| Definition | Synechococcus sp. PCC 7002 chromosome, complete genome. |
|---|---|
| Accession | NC_010475 |
| Length | 3,008,047 |
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The map label for this gene is coaBC [H]
Identifier: 170078036
GI number: 170078036
Start: 1499946
End: 1501157
Strand: Reverse
Name: coaBC [H]
Synonym: SYNPCC7002_A1427
Alternate gene names: 170078036
Gene position: 1501157-1499946 (Counterclockwise)
Preceding gene: 170078037
Following gene: 170078035
Centisome position: 49.9
GC content: 54.21
Gene sequence:
>1212_bases ATGCTCAACGAAAAAAAGATTGTCGTCGGCATTAGTGGGGGCATTGCCGCCTACAAAGTTTGTGAAGTCATTTCCCAACT GTTCCAGGCTGGGGCAGAGCTCAGGGTCGTCCTGACGGATTCGGCCCAACGTTTTATCACGCCCCTCACGGTGGCCACCC TCAGCCGTCACCCAGCCTATACAGACGAAGATTTTTGGGATAGCCACCGCCCCCGACCGGTGCATATCGACCTGGGAGAA TGGGCAGATTTAATTTTGCTAGCCCCCCTAACGGCGAATACCCTCGCAAAAGTAAGCCTGGGCCTTGCGGATACGTTGCT GACAAACATTATTTTGGCCTCCACTTGCCCAGTTTTAGTCGCCCCGGCGATGAATACGGACATGTGGCAACAGCTCTCGG TGCAGTCCAATTGGCGGCGACTCCAACAGGATCAGCGCTATCACATCCTCGACCCAAATAGTGGTTTGTTGGCCTGCGAT CGCCAAGGCAAAGGACGCATGGCAGAACCCGTGCAGATTATTAAAGCGGTTCAAGCACTGATCCACAGTCGGGGCCGAGC GGATCTCGCAGGCAAAAAAATTCTCGTCAGCGCCGGAGGAACCAGGGAGCATTTTGACCCCGTGCGCTTTATTAGTAATC CTTCGACGGGAAAAATGGGTTTAGCGATCGCCGAAGCCGCTGCCTATCGAGGCGCCACTGTGACCCTAGTCCATGGGCCG ATGGAAAGTCGCTTGTTAGAAAATTTAGCGAATCTCCACCGCTTTCCCGTCACTAGCGCCGCCGAAATGGAGCAAATGAT GCTATCCCAGGCGGATCAGTTTGATTGGCTCATTCTGTGTGCAGCGGTCGGTGATGTGCGGCCCACGGTGAACTATGACC ATAAGCTCGCGAAGGCAGAGTTGCCCGAAAGCCTTGCCTTAGAGGAAATTCCTGACATCGCCGCCCAACTGGGTCAACGG AAACGCCCCGACCAAAAATTAATCGGTTTTGCGGCCCAGACGGGGGAAATTACGGCCCCCGCCCTGGCTAAATTGCAACG GAAAAAACTCGATGCGATCGCCGCCAATGCCGTGGATCAAGCTAATTCCGGTTTTGCTAGTGAGACGAACCAACTGATTT TCCTCGACAAAGAAGGCCGCAAGGCGACAATTCCCCAGGCCAGCAAGGGGGCGATCGCCCATCATCTACTAGACTTTATC AAGCAACTTTAA
Upstream 100 bases:
>100_bases CCAGGATTGGCACTTGTTGCGGGCGATCGCCTTTCAACGGCAAGAGTTAGTCGAACCCTACTGGCACCTCTTGGACATCG AAGCCTACGACGAATCGTAA
Downstream 100 bases:
>100_bases ACAAAATTTCTGCCCCTGCGATGAACGCCCTTTCCTTTCCCACTTGGATTGTCCACATCTCTAGCGTTTTGGAGTGGATT TTGGCTATTTGGCTGATCCA
Product: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase
Products: NA
Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]
Number of amino acids: Translated: 403; Mature: 403
Protein sequence:
>403_residues MLNEKKIVVGISGGIAAYKVCEVISQLFQAGAELRVVLTDSAQRFITPLTVATLSRHPAYTDEDFWDSHRPRPVHIDLGE WADLILLAPLTANTLAKVSLGLADTLLTNIILASTCPVLVAPAMNTDMWQQLSVQSNWRRLQQDQRYHILDPNSGLLACD RQGKGRMAEPVQIIKAVQALIHSRGRADLAGKKILVSAGGTREHFDPVRFISNPSTGKMGLAIAEAAAYRGATVTLVHGP MESRLLENLANLHRFPVTSAAEMEQMMLSQADQFDWLILCAAVGDVRPTVNYDHKLAKAELPESLALEEIPDIAAQLGQR KRPDQKLIGFAAQTGEITAPALAKLQRKKLDAIAANAVDQANSGFASETNQLIFLDKEGRKATIPQASKGAIAHHLLDFI KQL
Sequences:
>Translated_403_residues MLNEKKIVVGISGGIAAYKVCEVISQLFQAGAELRVVLTDSAQRFITPLTVATLSRHPAYTDEDFWDSHRPRPVHIDLGE WADLILLAPLTANTLAKVSLGLADTLLTNIILASTCPVLVAPAMNTDMWQQLSVQSNWRRLQQDQRYHILDPNSGLLACD RQGKGRMAEPVQIIKAVQALIHSRGRADLAGKKILVSAGGTREHFDPVRFISNPSTGKMGLAIAEAAAYRGATVTLVHGP MESRLLENLANLHRFPVTSAAEMEQMMLSQADQFDWLILCAAVGDVRPTVNYDHKLAKAELPESLALEEIPDIAAQLGQR KRPDQKLIGFAAQTGEITAPALAKLQRKKLDAIAANAVDQANSGFASETNQLIFLDKEGRKATIPQASKGAIAHHLLDFI KQL >Mature_403_residues MLNEKKIVVGISGGIAAYKVCEVISQLFQAGAELRVVLTDSAQRFITPLTVATLSRHPAYTDEDFWDSHRPRPVHIDLGE WADLILLAPLTANTLAKVSLGLADTLLTNIILASTCPVLVAPAMNTDMWQQLSVQSNWRRLQQDQRYHILDPNSGLLACD RQGKGRMAEPVQIIKAVQALIHSRGRADLAGKKILVSAGGTREHFDPVRFISNPSTGKMGLAIAEAAAYRGATVTLVHGP MESRLLENLANLHRFPVTSAAEMEQMMLSQADQFDWLILCAAVGDVRPTVNYDHKLAKAELPESLALEEIPDIAAQLGQR KRPDQKLIGFAAQTGEITAPALAKLQRKKLDAIAANAVDQANSGFASETNQLIFLDKEGRKATIPQASKGAIAHHLLDFI KQL
Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]
COG id: COG0452
COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]
Homologues:
Organism=Homo sapiens, GI71725351, Length=193, Percent_Identity=37.8238341968912, Blast_Score=100, Evalue=4e-21, Organism=Escherichia coli, GI87082301, Length=402, Percent_Identity=40.7960199004975, Blast_Score=234, Evalue=6e-63, Organism=Caenorhabditis elegans, GI17560194, Length=182, Percent_Identity=35.1648351648352, Blast_Score=91, Evalue=2e-18, Organism=Saccharomyces cerevisiae, GI6322762, Length=206, Percent_Identity=32.0388349514563, Blast_Score=91, Evalue=2e-19, Organism=Saccharomyces cerevisiae, GI6324629, Length=122, Percent_Identity=36.8852459016393, Blast_Score=83, Evalue=8e-17, Organism=Saccharomyces cerevisiae, GI6322925, Length=93, Percent_Identity=39.7849462365591, Blast_Score=76, Evalue=1e-14, Organism=Drosophila melanogaster, GI24657262, Length=186, Percent_Identity=32.258064516129, Blast_Score=89, Evalue=7e-18,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR005252 - InterPro: IPR007085 - InterPro: IPR003382 [H]
Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]
EC number: =4.1.1.36; =6.3.2.5 [H]
Molecular weight: Translated: 43916; Mature: 43916
Theoretical pI: Translated: 7.69; Mature: 7.69
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.0 %Cys (Translated Protein) 2.2 %Met (Translated Protein) 3.2 %Cys+Met (Translated Protein) 1.0 %Cys (Mature Protein) 2.2 %Met (Mature Protein) 3.2 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MLNEKKIVVGISGGIAAYKVCEVISQLFQAGAELRVVLTDSAQRFITPLTVATLSRHPAY CCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHCCCCCC TDEDFWDSHRPRPVHIDLGEWADLILLAPLTANTLAKVSLGLADTLLTNIILASTCPVLV CCCCHHCCCCCCEEEEECCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEE APAMNTDMWQQLSVQSNWRRLQQDQRYHILDPNSGLLACDRQGKGRMAEPVQIIKAVQAL ECCCCHHHHHHHHHHHHHHHHHHCCCEEEECCCCCEEEECCCCCCCCCHHHHHHHHHHHH IHSRGRADLAGKKILVSAGGTREHFDPVRFISNPSTGKMGLAIAEAAAYRGATVTLVHGP HHCCCCCCCCCCEEEEECCCCCHHCCCHHHCCCCCCCCHHHHHHHHHHHCCCEEEEEECC MESRLLENLANLHRFPVTSAAEMEQMMLSQADQFDWLILCAAVGDVRPTVNYDHKLAKAE HHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCEEEEEHHCCCCCCCCCCHHHHHHH LPESLALEEIPDIAAQLGQRKRPDQKLIGFAAQTGEITAPALAKLQRKKLDAIAANAVDQ CCHHHHHHHHHHHHHHHHCCCCCCHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHH ANSGFASETNQLIFLDKEGRKATIPQASKGAIAHHLLDFIKQL CCCCCCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHC >Mature Secondary Structure MLNEKKIVVGISGGIAAYKVCEVISQLFQAGAELRVVLTDSAQRFITPLTVATLSRHPAY CCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHCCCCCC TDEDFWDSHRPRPVHIDLGEWADLILLAPLTANTLAKVSLGLADTLLTNIILASTCPVLV CCCCHHCCCCCCEEEEECCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEE APAMNTDMWQQLSVQSNWRRLQQDQRYHILDPNSGLLACDRQGKGRMAEPVQIIKAVQAL ECCCCHHHHHHHHHHHHHHHHHHCCCEEEECCCCCEEEECCCCCCCCCHHHHHHHHHHHH IHSRGRADLAGKKILVSAGGTREHFDPVRFISNPSTGKMGLAIAEAAAYRGATVTLVHGP HHCCCCCCCCCCEEEEECCCCCHHCCCHHHCCCCCCCCHHHHHHHHHHHCCCEEEEEECC MESRLLENLANLHRFPVTSAAEMEQMMLSQADQFDWLILCAAVGDVRPTVNYDHKLAKAE HHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCEEEEEHHCCCCCCCCCCHHHHHHH LPESLALEEIPDIAAQLGQRKRPDQKLIGFAAQTGEITAPALAKLQRKKLDAIAANAVDQ CCHHHHHHHHHHHHHHHHCCCCCCHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHH ANSGFASETNQLIFLDKEGRKATIPQASKGAIAHHLLDFIKQL CCCCCCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 8905231 [H]