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The map label for this gene is coaBC [H]

Identifier: 170747235

GI number: 170747235

Start: 844225

End: 845448

Strand: Reverse

Name: coaBC [H]

Synonym: Mrad2831_0801

Alternate gene names: 170747235

Gene position: 845448-844225 (Counterclockwise)

Preceding gene: 170747236

Following gene: 170747234

Centisome position: 13.91

GC content: 75.33

Gene sequence:

>1224_bases
ATGACCGAGACCCTCGCCCAACGCCGCGTCCTCCTCGTCATCGGCGGCGGCATCGCGGCCTACAAGGCCCTCGACCTGAT
TCGGCGGCTGCGCGAGCGGGGCGCCAGCGTCTGCCCGGTGCTGACCGCGGGGGCCCAGGAATTCGTGACGCCGCTGGCGG
CGGCCGCGCTCGCGGGTGAGCGGGCGCATACCGACCTGTTCGACCGGGCCTCTGAGGCCGAGATCGGCCACATCAAGCTC
GCCCGTCAGGCGGATGCCGTGGTGGTGGCGCCCGCGACCGCCAACCTGATGGCCCGGATGGCCGGCGGCCACGCGGCCGA
CCTCGCGACCACGATCCTGCTGGCCACGACTCTGCCGATCCTGATCGCGCCGGCCATGAACGTCCAGATGTGGGCGCACC
CCGCCACCCGCCGGAACCGCGCGGTCCTGGAGGGGGACGGCGTCCGGATCGTCGGCCCGAACGCCGGCCGGATGGCCGAA
CCCGAATCCGGGCCGGGCCGCATGGCCGAGCCCAACGAGATCGCCGACGCGCTGGAACGGATGCTCGGCGCCCCGGCCGG
GGACAGGCCCCTGGCCGGCCGCCGGGTGCTCGTGACGTCGGGGCCCACCCACGAGCCGATCGACCCGGTCCGCTACATCG
CCAACCGCTCCTCCGGCCGCCAGGGTCACGCCATCGCCGCGGCCGCCGCCGCGGCCGGTGCCGCCGTGACCCTGGTCTCC
GGGCCGGTGGCGATCCCCGACCCGCCGGGCGTCGCCGTCGTGCGGGTCGAGACCGCCCGGCAGATGCTGGCCGCCGTCGA
GGCGGCGCTGCCGGCCGACATCGCGGTCTTCGCCGCCGCGGTCGCCGACTGGCGCCCGGAGCAGGAGGCCGGCAGCAAGA
AGATCAAGAAGGACGGCACCGGGCCGGCGCCGATGCCGCTGGTCGAGAATCCCGACATCCTCGCCACGGTGGCGCGCCGG
CCGTCCGGGCGCCCGCCCCTCGTGGTCGGGTTCGCCGCCGAGACCGACGCGGTGGTCGAACACGCCCGGACGAAGATCGC
CCGGAAGGGCTGCGACCTGATCGTGGCCAACGACGTGTCGGCGGAGGGCGGCGTCATGGGCGGCGTCGACAACACGGTGC
ACCTGATCGGGCGGGACGGCGCGGTAGAGACCTGGCCGCGCCTGGGAAAAGACGAGGTCGCGCGCCGGCTCGTGGCCCAT
CTCGCGGCCCTGCTGGCCGGCTGA

Upstream 100 bases:

>100_bases
CGCCGCGAGCGCCGGTTCGGCGGGCTGAAGGCACCGGCCGTCCCGGCCGCGGCCTGAGGCCGCTTGACGCGCGCGCGCCG
GCGCGCAGAGGGTCGGCGGC

Downstream 100 bases:

>100_bases
CGCCGCCCTGCGGGTTCGCCGCCGGTATCCGAGCCGGACTCGCCAAACGGCGTGACTCGTTCCGGGGCCGAAGGCCGTTG
CGCACAGGGAAGATAGAAGT

Product: phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 407; Mature: 406

Protein sequence:

>407_residues
MTETLAQRRVLLVIGGGIAAYKALDLIRRLRERGASVCPVLTAGAQEFVTPLAAAALAGERAHTDLFDRASEAEIGHIKL
ARQADAVVVAPATANLMARMAGGHAADLATTILLATTLPILIAPAMNVQMWAHPATRRNRAVLEGDGVRIVGPNAGRMAE
PESGPGRMAEPNEIADALERMLGAPAGDRPLAGRRVLVTSGPTHEPIDPVRYIANRSSGRQGHAIAAAAAAAGAAVTLVS
GPVAIPDPPGVAVVRVETARQMLAAVEAALPADIAVFAAAVADWRPEQEAGSKKIKKDGTGPAPMPLVENPDILATVARR
PSGRPPLVVGFAAETDAVVEHARTKIARKGCDLIVANDVSAEGGVMGGVDNTVHLIGRDGAVETWPRLGKDEVARRLVAH
LAALLAG

Sequences:

>Translated_407_residues
MTETLAQRRVLLVIGGGIAAYKALDLIRRLRERGASVCPVLTAGAQEFVTPLAAAALAGERAHTDLFDRASEAEIGHIKL
ARQADAVVVAPATANLMARMAGGHAADLATTILLATTLPILIAPAMNVQMWAHPATRRNRAVLEGDGVRIVGPNAGRMAE
PESGPGRMAEPNEIADALERMLGAPAGDRPLAGRRVLVTSGPTHEPIDPVRYIANRSSGRQGHAIAAAAAAAGAAVTLVS
GPVAIPDPPGVAVVRVETARQMLAAVEAALPADIAVFAAAVADWRPEQEAGSKKIKKDGTGPAPMPLVENPDILATVARR
PSGRPPLVVGFAAETDAVVEHARTKIARKGCDLIVANDVSAEGGVMGGVDNTVHLIGRDGAVETWPRLGKDEVARRLVAH
LAALLAG
>Mature_406_residues
TETLAQRRVLLVIGGGIAAYKALDLIRRLRERGASVCPVLTAGAQEFVTPLAAAALAGERAHTDLFDRASEAEIGHIKLA
RQADAVVVAPATANLMARMAGGHAADLATTILLATTLPILIAPAMNVQMWAHPATRRNRAVLEGDGVRIVGPNAGRMAEP
ESGPGRMAEPNEIADALERMLGAPAGDRPLAGRRVLVTSGPTHEPIDPVRYIANRSSGRQGHAIAAAAAAAGAAVTLVSG
PVAIPDPPGVAVVRVETARQMLAAVEAALPADIAVFAAAVADWRPEQEAGSKKIKKDGTGPAPMPLVENPDILATVARRP
SGRPPLVVGFAAETDAVVEHARTKIARKGCDLIVANDVSAEGGVMGGVDNTVHLIGRDGAVETWPRLGKDEVARRLVAHL
AALLAG

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=196, Percent_Identity=30.6122448979592, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI87082301, Length=380, Percent_Identity=48.4210526315789, Blast_Score=288, Evalue=5e-79,
Organism=Caenorhabditis elegans, GI17560194, Length=172, Percent_Identity=30.8139534883721, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 42017; Mature: 41886

Theoretical pI: Translated: 8.29; Mature: 8.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTETLAQRRVLLVIGGGIAAYKALDLIRRLRERGASVCPVLTAGAQEFVTPLAAAALAGE
CCCCHHHCEEEEEECCCHHHHHHHHHHHHHHHCCCCCCHHHHCCHHHHHHHHHHHHHHCC
RAHTDLFDRASEAEIGHIKLARQADAVVVAPATANLMARMAGGHAADLATTILLATTLPI
HHHHHHHHCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHH
LIAPAMNVQMWAHPATRRNRAVLEGDGVRIVGPNAGRMAEPESGPGRMAEPNEIADALER
HHHCCCCEEEEECCCCCCCCEEEECCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHH
MLGAPAGDRPLAGRRVLVTSGPTHEPIDPVRYIANRSSGRQGHAIAAAAAAAGAAVTLVS
HHCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHCCCEEEEEE
GPVAIPDPPGVAVVRVETARQMLAAVEAALPADIAVFAAAVADWRPEQEAGSKKIKKDGT
CCEECCCCCCEEEEEEHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCC
GPAPMPLVENPDILATVARRPSGRPPLVVGFAAETDAVVEHARTKIARKGCDLIVANDVS
CCCCCCCCCCCCHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCEEEECCCC
AEGGVMGGVDNTVHLIGRDGAVETWPRLGKDEVARRLVAHLAALLAG
CCCCEECCCCCEEEEEECCCCCHHHHCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TETLAQRRVLLVIGGGIAAYKALDLIRRLRERGASVCPVLTAGAQEFVTPLAAAALAGE
CCCHHHCEEEEEECCCHHHHHHHHHHHHHHHCCCCCCHHHHCCHHHHHHHHHHHHHHCC
RAHTDLFDRASEAEIGHIKLARQADAVVVAPATANLMARMAGGHAADLATTILLATTLPI
HHHHHHHHCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHH
LIAPAMNVQMWAHPATRRNRAVLEGDGVRIVGPNAGRMAEPESGPGRMAEPNEIADALER
HHHCCCCEEEEECCCCCCCCEEEECCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHH
MLGAPAGDRPLAGRRVLVTSGPTHEPIDPVRYIANRSSGRQGHAIAAAAAAAGAAVTLVS
HHCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHCCCEEEEEE
GPVAIPDPPGVAVVRVETARQMLAAVEAALPADIAVFAAAVADWRPEQEAGSKKIKKDGT
CCEECCCCCCEEEEEEHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCC
GPAPMPLVENPDILATVARRPSGRPPLVVGFAAETDAVVEHARTKIARKGCDLIVANDVS
CCCCCCCCCCCCHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCEEEECCCC
AEGGVMGGVDNTVHLIGRDGAVETWPRLGKDEVARRLVAHLAALLAG
CCCCEECCCCCEEEEEECCCCCHHHHCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]