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The map label for this gene is mdtA [H]

Identifier: 170749189

GI number: 170749189

Start: 2921109

End: 2922272

Strand: Reverse

Name: mdtA [H]

Synonym: Mrad2831_2782

Alternate gene names: 170749189

Gene position: 2922272-2921109 (Counterclockwise)

Preceding gene: 170749191

Following gene: 170749188

Centisome position: 48.08

GC content: 71.05

Gene sequence:

>1164_bases
ATGGATGGCGTAGGAACGCGCCACGCAATTCGCACGAATCGCGCCGACGCAGTCGATCGCATGAACCGCATCGCCTTCCT
TCCATCGACATCCGTTCTGCTGGTGTTAACCGCGCTCGCTTCGATCGGGTGCGCCCGAGCCGAGCCGGAAACGGCCTTCG
ATCCGGCTCTGGCCCGGGTGCGGGTGGTGCAGGCGCACCGGACGCCGCTGGCGCTCGACGTCGTGGTGACCGGCGACATC
CAGGCCCAGGCGCAGGTGAACGTGTCGTTCCGGACGAACGGAAAGGTCGCCGAGCGGCGCGTCGAGGTCGGCGACCACGT
CGCCGCCAATCAGGTCCTCGCCGTCCTCGAACCCCTGACGCAGCAGGCCAATCTCGACAACGCCAAGGCCGCCCTCGCTT
CGGCCGAGGCGCTGCTGACACAGGCCAAGATGTCCTACGAGCGTCAGAAGCAGCTCCTCGCCGGCGGCTTCACCACCCGC
TCGACCTACGACAACGCCGAGCAGGAGCTGCGCACGACCCAGGCGGCGGTCGACTCGGCCAAGGCGGCGCTGGGGACCGC
GCAGGAGCAGTTCTCGTACACGGAGCTGCGCGCGGGGGTGTCCGGCGTGGTGACGAGCCGCAGCTTCGAGGTCGGCCAAG
TCGTCCAGGCGGGCCAGACCGTGCTGGTCGTGGCGCAGGACGGGCCCCGCGACGCGGTCTTCAACGTCTACGAATCGCTG
CTGGCCCAGCCGCCGGCCAGCGACACCATCGCGGTGGCCCTCCAGTCGGACCCGTCCGTCACCGCGGTCGGGACCGTGCG
GGAGATCTCGCCCACGGTGGACGCCGCGAGCGGCACGGTGCGGGTCAAGATCGGTCTGAAGGCGACGCCCGCCGCCATGG
GGCTCGGCGCCGTCGTCGTCGGCCGCGGCCGCTTCGCGCCGCACGAAGCGGTCGTCCTGCCCTGGTCGGCACTGTACCGC
TACGACGGGCGGCCCTCGGTGTGGATCTACGATCCGGACCGCAGGACCGTCTCGGTGCGCGCGGTGGAGATCGACCGCTT
CGGGCCCGACATCATCGCGCTGAAGCGCGGCGTCGAGCCGGGCGAGCGCGTGGTCGTCGCCGGCATCCAGTTCCTGCGCC
CCGGCCAGACCGTCGCGGCCGCCGAGATCGGAGACCGCCCATGA

Upstream 100 bases:

>100_bases
GGCCGCGGCCGCCTCCAGGATGATCTCGGGCCGCGCCGCCAGTCGCTGTCGCTTCACCTGCATCACAAGCCTGCACTAAA
GACCGTCTGGACGGTATGTA

Downstream 100 bases:

>100_bases
AGACGCGCGCGTATCTCGCACTCGGACTCGTCACGGCGGCGCTTGCCGGCTGCAACGGTCACGGCGAGGAGGGCGGCGAG
GCCGCTGCCGTCCGTCCGGT

Product: RND family efflux transporter MFP subunit

Products: NA

Alternate protein names: Multidrug transporter mdtA [H]

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MDGVGTRHAIRTNRADAVDRMNRIAFLPSTSVLLVLTALASIGCARAEPETAFDPALARVRVVQAHRTPLALDVVVTGDI
QAQAQVNVSFRTNGKVAERRVEVGDHVAANQVLAVLEPLTQQANLDNAKAALASAEALLTQAKMSYERQKQLLAGGFTTR
STYDNAEQELRTTQAAVDSAKAALGTAQEQFSYTELRAGVSGVVTSRSFEVGQVVQAGQTVLVVAQDGPRDAVFNVYESL
LAQPPASDTIAVALQSDPSVTAVGTVREISPTVDAASGTVRVKIGLKATPAAMGLGAVVVGRGRFAPHEAVVLPWSALYR
YDGRPSVWIYDPDRRTVSVRAVEIDRFGPDIIALKRGVEPGERVVVAGIQFLRPGQTVAAAEIGDRP

Sequences:

>Translated_387_residues
MDGVGTRHAIRTNRADAVDRMNRIAFLPSTSVLLVLTALASIGCARAEPETAFDPALARVRVVQAHRTPLALDVVVTGDI
QAQAQVNVSFRTNGKVAERRVEVGDHVAANQVLAVLEPLTQQANLDNAKAALASAEALLTQAKMSYERQKQLLAGGFTTR
STYDNAEQELRTTQAAVDSAKAALGTAQEQFSYTELRAGVSGVVTSRSFEVGQVVQAGQTVLVVAQDGPRDAVFNVYESL
LAQPPASDTIAVALQSDPSVTAVGTVREISPTVDAASGTVRVKIGLKATPAAMGLGAVVVGRGRFAPHEAVVLPWSALYR
YDGRPSVWIYDPDRRTVSVRAVEIDRFGPDIIALKRGVEPGERVVVAGIQFLRPGQTVAAAEIGDRP
>Mature_387_residues
MDGVGTRHAIRTNRADAVDRMNRIAFLPSTSVLLVLTALASIGCARAEPETAFDPALARVRVVQAHRTPLALDVVVTGDI
QAQAQVNVSFRTNGKVAERRVEVGDHVAANQVLAVLEPLTQQANLDNAKAALASAEALLTQAKMSYERQKQLLAGGFTTR
STYDNAEQELRTTQAAVDSAKAALGTAQEQFSYTELRAGVSGVVTSRSFEVGQVVQAGQTVLVVAQDGPRDAVFNVYESL
LAQPPASDTIAVALQSDPSVTAVGTVREISPTVDAASGTVRVKIGLKATPAAMGLGAVVVGRGRFAPHEAVVLPWSALYR
YDGRPSVWIYDPDRRTVSVRAVEIDRFGPDIIALKRGVEPGERVVVAGIQFLRPGQTVAAAEIGDRP

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789929, Length=298, Percent_Identity=26.8456375838926, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI87082036, Length=314, Percent_Identity=26.1146496815287, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI1789665, Length=378, Percent_Identity=25.9259259259259, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI1786668, Length=384, Percent_Identity=27.0833333333333, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI87081951, Length=147, Percent_Identity=30.6122448979592, Blast_Score=65, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022824
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 41037; Mature: 41037

Theoretical pI: Translated: 7.66; Mature: 7.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDGVGTRHAIRTNRADAVDRMNRIAFLPSTSVLLVLTALASIGCARAEPETAFDPALARV
CCCCCCCHHHHCCCHHHHHHHHHEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHH
RVVQAHRTPLALDVVVTGDIQAQAQVNVSFRTNGKVAERRVEVGDHVAANQVLAVLEPLT
EEEHHCCCCEEEEEEEECCCEEEEEEEEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHH
QQANLDNAKAALASAEALLTQAKMSYERQKQLLAGGFTTRSTYDNAEQELRTTQAAVDSA
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
KAALGTAQEQFSYTELRAGVSGVVTSRSFEVGQVVQAGQTVLVVAQDGPRDAVFNVYESL
HHHHCCHHHHHHHHHHHCCHHHEEECCCCCHHHHHHCCCEEEEEECCCCCHHHHHHHHHH
LAQPPASDTIAVALQSDPSVTAVGTVREISPTVDAASGTVRVKIGLKATPAAMGLGAVVV
HCCCCCCCEEEEEEECCCCEEEEEEHHHCCCCCCCCCCEEEEEEECEECCHHHCCCEEEE
GRGRFAPHEAVVLPWSALYRYDGRPSVWIYDPDRRTVSVRAVEIDRFGPDIIALKRGVEP
ECCCCCCCCEEEEEHHHHHEECCCCEEEEECCCCCEEEEEEEEECCCCCCEEEECCCCCC
GERVVVAGIQFLRPGQTVAAAEIGDRP
CCEEEEECHHHCCCCCEEEECCCCCCC
>Mature Secondary Structure
MDGVGTRHAIRTNRADAVDRMNRIAFLPSTSVLLVLTALASIGCARAEPETAFDPALARV
CCCCCCCHHHHCCCHHHHHHHHHEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHH
RVVQAHRTPLALDVVVTGDIQAQAQVNVSFRTNGKVAERRVEVGDHVAANQVLAVLEPLT
EEEHHCCCCEEEEEEEECCCEEEEEEEEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHH
QQANLDNAKAALASAEALLTQAKMSYERQKQLLAGGFTTRSTYDNAEQELRTTQAAVDSA
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
KAALGTAQEQFSYTELRAGVSGVVTSRSFEVGQVVQAGQTVLVVAQDGPRDAVFNVYESL
HHHHCCHHHHHHHHHHHCCHHHEEECCCCCHHHHHHCCCEEEEEECCCCCHHHHHHHHHH
LAQPPASDTIAVALQSDPSVTAVGTVREISPTVDAASGTVRVKIGLKATPAAMGLGAVVV
HCCCCCCCEEEEEEECCCCEEEEEEHHHCCCCCCCCCCEEEEEEECEECCHHHCCCEEEE
GRGRFAPHEAVVLPWSALYRYDGRPSVWIYDPDRRTVSVRAVEIDRFGPDIIALKRGVEP
ECCCCCCCCEEEEEHHHHHEECCCCEEEEECCCCCEEEEEEEEECCCCCCEEEECCCCCC
GERVVVAGIQFLRPGQTVAAAEIGDRP
CCEEEEECHHHCCCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 14528314 [H]