Click here to switch to the map view.

The map label for this gene is proA

Identifier: 170079208

GI number: 170079208

Start: 2742943

End: 2744229

Strand: Direct

Name: proA

Synonym: SYNPCC7002_A2614

Alternate gene names: 170079208

Gene position: 2742943-2744229 (Clockwise)

Preceding gene: 170079207

Following gene: 170079209

Centisome position: 91.19

GC content: 53.07

Gene sequence:

>1287_bases
ATGGCAACTCAGCTAATTGACTTGGCGCAACAAACGCGGGCAGCAGCCCAAAAACTAGGCACCTTAAGCCTGGCCCAGCG
CAATGATGCTTTGGCAAAAGTGGCCCAGGCCCTCGCGGCCAATCAGGCGAAAATCGTCGCGGCAAACCAGGCAGACTGTG
AAGCGGCCCAGCGAGATGGGATTGCGCCAGCCCTCTATGCCCGTCTGAAATTGGGAGAGAGCAAATTACAAGGGGCGATC
GCCGGTATCCATGACGTGATTAATCTCCCCGATCCCGTCGGCCATCTCCAGCTACACCGAGAATTAGATCAAGATTTAGT
GCTGAAGCGGGTCACTTGTCCCCTGGGGGTTTTAGGGATTATTTTTGAAGCTCGCCCGGAAGCTCTGATCCAAATCACCA
GCCTCGCAATTAAATCGGGTAATGGTGTGATTCTCAAAGGGGGCAAAGAAGCGATCCAATCCTGCACTGTGTTGACAGAA
ATTATCCAAACCGCCCTCCAGGACACGGCTGTTTCCCCCCAGGCTGTCACCCTCCTGACCACCCGCGAAGAAATTAAAAC
CCTCCTGTCCCTCGATCAGTATGTGGATTTGATCATCCCGCGCGGTTCCAATGCCTTTGTGCAATATGTGCAGCAAAATA
CGACTATCCCCGTGCTGGGCCACGCCGATGGCGTTTGTCACCTATATGTTGATGTGGCGGCAGATTTAAGCAAAACCATT
CCGATTGTCGTCGATGCGAAAACCCAGTATCCGGCGGCTTGTAATGCGGTGGAAACGCTGTTAATTCACGAAAAAATTGC
CCCAGAATTTTTACCCCAGATTGCCGCAGCTTTAACGGCGAAACAGGTCACTTTACGCGGCGATGCGGCAACCCAAAAGA
TTATGCCTGTCCAGCCTGCGACGGCAGAAGATTGGCGCACAGAATATAGCGATTTAGTCCTGGCAATTAAAATTGTGCCC
GATGTCGAAGCGGCGATCGCCCACATCAATACCTACGGCTCCAAGCACACCGACGGGATTATCACAGAAGATGCGGCCAC
GGCCCAGATTTTCCTCAATGAAGTGAAAGCAGCGGGCGTTTACCATAATTGCTCGACCCGGTTTGCCGATGGTTTCCGCT
ACGGCTTTGGTGCAGAAGTAGGCATCAGCACCCAAACTCTGCCACCCCGTGGCCCCGTGGGTTTAGAAGGACTTGTGACC
TACAAATATCATCTCGTTGGCAATGGTCAAATCGCCGCGACCTATAGTGGCCCCGATGCCAAGCCTTTTACCCACCGAGA
TCTCTAG

Upstream 100 bases:

>100_bases
ATCACAGAAAAGCCTATTTCGATGGGCTTTTTTCGTTGTTGGGTCGGGCGACGGGTGATGTTAAATAGAACCATAGGACT
GGATAAATTTGGAGGGAATC

Downstream 100 bases:

>100_bases
CGATTATGGCGATCGCCGGATAGATGAAATTCCAATTTGCCCCTAGCTTTGGGGCATTTTTTTTGTGATCAGTGGGATTA
ATTGACTTTATAAGCAACTT

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase

Number of amino acids: Translated: 428; Mature: 427

Protein sequence:

>428_residues
MATQLIDLAQQTRAAAQKLGTLSLAQRNDALAKVAQALAANQAKIVAANQADCEAAQRDGIAPALYARLKLGESKLQGAI
AGIHDVINLPDPVGHLQLHRELDQDLVLKRVTCPLGVLGIIFEARPEALIQITSLAIKSGNGVILKGGKEAIQSCTVLTE
IIQTALQDTAVSPQAVTLLTTREEIKTLLSLDQYVDLIIPRGSNAFVQYVQQNTTIPVLGHADGVCHLYVDVAADLSKTI
PIVVDAKTQYPAACNAVETLLIHEKIAPEFLPQIAAALTAKQVTLRGDAATQKIMPVQPATAEDWRTEYSDLVLAIKIVP
DVEAAIAHINTYGSKHTDGIITEDAATAQIFLNEVKAAGVYHNCSTRFADGFRYGFGAEVGISTQTLPPRGPVGLEGLVT
YKYHLVGNGQIAATYSGPDAKPFTHRDL

Sequences:

>Translated_428_residues
MATQLIDLAQQTRAAAQKLGTLSLAQRNDALAKVAQALAANQAKIVAANQADCEAAQRDGIAPALYARLKLGESKLQGAI
AGIHDVINLPDPVGHLQLHRELDQDLVLKRVTCPLGVLGIIFEARPEALIQITSLAIKSGNGVILKGGKEAIQSCTVLTE
IIQTALQDTAVSPQAVTLLTTREEIKTLLSLDQYVDLIIPRGSNAFVQYVQQNTTIPVLGHADGVCHLYVDVAADLSKTI
PIVVDAKTQYPAACNAVETLLIHEKIAPEFLPQIAAALTAKQVTLRGDAATQKIMPVQPATAEDWRTEYSDLVLAIKIVP
DVEAAIAHINTYGSKHTDGIITEDAATAQIFLNEVKAAGVYHNCSTRFADGFRYGFGAEVGISTQTLPPRGPVGLEGLVT
YKYHLVGNGQIAATYSGPDAKPFTHRDL
>Mature_427_residues
ATQLIDLAQQTRAAAQKLGTLSLAQRNDALAKVAQALAANQAKIVAANQADCEAAQRDGIAPALYARLKLGESKLQGAIA
GIHDVINLPDPVGHLQLHRELDQDLVLKRVTCPLGVLGIIFEARPEALIQITSLAIKSGNGVILKGGKEAIQSCTVLTEI
IQTALQDTAVSPQAVTLLTTREEIKTLLSLDQYVDLIIPRGSNAFVQYVQQNTTIPVLGHADGVCHLYVDVAADLSKTIP
IVVDAKTQYPAACNAVETLLIHEKIAPEFLPQIAAALTAKQVTLRGDAATQKIMPVQPATAEDWRTEYSDLVLAIKIVPD
VEAAIAHINTYGSKHTDGIITEDAATAQIFLNEVKAAGVYHNCSTRFADGFRYGFGAEVGISTQTLPPRGPVGLEGLVTY
KYHLVGNGQIAATYSGPDAKPFTHRDL

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family

Homologues:

Organism=Homo sapiens, GI62912457, Length=424, Percent_Identity=43.1603773584906, Blast_Score=332, Evalue=4e-91,
Organism=Homo sapiens, GI21361368, Length=424, Percent_Identity=43.1603773584906, Blast_Score=332, Evalue=5e-91,
Organism=Escherichia coli, GI1786438, Length=408, Percent_Identity=40.6862745098039, Blast_Score=310, Evalue=2e-85,
Organism=Caenorhabditis elegans, GI17569967, Length=413, Percent_Identity=41.8886198547215, Blast_Score=316, Evalue=2e-86,
Organism=Caenorhabditis elegans, GI17569969, Length=413, Percent_Identity=41.8886198547215, Blast_Score=315, Evalue=2e-86,
Organism=Saccharomyces cerevisiae, GI6324899, Length=443, Percent_Identity=44.4695259593679, Blast_Score=368, Evalue=1e-103,
Organism=Drosophila melanogaster, GI21357643, Length=424, Percent_Identity=43.3962264150943, Blast_Score=338, Evalue=4e-93,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PROA_SYNP2 (B1XLA4)

Other databases:

- EMBL:   CP000951
- RefSeq:   YP_001735846.1
- ProteinModelPortal:   B1XLA4
- SMR:   B1XLA4
- GeneID:   6057241
- GenomeReviews:   CP000951_GR
- KEGG:   syp:SYNPCC7002_A2614
- HOGENOM:   HBG318080
- OMA:   QYPAACN
- GO:   GO:0005737
- HAMAP:   MF_00412
- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134
- Gene3D:   G3DSA:3.40.309.10
- Gene3D:   G3DSA:3.40.605.10
- PIRSF:   PIRSF000151
- TIGRFAMs:   TIGR00407

Pfam domain/function: PF00171 Aldedh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.2.1.41

Molecular weight: Translated: 45650; Mature: 45519

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.2 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATQLIDLAQQTRAAAQKLGTLSLAQRNDALAKVAQALAANQAKIVAANQADCEAAQRDG
CCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHCC
IAPALYARLKLGESKLQGAIAGIHDVINLPDPVGHLQLHRELDQDLVLKRVTCPLGVLGI
CCHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHH
IFEARPEALIQITSLAIKSGNGVILKGGKEAIQSCTVLTEIIQTALQDTAVSPQAVTLLT
HHHCCCHHHHEEEHHEEECCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEE
TREEIKTLLSLDQYVDLIIPRGSNAFVQYVQQNTTIPVLGHADGVCHLYVDVAADLSKTI
CHHHHHHHHHHHHHHEEEEECCCHHHHHHHHCCCCEEEEECCCCEEEEEEEEHHHHCCCC
PIVVDAKTQYPAACNAVETLLIHEKIAPEFLPQIAAALTAKQVTLRGDAATQKIMPVQPA
CEEEECCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHEEEECCCCCCCEECCCCC
TAEDWRTEYSDLVLAIKIVPDVEAAIAHINTYGSKHTDGIITEDAATAQIFLNEVKAAGV
CCHHHHHHHCCEEEEEEECCCHHHHHHHHHHCCCCCCCCEEECCCHHHHHHHHHHHHCCE
YHNCSTRFADGFRYGFGAEVGISTQTLPPRGPVGLEGLVTYKYHLVGNGQIAATYSGPDA
EECCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEEECCEEEEEECCCCC
KPFTHRDL
CCCCCCCC
>Mature Secondary Structure 
ATQLIDLAQQTRAAAQKLGTLSLAQRNDALAKVAQALAANQAKIVAANQADCEAAQRDG
CCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHCC
IAPALYARLKLGESKLQGAIAGIHDVINLPDPVGHLQLHRELDQDLVLKRVTCPLGVLGI
CCHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHH
IFEARPEALIQITSLAIKSGNGVILKGGKEAIQSCTVLTEIIQTALQDTAVSPQAVTLLT
HHHCCCHHHHEEEHHEEECCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEE
TREEIKTLLSLDQYVDLIIPRGSNAFVQYVQQNTTIPVLGHADGVCHLYVDVAADLSKTI
CHHHHHHHHHHHHHHEEEEECCCHHHHHHHHCCCCEEEEECCCCEEEEEEEEHHHHCCCC
PIVVDAKTQYPAACNAVETLLIHEKIAPEFLPQIAAALTAKQVTLRGDAATQKIMPVQPA
CEEEECCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHEEEECCCCCCCEECCCCC
TAEDWRTEYSDLVLAIKIVPDVEAAIAHINTYGSKHTDGIITEDAATAQIFLNEVKAAGV
CCHHHHHHHCCEEEEEEECCCHHHHHHHHHHCCCCCCCCEEECCCHHHHHHHHHHHHCCE
YHNCSTRFADGFRYGFGAEVGISTQTLPPRGPVGLEGLVTYKYHLVGNGQIAATYSGPDA
EECCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEEECCEEEEEECCCCC
KPFTHRDL
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA