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The map label for this gene is prs [H]

Identifier: 169824846

GI number: 169824846

Start: 1249995

End: 1251101

Strand: Direct

Name: prs [H]

Synonym: FMG_1149

Alternate gene names: 169824846

Gene position: 1249995-1251101 (Clockwise)

Preceding gene: 169824840

Following gene: 169824847

Centisome position: 69.54

GC content: 32.97

Gene sequence:

>1107_bases
ATGTCAGAATCAAAATTTGAAGAGTTTCCATACGGAGAACTTGGAATCATAGCTATGAAAAACATTGAAGGTTTGGCAAA
AGAAGTTGACGAACTTTTAATGAAAAAAAACGGTGCAACACAAAGTTATTTATTAAAAATAACAGAATCCAGATTTAGTA
ACGGCGAAGGAAAAGTTACAATCGATGAATCAGTTAGAGGTCGTGATATTTTAATCATATCAGACGTTGGAAATTATGGA
TTGAAGTACAATATGTTTGGTGAACAAACTATAATTGGTCCAGATGAACACTTCCAAGATATCAAAAGAGTAATCTCCGC
AATCAATGGAAAAGCTTCTCGTATCAATGTAATGATGCCTCTTTTATATTCATCTCGTCAACACAGACGTAAATCAAGAG
AATCGCTTGATTGTGCAATGGCACTTCAAGAATTAGAATCCATGGGAGTAGATGGAATTTACACATTTGATGTGCATGAT
CCAAACGTCCAAAACGCAATCCCATTGATGACATTTGAAAACATCTATCCTACAGCAGAAATAGTTAATTATTTCCTAGA
AAAAGAAGAAATAACTACTGATGAATTAGACAAAAAAGACATGATTATAATTTCACCAGATACAGGCGCAATGGATAGAG
CAATTTACTATTCAAATATTTTAAAACAAGACATAGGTTTATTCTACAAAAGACGTGATTACACTAAAGTTGTAGACGGC
AAGAACCCTATAATCGAACACAAATACATCGGACGTGAAGTTGATGGAAAAGATATTTTAATCGTAGATGATATGATTGC
TTCTGGTGGATCTGTTATTGATATAGCAAAACAATTGAAAAAACAAAACGCTAAGAGAATATTCTGCGCAGTAAGCTTCG
CATTGTTTACTGAAGGCCCTGACAAATTTGACCAAATGTACAATGAAGGATTTATCAACGGAGTTTATTCTACAAACTTA
ACTTACGTACCTGAATCAATTAAAAATAAAGAATGGTTCCACGCTGTAGATATGAGTGAATTGATGAGTGAATTCATTCA
CCACATCAATAGAGAAGAATCCATCTCAATATTGTTAGATAAAACAAGAGGTATTAACATTTTATAA

Upstream 100 bases:

>100_bases
TTCCTATCCGATTATATCAAATTGTTTGTATTATTTAAATTTGAATACGTAAATCGTTTGTGATATTCTTTATATATAAT
GTAGTATTTAAGGAGGACTT

Downstream 100 bases:

>100_bases
GGAGAAAATAATGAAATCATCTCACGGAGCAAATCTTTTTGAAATACAAAAAGAATACGGATTTAATATAGATGAAATCA
AGGATTTCAGTTCTAATGTC

Product: phosphoribosylpyrophosphate synthetase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 368; Mature: 367

Protein sequence:

>368_residues
MSESKFEEFPYGELGIIAMKNIEGLAKEVDELLMKKNGATQSYLLKITESRFSNGEGKVTIDESVRGRDILIISDVGNYG
LKYNMFGEQTIIGPDEHFQDIKRVISAINGKASRINVMMPLLYSSRQHRRKSRESLDCAMALQELESMGVDGIYTFDVHD
PNVQNAIPLMTFENIYPTAEIVNYFLEKEEITTDELDKKDMIIISPDTGAMDRAIYYSNILKQDIGLFYKRRDYTKVVDG
KNPIIEHKYIGREVDGKDILIVDDMIASGGSVIDIAKQLKKQNAKRIFCAVSFALFTEGPDKFDQMYNEGFINGVYSTNL
TYVPESIKNKEWFHAVDMSELMSEFIHHINREESISILLDKTRGINIL

Sequences:

>Translated_368_residues
MSESKFEEFPYGELGIIAMKNIEGLAKEVDELLMKKNGATQSYLLKITESRFSNGEGKVTIDESVRGRDILIISDVGNYG
LKYNMFGEQTIIGPDEHFQDIKRVISAINGKASRINVMMPLLYSSRQHRRKSRESLDCAMALQELESMGVDGIYTFDVHD
PNVQNAIPLMTFENIYPTAEIVNYFLEKEEITTDELDKKDMIIISPDTGAMDRAIYYSNILKQDIGLFYKRRDYTKVVDG
KNPIIEHKYIGREVDGKDILIVDDMIASGGSVIDIAKQLKKQNAKRIFCAVSFALFTEGPDKFDQMYNEGFINGVYSTNL
TYVPESIKNKEWFHAVDMSELMSEFIHHINREESISILLDKTRGINIL
>Mature_367_residues
SESKFEEFPYGELGIIAMKNIEGLAKEVDELLMKKNGATQSYLLKITESRFSNGEGKVTIDESVRGRDILIISDVGNYGL
KYNMFGEQTIIGPDEHFQDIKRVISAINGKASRINVMMPLLYSSRQHRRKSRESLDCAMALQELESMGVDGIYTFDVHDP
NVQNAIPLMTFENIYPTAEIVNYFLEKEEITTDELDKKDMIIISPDTGAMDRAIYYSNILKQDIGLFYKRRDYTKVVDGK
NPIIEHKYIGREVDGKDILIVDDMIASGGSVIDIAKQLKKQNAKRIFCAVSFALFTEGPDKFDQMYNEGFINGVYSTNLT
YVPESIKNKEWFHAVDMSELMSEFIHHINREESISILLDKTRGINIL

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506127, Length=321, Percent_Identity=25.5451713395639, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI28557709, Length=321, Percent_Identity=26.791277258567, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI4506129, Length=321, Percent_Identity=25.5451713395639, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI84875539, Length=324, Percent_Identity=25, Blast_Score=90, Evalue=4e-18,
Organism=Escherichia coli, GI1787458, Length=316, Percent_Identity=26.8987341772152, Blast_Score=104, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI25149168, Length=318, Percent_Identity=26.1006289308176, Blast_Score=88, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17554704, Length=318, Percent_Identity=26.1006289308176, Blast_Score=87, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17554702, Length=318, Percent_Identity=26.1006289308176, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71989924, Length=318, Percent_Identity=26.1006289308176, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6321776, Length=356, Percent_Identity=26.685393258427, Blast_Score=96, Evalue=8e-21,
Organism=Saccharomyces cerevisiae, GI6320946, Length=352, Percent_Identity=25.8522727272727, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6319403, Length=362, Percent_Identity=24.585635359116, Blast_Score=84, Evalue=5e-17,
Organism=Drosophila melanogaster, GI21355239, Length=320, Percent_Identity=25.625, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI45551540, Length=343, Percent_Identity=23.6151603498542, Blast_Score=80, Evalue=3e-15,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 41944; Mature: 41812

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSESKFEEFPYGELGIIAMKNIEGLAKEVDELLMKKNGATQSYLLKITESRFSNGEGKVT
CCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCCCCHHHHEEEHHHHCCCCCCEEE
IDESVRGRDILIISDVGNYGLKYNMFGEQTIIGPDEHFQDIKRVISAINGKASRINVMMP
ECCCCCCCEEEEEECCCCCCEEEEECCCEEEECCHHHHHHHHHHHHHHCCCCCEEEEEHH
LLYSSRQHRRKSRESLDCAMALQELESMGVDGIYTFDVHDPNVQNAIPLMTFENIYPTAE
HHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCEEEECCCCCHHH
IVNYFLEKEEITTDELDKKDMIIISPDTGAMDRAIYYSNILKQDIGLFYKRRDYTKVVDG
HHHHHHHHHCCCHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEECCC
KNPIIEHKYIGREVDGKDILIVDDMIASGGSVIDIAKQLKKQNAKRIFCAVSFALFTEGP
CCCCCCHHHCCCCCCCCEEEEEEHHHHCCCCHHHHHHHHHHCCCCEEEEEEEEHHHCCCH
DKFDQMYNEGFINGVYSTNLTYVPESIKNKEWFHAVDMSELMSEFIHHINREESISILLD
HHHHHHHHCCCCCCEEECCCEECCHHHCCCCCEEECCHHHHHHHHHHHCCCCCCEEEEEE
KTRGINIL
CCCCCCCC
>Mature Secondary Structure 
SESKFEEFPYGELGIIAMKNIEGLAKEVDELLMKKNGATQSYLLKITESRFSNGEGKVT
CCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCCCCHHHHEEEHHHHCCCCCCEEE
IDESVRGRDILIISDVGNYGLKYNMFGEQTIIGPDEHFQDIKRVISAINGKASRINVMMP
ECCCCCCCEEEEEECCCCCCEEEEECCCEEEECCHHHHHHHHHHHHHHCCCCCEEEEEHH
LLYSSRQHRRKSRESLDCAMALQELESMGVDGIYTFDVHDPNVQNAIPLMTFENIYPTAE
HHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCEEEECCCCCHHH
IVNYFLEKEEITTDELDKKDMIIISPDTGAMDRAIYYSNILKQDIGLFYKRRDYTKVVDG
HHHHHHHHHCCCHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEECCC
KNPIIEHKYIGREVDGKDILIVDDMIASGGSVIDIAKQLKKQNAKRIFCAVSFALFTEGP
CCCCCCHHHCCCCCCCCEEEEEEHHHHCCCCHHHHHHHHHHCCCCEEEEEEEEHHHCCCH
DKFDQMYNEGFINGVYSTNLTYVPESIKNKEWFHAVDMSELMSEFIHHINREESISILLD
HHHHHHHHCCCCCCEEECCCEECCHHHCCCCCEEECCHHHHHHHHHHHCCCCCCEEEEEE
KTRGINIL
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8948633 [H]