| Definition | Mycobacterium abscessus ATCC 19977 chromosome chromosome 1, complete sequence. |
|---|---|
| Accession | NC_010397 |
| Length | 5,067,172 |
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The map label for this gene is purK [H]
Identifier: 169630699
GI number: 169630699
Start: 3668671
End: 3669876
Strand: Reverse
Name: purK [H]
Synonym: MAB_3620c
Alternate gene names: 169630699
Gene position: 3669876-3668671 (Counterclockwise)
Preceding gene: 169630700
Following gene: 169630698
Centisome position: 72.42
GC content: 67.41
Gene sequence:
>1206_bases GTGTCCGCGACTCCCGTGGTCACCATGATCGGTGGCGGTCAGCTGGCCCGGATGACCCACCAGGCGTCGATCGCCCTGGG TCAGACCCTGCGGGTACTCGCCCACGCCGCCGACGAGCCGGCGGCGCAGGTAACCCCCGATATCGTGCTTGGTTCGCATA CCGAGCTGGACGATCTGCGCCGGGCGGCCAAGGATGCCACCGTCGTCACCTTTGACCACGAGCATGTTCCGACCGCGTTC CTGGAGACCCTGCAGGGCGAGGGCGTCAACGTGCAGCCGCCGCCGTCGGCCCTCATCTACGCGCAGGACAAGACGCTCAT GCGGCGCAAGCTGCGGGACATTGGTGCGCCGGTGCCGGGATTCGCCGACATTCGGGCTGTCTCCGATGTCGAACGATTCG CCGCGGAGACGGGCAGCCACGTCGTGCTGAAGGCGGTGCGCGGCGGTTACGACGGCCGTGGCGTATGGATCACCGACACT CTCGATGAGGCGCGCACAGTGGCCGCCGAACAGCTGGCCGCGGGTGTCGAGCTATTGGCCGAGGAGCGCGTCGACATGCG CCGCGAGCTTTCGGCGATGGTGGCCCGTTCGCCCTTTGGGCAGGGTGCCGCCTGGCCGGTGGTGGAAACCGTTCAGCGCG AAGGCATTTGCGCCGTGGTGATCGCGCCGGCTCCGCAGCTGCCCGAGGAGCTGGCGCTGCAGGCCGAGCAGCTCGCGCTG CGGATCGCCAACGAGCTTGGCGTGACGGGGTGTCTGGCGGTGGAGCTGTTCGAGACCAACGACGGCCGGCTCTTGGTCAA CGAATTGGCGATGCGACCGCACAACTCGGGGCATTGGAGCATGGACGGGGCGCGCACCGGACAGTTCGAGCAGCACCTGC GTGCGGTGCTCGATTACCCGCTCGGATCCACCGAACCACTGGCTCCCGTTACCGTCATGGCGAATGTATTGGGCGCTCCG CAGACGCCCGCGATGTCGCTCGACGAACGGATGCATCACCTGATGGGCCGCATCCCGGAGGCAAAGGTGCACCTGTACGG CAAGGGCGAGCGCCCGGGCCGCAAGCTCGGACATGTGAATATCCAAGGCCGCGAGGATGGTTCGCTGGCAGATCCGGGAT ATGTGGCAGAGGTGCGTGAGCGCGCGGAGCGTGCCGCGCACTGGTTGTCGCACGCGGTATGGACCGATGGATGGGAAGGA CACTAG
Upstream 100 bases:
>100_bases CGAGCCGGTATTTGCGGAGACATACCGTTCTCATAGGGCGCCGCGGTCCGCATGACAACATATGTCTGTGTCTGATGGTC TTCGCGCAAGCGGCTCATCC
Downstream 100 bases:
>100_bases AACGTGAGCGCACGGGTCGGCCTGATCATGGGTAGCGACAGCGACTGGTCGGTGATGTCGGATGCCGCGAACGCCTTGGC GGAGTTCGAGATTCCATTCG
Product: phosphoribosylaminoimidazole carboxylase ATPase subunit
Products: NA
Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]
Number of amino acids: Translated: 401; Mature: 400
Protein sequence:
>401_residues MSATPVVTMIGGGQLARMTHQASIALGQTLRVLAHAADEPAAQVTPDIVLGSHTELDDLRRAAKDATVVTFDHEHVPTAF LETLQGEGVNVQPPPSALIYAQDKTLMRRKLRDIGAPVPGFADIRAVSDVERFAAETGSHVVLKAVRGGYDGRGVWITDT LDEARTVAAEQLAAGVELLAEERVDMRRELSAMVARSPFGQGAAWPVVETVQREGICAVVIAPAPQLPEELALQAEQLAL RIANELGVTGCLAVELFETNDGRLLVNELAMRPHNSGHWSMDGARTGQFEQHLRAVLDYPLGSTEPLAPVTVMANVLGAP QTPAMSLDERMHHLMGRIPEAKVHLYGKGERPGRKLGHVNIQGREDGSLADPGYVAEVRERAERAAHWLSHAVWTDGWEG H
Sequences:
>Translated_401_residues MSATPVVTMIGGGQLARMTHQASIALGQTLRVLAHAADEPAAQVTPDIVLGSHTELDDLRRAAKDATVVTFDHEHVPTAF LETLQGEGVNVQPPPSALIYAQDKTLMRRKLRDIGAPVPGFADIRAVSDVERFAAETGSHVVLKAVRGGYDGRGVWITDT LDEARTVAAEQLAAGVELLAEERVDMRRELSAMVARSPFGQGAAWPVVETVQREGICAVVIAPAPQLPEELALQAEQLAL RIANELGVTGCLAVELFETNDGRLLVNELAMRPHNSGHWSMDGARTGQFEQHLRAVLDYPLGSTEPLAPVTVMANVLGAP QTPAMSLDERMHHLMGRIPEAKVHLYGKGERPGRKLGHVNIQGREDGSLADPGYVAEVRERAERAAHWLSHAVWTDGWEG H >Mature_400_residues SATPVVTMIGGGQLARMTHQASIALGQTLRVLAHAADEPAAQVTPDIVLGSHTELDDLRRAAKDATVVTFDHEHVPTAFL ETLQGEGVNVQPPPSALIYAQDKTLMRRKLRDIGAPVPGFADIRAVSDVERFAAETGSHVVLKAVRGGYDGRGVWITDTL DEARTVAAEQLAAGVELLAEERVDMRRELSAMVARSPFGQGAAWPVVETVQREGICAVVIAPAPQLPEELALQAEQLALR IANELGVTGCLAVELFETNDGRLLVNELAMRPHNSGHWSMDGARTGQFEQHLRAVLDYPLGSTEPLAPVTVMANVLGAPQ TPAMSLDERMHHLMGRIPEAKVHLYGKGERPGRKLGHVNIQGREDGSLADPGYVAEVRERAERAAHWLSHAVWTDGWEGH
Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]
COG id: COG0026
COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 ATP-grasp domain [H]
Homologues:
Organism=Escherichia coli, GI1786733, Length=367, Percent_Identity=29.9727520435967, Blast_Score=120, Evalue=2e-28, Organism=Saccharomyces cerevisiae, GI6324702, Length=368, Percent_Identity=33.695652173913, Blast_Score=184, Evalue=2e-47,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR005875 - InterPro: IPR011761 - InterPro: IPR003135 - InterPro: IPR013815 - InterPro: IPR013816 - InterPro: IPR013817 - InterPro: IPR016185 - InterPro: IPR011054 [H]
Pfam domain/function: PF02222 ATP-grasp [H]
EC number: =6.3.4.18 [H]
Molecular weight: Translated: 43316; Mature: 43185
Theoretical pI: Translated: 5.54; Mature: 5.54
Prosite motif: PS50975 ATP_GRASP
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.5 %Cys (Translated Protein) 3.0 %Met (Translated Protein) 3.5 %Cys+Met (Translated Protein) 0.5 %Cys (Mature Protein) 2.8 %Met (Mature Protein) 3.2 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MSATPVVTMIGGGQLARMTHQASIALGQTLRVLAHAADEPAAQVTPDIVLGSHTELDDLR CCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCEEECCCCCHHHHH RAAKDATVVTFDHEHVPTAFLETLQGEGVNVQPPPSALIYAQDKTLMRRKLRDIGAPVPG HHHCCCEEEEECCCCCCHHHHHHHCCCCCCCCCCCCEEEEECCHHHHHHHHHHHCCCCCC FADIRAVSDVERFAAETGSHVVLKAVRGGYDGRGVWITDTLDEARTVAAEQLAAGVELLA HHHHHHHHHHHHHHHCCCCCEEEEHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHH EERVDMRRELSAMVARSPFGQGAAWPVVETVQREGICAVVIAPAPQLPEELALQAEQLAL HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHH RIANELGVTGCLAVELFETNDGRLLVNELAMRPHNSGHWSMDGARTGQFEQHLRAVLDYP HHHHHCCCCEEEEEEEEECCCCEEEHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCC LGSTEPLAPVTVMANVLGAPQTPAMSLDERMHHLMGRIPEAKVHLYGKGERPGRKLGHVN CCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCEEE IQGREDGSLADPGYVAEVRERAERAAHWLSHAVWTDGWEGH EECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC >Mature Secondary Structure SATPVVTMIGGGQLARMTHQASIALGQTLRVLAHAADEPAAQVTPDIVLGSHTELDDLR CCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCEEECCCCCHHHHH RAAKDATVVTFDHEHVPTAFLETLQGEGVNVQPPPSALIYAQDKTLMRRKLRDIGAPVPG HHHCCCEEEEECCCCCCHHHHHHHCCCCCCCCCCCCEEEEECCHHHHHHHHHHHCCCCCC FADIRAVSDVERFAAETGSHVVLKAVRGGYDGRGVWITDTLDEARTVAAEQLAAGVELLA HHHHHHHHHHHHHHHCCCCCEEEEHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHH EERVDMRRELSAMVARSPFGQGAAWPVVETVQREGICAVVIAPAPQLPEELALQAEQLAL HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHH RIANELGVTGCLAVELFETNDGRLLVNELAMRPHNSGHWSMDGARTGQFEQHLRAVLDYP HHHHHCCCCEEEEEEEEECCCCEEEHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCC LGSTEPLAPVTVMANVLGAPQTPAMSLDERMHHLMGRIPEAKVHLYGKGERPGRKLGHVN CCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCEEE IQGREDGSLADPGYVAEVRERAERAAHWLSHAVWTDGWEGH EECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 12788972 [H]