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The map label for this gene is panE [C]

Identifier: 169630635

GI number: 169630635

Start: 3599556

End: 3600500

Strand: Direct

Name: panE [C]

Synonym: MAB_3554

Alternate gene names: 169630635

Gene position: 3599556-3600500 (Clockwise)

Preceding gene: 169630634

Following gene: 169630636

Centisome position: 71.04

GC content: 60.85

Gene sequence:

>945_bases
GTGCTGGTATTCGGCGCGGGGGGCGTCGGTCTGTATTTCTCGGCCGTTCTCGCGCAAGCCGGTCACCACGTGACCATTGT
TGGCCGGCCGGCCACCGTGACTGCCGCCGGCCAGTCCGACTTACAGCTGACCACCAGTAGCGGGGTCTTGGCGGTGAGCG
GCATTCACGTAGTCGCGGATATCGCTGAGGCTCGCATAGATCCGACCGCCGACTTGATAATCGTCGCGGTCAAGGCGTGG
CAGGTCAGTGCGGCAGCGACCGCCATCGCACCATTGGTGGGAGCACACACAATCGTATTGCCGCTACAGAACGGCATCGA
GGCAGCCGACGATCTCGCCAATGTTATAGGGCCGCAACATGTATTGGGCTGTTCCTGTGTGGTCATCGCGAAACGGACCA
AACCGTGGGCGGTGACTTGCCTCGGTGCGCACGCGCACCTGGAAATCGGCCCGATATCGGACTCCTTTGCGGGAGAACTC
ACTTCCCTCGTTGCTGCACTGCACCAGGCGCACATATCTGTCACACTGTCCAGTGACATCCGCGCCACTCTCTGGCGCAA
GTTCATGCTTATCTCGTCCTACGGCGGCGTCGGCGTGCTGTGCCGGCAGCCTGTCGGAGTAACCTCCACAACCCCTGAGA
CTGCGGCCTTGATTCGTGACGCCATGTTCGAAGTCCTCGCGGTCGGGCAGGCGCACGGCGTGGCCCTGTCACATCAAGAT
GTCGATTCAATGATGGCTGTTTTCCATGCATTTGATCCACTCACCACGTCGTCAATGCACCGAGACCTGTTGGAGGGCCG
TCCGTCGGAACTGGAGCATCAAAGTGGTGCTGTCCTGAGATATGGTCGTGCCGTCGGAGTGACGACGCCCATCCATTGGT
GTATCTACGCCTCCCAGTTGCCGGCAGAAATCGCTGCGCGCAAACCCACGGAACACGCACCGTGA

Upstream 100 bases:

>100_bases
ATTTCTACACCGAGATGGTCCGTCTCGATGACGTCCGAGACTGCGCATTGGAGGTGTTGCGAGATCGTGGGAGCGCGCAC
GCGAAGGTCGCGTCGTGAGA

Downstream 100 bases:

>100_bases
CAGAACAGCTTCGCGCGCAACCCTTGTCGATGATGGGCGTGGTGGGAGCCAGCATCGGAAATTTCCTCGTCGCCTTCGAC
GCATCTGCGATCAATGTCGC

Product: ketopantoate reductase ApbA/PanE

Products: NA

Alternate protein names: Ketopantoate reductase; KPA reductase; KPR [H]

Number of amino acids: Translated: 314; Mature: 314

Protein sequence:

>314_residues
MLVFGAGGVGLYFSAVLAQAGHHVTIVGRPATVTAAGQSDLQLTTSSGVLAVSGIHVVADIAEARIDPTADLIIVAVKAW
QVSAAATAIAPLVGAHTIVLPLQNGIEAADDLANVIGPQHVLGCSCVVIAKRTKPWAVTCLGAHAHLEIGPISDSFAGEL
TSLVAALHQAHISVTLSSDIRATLWRKFMLISSYGGVGVLCRQPVGVTSTTPETAALIRDAMFEVLAVGQAHGVALSHQD
VDSMMAVFHAFDPLTTSSMHRDLLEGRPSELEHQSGAVLRYGRAVGVTTPIHWCIYASQLPAEIAARKPTEHAP

Sequences:

>Translated_314_residues
MLVFGAGGVGLYFSAVLAQAGHHVTIVGRPATVTAAGQSDLQLTTSSGVLAVSGIHVVADIAEARIDPTADLIIVAVKAW
QVSAAATAIAPLVGAHTIVLPLQNGIEAADDLANVIGPQHVLGCSCVVIAKRTKPWAVTCLGAHAHLEIGPISDSFAGEL
TSLVAALHQAHISVTLSSDIRATLWRKFMLISSYGGVGVLCRQPVGVTSTTPETAALIRDAMFEVLAVGQAHGVALSHQD
VDSMMAVFHAFDPLTTSSMHRDLLEGRPSELEHQSGAVLRYGRAVGVTTPIHWCIYASQLPAEIAARKPTEHAP
>Mature_314_residues
MLVFGAGGVGLYFSAVLAQAGHHVTIVGRPATVTAAGQSDLQLTTSSGVLAVSGIHVVADIAEARIDPTADLIIVAVKAW
QVSAAATAIAPLVGAHTIVLPLQNGIEAADDLANVIGPQHVLGCSCVVIAKRTKPWAVTCLGAHAHLEIGPISDSFAGEL
TSLVAALHQAHISVTLSSDIRATLWRKFMLISSYGGVGVLCRQPVGVTSTTPETAALIRDAMFEVLAVGQAHGVALSHQD
VDSMMAVFHAFDPLTTSSMHRDLLEGRPSELEHQSGAVLRYGRAVGVTTPIHWCIYASQLPAEIAARKPTEHAP

Specific function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid [H]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786627, Length=314, Percent_Identity=26.4331210191083, Blast_Score=72, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: =1.1.1.169 [H]

Molecular weight: Translated: 32677; Mature: 32677

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVFGAGGVGLYFSAVLAQAGHHVTIVGRPATVTAAGQSDLQLTTSSGVLAVSGIHVVAD
CEEECCCCHHHHHHHHHHHCCCEEEEEECCEEEEECCCCCEEEEECCCEEEEECHHHHHH
IAEARIDPTADLIIVAVKAWQVSAAATAIAPLVGAHTIVLPLQNGIEAADDLANVIGPQH
HHHHCCCCCCCEEEEEEEHHHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHCCCHH
VLGCSCVVIAKRTKPWAVTCLGAHAHLEIGPISDSFAGELTSLVAALHQAHISVTLSSDI
HHCCEEEEEEECCCCEEEEEECCEEEEEEECCCCHHHHHHHHHHHHHHHHEEEEEECCCH
RATLWRKFMLISSYGGVGVLCRQPVGVTSTTPETAALIRDAMFEVLAVGQAHGVALSHQD
HHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEECCCC
VDSMMAVFHAFDPLTTSSMHRDLLEGRPSELEHQSGAVLRYGRAVGVTTPIHWCIYASQL
HHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHCCCCCCEEEECCEECCCCCCEEEEECCCC
PAEIAARKPTEHAP
CHHHHCCCCCCCCC
>Mature Secondary Structure
MLVFGAGGVGLYFSAVLAQAGHHVTIVGRPATVTAAGQSDLQLTTSSGVLAVSGIHVVAD
CEEECCCCHHHHHHHHHHHCCCEEEEEECCEEEEECCCCCEEEEECCCEEEEECHHHHHH
IAEARIDPTADLIIVAVKAWQVSAAATAIAPLVGAHTIVLPLQNGIEAADDLANVIGPQH
HHHHCCCCCCCEEEEEEEHHHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHCCCHH
VLGCSCVVIAKRTKPWAVTCLGAHAHLEIGPISDSFAGELTSLVAALHQAHISVTLSSDI
HHCCEEEEEEECCCCEEEEEECCEEEEEEECCCCHHHHHHHHHHHHHHHHEEEEEECCCH
RATLWRKFMLISSYGGVGVLCRQPVGVTSTTPETAALIRDAMFEVLAVGQAHGVALSHQD
HHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEECCCC
VDSMMAVFHAFDPLTTSSMHRDLLEGRPSELEHQSGAVLRYGRAVGVTTPIHWCIYASQL
HHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHCCCCCCEEEECCEECCCCCCEEEEECCCC
PAEIAARKPTEHAP
CHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]