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The map label for this gene is cobD [H]

Identifier: 169824847

GI number: 169824847

Start: 1251112

End: 1252188

Strand: Direct

Name: cobD [H]

Synonym: FMG_1150

Alternate gene names: 169824847

Gene position: 1251112-1252188 (Clockwise)

Preceding gene: 169824846

Following gene: 169824854

Centisome position: 69.6

GC content: 30.27

Gene sequence:

>1077_bases
ATGAAATCATCTCACGGAGCAAATCTTTTTGAAATACAAAAAGAATACGGATTTAATATAGATGAAATCAAGGATTTCAG
TTCTAATGTCAATCCTTTAGGCCCAAGCCCTAAAGCGATGACTAAGCTTGAAAAAAATCTTAATAAAGTCGGAGTTTATC
CCGACCCAAATTACGATCAATTGCTATCATCTATTGAAGAATACACCAATGTATCAAGAGACAAAATCTTGCTTACATCC
GGAAGCACTAATTTGATTTCATCATTTATATCCCTTATCAATCCAAAAAACGCAATAATATTCAACCCTAGTTATTCAGA
ATATGAAAGGGAACTTAATAAAATCAACTCCAATATAATTTCTTATGATTTGGATAAATCAAATGATTTCGCAATAGATT
GTGAGAAATTAACGAGAATGATAAAAGAAAATGACGTAAGTCTTGTAATATTAACAAATCCCAACAATCCAACAGGATAC
GCTATTGAAAACGAAAAACTTAAAAATCTCATTAAATCAAGTAATTGCTATTTCATGATAGATGAAACTTATGTTGAGTT
TTCAGATGTAGACAAGTATTCAGCAGTTAAGTTAACTCAATCATGTGATAACCTGCTTGTTATACGCTCCACATCAAAAT
TTTTCGCAGCCGCTGGAATAAGATTGGGATACGGTATAACCGGAAACAAAAAACTTTACGATGATATAAATAAGCACACT
AATTTGTGGAACATAAATATCTTCGCTGATATTCTTGGTGGTGAAATGTTTACAGACACTGATTACCACAAAAAAGTGTT
CGAATTTATTAATCGTGAAAAAGAAAAAATGATATCTACTCTGAAAAAGATAGATTGCTTGAAAGTGTATCCTTCAAAAT
CAAATTTCGTGTTATGCGAAATATTGGATAAAAAAATGACCGCACATGATTTAAGAGAAAAACTAATTCCTTATGCTCTT
ATCATAAGAGACTGTGCCTCATTTAATAACTTGAATGAATACTTTTTTAGATTTTGCATTTTGGATGAACAATCAAACGA
CAAATTGCTAAAATTGATTGAAAATATTTTAAAATAA

Upstream 100 bases:

>100_bases
GAATTGATGAGTGAATTCATTCACCACATCAATAGAGAAGAATCCATCTCAATATTGTTAGATAAAACAAGAGGTATTAA
CATTTTATAAGGAGAAAATA

Downstream 100 bases:

>100_bases
TCGCAATTTAAAAGATCTCAGATAATAAAATCTGAGATCTTTTTTTGTTTGGTTATATTACTTTTTTATCTTTTTTGTGT
TCATCTGATATTAAAGTTGC

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: L-threonine-O-3-phosphate decarboxylase [H]

Number of amino acids: Translated: 358; Mature: 358

Protein sequence:

>358_residues
MKSSHGANLFEIQKEYGFNIDEIKDFSSNVNPLGPSPKAMTKLEKNLNKVGVYPDPNYDQLLSSIEEYTNVSRDKILLTS
GSTNLISSFISLINPKNAIIFNPSYSEYERELNKINSNIISYDLDKSNDFAIDCEKLTRMIKENDVSLVILTNPNNPTGY
AIENEKLKNLIKSSNCYFMIDETYVEFSDVDKYSAVKLTQSCDNLLVIRSTSKFFAAAGIRLGYGITGNKKLYDDINKHT
NLWNINIFADILGGEMFTDTDYHKKVFEFINREKEKMISTLKKIDCLKVYPSKSNFVLCEILDKKMTAHDLREKLIPYAL
IIRDCASFNNLNEYFFRFCILDEQSNDKLLKLIENILK

Sequences:

>Translated_358_residues
MKSSHGANLFEIQKEYGFNIDEIKDFSSNVNPLGPSPKAMTKLEKNLNKVGVYPDPNYDQLLSSIEEYTNVSRDKILLTS
GSTNLISSFISLINPKNAIIFNPSYSEYERELNKINSNIISYDLDKSNDFAIDCEKLTRMIKENDVSLVILTNPNNPTGY
AIENEKLKNLIKSSNCYFMIDETYVEFSDVDKYSAVKLTQSCDNLLVIRSTSKFFAAAGIRLGYGITGNKKLYDDINKHT
NLWNINIFADILGGEMFTDTDYHKKVFEFINREKEKMISTLKKIDCLKVYPSKSNFVLCEILDKKMTAHDLREKLIPYAL
IIRDCASFNNLNEYFFRFCILDEQSNDKLLKLIENILK
>Mature_358_residues
MKSSHGANLFEIQKEYGFNIDEIKDFSSNVNPLGPSPKAMTKLEKNLNKVGVYPDPNYDQLLSSIEEYTNVSRDKILLTS
GSTNLISSFISLINPKNAIIFNPSYSEYERELNKINSNIISYDLDKSNDFAIDCEKLTRMIKENDVSLVILTNPNNPTGY
AIENEKLKNLIKSSNCYFMIDETYVEFSDVDKYSAVKLTQSCDNLLVIRSTSKFFAAAGIRLGYGITGNKKLYDDINKHT
NLWNINIFADILGGEMFTDTDYHKKVFEFINREKEKMISTLKKIDCLKVYPSKSNFVLCEILDKKMTAHDLREKLIPYAL
IIRDCASFNNLNEYFFRFCILDEQSNDKLLKLIENILK

Specific function: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1- amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin [H]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=264, Percent_Identity=24.2424242424242, Blast_Score=73, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6322075, Length=281, Percent_Identity=25.2669039145907, Blast_Score=77, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005860
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.1.1.81 [H]

Molecular weight: Translated: 41123; Mature: 41123

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSSHGANLFEIQKEYGFNIDEIKDFSSNVNPLGPSPKAMTKLEKNLNKVGVYPDPNYDQ
CCCCCCCCCEEEHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHH
LLSSIEEYTNVSRDKILLTSGSTNLISSFISLINPKNAIIFNPSYSEYERELNKINSNII
HHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHCCCCE
SYDLDKSNDFAIDCEKLTRMIKENDVSLVILTNPNNPTGYAIENEKLKNLIKSSNCYFMI
EEECCCCCCCEEEHHHHHHHHHHCCCEEEEEECCCCCCCEEECHHHHHHHHHCCCCEEEE
DETYVEFSDVDKYSAVKLTQSCDNLLVIRSTSKFFAAAGIRLGYGITGNKKLYDDINKHT
ECCEEEHHCCCCHHHHHHHHCCCCEEEEECCCHHHHHCCCEEECCCCCCCHHHHHHHCCC
NLWNINIFADILGGEMFTDTDYHKKVFEFINREKEKMISTLKKIDCLKVYPSKSNFVLCE
CEEEEEEEEEHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCEEEEE
ILDKKMTAHDLREKLIPYALIIRDCASFNNLNEYFFRFCILDEQSNDKLLKLIENILK
EHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHEEEEECCCCCCHHHHHHHHHHC
>Mature Secondary Structure
MKSSHGANLFEIQKEYGFNIDEIKDFSSNVNPLGPSPKAMTKLEKNLNKVGVYPDPNYDQ
CCCCCCCCCEEEHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHH
LLSSIEEYTNVSRDKILLTSGSTNLISSFISLINPKNAIIFNPSYSEYERELNKINSNII
HHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHCCCCE
SYDLDKSNDFAIDCEKLTRMIKENDVSLVILTNPNNPTGYAIENEKLKNLIKSSNCYFMI
EEECCCCCCCEEEHHHHHHHHHHCCCEEEEEECCCCCCCEEECHHHHHHHHHCCCCEEEE
DETYVEFSDVDKYSAVKLTQSCDNLLVIRSTSKFFAAAGIRLGYGITGNKKLYDDINKHT
ECCEEEHHCCCCHHHHHHHHCCCCEEEEECCCHHHHHCCCEEECCCCCCCHHHHHHHCCC
NLWNINIFADILGGEMFTDTDYHKKVFEFINREKEKMISTLKKIDCLKVYPSKSNFVLCE
CEEEEEEEEEHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCEEEEE
ILDKKMTAHDLREKLIPYALIIRDCASFNNLNEYFFRFCILDEQSNDKLLKLIENILK
EHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHEEEEECCCCCCHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]