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The map label for this gene is neuC [H]

Identifier: 170683594

GI number: 170683594

Start: 3302196

End: 3303371

Strand: Reverse

Name: neuC [H]

Synonym: EcSMS35_3230

Alternate gene names: 170683594

Gene position: 3303371-3302196 (Counterclockwise)

Preceding gene: 170683470

Following gene: 170682958

Centisome position: 65.18

GC content: 32.14

Gene sequence:

>1176_bases
ATGAAAAAAATATTATACGTAACTGGATCTAGAGCTGAATATGGAATAGTTCGGAGACTTTTGACAATGCTAAGAGAAAC
TCCAGAAATACAGCTTGATTTGGCAGTTACAGGAATGCATTGTGATAATGCGTATGGAAATACAATACATATTATAGAAC
AAGATAATTTTAATATTATCAAGGTTGTGGATATAAATATCAATACAACTTCACATACTCACATTCTCCATTCAATGAGT
GTTTGCCTCAATTCGTTTGGTGATTTTTTTTCAAATAACACATATGATGCGGTTATGGTTTTAGGCGATAGATATGAAAT
ATTTTCAGTCGCTATCGCAGCATCAATGCATAATATTCCATTAATTCATATTCATGGTGGTGAAAAGACATTAGCTAATT
ATGATGAGTTTATTAGGCATTCAATTACTAAAATGAGTAAACTCCATCTTACTTCTACAGAAGAGTATAAAAAACGAGTA
ATTCAACTAGGTGAAAAGCCTGGTAGTGTGTTTAATATTGGTTCTCTTGGTGCAGAAAATGCTCTTTCATTGCATTTACC
AAATAAGCAGGAGTTGGAACTAAAATATGGTTCACTGTTAAAACGGTACTTTGTTGTAGTATTCCATCCTGAAACACTTT
CCACGCAGTCGGTTAATGATCAAATAGATGAGTTATTGTCAGCGATTTCTTTTTTTAAAAATACTCACGACTTTATTTTT
ATTGGCAGTAACGCTGACACTGGTTCTGATATAATTCAGAGAAAAGTAAAATATTTTTGCAAAGAGTATAAGTTCAGATA
TTTGATTTCTATTCGTTCAGAAGATTATTTGGCAATGATTAAATGCTCTTGTGGGCTAATTGGGAACTCCTCCTCTGGTT
TAATTGAGGTTCCATCTTTAAAAGTTGCAACAATTAACATTGGTGATAGGCAGAAAGGCCGTGTTCGTGGAGCCAGTGTA
ATAGATGTACCCGTTGAAAAAAATGCAATCGTCAGAGGGATAAATATATCTCAAGATGAAAAATTTATTAGTGTTGTACA
GTCATCTAGTAATCCTTATTTTAAAGAAAATGCTTTAATTAATGCTGTTAGAATTATTAAGGATTTTATTAAATCAAAAA
ATAAAGATTACAAAGATTTTTATGACATCCCGGAATGTACCACCAGTTATGACTAG

Upstream 100 bases:

>100_bases
ACTCTTATGGCAATCTAAATAAAATGTATACTTATGATGGCTTACATTTTAATAGTAATGGGTATACAGTATTAGAAAAC
GAAATAGCGGAGATTGTTAA

Downstream 100 bases:

>100_bases
AAAAAAAGTGCTTTGTTTTGTCTTTCGTTATGATTCTCATTTTTTAGCTTTGAAAAATATTTTTGAGCAGATAGATGTTG
ATTCATATGATTTATTTTTT

Product: polysialic acid capsule biosynthesis protein NeuC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MKKILYVTGSRAEYGIVRRLLTMLRETPEIQLDLAVTGMHCDNAYGNTIHIIEQDNFNIIKVVDININTTSHTHILHSMS
VCLNSFGDFFSNNTYDAVMVLGDRYEIFSVAIAASMHNIPLIHIHGGEKTLANYDEFIRHSITKMSKLHLTSTEEYKKRV
IQLGEKPGSVFNIGSLGAENALSLHLPNKQELELKYGSLLKRYFVVVFHPETLSTQSVNDQIDELLSAISFFKNTHDFIF
IGSNADTGSDIIQRKVKYFCKEYKFRYLISIRSEDYLAMIKCSCGLIGNSSSGLIEVPSLKVATINIGDRQKGRVRGASV
IDVPVEKNAIVRGINISQDEKFISVVQSSSNPYFKENALINAVRIIKDFIKSKNKDYKDFYDIPECTTSYD

Sequences:

>Translated_391_residues
MKKILYVTGSRAEYGIVRRLLTMLRETPEIQLDLAVTGMHCDNAYGNTIHIIEQDNFNIIKVVDININTTSHTHILHSMS
VCLNSFGDFFSNNTYDAVMVLGDRYEIFSVAIAASMHNIPLIHIHGGEKTLANYDEFIRHSITKMSKLHLTSTEEYKKRV
IQLGEKPGSVFNIGSLGAENALSLHLPNKQELELKYGSLLKRYFVVVFHPETLSTQSVNDQIDELLSAISFFKNTHDFIF
IGSNADTGSDIIQRKVKYFCKEYKFRYLISIRSEDYLAMIKCSCGLIGNSSSGLIEVPSLKVATINIGDRQKGRVRGASV
IDVPVEKNAIVRGINISQDEKFISVVQSSSNPYFKENALINAVRIIKDFIKSKNKDYKDFYDIPECTTSYD
>Mature_391_residues
MKKILYVTGSRAEYGIVRRLLTMLRETPEIQLDLAVTGMHCDNAYGNTIHIIEQDNFNIIKVVDININTTSHTHILHSMS
VCLNSFGDFFSNNTYDAVMVLGDRYEIFSVAIAASMHNIPLIHIHGGEKTLANYDEFIRHSITKMSKLHLTSTEEYKKRV
IQLGEKPGSVFNIGSLGAENALSLHLPNKQELELKYGSLLKRYFVVVFHPETLSTQSVNDQIDELLSAISFFKNTHDFIF
IGSNADTGSDIIQRKVKYFCKEYKFRYLISIRSEDYLAMIKCSCGLIGNSSSGLIEVPSLKVATINIGDRQKGRVRGASV
IDVPVEKNAIVRGINISQDEKFISVVQSSSNPYFKENALINAVRIIKDFIKSKNKDYKDFYDIPECTTSYD

Specific function: May be involved in the synthesis of polysialic acid (PSA) [H]

COG id: COG0381

COG function: function code M; UDP-N-acetylglucosamine 2-epimerase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI298566312, Length=330, Percent_Identity=28.4848484848485, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI190014632, Length=330, Percent_Identity=28.4848484848485, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI4885285, Length=330, Percent_Identity=28.4848484848485, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI298566325, Length=285, Percent_Identity=28.4210526315789, Blast_Score=93, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020004
- InterPro:   IPR003331 [H]

Pfam domain/function: PF02350 Epimerase_2 [H]

EC number: NA

Molecular weight: Translated: 44151; Mature: 44151

Theoretical pI: Translated: 7.63; Mature: 7.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKILYVTGSRAEYGIVRRLLTMLRETPEIQLDLAVTGMHCDNAYGNTIHIIEQDNFNII
CCEEEEEECCCCHHHHHHHHHHHHHCCCCEEEEEEEEEEECCCCCCCEEEEEECCCCCEE
KVVDININTTSHTHILHSMSVCLNSFGDFFSNNTYDAVMVLGDRYEIFSVAIAASMHNIP
EEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEHHHHHHHHHCCCE
LIHIHGGEKTLANYDEFIRHSITKMSKLHLTSTEEYKKRVIQLGEKPGSVFNIGSLGAEN
EEEEECCCCHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHCCCCCCCEEEECCCCCCC
ALSLHLPNKQELELKYGSLLKRYFVVVFHPETLSTQSVNDQIDELLSAISFFKNTHDFIF
EEEEECCCCHHEEEHHHHHHHHEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEE
IGSNADTGSDIIQRKVKYFCKEYKFRYLISIRSEDYLAMIKCSCGLIGNSSSGLIEVPSL
EECCCCCHHHHHHHHHHHHHHHCCEEEEEEECCCCEEEEEEEECEEECCCCCCEEECCCE
KVATINIGDRQKGRVRGASVIDVPVEKNAIVRGINISQDEKFISVVQSSSNPYFKENALI
EEEEEECCCCCCCCCCCCEEEEECCCCCCEEEECCCCCCHHHHHHHHCCCCCCCHHHHHH
NAVRIIKDFIKSKNKDYKDFYDIPECTTSYD
HHHHHHHHHHHCCCCCCHHHCCCCCCCCCCC
>Mature Secondary Structure
MKKILYVTGSRAEYGIVRRLLTMLRETPEIQLDLAVTGMHCDNAYGNTIHIIEQDNFNII
CCEEEEEECCCCHHHHHHHHHHHHHCCCCEEEEEEEEEEECCCCCCCEEEEEECCCCCEE
KVVDININTTSHTHILHSMSVCLNSFGDFFSNNTYDAVMVLGDRYEIFSVAIAASMHNIP
EEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEHHHHHHHHHCCCE
LIHIHGGEKTLANYDEFIRHSITKMSKLHLTSTEEYKKRVIQLGEKPGSVFNIGSLGAEN
EEEEECCCCHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHCCCCCCCEEEECCCCCCC
ALSLHLPNKQELELKYGSLLKRYFVVVFHPETLSTQSVNDQIDELLSAISFFKNTHDFIF
EEEEECCCCHHEEEHHHHHHHHEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEE
IGSNADTGSDIIQRKVKYFCKEYKFRYLISIRSEDYLAMIKCSCGLIGNSSSGLIEVPSL
EECCCCCHHHHHHHHHHHHHHHCCEEEEEEECCCCEEEEEEEECEEECCCCCCEEECCCE
KVATINIGDRQKGRVRGASVIDVPVEKNAIVRGINISQDEKFISVVQSSSNPYFKENALI
EEEEEECCCCCCCCCCCCEEEEECCCCCCEEEECCCCCCHHHHHHHHCCCCCCCHHHHHH
NAVRIIKDFIKSKNKDYKDFYDIPECTTSYD
HHHHHHHHHHHCCCCCCHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1729218 [H]