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The map label for this gene is neuA [H]

Identifier: 170683470

GI number: 170683470

Start: 3303368

End: 3304624

Strand: Reverse

Name: neuA [H]

Synonym: EcSMS35_3231

Alternate gene names: 170683470

Gene position: 3304624-3303368 (Counterclockwise)

Preceding gene: 170684121

Following gene: 170683594

Centisome position: 65.2

GC content: 30.95

Gene sequence:

>1257_bases
ATGAGAACAAAAATTATTGCGATAATTCCAGCCCGTAGTGGATCTAAAGGGTTGAGAAATAAAAATGCTTTGATGCTGAT
AGATAAACCTCTTCTTGCTTATACAATTGAAGCTGCCTTGCAGTCAGAAATGTTTGAGAAAGTAATTGTGACAACTGACT
CCGAACAGTATGGAGCAATAGCAGAGTCATATGGTGCTGATTTTTTGCTGAGACCGGAAGAACTAGCAACTGATAAAGCA
TCATCATTTGAATTTATAAAACATGCGTTAAGTATATATACTGATTATGAGAACTTTGCTTTATTACAACCAACTTCACC
CTTTAGAGATTCGACCCATATTATTGAGGCTGTAAAGTTATATCAAACTTTAGAAAAATACCAATGTGTTGTTTCTGTTA
CTAGAAGCAATAAGCCATCACAAATAATTAGACCATTAGATGATTACTCGACACTGTCTTTTTTTGACCTTGATTATAGT
AAATATAATCGAAACTCAATAGTAGAATATCATCCGAATGGAGCTATATTTATAGCTAATAAGCAGCATTATCTTCATAC
AAAGCATTTTTTTGGTCGCTATTCACTAGCTTATATTATGGATAAGGAAAGCTCTTTAGATATAGATGATAGAATGGATT
TCGAACTTGCAATTACCATTCAGCAAAAAAAAAATAGACAAAAAATACTTTATCAAAACATACATAATAGAATCAATGAG
AAACGAAATGAATTTGATAGTGTAAGTGATATAACTTTAATTGGACACTCGCTGTTTGATTATTGGGACGTAAAAAAAAT
AAATGATATAGAAGTTAATAACTTAGGTATCGCTGGTATAAACTCGAAGGAGTACTATGAATATATTATTGAGAAAGAGC
GGATTGTTAATTTCGGAGAGTTTGTTTTCATCTTTTTTGGAACTAATGATATAGTTGTTAGTGATTGGAAAAAAGAAGAC
ACATTGTGGTATTTGAAGAAAACATGCCAGTATATAAAGAAGAAAAATGCTGCATCAAAAATTTATTTATTGTCGGTTCC
TCCTGTTTTTGGGCGTATTGATCGAGATAATAGAATAATTAATGATTTAAATTCTTATCTTCGAGAGAATGTAGATTTTG
CGAAGTTTATTAGCTTGGATCACGTTTTAAAAGACTCTTATGGCAATCTAAATAAAATGTATACTTATGATGGCTTACAT
TTTAATAGTAATGGGTATACAGTATTAGAAAACGAAATAGCGGAGATTGTTAAATGA

Upstream 100 bases:

>100_bases
GTCCGATGGAGTGGTATAATTTATTGGGTAAAATTGCAGAGCAAGACTTTATTCCAGATGAATTAATAATTCATAGCGAA
TTCAAAAATCAGGGGGAATA

Downstream 100 bases:

>100_bases
AAAAAATATTATACGTAACTGGATCTAGAGCTGAATATGGAATAGTTCGGAGACTTTTGACAATGCTAAGAGAAACTCCA
GAAATACAGCTTGATTTGGC

Product: polysialic acid capsule biosynthesis N-acylneuraminate cytidylyltransferase NeuA

Products: NA

Alternate protein names: CMP-N-acetylneuraminic acid synthase; CMP-NeuNAc synthase [H]

Number of amino acids: Translated: 418; Mature: 418

Protein sequence:

>418_residues
MRTKIIAIIPARSGSKGLRNKNALMLIDKPLLAYTIEAALQSEMFEKVIVTTDSEQYGAIAESYGADFLLRPEELATDKA
SSFEFIKHALSIYTDYENFALLQPTSPFRDSTHIIEAVKLYQTLEKYQCVVSVTRSNKPSQIIRPLDDYSTLSFFDLDYS
KYNRNSIVEYHPNGAIFIANKQHYLHTKHFFGRYSLAYIMDKESSLDIDDRMDFELAITIQQKKNRQKILYQNIHNRINE
KRNEFDSVSDITLIGHSLFDYWDVKKINDIEVNNLGIAGINSKEYYEYIIEKERIVNFGEFVFIFFGTNDIVVSDWKKED
TLWYLKKTCQYIKKKNAASKIYLLSVPPVFGRIDRDNRIINDLNSYLRENVDFAKFISLDHVLKDSYGNLNKMYTYDGLH
FNSNGYTVLENEIAEIVK

Sequences:

>Translated_418_residues
MRTKIIAIIPARSGSKGLRNKNALMLIDKPLLAYTIEAALQSEMFEKVIVTTDSEQYGAIAESYGADFLLRPEELATDKA
SSFEFIKHALSIYTDYENFALLQPTSPFRDSTHIIEAVKLYQTLEKYQCVVSVTRSNKPSQIIRPLDDYSTLSFFDLDYS
KYNRNSIVEYHPNGAIFIANKQHYLHTKHFFGRYSLAYIMDKESSLDIDDRMDFELAITIQQKKNRQKILYQNIHNRINE
KRNEFDSVSDITLIGHSLFDYWDVKKINDIEVNNLGIAGINSKEYYEYIIEKERIVNFGEFVFIFFGTNDIVVSDWKKED
TLWYLKKTCQYIKKKNAASKIYLLSVPPVFGRIDRDNRIINDLNSYLRENVDFAKFISLDHVLKDSYGNLNKMYTYDGLH
FNSNGYTVLENEIAEIVK
>Mature_418_residues
MRTKIIAIIPARSGSKGLRNKNALMLIDKPLLAYTIEAALQSEMFEKVIVTTDSEQYGAIAESYGADFLLRPEELATDKA
SSFEFIKHALSIYTDYENFALLQPTSPFRDSTHIIEAVKLYQTLEKYQCVVSVTRSNKPSQIIRPLDDYSTLSFFDLDYS
KYNRNSIVEYHPNGAIFIANKQHYLHTKHFFGRYSLAYIMDKESSLDIDDRMDFELAITIQQKKNRQKILYQNIHNRINE
KRNEFDSVSDITLIGHSLFDYWDVKKINDIEVNNLGIAGINSKEYYEYIIEKERIVNFGEFVFIFFGTNDIVVSDWKKED
TLWYLKKTCQYIKKKNAASKIYLLSVPPVFGRIDRDNRIINDLNSYLRENVDFAKFISLDHVLKDSYGNLNKMYTYDGLH
FNSNGYTVLENEIAEIVK

Specific function: Unknown

COG id: COG1083

COG function: function code M; CMP-N-acetylneuraminic acid synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CMP-NeuNAc synthase family [H]

Homologues:

Organism=Homo sapiens, GI8923900, Length=217, Percent_Identity=29.0322580645161, Blast_Score=81, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003329
- InterPro:   IPR013830
- InterPro:   IPR013831 [H]

Pfam domain/function: PF02348 CTP_transf_3 [H]

EC number: =2.7.7.43 [H]

Molecular weight: Translated: 48692; Mature: 48692

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTKIIAIIPARSGSKGLRNKNALMLIDKPLLAYTIEAALQSEMFEKVIVTTDSEQYGAI
CCCEEEEEEECCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHEEEEEECCHHHCCH
AESYGADFLLRPEELATDKASSFEFIKHALSIYTDYENFALLQPTSPFRDSTHIIEAVKL
HHHCCCCEEECCHHHCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHH
YQTLEKYQCVVSVTRSNKPSQIIRPLDDYSTLSFFDLDYSKYNRNSIVEYHPNGAIFIAN
HHHHHHHEEEEEEECCCCCHHHHCCCCCCCCEEEEECCHHHCCCCCEEEECCCCEEEEEC
KQHYLHTKHFFGRYSLAYIMDKESSLDIDDRMDFELAITIQQKKNRQKILYQNIHNRINE
CCCEEEHHHHHCCEEEEEEEECCCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHH
KRNEFDSVSDITLIGHSLFDYWDVKKINDIEVNNLGIAGINSKEYYEYIIEKERIVNFGE
HHHHHCCCCHHHHHHHHHHHHHCCCCCCCEEECCEEEEECCCHHHHHHHHHHHHHCCCCC
FVFIFFGTNDIVVSDWKKEDTLWYLKKTCQYIKKKNAASKIYLLSVPPVFGRIDRDNRII
EEEEEECCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCHHCCCCCCCHHH
NDLNSYLRENVDFAKFISLDHVLKDSYGNLNKMYTYDGLHFNSNGYTVLENEIAEIVK
HHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCEEEEECCEEECCCCCEEEHHHHHHHCC
>Mature Secondary Structure
MRTKIIAIIPARSGSKGLRNKNALMLIDKPLLAYTIEAALQSEMFEKVIVTTDSEQYGAI
CCCEEEEEEECCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHEEEEEECCHHHCCH
AESYGADFLLRPEELATDKASSFEFIKHALSIYTDYENFALLQPTSPFRDSTHIIEAVKL
HHHCCCCEEECCHHHCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHH
YQTLEKYQCVVSVTRSNKPSQIIRPLDDYSTLSFFDLDYSKYNRNSIVEYHPNGAIFIAN
HHHHHHHEEEEEEECCCCCHHHHCCCCCCCCEEEEECCHHHCCCCCEEEECCCCEEEEEC
KQHYLHTKHFFGRYSLAYIMDKESSLDIDDRMDFELAITIQQKKNRQKILYQNIHNRINE
CCCEEEHHHHHCCEEEEEEEECCCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHH
KRNEFDSVSDITLIGHSLFDYWDVKKINDIEVNNLGIAGINSKEYYEYIIEKERIVNFGE
HHHHHCCCCHHHHHHHHHHHHHCCCCCCCEEECCEEEEECCCHHHHHHHHHHHHHCCCCC
FVFIFFGTNDIVVSDWKKEDTLWYLKKTCQYIKKKNAASKIYLLSVPPVFGRIDRDNRII
EEEEEECCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCHHCCCCCCCHHH
NDLNSYLRENVDFAKFISLDHVLKDSYGNLNKMYTYDGLHFNSNGYTVLENEIAEIVK
HHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCEEEEECCEEECCCCCEEEHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2549035 [H]