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The map label for this gene is hisG

Identifier: 170077244

GI number: 170077244

Start: 650633

End: 651265

Strand: Reverse

Name: hisG

Synonym: SYNPCC7002_A0620

Alternate gene names: 170077244

Gene position: 651265-650633 (Counterclockwise)

Preceding gene: 170077245

Following gene: 170077243

Centisome position: 21.65

GC content: 54.98

Gene sequence:

>633_bases
ATGCTTACCATTGCCATTCCCAAAGGTGGCCTCCTCCCAGAGGCGATCGCCCTCCTCCAACAAGTCGGGTTAGACTTTAG
CGCCTTCCTCGATAAAAAAAATCGCCAACTGCAAATCACCGATCCCACTGGCACCGCCCGGGCGATGCTCGTGCGCACCC
ATGACGTTCCCGTCTATGTCGAATATGGCCAGGCCCAACTAGGGTTTGCGGGTTACGATGTCCTCCGGGAGAAAAAACCC
GATGTCGCGAATCTGTTAGACTTAGGATTCGGTGGTTGTCGCCTCTCCGTTGCCGTCCCCAAGGCCAGCCCCTACAAAAA
TCCCCGGCAACTCCCCCCCAACTGCCGTGTAGCCTCCAAATTTGTTAATTGCGCCAAAGACTACTTCCGCGATCTCGATC
TCCCCATCGAAGTCATCCCCCTCCACGGCTCCGTCGAACTTGGCCCCATTACTGGCATGTCCGAGGCGATCGTTGACCTT
GTTTCCACTGGGAATACCCTCAGGGAAAATAACCTCGAAGAAGTTGAAGTGCTCTTCCATAGCACCGTTCGCCTCATTGC
CCACCCCACCAGCTACCGTGCCAACCGTCACAACATGCTCGATTGGGTGCAAAAATTGGAGCAAATCCTCTAA

Upstream 100 bases:

>100_bases
CCCACCTCGCCTGGATTGACCCCAGTGGCGAACCCAAACTCGAAACCCTCTAACTTAAATTCTGTTTCCTTAAGATTTTT
GAATCACTGCTAACGAAAAA

Downstream 100 bases:

>100_bases
ATTTTTGGACAAATGGTAACAAGGTTTGCTGACAAATTCCTAAAAAATATTTCAGCATCGCCCCAAGATCCGTTACAATG
CATTAAGAAATCGTTCCTAG

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 210; Mature: 210

Protein sequence:

>210_residues
MLTIAIPKGGLLPEAIALLQQVGLDFSAFLDKKNRQLQITDPTGTARAMLVRTHDVPVYVEYGQAQLGFAGYDVLREKKP
DVANLLDLGFGGCRLSVAVPKASPYKNPRQLPPNCRVASKFVNCAKDYFRDLDLPIEVIPLHGSVELGPITGMSEAIVDL
VSTGNTLRENNLEEVEVLFHSTVRLIAHPTSYRANRHNMLDWVQKLEQIL

Sequences:

>Translated_210_residues
MLTIAIPKGGLLPEAIALLQQVGLDFSAFLDKKNRQLQITDPTGTARAMLVRTHDVPVYVEYGQAQLGFAGYDVLREKKP
DVANLLDLGFGGCRLSVAVPKASPYKNPRQLPPNCRVASKFVNCAKDYFRDLDLPIEVIPLHGSVELGPITGMSEAIVDL
VSTGNTLRENNLEEVEVLFHSTVRLIAHPTSYRANRHNMLDWVQKLEQIL
>Mature_210_residues
MLTIAIPKGGLLPEAIALLQQVGLDFSAFLDKKNRQLQITDPTGTARAMLVRTHDVPVYVEYGQAQLGFAGYDVLREKKP
DVANLLDLGFGGCRLSVAVPKASPYKNPRQLPPNCRVASKFVNCAKDYFRDLDLPIEVIPLHGSVELGPITGMSEAIVDL
VSTGNTLRENNLEEVEVLFHSTVRLIAHPTSYRANRHNMLDWVQKLEQIL

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=160, Percent_Identity=35.625, Blast_Score=92, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6320896, Length=193, Percent_Identity=33.6787564766839, Blast_Score=95, Evalue=8e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_SYNP2 (B1XPZ8)

Other databases:

- EMBL:   CP000951
- RefSeq:   YP_001733882.1
- ProteinModelPortal:   B1XPZ8
- SMR:   B1XPZ8
- GeneID:   6055627
- GenomeReviews:   CP000951_GR
- KEGG:   syp:SYNPCC7002_A0620
- HOGENOM:   HBG391868
- OMA:   LLMFRAE
- ProtClustDB:   PRK01686
- GO:   GO:0005737
- HAMAP:   MF_01018
- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070

Pfam domain/function: PF01634 HisG

EC number: =2.4.2.17

Molecular weight: Translated: 23259; Mature: 23259

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTIAIPKGGLLPEAIALLQQVGLDFSAFLDKKNRQLQITDPTGTARAMLVRTHDVPVYV
CEEEEECCCCCCHHHHHHHHHHCCCHHHHHCCCCCEEEEECCCCCCEEEEEEECCCEEEE
EYGQAQLGFAGYDVLREKKPDVANLLDLGFGGCRLSVAVPKASPYKNPRQLPPNCRVASK
ECCCEECCHHHHHHHHHCCCCHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHH
FVNCAKDYFRDLDLPIEVIPLHGSVELGPITGMSEAIVDLVSTGNTLRENNLEEVEVLFH
HHHHHHHHHHCCCCCEEEEECCCCEEECCCCCHHHHHHHHHHCCCCHHHCCHHHHHHHHH
STVRLIAHPTSYRANRHNMLDWVQKLEQIL
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHC
>Mature Secondary Structure
MLTIAIPKGGLLPEAIALLQQVGLDFSAFLDKKNRQLQITDPTGTARAMLVRTHDVPVYV
CEEEEECCCCCCHHHHHHHHHHCCCHHHHHCCCCCEEEEECCCCCCEEEEEEECCCEEEE
EYGQAQLGFAGYDVLREKKPDVANLLDLGFGGCRLSVAVPKASPYKNPRQLPPNCRVASK
ECCCEECCHHHHHHHHHCCCCHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHH
FVNCAKDYFRDLDLPIEVIPLHGSVELGPITGMSEAIVDLVSTGNTLRENNLEEVEVLFH
HHHHHHHHHHCCCCCEEEEECCCCEEECCCCCHHHHHHHHHHCCCCHHHCCHHHHHHHHH
STVRLIAHPTSYRANRHNMLDWVQKLEQIL
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA