Click here to switch to the map view.

The map label for this gene is femA [H]

Identifier: 169833676

GI number: 169833676

Start: 658250

End: 659482

Strand: Direct

Name: femA [H]

Synonym: SPH_0709

Alternate gene names: 169833676

Gene position: 658250-659482 (Clockwise)

Preceding gene: 169834190

Following gene: 169832925

Centisome position: 29.31

GC content: 35.69

Gene sequence:

>1233_bases
ATGGCACTAACTACACTCACGAAAGAAGAGTTTCGTACTTATTCTGATCAGGTTTCTTCTCGTTCCTTTATGCAATCGGT
CCAGATGGGGGACTTGTTAGACAAAAGAGGGGCTCGAATTGTTTATCTTGCTTTGAAACAAGAAGGAGAGATTCAAGTTG
CAGCTCTGGTTTATAGCTTGCCCATGCTGGGGGGGCTGCATATGGAGCTCAATTCGGGTCCGATTTATACCCAACAAGAT
GCTCTTCCAGTTTTTTATGCGGAGTTAAAAGAATATGCTAAGCAAAATGGTGTATTAGAGTTGCTTGTAAAACCTTATGA
AACGTATCAAACTTTTGATAGTGAAGGTAATCCAATAGATGCTGAGAAAAAAAGTATCATTCAAGGTTTAACTGATTTAG
GTTATCAATTTGATGGATTGACAATGGGTTATCCAGGTGGAGAACCAGATTGGTTATACTATAAAGATTTGACTGAATTA
ACTGAAAAGAATTTGCTTAAAAGTTTTAGCAAAAAGGGTAAACCCTTGGTGAAAAAGGCTGAAACGTTTGGCATTCGGTT
GAAAAAGTTAAAACGTGAAGAACTATCGATTTTTAAGAATATAACAAAAGAAACCTCTGAACGTAGAGAATATAGTGATA
AAAGTTTAGAATATTATGAGCACTTTTATGATTCATTTGGAGAACAGGCGGAGTTTCTTATAGCAAGCTTAAATTTTTCG
GAGTATATGAGCAAATTGCAAGGTGAACAAAGTAAACTAGAAGAAATCTTGGACAAGTTGCGACTTGATTTGAGTAAAAA
TCCTCATTCTGAGAAAAAACAAAATCAACTGAGAGAATATTCTAGTCAATTTGAAACGTTTGAAGTTCGAAAAGCAGAAG
CGCGAGACTTGATTGAAAAATATGGAGAAGAAGATATTGTTTTAGCTGGGAGTTTATTTGTTTATATGCCTCAGGAAACG
ACTTATCTCTTTAGTGGTTCCTACACTGAGTTTAATAAGTTCTATGCCCCTGCACTGCTTCAAAAATATGTTATGTTGGA
AAGCATAAAACGTGGAATACCTAAATACAACTTCCTAGGCATTCAAGGGATTTTTGATGGAAGTGATGGTGTTTTGCGTT
TTAAACAGAATTTTAATGGCTATATTGTACGCAAAGCAGGTACTTTCCGTTACCATCCATCGCCTTTAAAATACAAAGCT
ATCCAGTTACTCAAAAAAATAGTAGGACGTTAA

Upstream 100 bases:

>100_bases
TTGGGTGAATTTACAATGCCCACTCATCCTCTCTATCCTCTGTTAAGACTTGCTCTTGATTTCCGTAAAACATTAAGAAA
AAAACATAGAAAGTAAGTAT

Downstream 100 bases:

>100_bases
GATGAAAAAGTCAGTATTTAGATTTCTTTTAGCTTCTTTTAGTAAAATAATTTTTATTTGCTAGAAAGGTGGAGAGACAT
GCGCTGGCTTTTTCGTTTGA

Product: MurN

Products: NA

Alternate protein names: Factor essential for expression of methicillin resistance A [H]

Number of amino acids: Translated: 410; Mature: 409

Protein sequence:

>410_residues
MALTTLTKEEFRTYSDQVSSRSFMQSVQMGDLLDKRGARIVYLALKQEGEIQVAALVYSLPMLGGLHMELNSGPIYTQQD
ALPVFYAELKEYAKQNGVLELLVKPYETYQTFDSEGNPIDAEKKSIIQGLTDLGYQFDGLTMGYPGGEPDWLYYKDLTEL
TEKNLLKSFSKKGKPLVKKAETFGIRLKKLKREELSIFKNITKETSERREYSDKSLEYYEHFYDSFGEQAEFLIASLNFS
EYMSKLQGEQSKLEEILDKLRLDLSKNPHSEKKQNQLREYSSQFETFEVRKAEARDLIEKYGEEDIVLAGSLFVYMPQET
TYLFSGSYTEFNKFYAPALLQKYVMLESIKRGIPKYNFLGIQGIFDGSDGVLRFKQNFNGYIVRKAGTFRYHPSPLKYKA
IQLLKKIVGR

Sequences:

>Translated_410_residues
MALTTLTKEEFRTYSDQVSSRSFMQSVQMGDLLDKRGARIVYLALKQEGEIQVAALVYSLPMLGGLHMELNSGPIYTQQD
ALPVFYAELKEYAKQNGVLELLVKPYETYQTFDSEGNPIDAEKKSIIQGLTDLGYQFDGLTMGYPGGEPDWLYYKDLTEL
TEKNLLKSFSKKGKPLVKKAETFGIRLKKLKREELSIFKNITKETSERREYSDKSLEYYEHFYDSFGEQAEFLIASLNFS
EYMSKLQGEQSKLEEILDKLRLDLSKNPHSEKKQNQLREYSSQFETFEVRKAEARDLIEKYGEEDIVLAGSLFVYMPQET
TYLFSGSYTEFNKFYAPALLQKYVMLESIKRGIPKYNFLGIQGIFDGSDGVLRFKQNFNGYIVRKAGTFRYHPSPLKYKA
IQLLKKIVGR
>Mature_409_residues
ALTTLTKEEFRTYSDQVSSRSFMQSVQMGDLLDKRGARIVYLALKQEGEIQVAALVYSLPMLGGLHMELNSGPIYTQQDA
LPVFYAELKEYAKQNGVLELLVKPYETYQTFDSEGNPIDAEKKSIIQGLTDLGYQFDGLTMGYPGGEPDWLYYKDLTELT
EKNLLKSFSKKGKPLVKKAETFGIRLKKLKREELSIFKNITKETSERREYSDKSLEYYEHFYDSFGEQAEFLIASLNFSE
YMSKLQGEQSKLEEILDKLRLDLSKNPHSEKKQNQLREYSSQFETFEVRKAEARDLIEKYGEEDIVLAGSLFVYMPQETT
YLFSGSYTEFNKFYAPALLQKYVMLESIKRGIPKYNFLGIQGIFDGSDGVLRFKQNFNGYIVRKAGTFRYHPSPLKYKAI
QLLKKIVGR

Specific function: Catalyzes the formation of the pentaglycine interpeptide bridge, which is characteristic of the S.aureus peptidoglycan. Adds glycines 2 and 3 of the pentaglycine bridge, using glycyl- tRNA(Gly) as donor. Involved in resistance to methicillin [H]

COG id: COG2348

COG function: function code V; Uncharacterized protein involved in methicillin resistance

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the femABX family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016181
- InterPro:   IPR003447
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02388 FemAB [H]

EC number: NA

Molecular weight: Translated: 47371; Mature: 47240

Theoretical pI: Translated: 7.70; Mature: 7.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALTTLTKEEFRTYSDQVSSRSFMQSVQMGDLLDKRGARIVYLALKQEGEIQVAALVYSL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEHHHHHHHH
PMLGGLHMELNSGPIYTQQDALPVFYAELKEYAKQNGVLELLVKPYETYQTFDSEGNPID
HHHCCEEEEECCCCCEECCCCCHHHHHHHHHHHHHCCEEEEHHCCHHHHHHHCCCCCCCC
AEKKSIIQGLTDLGYQFDGLTMGYPGGEPDWLYYKDLTELTEKNLLKSFSKKGKPLVKKA
HHHHHHHHHHHHCCCEECCEEECCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCHHHHHH
ETFGIRLKKLKREELSIFKNITKETSERREYSDKSLEYYEHFYDSFGEQAEFLIASLNFS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCHHHHHEEECCHH
EYMSKLQGEQSKLEEILDKLRLDLSKNPHSEKKQNQLREYSSQFETFEVRKAEARDLIEK
HHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YGEEDIVLAGSLFVYMPQETTYLFSGSYTEFNKFYAPALLQKYVMLESIKRGIPKYNFLG
HCCCCEEEECEEEEEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
IQGIFDGSDGVLRFKQNFNGYIVRKAGTFRYHPSPLKYKAIQLLKKIVGR
EEEEEECCCCEEEEEECCCEEEEEECCCEEECCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
ALTTLTKEEFRTYSDQVSSRSFMQSVQMGDLLDKRGARIVYLALKQEGEIQVAALVYSL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEHHHHHHHH
PMLGGLHMELNSGPIYTQQDALPVFYAELKEYAKQNGVLELLVKPYETYQTFDSEGNPID
HHHCCEEEEECCCCCEECCCCCHHHHHHHHHHHHHCCEEEEHHCCHHHHHHHCCCCCCCC
AEKKSIIQGLTDLGYQFDGLTMGYPGGEPDWLYYKDLTELTEKNLLKSFSKKGKPLVKKA
HHHHHHHHHHHHCCCEECCEEECCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCHHHHHH
ETFGIRLKKLKREELSIFKNITKETSERREYSDKSLEYYEHFYDSFGEQAEFLIASLNFS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCHHHHHEEECCHH
EYMSKLQGEQSKLEEILDKLRLDLSKNPHSEKKQNQLREYSSQFETFEVRKAEARDLIEK
HHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YGEEDIVLAGSLFVYMPQETTYLFSGSYTEFNKFYAPALLQKYVMLESIKRGIPKYNFLG
HCCCCEEEECEEEEEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
IQGIFDGSDGVLRFKQNFNGYIVRKAGTFRYHPSPLKYKAIQLLKKIVGR
EEEEEECCCCEEEEEECCCEEEEEECCCEEECCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA