACGCGCTGATGCGCTCCGTGCCCGTCATTCCGGTCC
TGGTGATCGACGACGCGGCC

Product: phosphogluconate dehydratase

Products: NA

Alternate protein names: 6-phosphogluconate dehydratase [H]

Number of amino acids: Translated: 608; Mature: 607

Protein sequence:

>608_residues
MTELHPEVAAVTERVVARSRETRRAYLDLIAREREAGVRRGKLACGNLAHGFAASGEDKAAIRDERTVMNIGIVTAYNDM
LSAHQPYGRYPEQIKLFARERGATAQVAGGTPAMCDGVTQGQSGMELSLFSRDTIALSTAVALSHGMFDGAALLGICDKI
VPGLLIGALRFGHLPTILIPAGPMPSGLANKEKQRIRQLYAEGKVGRAELLESESASYHAAGTCTFYGTANSNQMMMDMM
GLHMPGASFINPGTKLRQAVTRAAIHRLTEIGGAGNDYRPLGLCVDEKAIVNAAVGLLATGGSTNHAIHLPAIARAAGIV
IDWEDIDRLSSAVPLIARVYPNGAGDVNHFHAAGGMSFVMAALLDAGLLHDDILTVAGQSLRDHARDPKLDGEDLVFEDA
VPESLDDTMLRRPGNPFQPDGGMRLVKGNLGRATFKTSAVEEHRRTIEAPARVFSDQDEVLKAFKAGELERDVVVVVRFQ
GPKANGMPELHKLTPPLGVLQDRGHRVALVTDGRMSGASGKVPAAIHLSPEALGGGPIGRIRDGDIVRLSAADGLLQVLV
DDAEFAARPEAEAPEAAQGTGRELFAFMRQGADTAERGASAMLAAAGL

Sequences:

>Translated_608_residues
MTELHPEVAAVTERVVARSRETRRAYLDLIAREREAGVRRGKLACGNLAHGFAASGEDKAAIRDERTVMNIGIVTAYNDM
LSAHQPYGRYPEQIKLFARERGATAQVAGGTPAMCDGVTQGQSGMELSLFSRDTIALSTAVALSHGMFDGAALLGICDKI
VPGLLIGALRFGHLPTILIPAGPMPSGLANKEKQRIRQLYAEGKVGRAELLESESASYHAAGTCTFYGTANSNQMMMDMM
GLHMPGASFINPGTKLRQAVTRAAIHRLTEIGGAGNDYRPLGLCVDEKAIVNAAVGLLATGGSTNHAIHLPAIARAAGIV
IDWEDIDRLSSAVPLIARVYPNGAGDVNHFHAAGGMSFVMAALLDAGLLHDDILTVAGQSLRDHARDPKLDGEDLVFEDA
VPESLDDTMLRRPGNPFQPDGGMRLVKGNLGRATFKTSAVEEHRRTIEAPARVFSDQDEVLKAFKAGELERDVVVVVRFQ
GPKANGMPELHKLTPPLGVLQDRGHRVALVTDGRMSGASGKVPAAIHLSPEALGGGPIGRIRDGDIVRLSAADGLLQVLV
DDAEFAARPEAEAPEAAQGTGRELFAFMRQGADTAERGASAMLAAAGL
>Mature_607_residues
TELHPEVAAVTERVVARSRETRRAYLDLIAREREAGVRRGKLACGNLAHGFAASGEDKAAIRDERTVMNIGIVTAYNDML
SAHQPYGRYPEQIKLFARERGATAQVAGGTPAMCDGVTQGQSGMELSLFSRDTIALSTAVALSHGMFDGAALLGICDKIV
PGLLIGALRFGHLPTILIPAGPMPSGLANKEKQRIRQLYAEGKVGRAELLESESASYHAAGTCTFYGTANSNQMMMDMMG
LHMPGASFINPGTKLRQAVTRAAIHRLTEIGGAGNDYRPLGLCVDEKAIVNAAVGLLATGGSTNHAIHLPAIARAAGIVI
DWEDIDRLSSAVPLIARVYPNGAGDVNHFHAAGGMSFVMAALLDAGLLHDDILTVAGQSLRDHARDPKLDGEDLVFEDAV
PESLDDTMLRRPGNPFQPDGGMRLVKGNLGRATFKTSAVEEHRRTIEAPARVFSDQDEVLKAFKAGELERDVVVVVRFQG
PKANGMPELHKLTPPLGVLQDRGHRVALVTDGRMSGASGKVPAAIHLSPEALGGGPIGRIRDGDIVRLSAADGLLQVLVD
DAEFAARPEAEAPEAAQGTGRELFAFMRQGADTAERGASAMLAAAGL

Specific function: KEY ENZYME IN THE ENTNER-DOUDOROFF PATHWAY. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI1788157, Length=603, Percent_Identity=57.87728026534, Blast_Score=702, Evalue=0.0,
Organism=Escherichia coli, GI48994964, Length=521, Percent_Identity=32.0537428023033, Blast_Score=199, Evalue=4e-52,
Organism=Escherichia coli, GI1786464, Length=469, Percent_Identity=32.409381663113, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI2367371, Length=465, Percent_Identity=29.6774193548387, Blast_Score=154, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6322476, Length=494, Percent_Identity=29.9595141700405, Blast_Score=175, Evalue=1e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004786
- InterPro:   IPR015928
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.12 [H]

Molecular weight: Translated: 64403; Mature: 64272

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00136 SUBTILASE_ASP ; PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTELHPEVAAVTERVVARSRETRRAYLDLIAREREAGVRRGKLACGNLAHGFAASGEDKA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCH
AIRDERTVMNIGIVTAYNDMLSAHQPYGRYPEQIKLFARERGATAQVAGGTPAMCDGVTQ
HHCCCCEEEEEEEEEHHHHHHHCCCCCCCCHHHHHHHHHHCCCEEEECCCCCHHHCCCCC
GQSGMELSLFSRDTIALSTAVALSHGMFDGAALLGICDKIVPGLLIGALRFGHLPTILIP
CCCCCEEEEECCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
AGPMPSGLANKEKQRIRQLYAEGKVGRAELLESESASYHAAGTCTFYGTANSNQMMMDMM
CCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHCCCCCEEECEEEEEEECCCCCHHHHHHH
GLHMPGASFINPGTKLRQAVTRAAIHRLTEIGGAGNDYRPLGLCVDEKAIVNAAVGLLAT
HCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECHHHHHHHHHHHEEC
GGSTNHAIHLPAIARAAGIVIDWEDIDRLSSAVPLIARVYPNGAGDVNHFHAAGGMSFVM
CCCCCCEEECCHHHHHCCEEEEHHHHHHHHHHHCCHHEECCCCCCCCCCEECCCHHHHHH
AALLDAGLLHDDILTVAGQSLRDHARDPKLDGEDLVFEDAVPESLDDTMLRRPGNPFQPD
HHHHHCCCHHHHHHHHHCHHHHHHCCCCCCCCCCEEECCCCCCHHHHHHHHCCCCCCCCC
GGMRLVKGNLGRATFKTSAVEEHRRTIEAPARVFSDQDEVLKAFKAGELERDVVVVVRFQ
CCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCEEEEEEEC
GPKANGMPELHKLTPPLGVLQDRGHRVALVTDGRMSGASGKVPAAIHLSPEALGGGPIGR
CCCCCCCCHHHHCCCCHHHHHCCCCEEEEEECCCCCCCCCCCCEEEEECHHHCCCCCCCC
IRDGDIVRLSAADGLLQVLVDDAEFAARPEAEAPEAAQGTGRELFAFMRQGADTAERGAS
CCCCCEEEEECCCHHHHHHHCCHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHH
AMLAAAGL
HHHHHCCC
>Mature Secondary Structure 
TELHPEVAAVTERVVARSRETRRAYLDLIAREREAGVRRGKLACGNLAHGFAASGEDKA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCH
AIRDERTVMNIGIVTAYNDMLSAHQPYGRYPEQIKLFARERGATAQVAGGTPAMCDGVTQ
HHCCCCEEEEEEEEEHHHHHHHCCCCCCCCHHHHHHHHHHCCCEEEECCCCCHHHCCCCC
GQSGMELSLFSRDTIALSTAVALSHGMFDGAALLGICDKIVPGLLIGALRFGHLPTILIP
CCCCCEEEEECCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
AGPMPSGLANKEKQRIRQLYAEGKVGRAELLESESASYHAAGTCTFYGTANSNQMMMDMM
CCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHCCCCCEEECEEEEEEECCCCCHHHHHHH
GLHMPGASFINPGTKLRQAVTRAAIHRLTEIGGAGNDYRPLGLCVDEKAIVNAAVGLLAT
HCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECHHHHHHHHHHHEEC
GGSTNHAIHLPAIARAAGIVIDWEDIDRLSSAVPLIARVYPNGAGDVNHFHAAGGMSFVM
CCCCCCEEECCHHHHHCCEEEEHHHHHHHHHHHCCHHEECCCCCCCCCCEECCCHHHHHH
AALLDAGLLHDDILTVAGQSLRDHARDPKLDGEDLVFEDAVPESLDDTMLRRPGNPFQPD
HHHHHCCCHHHHHHHHHCHHHHHHCCCCCCCCCCEEECCCCCCHHHHHHHHCCCCCCCCC
GGMRLVKGNLGRATFKTSAVEEHRRTIEAPARVFSDQDEVLKAFKAGELERDVVVVVRFQ
CCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCEEEEEEEC
GPKANGMPELHKLTPPLGVLQDRGHRVALVTDGRMSGASGKVPAAIHLSPEALGGGPIGR
CCCCCCCCHHHHCCCCHHHHHCCCCEEEEEECCCCCCCCCCCCEEEEECHHHCCCCCCCC
IRDGDIVRLSAADGLLQVLVDDAEFAARPEAEAPEAAQGTGRELFAFMRQGADTAERGAS
CCCCCEEEEECCCHHHHHHHCCHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHH
AMLAAAGL
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2254282 [H]