Click here to switch to the map view.

The map label for this gene is lsrK [H]

Identifier: 170025863

GI number: 170025863

Start: 4026960

End: 4028552

Strand: Reverse

Name: lsrK [H]

Synonym: YPK_3648

Alternate gene names: 170025863

Gene position: 4028552-4026960 (Counterclockwise)

Preceding gene: 170025864

Following gene: 170025862

Centisome position: 85.91

GC content: 54.3

Gene sequence:

>1593_bases
ATGAGTCAACTCGATACGACTACCCCATCAGGTGATTACTTGATGGCGCTGGATGCCGGTACCGGCAGTGTCCGGGCGGT
GATATTTGATCTTAATGGTAATCAGATTGCCGCCGGGCAGGCGGAGTGGCTGCATCTGCCGGTACCCGATGTTCCGGGGT
CGATGGAGTTTGATTTAACCACCAATTGGCAACTCATGTGCCAGTGTATCCGCCAGGCACTGCATTTGGCTAAGTTACCG
GCCAGTGCTATCCGTGCTGTCGCTGCCTGTTCAATGCGTGAAGGGATCGTACTCTATGATCGCAGTGGAACCCCGATCTG
GGCCTGTGCCAATGTGGATGCTCGCGCCAGCCGTGAAGTCAGCGAATTAAAAGAGCTGCACAATAATGGATTTGAGTTAG
AAGTCTATCAATGCTCCGGCCAGACGCTGGCACTGAGTGCCATGCCCCGGTTGTTGTGGTTGGCGCACTATCGGCCCGAT
ATTTATCGTCAGGCAGGAACACTGACCATGATCAGTGACTGGCTGGCCAATATGCTCAGTGGGGAGCTGGCGGTCGATCC
CTCCAACGCGGGGACCACGGGTATGCTGGATCTCGTCACCCGTAACTGGCAACCGAACTTGCTGGAAATGGCCGGGTTAC
GTGCGGATATTCTCTCGCCAGTGAAAGAGACAGGCACCTTGCTGGGCCATGTCACGGCGAAGGCCGCGCAAGAATGTGGT
TTGCTGGCCGGAACGCCGGTGGTGATGGGCGGTGGCGATGTACAACTGGGTTGTTTGGGGTTGGGAGTGGTGCACGCAGG
CCAGACGGCGGTATTGGGCGGTACTTTCTGGCAGCAGGTGGTTAATTTACCGCAGCCGATTATTGATCCCAATATGAATA
CCCGAATAAACCCTCATGTTATCCCCGGTATGGTTCAGGCGGAGTCCATCAGCTTCTTTACTGGTCTGACAATGCGCTGG
TTCCGTGATGCGTTTTGCGCCGAAGAAAAATTACTGGCGCAGCGATTGGGGATTGATACCTACAGTTTATTGGAGGATAT
GGCCGCCAGGGTTCCCGCCGGTGCTTATGGGGTTATGCCTATCTTCTCTGATGTGATGCGTTTTAAATCTTGGTATCACG
CTGCGCCTTCATTTATTAACCTCTCACTCGATCCTGAAAAATGTAATAAAGCCACGTTATTCCGTGCGCTGGAAGAGAAT
GCGGCCATCGTCTCGGCCTGTAATTTAGCGCAAATTGCTGAATTCTCTGGCGTGAAAGCCTCGTCGGTGGTTTTTGCTGG
CGGTGGCGCGAAAGGCAAACTGTGGAGCCAGATTCTGGCTGATGTCACCGGTGTTCCGGTGAAGGTGCCGGTGGTCAAAG
AAGCAACCGCATTAGGCTGCGCGATTGCCGCCGGTGTTGGTGTCGGCCTATATGAAGCATTGGATAAAACCGGCGAGCGG
CTCGTGCGCTGGGAGCGGGAATACATCCCGAATACTGAGCATAAAGCGCTCTATCAAGCGGCAAAAACTAACTGGCAAGC
GGTGTATACCGATCAACTGGGGCTGGTGGATTGTGGGTTGACGACGTCTCTTTGGAAGGCTCCTGGCCTCTAA

Upstream 100 bases:

>100_bases
AGGCTCCGATCTCTGCGCGCGGTCCCACAGGCAACTTGAAATATGACGGGTAAACACTGCGGTGACGCCAAATAAGCAGG
GTATTCAAGAGGAGCGCGCA

Downstream 100 bases:

>100_bases
AATGGATTATCTTCATTAATTGACTATCTTCATTCATTAACTATTTTGATTAATTAACTAGCTTGATTAATTAATAGCGA
AAAGCGGCCAGCTTGCGCTT

Product: autoinducer-2 (AI-2) kinase

Products: NA

Alternate protein names: AI-2 kinase [H]

Number of amino acids: Translated: 530; Mature: 529

Protein sequence:

>530_residues
MSQLDTTTPSGDYLMALDAGTGSVRAVIFDLNGNQIAAGQAEWLHLPVPDVPGSMEFDLTTNWQLMCQCIRQALHLAKLP
ASAIRAVAACSMREGIVLYDRSGTPIWACANVDARASREVSELKELHNNGFELEVYQCSGQTLALSAMPRLLWLAHYRPD
IYRQAGTLTMISDWLANMLSGELAVDPSNAGTTGMLDLVTRNWQPNLLEMAGLRADILSPVKETGTLLGHVTAKAAQECG
LLAGTPVVMGGGDVQLGCLGLGVVHAGQTAVLGGTFWQQVVNLPQPIIDPNMNTRINPHVIPGMVQAESISFFTGLTMRW
FRDAFCAEEKLLAQRLGIDTYSLLEDMAARVPAGAYGVMPIFSDVMRFKSWYHAAPSFINLSLDPEKCNKATLFRALEEN
AAIVSACNLAQIAEFSGVKASSVVFAGGGAKGKLWSQILADVTGVPVKVPVVKEATALGCAIAAGVGVGLYEALDKTGER
LVRWEREYIPNTEHKALYQAAKTNWQAVYTDQLGLVDCGLTTSLWKAPGL

Sequences:

>Translated_530_residues
MSQLDTTTPSGDYLMALDAGTGSVRAVIFDLNGNQIAAGQAEWLHLPVPDVPGSMEFDLTTNWQLMCQCIRQALHLAKLP
ASAIRAVAACSMREGIVLYDRSGTPIWACANVDARASREVSELKELHNNGFELEVYQCSGQTLALSAMPRLLWLAHYRPD
IYRQAGTLTMISDWLANMLSGELAVDPSNAGTTGMLDLVTRNWQPNLLEMAGLRADILSPVKETGTLLGHVTAKAAQECG
LLAGTPVVMGGGDVQLGCLGLGVVHAGQTAVLGGTFWQQVVNLPQPIIDPNMNTRINPHVIPGMVQAESISFFTGLTMRW
FRDAFCAEEKLLAQRLGIDTYSLLEDMAARVPAGAYGVMPIFSDVMRFKSWYHAAPSFINLSLDPEKCNKATLFRALEEN
AAIVSACNLAQIAEFSGVKASSVVFAGGGAKGKLWSQILADVTGVPVKVPVVKEATALGCAIAAGVGVGLYEALDKTGER
LVRWEREYIPNTEHKALYQAAKTNWQAVYTDQLGLVDCGLTTSLWKAPGL
>Mature_529_residues
SQLDTTTPSGDYLMALDAGTGSVRAVIFDLNGNQIAAGQAEWLHLPVPDVPGSMEFDLTTNWQLMCQCIRQALHLAKLPA
SAIRAVAACSMREGIVLYDRSGTPIWACANVDARASREVSELKELHNNGFELEVYQCSGQTLALSAMPRLLWLAHYRPDI
YRQAGTLTMISDWLANMLSGELAVDPSNAGTTGMLDLVTRNWQPNLLEMAGLRADILSPVKETGTLLGHVTAKAAQECGL
LAGTPVVMGGGDVQLGCLGLGVVHAGQTAVLGGTFWQQVVNLPQPIIDPNMNTRINPHVIPGMVQAESISFFTGLTMRWF
RDAFCAEEKLLAQRLGIDTYSLLEDMAARVPAGAYGVMPIFSDVMRFKSWYHAAPSFINLSLDPEKCNKATLFRALEENA
AIVSACNLAQIAEFSGVKASSVVFAGGGAKGKLWSQILADVTGVPVKVPVVKEATALGCAIAAGVGVGLYEALDKTGERL
VRWEREYIPNTEHKALYQAAKTNWQAVYTDQLGLVDCGLTTSLWKAPGL

Specific function: Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2 [H]

COG id: COG1070

COG function: function code G; Sugar (pentulose and hexulose) kinases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Homo sapiens, GI42794763, Length=477, Percent_Identity=24.5283018867925, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI1787789, Length=530, Percent_Identity=78.4905660377359, Blast_Score=872, Evalue=0.0,
Organism=Escherichia coli, GI1790005, Length=501, Percent_Identity=25.1497005988024, Blast_Score=116, Evalue=4e-27,
Organism=Escherichia coli, GI1790361, Length=496, Percent_Identity=25.8064516129032, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1789168, Length=498, Percent_Identity=23.8955823293173, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1789138, Length=525, Percent_Identity=23.4285714285714, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1789987, Length=522, Percent_Identity=23.9463601532567, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17535599, Length=462, Percent_Identity=25.5411255411255, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018484 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: NA

Molecular weight: Translated: 57025; Mature: 56894

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQLDTTTPSGDYLMALDAGTGSVRAVIFDLNGNQIAAGQAEWLHLPVPDVPGSMEFDLT
CCCCCCCCCCCCEEEEEECCCCCEEEEEEECCCCEEECCCCCEEEECCCCCCCCEEEEEC
TNWQLMCQCIRQALHLAKLPASAIRAVAACSMREGIVLYDRSGTPIWACANVDARASREV
CCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEECCCCCEEEECCCCHHHHHHH
SELKELHNNGFELEVYQCSGQTLALSAMPRLLWLAHYRPDIYRQAGTLTMISDWLANMLS
HHHHHHHCCCCEEEEEEECCCEEEHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHC
GELAVDPSNAGTTGMLDLVTRNWQPNLLEMAGLRADILSPVKETGTLLGHVTAKAAQECG
CCEEECCCCCCCCCHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
LLAGTPVVMGGGDVQLGCLGLGVVHAGQTAVLGGTFWQQVVNLPQPIIDPNMNTRINPHV
CEECCCEEECCCCEEEEEEEEEHEECCCEEEECHHHHHHHHCCCCCCCCCCCCCCCCCCC
IPGMVQAESISFFTGLTMRWFRDAFCAEEKLLAQRLGIDTYSLLEDMAARVPAGAYGVMP
CCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHH
IFSDVMRFKSWYHAAPSFINLSLDPEKCNKATLFRALEENAAIVSACNLAQIAEFSGVKA
HHHHHHHHHHHHHCCCCEEEEEECHHHCCHHHHHHHHHCCCCEEHHCCHHHHHHHCCCCC
SSVVFAGGGAKGKLWSQILADVTGVPVKVPVVKEATALGCAIAAGVGVGLYEALDKTGER
CEEEEECCCCCHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
LVRWEREYIPNTEHKALYQAAKTNWQAVYTDQLGLVDCGLTTSLWKAPGL
HHHHHHHHCCCCHHHHHHHHHCCCCEEEEECCCCEEECCCCHHHHCCCCC
>Mature Secondary Structure 
SQLDTTTPSGDYLMALDAGTGSVRAVIFDLNGNQIAAGQAEWLHLPVPDVPGSMEFDLT
CCCCCCCCCCCEEEEEECCCCCEEEEEEECCCCEEECCCCCEEEECCCCCCCCEEEEEC
TNWQLMCQCIRQALHLAKLPASAIRAVAACSMREGIVLYDRSGTPIWACANVDARASREV
CCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEECCCCCEEEECCCCHHHHHHH
SELKELHNNGFELEVYQCSGQTLALSAMPRLLWLAHYRPDIYRQAGTLTMISDWLANMLS
HHHHHHHCCCCEEEEEEECCCEEEHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHC
GELAVDPSNAGTTGMLDLVTRNWQPNLLEMAGLRADILSPVKETGTLLGHVTAKAAQECG
CCEEECCCCCCCCCHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
LLAGTPVVMGGGDVQLGCLGLGVVHAGQTAVLGGTFWQQVVNLPQPIIDPNMNTRINPHV
CEECCCEEECCCCEEEEEEEEEHEECCCEEEECHHHHHHHHCCCCCCCCCCCCCCCCCCC
IPGMVQAESISFFTGLTMRWFRDAFCAEEKLLAQRLGIDTYSLLEDMAARVPAGAYGVMP
CCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHH
IFSDVMRFKSWYHAAPSFINLSLDPEKCNKATLFRALEENAAIVSACNLAQIAEFSGVKA
HHHHHHHHHHHHHCCCCEEEEEECHHHCCHHHHHHHHHCCCCEEHHCCHHHHHHHCCCCC
SSVVFAGGGAKGKLWSQILADVTGVPVKVPVVKEATALGCAIAAGVGVGLYEALDKTGER
CEEEEECCCCCHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
LVRWEREYIPNTEHKALYQAAKTNWQAVYTDQLGLVDCGLTTSLWKAPGL
HHHHHHHHCCCCHHHHHHHHHCCCCEEEEECCCCEEECCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA