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The map label for this gene is uppS1 [H]

Identifier: 170747236

GI number: 170747236

Start: 845492

End: 846214

Strand: Reverse

Name: uppS1 [H]

Synonym: Mrad2831_0802

Alternate gene names: 170747236

Gene position: 846214-845492 (Counterclockwise)

Preceding gene: 170747237

Following gene: 170747235

Centisome position: 13.92

GC content: 74.27

Gene sequence:

>723_bases
ATGCAAAGCGAAGCGGTGCCGGGAGCCCTGCACGCCGCGATCATCATGGACGGCAACGGGCGCTGGGCGACGCAGCGCGG
CTTGCCGCGGCTGGCCGGCCACCACCGGGGCGTCGAGGCGATCCGCCGCACCGCCGAGGCCTGCCCGGATCACGGCATCG
GCACGCTCACGCTCTACGCCTTCTCGGCGGACAACTGGCAGCGGCCGGCCGAGGAGGTGGGCGGTCTGATGCGGCTCCTG
CGCTCGTACCTGCGCAACGAGACGCAGCGCCTCGCCCGCACCGGTACCCGCCTCAGCGTCGTCGGCCGGCGCGACCGTCT
GCCGGACGGCATTCCCCAGGCGATCGCGGCCGCGGAGGCTGCCACGGCGGGGGGAACCCGGCTGCACCTGCGGATCTGCG
TCGACTACTCGGCCCGCGACGCGATCATCGCGGCAGCCCAGGGCCTCGCCGGCGAGGAGCCGACGCGCGAGAGCTTCGGC
AAGCTGGTCGCCGGCCCGATGCACGGCTCCCCGGTGGATGTCGATCTGCTGATCCGCACCGGCGGCGAGCGGCGCCTCTC
CGACTTCATGCTGTGGGAAGCCGCCTACGCCGAGCTGCTGTTCACCGAGCGGATGTGGCCCGATTTCGGCCCCGACGACC
TCGCCGAGGCCGTGGCCGAGTTCGGCCGCCGCGAGCGCCGGTTCGGCGGGCTGAAGGCACCGGCCGTCCCGGCCGCGGCC
TGA

Upstream 100 bases:

>100_bases
GATCCGGCCACGAAAACGGCGTGAGACCGCCCGTCCCGCCGGGAATGTTAACCCCGTTTCGATAGACCTCTGCGCCACGC
CCATGCCGGGAGACTTTACG

Downstream 100 bases:

>100_bases
GGCCGCTTGACGCGCGCGCGCCGGCGCGCAGAGGGTCGGCGGCATGACCGAGACCCTCGCCCAACGCCGCGTCCTCCTCG
TCATCGGCGGCGGCATCGCG

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase 1; Di-trans,poly-cis-decaprenylcistransferase 1; Undecaprenyl diphosphate synthase 1; UDS 1 [H]

Number of amino acids: Translated: 240; Mature: 240

Protein sequence:

>240_residues
MQSEAVPGALHAAIIMDGNGRWATQRGLPRLAGHHRGVEAIRRTAEACPDHGIGTLTLYAFSADNWQRPAEEVGGLMRLL
RSYLRNETQRLARTGTRLSVVGRRDRLPDGIPQAIAAAEAATAGGTRLHLRICVDYSARDAIIAAAQGLAGEEPTRESFG
KLVAGPMHGSPVDVDLLIRTGGERRLSDFMLWEAAYAELLFTERMWPDFGPDDLAEAVAEFGRRERRFGGLKAPAVPAAA

Sequences:

>Translated_240_residues
MQSEAVPGALHAAIIMDGNGRWATQRGLPRLAGHHRGVEAIRRTAEACPDHGIGTLTLYAFSADNWQRPAEEVGGLMRLL
RSYLRNETQRLARTGTRLSVVGRRDRLPDGIPQAIAAAEAATAGGTRLHLRICVDYSARDAIIAAAQGLAGEEPTRESFG
KLVAGPMHGSPVDVDLLIRTGGERRLSDFMLWEAAYAELLFTERMWPDFGPDDLAEAVAEFGRRERRFGGLKAPAVPAAA
>Mature_240_residues
MQSEAVPGALHAAIIMDGNGRWATQRGLPRLAGHHRGVEAIRRTAEACPDHGIGTLTLYAFSADNWQRPAEEVGGLMRLL
RSYLRNETQRLARTGTRLSVVGRRDRLPDGIPQAIAAAEAATAGGTRLHLRICVDYSARDAIIAAAQGLAGEEPTRESFG
KLVAGPMHGSPVDVDLLIRTGGERRLSDFMLWEAAYAELLFTERMWPDFGPDDLAEAVAEFGRRERRFGGLKAPAVPAAA

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=227, Percent_Identity=35.6828193832599, Blast_Score=132, Evalue=3e-31,
Organism=Homo sapiens, GI45580742, Length=227, Percent_Identity=35.6828193832599, Blast_Score=132, Evalue=3e-31,
Organism=Escherichia coli, GI1786371, Length=239, Percent_Identity=43.5146443514644, Blast_Score=186, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI71993029, Length=230, Percent_Identity=30, Blast_Score=121, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6319474, Length=235, Percent_Identity=33.6170212765957, Blast_Score=118, Evalue=8e-28,
Organism=Saccharomyces cerevisiae, GI6323748, Length=218, Percent_Identity=32.1100917431193, Blast_Score=112, Evalue=6e-26,
Organism=Drosophila melanogaster, GI18857969, Length=208, Percent_Identity=36.0576923076923, Blast_Score=129, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 25989; Mature: 25989

Theoretical pI: Translated: 7.67; Mature: 7.67

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSEAVPGALHAAIIMDGNGRWATQRGLPRLAGHHRGVEAIRRTAEACPDHGIGTLTLYA
CCCCCCCCCEEEEEEECCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEE
FSADNWQRPAEEVGGLMRLLRSYLRNETQRLARTGTRLSVVGRRDRLPDGIPQAIAAAEA
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHH
ATAGGTRLHLRICVDYSARDAIIAAAQGLAGEEPTRESFGKLVAGPMHGSPVDVDLLIRT
HCCCCCEEEEEEEECCCCHHHHHHHHHCCCCCCCCHHHHHHHEECCCCCCCCCEEEEEEC
GGERRLSDFMLWEAAYAELLFTERMWPDFGPDDLAEAVAEFGRRERRFGGLKAPAVPAAA
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MQSEAVPGALHAAIIMDGNGRWATQRGLPRLAGHHRGVEAIRRTAEACPDHGIGTLTLYA
CCCCCCCCCEEEEEEECCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEE
FSADNWQRPAEEVGGLMRLLRSYLRNETQRLARTGTRLSVVGRRDRLPDGIPQAIAAAEA
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHH
ATAGGTRLHLRICVDYSARDAIIAAAQGLAGEEPTRESFGKLVAGPMHGSPVDVDLLIRT
HCCCCCEEEEEEEECCCCHHHHHHHHHCCCCCCCCHHHHHHHEECCCCCCCCCEEEEEEC
GGERRLSDFMLWEAAYAELLFTERMWPDFGPDDLAEAVAEFGRRERRFGGLKAPAVPAAA
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]