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The map label for this gene is serA [H]

Identifier: 170749806

GI number: 170749806

Start: 3614394

End: 3615431

Strand: Direct

Name: serA [H]

Synonym: Mrad2831_3405

Alternate gene names: 170749806

Gene position: 3614394-3615431 (Clockwise)

Preceding gene: 170749805

Following gene: 170749807

Centisome position: 59.47

GC content: 75.05

Gene sequence:

>1038_bases
GTGGCGGTCCGCAAGCGCGTCTGCCGATTCAACGTCTGGATCAACCCGGTCTTCGACGCGCGCCTGGGGGCCGAGCCCGA
CATCGACCTGCAGGTCGGCGACCTGCAGGGACCGGAGGACGCGCTCGCCGCGCTGCTGGCGCGGGCCCACGTCCTCCACG
TCTCGCCGGCGCGGGACGAGCTGCCGCGCCGCTGGCACGTGACCGACGCGCTGCTCGCCGAATGCCCCGACCTCCTGGCG
GTCTCGTCGGCCGGGGCGGGCTTCGACACGGTGGACGCCGCCGCCTGCACCCGGGCCGGCGTCGCGGTGGTGAACCAAGT
GGGCGGCAATGCCCGCTCGGTGGCCGAGCTGGCGATCGGCCTGATGCTCGCCGTCTCGCGCAAGATCTGCGTCTCGGACC
GGCTGCTCCGGACCGCGCGCGGCTTCACCCGCGAATCGCTCATGGGCCACGAGATCGGCGGCGCGACCCTGGGCCTGATC
GGGATCGGCCATACCGGCCGGGAGGTCGCCAAGCTGGCCCGCGGCTTCGACATGCGGGTCTTCGCCCACGACCCCCTGCT
CTCGGGCGATGAGATCCGGGCCCGCGGCGCGGAGCCGGTCGACCGGGCGCGACTGCTCGCCGAGTCCGACATCGTGTCCC
TGCACTGCCCCCTCGACGACACGACCCGCGGCAGCTTCGACGCCGAGAGCTTCGCGGCGATGAGGCCGGGGGCACTGTTC
ATCACCACCGCCCGCGGCGGCGTCCACGACGAGGCCGCGCTCGCCGCGGCGCTGACCGCCGGCCACCTCGCGGGGGCGGG
CCTCGACGTCTGGTCGCCGGAGCCGCCGCCCCTCAACGCGGCCCTGCTGCAGCTCGACACCGTGGTGGCGACCTACCACA
CCGCCGGCGTCACCCACGAGGCACGGCGCAACGTGGCCGCCTGGGGGGCCGAGCAGATCGTCGGCCTGCTCCGCGGCGAG
ACGCCGCCGCGCCTCGTCAATCCGGAGGTCTGGCCCGCCGTGCTGGAGCGCCGGGCGGTGCTGTTCGGCGACGCGTGA

Upstream 100 bases:

>100_bases
CGCTCTGGAGACCGGCCGGATCTGCGTGGCCGCGGTCAACACCCACAACATCGACCACGTCATCGACGCGATCGACGCGG
TGGTGAAGGGCTGATCCCGC

Downstream 100 bases:

>100_bases
CCCGGAGCGGGTCCGGCGCCGCGCCGGTGGCGCACGATCCTGTGGACTATTCCCGCGCGACGCGGCGGACTCGGGCCGTC
CGACACTGAACCGCTCCCGG

Product: NAD-binding D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MAVRKRVCRFNVWINPVFDARLGAEPDIDLQVGDLQGPEDALAALLARAHVLHVSPARDELPRRWHVTDALLAECPDLLA
VSSAGAGFDTVDAAACTRAGVAVVNQVGGNARSVAELAIGLMLAVSRKICVSDRLLRTARGFTRESLMGHEIGGATLGLI
GIGHTGREVAKLARGFDMRVFAHDPLLSGDEIRARGAEPVDRARLLAESDIVSLHCPLDDTTRGSFDAESFAAMRPGALF
ITTARGGVHDEAALAAALTAGHLAGAGLDVWSPEPPPLNAALLQLDTVVATYHTAGVTHEARRNVAAWGAEQIVGLLRGE
TPPRLVNPEVWPAVLERRAVLFGDA

Sequences:

>Translated_345_residues
MAVRKRVCRFNVWINPVFDARLGAEPDIDLQVGDLQGPEDALAALLARAHVLHVSPARDELPRRWHVTDALLAECPDLLA
VSSAGAGFDTVDAAACTRAGVAVVNQVGGNARSVAELAIGLMLAVSRKICVSDRLLRTARGFTRESLMGHEIGGATLGLI
GIGHTGREVAKLARGFDMRVFAHDPLLSGDEIRARGAEPVDRARLLAESDIVSLHCPLDDTTRGSFDAESFAAMRPGALF
ITTARGGVHDEAALAAALTAGHLAGAGLDVWSPEPPPLNAALLQLDTVVATYHTAGVTHEARRNVAAWGAEQIVGLLRGE
TPPRLVNPEVWPAVLERRAVLFGDA
>Mature_344_residues
AVRKRVCRFNVWINPVFDARLGAEPDIDLQVGDLQGPEDALAALLARAHVLHVSPARDELPRRWHVTDALLAECPDLLAV
SSAGAGFDTVDAAACTRAGVAVVNQVGGNARSVAELAIGLMLAVSRKICVSDRLLRTARGFTRESLMGHEIGGATLGLIG
IGHTGREVAKLARGFDMRVFAHDPLLSGDEIRARGAEPVDRARLLAESDIVSLHCPLDDTTRGSFDAESFAAMRPGALFI
TTARGGVHDEAALAAALTAGHLAGAGLDVWSPEPPPLNAALLQLDTVVATYHTAGVTHEARRNVAAWGAEQIVGLLRGET
PPRLVNPEVWPAVLERRAVLFGDA

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=264, Percent_Identity=33.3333333333333, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI145580578, Length=258, Percent_Identity=33.7209302325581, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI4557499, Length=258, Percent_Identity=33.7209302325581, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI6912396, Length=255, Percent_Identity=30.5882352941176, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI4557497, Length=251, Percent_Identity=33.0677290836653, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI61743967, Length=251, Percent_Identity=33.0677290836653, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI145580575, Length=251, Percent_Identity=34.2629482071713, Blast_Score=107, Evalue=2e-23,
Organism=Escherichia coli, GI87082289, Length=276, Percent_Identity=34.7826086956522, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1789279, Length=281, Percent_Identity=33.0960854092527, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI1787645, Length=252, Percent_Identity=32.1428571428571, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1788660, Length=244, Percent_Identity=30.327868852459, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17532191, Length=299, Percent_Identity=30.7692307692308, Blast_Score=137, Evalue=7e-33,
Organism=Caenorhabditis elegans, GI25147481, Length=260, Percent_Identity=30.3846153846154, Blast_Score=110, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6322116, Length=281, Percent_Identity=30.9608540925267, Blast_Score=117, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6320925, Length=281, Percent_Identity=30.6049822064057, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6324055, Length=271, Percent_Identity=29.520295202952, Blast_Score=102, Evalue=8e-23,
Organism=Saccharomyces cerevisiae, GI6324964, Length=275, Percent_Identity=24.7272727272727, Blast_Score=87, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6324980, Length=116, Percent_Identity=31.8965517241379, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI19921140, Length=256, Percent_Identity=35.15625, Blast_Score=141, Evalue=5e-34,
Organism=Drosophila melanogaster, GI28574286, Length=266, Percent_Identity=31.9548872180451, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24585514, Length=256, Percent_Identity=32.8125, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI28574282, Length=256, Percent_Identity=32.8125, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI45552429, Length=256, Percent_Identity=32.8125, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI45551003, Length=256, Percent_Identity=32.8125, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI28574284, Length=256, Percent_Identity=32.8125, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24646446, Length=281, Percent_Identity=32.0284697508897, Blast_Score=114, Evalue=9e-26,
Organism=Drosophila melanogaster, GI24646448, Length=281, Percent_Identity=32.0284697508897, Blast_Score=114, Evalue=9e-26,
Organism=Drosophila melanogaster, GI24646452, Length=281, Percent_Identity=32.0284697508897, Blast_Score=114, Evalue=9e-26,
Organism=Drosophila melanogaster, GI24646450, Length=281, Percent_Identity=32.0284697508897, Blast_Score=114, Evalue=9e-26,
Organism=Drosophila melanogaster, GI24585516, Length=282, Percent_Identity=28.3687943262411, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI62472511, Length=274, Percent_Identity=32.1167883211679, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI28571528, Length=248, Percent_Identity=31.4516129032258, Blast_Score=110, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 36492; Mature: 36361

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVRKRVCRFNVWINPVFDARLGAEPDIDLQVGDLQGPEDALAALLARAHVLHVSPARDE
CCCHHCEEEEEEEECCEECCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHEEECCCHHH
LPRRWHVTDALLAECPDLLAVSSAGAGFDTVDAAACTRAGVAVVNQVGGNARSVAELAIG
CCCEECHHHHHHHCCCHHEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
LMLAVSRKICVSDRLLRTARGFTRESLMGHEIGGATLGLIGIGHTGREVAKLARGFDMRV
HHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHCCCCEEE
FAHDPLLSGDEIRARGAEPVDRARLLAESDIVSLHCPLDDTTRGSFDAESFAAMRPGALF
EECCCCCCCCHHHCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHCCCCEEE
ITTARGGVHDEAALAAALTAGHLAGAGLDVWSPEPPPLNAALLQLDTVVATYHTAGVTHE
EEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHH
ARRNVAAWGAEQIVGLLRGETPPRLVNPEVWPAVLERRAVLFGDA
HHHHHHHCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCHHEECCC
>Mature Secondary Structure 
AVRKRVCRFNVWINPVFDARLGAEPDIDLQVGDLQGPEDALAALLARAHVLHVSPARDE
CCHHCEEEEEEEECCEECCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHEEECCCHHH
LPRRWHVTDALLAECPDLLAVSSAGAGFDTVDAAACTRAGVAVVNQVGGNARSVAELAIG
CCCEECHHHHHHHCCCHHEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
LMLAVSRKICVSDRLLRTARGFTRESLMGHEIGGATLGLIGIGHTGREVAKLARGFDMRV
HHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHCCCCEEE
FAHDPLLSGDEIRARGAEPVDRARLLAESDIVSLHCPLDDTTRGSFDAESFAAMRPGALF
EECCCCCCCCHHHCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHCCCCEEE
ITTARGGVHDEAALAAALTAGHLAGAGLDVWSPEPPPLNAALLQLDTVVATYHTAGVTHE
EEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHH
ARRNVAAWGAEQIVGLLRGETPPRLVNPEVWPAVLERRAVLFGDA
HHHHHHHCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCHHEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]