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The map label for this gene is selB [H]

Identifier: 169824854

GI number: 169824854

Start: 1259183

End: 1261060

Strand: Direct

Name: selB [H]

Synonym: FMG_1157

Alternate gene names: 169824854

Gene position: 1259183-1261060 (Clockwise)

Preceding gene: 169824847

Following gene: 169824872

Centisome position: 70.05

GC content: 30.67

Gene sequence:

>1878_bases
ATGGATTTTATTATAGGTACATCTGGCCATATTGATCATGGAAAAACTACATTAATAAAAGCTTTAACCGGAAATAGCAC
TGATAGACTACCGGAAGAAAAAAAGAGAGGAATTTCTATCGATTTAGGTTTTAGCTATTTTGATCTTCCAAGTGGTCAAC
GAGCTGGAATAATTGACGTGCCAGGTCACGAAAAGTTTGTAAAAAATATGATGACTGGTACTTTTGGTATGGATATGATT
CTTTTATGTATCGACTGTAAAGAAGGCGTTATGCCTCAAACAGTTGAGCATTTGGATATACTTAGGTTTTTGAATAAAAC
TGAAGGAATTGTCGTGTTAACCAAAAGGGACTTGGCAACTGATGAAGAAACAGAAAAAACAGTCGAACAAGTTAAAGAAT
TAGTCAAAGGAACTTTCCTTGAAAATTGTCCTATTTGCGAAGTAGATTCTATTTCAAAAAGAGGAATAGATAATTTAATT
CAAATGATAGATTCTGAATCTAAAAAATTAAAGCAAAAGCATGCCGAGAGAGATTACAGAATGAATATCGACAGAAAATT
TAACGTAAAAGGAATTGGAACGGTTGTTACAGGAACTTTATTGGATGGAGATATCCACAAGGGAGAATCTTTTATTTATC
CAATAGAAAAAGATATCAACATTAAAAATATTCAAGTTCACAATAAAAATGTAAATGTCGCTCACCCATCACAAAGGGTT
GCTTTGAATATAAATCTAAATTTGGATGAAATTGACAGAGGTTTTGTAATCGCGAAGAAAAACTCACTAAAAGCTTTCAA
TATGATAGATGTTAGACTTACACTATTAGAAAGTGCTTCTCCTTTAAATCACTGGGACAGAGTTAGGTTATTCCACGGTA
CGAAAGAAATATTCGGAAGAGTTGTTCCTCTTGATAAGCAAGTGATTCAACCGGGAACTCAAGCTCTTGTTCAGATCAGA
CTTGAAGAAAAAATTTATGCAAAAACATCCGATCCATTTATTTTGAGACAATTTTCACCACAAGTTACAATCGGTGGTGG
TATTATAATTGATGGTTCTGTAAGAAAACATAAATTATTTGATGAAGAAATTATCGAAAATCTTAAAATAAAAGAAGAAG
GAAAAATCAAAGATATTATTTTAAATTATCTACAAGATGAGATTTTCCCTACTAAAATCGATGATTTGGTATTCTACTCT
TCTGAATCAAAAGACAAAGTTTTAAAGGAATTGGACGGATTAAAACAAGAAGATAAAGTTGTAATTAGAAACGACAAAGT
CTTGGAAAAAGAAGCTTACCTAAAATTATTAGGAAAATTAAAAATGTTTGTAATTTCATTCCACAAAACAAATCCTTTAT
TGCCTGGAATTAATAAAGAAGAACTTCTCAAAAAATTACAACTAGATGATGACAGACCTTTCTTTAATTACATGATTAAA
GATTTAATCGACCAAGAAGTTTTAATTGAAGAAAGTGGTATAGTTTCCTCTACAGGTCACAAAGTTAAATTAAGTGATGA
AGACGAAAAAATCAGAAAAAAAATGCTTCAAGATATTTGCCAAAATCAATTCGACAAATTATTAAAGATAGACAATGTTG
TCCACAACCAAAAAGACAAGACGATTTTGGGAATTTTATTACAAAAAGATGTAGTAATTTTAAGAGATAACTTTTTGATT
TCCAAGAAATGCTATGACAAATTTATTAAAACTGTCGATGATCACTTCAATAAGAACAAAACTTTGAATGTAAAAGAACT
CAAGGACATGCTCAATATCTCCAGAAAAAGTGCAATCACACTTTTGGAAACACTAGATATCAAAGGGTATACTAAGAGGA
TCGAAAACGACAGAGTTAAAGTAAAAGATTTTAAATAA

Upstream 100 bases:

>100_bases
TATTTTGACGTTCAAATAATTTATGAAAATAATTTCCTTATTTTTTCGGAATATAACGAAATATGATATAATATAAAATA
GTAAATTAATTGGAGGTTAT

Downstream 100 bases:

>100_bases
TAGAATAGGGCTTTGCACTGCGAAGCCTTATCTATTAAGAAATTTGTTACAGTTTTGTGAATTAGATGTAAAATAATTTG
TAAATTGCATGTATTTTTGG

Product: selenocysteine-specific elongation factor

Products: NA

Alternate protein names: SelB translation factor [H]

Number of amino acids: Translated: 625; Mature: 625

Protein sequence:

>625_residues
MDFIIGTSGHIDHGKTTLIKALTGNSTDRLPEEKKRGISIDLGFSYFDLPSGQRAGIIDVPGHEKFVKNMMTGTFGMDMI
LLCIDCKEGVMPQTVEHLDILRFLNKTEGIVVLTKRDLATDEETEKTVEQVKELVKGTFLENCPICEVDSISKRGIDNLI
QMIDSESKKLKQKHAERDYRMNIDRKFNVKGIGTVVTGTLLDGDIHKGESFIYPIEKDINIKNIQVHNKNVNVAHPSQRV
ALNINLNLDEIDRGFVIAKKNSLKAFNMIDVRLTLLESASPLNHWDRVRLFHGTKEIFGRVVPLDKQVIQPGTQALVQIR
LEEKIYAKTSDPFILRQFSPQVTIGGGIIIDGSVRKHKLFDEEIIENLKIKEEGKIKDIILNYLQDEIFPTKIDDLVFYS
SESKDKVLKELDGLKQEDKVVIRNDKVLEKEAYLKLLGKLKMFVISFHKTNPLLPGINKEELLKKLQLDDDRPFFNYMIK
DLIDQEVLIEESGIVSSTGHKVKLSDEDEKIRKKMLQDICQNQFDKLLKIDNVVHNQKDKTILGILLQKDVVILRDNFLI
SKKCYDKFIKTVDDHFNKNKTLNVKELKDMLNISRKSAITLLETLDIKGYTKRIENDRVKVKDFK

Sequences:

>Translated_625_residues
MDFIIGTSGHIDHGKTTLIKALTGNSTDRLPEEKKRGISIDLGFSYFDLPSGQRAGIIDVPGHEKFVKNMMTGTFGMDMI
LLCIDCKEGVMPQTVEHLDILRFLNKTEGIVVLTKRDLATDEETEKTVEQVKELVKGTFLENCPICEVDSISKRGIDNLI
QMIDSESKKLKQKHAERDYRMNIDRKFNVKGIGTVVTGTLLDGDIHKGESFIYPIEKDINIKNIQVHNKNVNVAHPSQRV
ALNINLNLDEIDRGFVIAKKNSLKAFNMIDVRLTLLESASPLNHWDRVRLFHGTKEIFGRVVPLDKQVIQPGTQALVQIR
LEEKIYAKTSDPFILRQFSPQVTIGGGIIIDGSVRKHKLFDEEIIENLKIKEEGKIKDIILNYLQDEIFPTKIDDLVFYS
SESKDKVLKELDGLKQEDKVVIRNDKVLEKEAYLKLLGKLKMFVISFHKTNPLLPGINKEELLKKLQLDDDRPFFNYMIK
DLIDQEVLIEESGIVSSTGHKVKLSDEDEKIRKKMLQDICQNQFDKLLKIDNVVHNQKDKTILGILLQKDVVILRDNFLI
SKKCYDKFIKTVDDHFNKNKTLNVKELKDMLNISRKSAITLLETLDIKGYTKRIENDRVKVKDFK
>Mature_625_residues
MDFIIGTSGHIDHGKTTLIKALTGNSTDRLPEEKKRGISIDLGFSYFDLPSGQRAGIIDVPGHEKFVKNMMTGTFGMDMI
LLCIDCKEGVMPQTVEHLDILRFLNKTEGIVVLTKRDLATDEETEKTVEQVKELVKGTFLENCPICEVDSISKRGIDNLI
QMIDSESKKLKQKHAERDYRMNIDRKFNVKGIGTVVTGTLLDGDIHKGESFIYPIEKDINIKNIQVHNKNVNVAHPSQRV
ALNINLNLDEIDRGFVIAKKNSLKAFNMIDVRLTLLESASPLNHWDRVRLFHGTKEIFGRVVPLDKQVIQPGTQALVQIR
LEEKIYAKTSDPFILRQFSPQVTIGGGIIIDGSVRKHKLFDEEIIENLKIKEEGKIKDIILNYLQDEIFPTKIDDLVFYS
SESKDKVLKELDGLKQEDKVVIRNDKVLEKEAYLKLLGKLKMFVISFHKTNPLLPGINKEELLKKLQLDDDRPFFNYMIK
DLIDQEVLIEESGIVSSTGHKVKLSDEDEKIRKKMLQDICQNQFDKLLKIDNVVHNQKDKTILGILLQKDVVILRDNFLI
SKKCYDKFIKTVDDHFNKNKTLNVKELKDMLNISRKSAITLLETLDIKGYTKRIENDRVKVKDFK

Specific function: Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP [H]

COG id: COG3276

COG function: function code J; Selenocysteine-specific translation elongation factor

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. SelB subfamily [H]

Homologues:

Organism=Homo sapiens, GI34147630, Length=383, Percent_Identity=27.9373368146214, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI54607086, Length=302, Percent_Identity=27.1523178807947, Blast_Score=112, Evalue=8e-25,
Organism=Homo sapiens, GI4503507, Length=248, Percent_Identity=28.6290322580645, Blast_Score=83, Evalue=7e-16,
Organism=Homo sapiens, GI223555963, Length=389, Percent_Identity=23.3933161953728, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI5729864, Length=389, Percent_Identity=23.3933161953728, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI2367247, Length=630, Percent_Identity=27.3015873015873, Blast_Score=243, Evalue=3e-65,
Organism=Escherichia coli, GI1790412, Length=383, Percent_Identity=27.6762402088773, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1789737, Length=383, Percent_Identity=27.6762402088773, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1789108, Length=158, Percent_Identity=29.746835443038, Blast_Score=66, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI25141371, Length=399, Percent_Identity=28.0701754385965, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17556456, Length=390, Percent_Identity=26.6666666666667, Blast_Score=112, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17506081, Length=260, Percent_Identity=28.4615384615385, Blast_Score=105, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6324761, Length=305, Percent_Identity=29.1803278688525, Blast_Score=115, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6320863, Length=244, Percent_Identity=25.8196721311475, Blast_Score=81, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6322937, Length=374, Percent_Identity=24.5989304812834, Blast_Score=68, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6324550, Length=130, Percent_Identity=32.3076923076923, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI281363316, Length=380, Percent_Identity=27.8947368421053, Blast_Score=130, Evalue=4e-30,
Organism=Drosophila melanogaster, GI17864358, Length=380, Percent_Identity=27.8947368421053, Blast_Score=130, Evalue=4e-30,
Organism=Drosophila melanogaster, GI19922690, Length=307, Percent_Identity=30.9446254071661, Blast_Score=125, Evalue=7e-29,
Organism=Drosophila melanogaster, GI19921738, Length=381, Percent_Identity=28.6089238845144, Blast_Score=119, Evalue=5e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015189
- InterPro:   IPR015190
- InterPro:   IPR015191
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR009001
- InterPro:   IPR004161
- InterPro:   IPR009000
- InterPro:   IPR004535
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2; PF09105 SelB-wing_1; PF09106 SelB-wing_2; PF09107 SelB-wing_3 [H]

EC number: NA

Molecular weight: Translated: 71608; Mature: 71608

Theoretical pI: Translated: 8.34; Mature: 8.34

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFIIGTSGHIDHGKTTLIKALTGNSTDRLPEEKKRGISIDLGFSYFDLPSGQRAGIIDV
CCEEECCCCCCCCCCEEEEEEECCCCCCCCCHHHHCCEEEEECCCEEECCCCCCCCEEEC
PGHEKFVKNMMTGTFGMDMILLCIDCKEGVMPQTVEHLDILRFLNKTEGIVVLTKRDLAT
CCHHHHHHHHHCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCC
DEETEKTVEQVKELVKGTFLENCPICEVDSISKRGIDNLIQMIDSESKKLKQKHAERDYR
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCHHHHHHHHCCHHHHHHHHHCCCCCE
MNIDRKFNVKGIGTVVTGTLLDGDIHKGESFIYPIEKDINIKNIQVHNKNVNVAHPSQRV
ECCCCEECCCCCCCEEEEEEECCCCCCCCEEEEECCCCCCEEEEEEECCCCCEECCCCEE
ALNINLNLDEIDRGFVIAKKNSLKAFNMIDVRLTLLESASPLNHWDRVRLFHGTKEIFGR
EEEEECCHHHCCCCEEEEECCCCCEEEEEEEEEEEECCCCCCCHHHHEEEEECCHHHHCC
VVPLDKQVIQPGTQALVQIRLEEKIYAKTSDPFILRQFSPQVTIGGGIIIDGSVRKHKLF
CCCCCHHHHCCCHHHHEEEEEHHHEEECCCCCEEEEECCCCEEECCCEEECCCCHHHHHH
DEEIIENLKIKEEGKIKDIILNYLQDEIFPTKIDDLVFYSSESKDKVLKELDGLKQEDKV
HHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHCCCCCCCCE
VIRNDKVLEKEAYLKLLGKLKMFVISFHKTNPLLPGINKEELLKKLQLDDDRPFFNYMIK
EEECCCHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHH
DLIDQEVLIEESGIVSSTGHKVKLSDEDEKIRKKMLQDICQNQFDKLLKIDNVVHNQKDK
HHCCHHHEEECCCCEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
TILGILLQKDVVILRDNFLISKKCYDKFIKTVDDHFNKNKTLNVKELKDMLNISRKSAIT
EEEEEHHHCCEEEEECCEEECHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
LLETLDIKGYTKRIENDRVKVKDFK
HHHHHCCCHHHHHHCCCCEEEECCC
>Mature Secondary Structure
MDFIIGTSGHIDHGKTTLIKALTGNSTDRLPEEKKRGISIDLGFSYFDLPSGQRAGIIDV
CCEEECCCCCCCCCCEEEEEEECCCCCCCCCHHHHCCEEEEECCCEEECCCCCCCCEEEC
PGHEKFVKNMMTGTFGMDMILLCIDCKEGVMPQTVEHLDILRFLNKTEGIVVLTKRDLAT
CCHHHHHHHHHCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCC
DEETEKTVEQVKELVKGTFLENCPICEVDSISKRGIDNLIQMIDSESKKLKQKHAERDYR
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCHHHHHHHHCCHHHHHHHHHCCCCCE
MNIDRKFNVKGIGTVVTGTLLDGDIHKGESFIYPIEKDINIKNIQVHNKNVNVAHPSQRV
ECCCCEECCCCCCCEEEEEEECCCCCCCCEEEEECCCCCCEEEEEEECCCCCEECCCCEE
ALNINLNLDEIDRGFVIAKKNSLKAFNMIDVRLTLLESASPLNHWDRVRLFHGTKEIFGR
EEEEECCHHHCCCCEEEEECCCCCEEEEEEEEEEEECCCCCCCHHHHEEEEECCHHHHCC
VVPLDKQVIQPGTQALVQIRLEEKIYAKTSDPFILRQFSPQVTIGGGIIIDGSVRKHKLF
CCCCCHHHHCCCHHHHEEEEEHHHEEECCCCCEEEEECCCCEEECCCEEECCCCHHHHHH
DEEIIENLKIKEEGKIKDIILNYLQDEIFPTKIDDLVFYSSESKDKVLKELDGLKQEDKV
HHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHCCCCCCCCE
VIRNDKVLEKEAYLKLLGKLKMFVISFHKTNPLLPGINKEELLKKLQLDDDRPFFNYMIK
EEECCCHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHH
DLIDQEVLIEESGIVSSTGHKVKLSDEDEKIRKKMLQDICQNQFDKLLKIDNVVHNQKDK
HHCCHHHEEECCCCEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
TILGILLQKDVVILRDNFLISKKCYDKFIKTVDDHFNKNKTLNVKELKDMLNISRKSAIT
EEEEEHHHCCEEEEECCEEECHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
LLETLDIKGYTKRIENDRVKVKDFK
HHHHHCCCHHHHHHCCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8893853 [H]