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The map label for this gene is dcuD [H]

Identifier: 170679599

GI number: 170679599

Start: 1128517

End: 1129878

Strand: Reverse

Name: dcuD [H]

Synonym: EcSMS35_1114

Alternate gene names: 170679599

Gene position: 1129878-1128517 (Counterclockwise)

Preceding gene: 170683987

Following gene: 170682695

Centisome position: 22.29

GC content: 48.16

Gene sequence:

>1362_bases
ATGATTAAAGTTGTTATCGCGCTTCTTGTTATCGTGATAGTTGCTCGCTTAATCCTGAAAGGATATCGTGCAGAACCCGT
GCTTTTTATTGCCGGGCTTGCGCTGATGGTTTGTACCTGGTTTACCGGTTGGGGCACAGTGTTACCGAAGGGCGTGTCCG
GTACAGGAATTAGTTTTCTTGATCCTTTCGAAGTCATGCGCAATTTATTCAGTACCCGTGCGGCTGATCTCGGTCTGATG
ATTATGACCCTGATGGGATTTGCGCATTACATGGACCATATCGGTGCGAATGAAGCGGTTGTCCGTGTGGTAACCCGGCC
ATTACGGACATTACGTTCCCCCTATGTTCTGCTTTTTTTCTCTTATCTTTTCGCCAGTCTTCTTCAACTGGCTATCCCCT
CAGCTACCGGACTTGCTGTTTTACTGATGGGAACCATGTTTCCTATTATGCTCGGACTCGGGCTGTCAGCAGCGTCTGCC
GCAGGGGTAATTGCCACCTCTCTTGGTGTGGCGTACACACCGACAGCCATTGACGCCATACGAGGCTCTGAAGCGGTAAA
TATGGATGTGGTGGAGTATGTTGTCTATCATCAGGGGCCTGCTGCTCTGGCGACTGTTCTGATTGTCGGTATCAGCCACT
TTTTCTGGCAGAAACACTGTGATCGTAAAGCTGGAACATTACCTCATGAAATTGGTACGACAACGGTCATAAAAGCAGGC
AGTACGCCGGCTTATTATGCTCTGCTACCTATGCTACCGATCCTGATGGCCGTTGGCTCATCGGAGATTTTTGTCACCGG
AATTAATCTCAATATCATTACGATTGTTCTTATCTCAATGGCAATTTGCATGCTGATCGAATGGGTCCGTAAATGTGATC
TGAAAGCTGTATGTGACGGGTTTACCCATTTCCTGAAAGGAATGGGGACAGCATTTACCGGCGTGGTGGGCTTACTGGTG
GCCGCAGGTGTGTTTGCTCATGGGATTAAAAGCATTGGCGCGATAGATCAATTAATTTTGATGGCAGAGCACGTTGGGTT
ACCCCCTTTTGCGATGGGCATCGTTTTTGCTCTGGTTACACTGGCTGCAGCTGTCATTATGGGATCGGGCAATGCGCCAT
TTCTGGCTTTTGTTGAACTGATACCACAAATCGCTGCCAGCATGGGCGTGAATGCCATATCGATGATCCTGCCTATGCAG
CAGGCTTCCCATATGGGGCGTGCGATGTCTCCCGTATCTGGCGTGGTTATAGCGGTTTCCAGTGGAGCAAATATAACTCC
CTTCGAAGTGGTAAAACGCACTGCTTTACCCCTGATAGTTGGTTTTGTTTTTCACTCTGCGATTATCGGTATTTTTTATT
AA

Upstream 100 bases:

>100_bases
ATGAATATCTTCCAGTCCGTTCACTTCGGGCGGCAAGTGATGTGGTTATTGCCATCATTCAGGAGACATTCAATGGGTTC
ACCACAGGGAATCGTGAGTC

Downstream 100 bases:

>100_bases
CTTGTTTTAGATTGTCATCCTCCACGCCCAGAAGGATGTGGATTCCTGCTAATCAGGCTATTGCCGGAATCATTTCGGTG
GGCTCCTGCTTAAACAAAAG

Product: anaerobic C4-dicarboxylate transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MIKVVIALLVIVIVARLILKGYRAEPVLFIAGLALMVCTWFTGWGTVLPKGVSGTGISFLDPFEVMRNLFSTRAADLGLM
IMTLMGFAHYMDHIGANEAVVRVVTRPLRTLRSPYVLLFFSYLFASLLQLAIPSATGLAVLLMGTMFPIMLGLGLSAASA
AGVIATSLGVAYTPTAIDAIRGSEAVNMDVVEYVVYHQGPAALATVLIVGISHFFWQKHCDRKAGTLPHEIGTTTVIKAG
STPAYYALLPMLPILMAVGSSEIFVTGINLNIITIVLISMAICMLIEWVRKCDLKAVCDGFTHFLKGMGTAFTGVVGLLV
AAGVFAHGIKSIGAIDQLILMAEHVGLPPFAMGIVFALVTLAAAVIMGSGNAPFLAFVELIPQIAASMGVNAISMILPMQ
QASHMGRAMSPVSGVVIAVSSGANITPFEVVKRTALPLIVGFVFHSAIIGIFY

Sequences:

>Translated_453_residues
MIKVVIALLVIVIVARLILKGYRAEPVLFIAGLALMVCTWFTGWGTVLPKGVSGTGISFLDPFEVMRNLFSTRAADLGLM
IMTLMGFAHYMDHIGANEAVVRVVTRPLRTLRSPYVLLFFSYLFASLLQLAIPSATGLAVLLMGTMFPIMLGLGLSAASA
AGVIATSLGVAYTPTAIDAIRGSEAVNMDVVEYVVYHQGPAALATVLIVGISHFFWQKHCDRKAGTLPHEIGTTTVIKAG
STPAYYALLPMLPILMAVGSSEIFVTGINLNIITIVLISMAICMLIEWVRKCDLKAVCDGFTHFLKGMGTAFTGVVGLLV
AAGVFAHGIKSIGAIDQLILMAEHVGLPPFAMGIVFALVTLAAAVIMGSGNAPFLAFVELIPQIAASMGVNAISMILPMQ
QASHMGRAMSPVSGVVIAVSSGANITPFEVVKRTALPLIVGFVFHSAIIGIFY
>Mature_453_residues
MIKVVIALLVIVIVARLILKGYRAEPVLFIAGLALMVCTWFTGWGTVLPKGVSGTGISFLDPFEVMRNLFSTRAADLGLM
IMTLMGFAHYMDHIGANEAVVRVVTRPLRTLRSPYVLLFFSYLFASLLQLAIPSATGLAVLLMGTMFPIMLGLGLSAASA
AGVIATSLGVAYTPTAIDAIRGSEAVNMDVVEYVVYHQGPAALATVLIVGISHFFWQKHCDRKAGTLPHEIGTTTVIKAG
STPAYYALLPMLPILMAVGSSEIFVTGINLNIITIVLISMAICMLIEWVRKCDLKAVCDGFTHFLKGMGTAFTGVVGLLV
AAGVFAHGIKSIGAIDQLILMAEHVGLPPFAMGIVFALVTLAAAVIMGSGNAPFLAFVELIPQIAASMGVNAISMILPMQ
QASHMGRAMSPVSGVVIAVSSGANITPFEVVKRTALPLIVGFVFHSAIIGIFY

Specific function: May have a role in the transport of dicarboxylates from the periplasm across the inner membrane. Seems not to be essential for growth. It is likely to be a cryptic gene, as no or low expression has been found under a number of growth conditions and when t

COG id: COG3069

COG function: function code C; C4-dicarboxylate transporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dcuC/dcuD transporter (TC 2.A.61) family [H]

Homologues:

Organism=Escherichia coli, GI1789622, Length=457, Percent_Identity=39.1684901531729, Blast_Score=322, Evalue=4e-89,
Organism=Escherichia coli, GI1786839, Length=425, Percent_Identity=43.5294117647059, Blast_Score=281, Evalue=6e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018385
- InterPro:   IPR004669 [H]

Pfam domain/function: PF03606 DcuC [H]

EC number: NA

Molecular weight: Translated: 47900; Mature: 47900

Theoretical pI: Translated: 8.69; Mature: 8.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure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CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]