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The map label for this gene is mmr [H]

Identifier: 169630636

GI number: 169630636

Start: 3600497

End: 3601900

Strand: Direct

Name: mmr [H]

Synonym: MAB_3555

Alternate gene names: 169630636

Gene position: 3600497-3601900 (Clockwise)

Preceding gene: 169630635

Following gene: 169630637

Centisome position: 71.06

GC content: 62.96

Gene sequence:

>1404_bases
GTGACAGAACAGCTTCGCGCGCAACCCTTGTCGATGATGGGCGTGGTGGGAGCCAGCATCGGAAATTTCCTCGTCGCCTT
CGACGCATCTGCGATCAATGTCGCGCTGCCGACCGCGACCGAGGAACTTCACGCGACAGTCGACGTTGGCCAATGGTTTC
TCGACGGCTACACCATTCCGCTCTGCGTGTTTCTGCTCGTTTCCGGCGCGATCGGGGATCGCTATGGCGCCGTCAAGGTG
TATCGCTGGTCAATGCTCGCATTCCTGGCCGCTTCGGTGGCTTGCGCGGCCGCCGACACCGCAGGGACCCTGATCGTCGC
GCGCATCGCGCAGGGGGTAGGCGCAAGCTTCGTGGTACCGATGACGCTTGCGATCCTGACCAAGGGGATACCCGATCCCC
GCCGGCGCTCGACAATGATCGGAGCGTGGGGCGTCGTCGGGGGTATCGGAATCGCCTCCGCACCCTTGCTGAGCGGACTG
ATTACCGAATACGCCGGCTGGCGTTGGCTCTTCCTGATCAACGTTCCCATTTGTGCGTTCGCGCTGCGGGCGACGCGGAC
CATCGCCAACATTCCCGCAGACCAACCCCGCCGATTCAATCCGATTTCCCAACTCTTGTTGTGCGTATTTCTTACCTGTA
TTGCGAGTGTGCTCATCGAGGGCAGACGCCTTGGCTGGTCGAGTGTGTCAACTCTCGCCATGGCCGGCATCGCGGTGCTG
TCCATGGCTGCCCTCTGGCAGGTCGAACGGCGGTCCGCCGAGCCGACGATCCCGCCGGCGCTGGCCCGCAATCGCTCATA
TCTGCTGATCGTCTGCGCAGGCAGCTTCTACCAGTTCGCCTCCTATGGCTCACTGCTGGTGCTCGCGCTCTTTCTGCAGG
TACGCCATGGTCTCCGCGCCGATCACGCCGGATATATCATGTCCATCTGCTGCGTCGCTTGGCTCCTCGGCAATGTGCTT
GCCGTGAAGGTGACGCCGGACAACCGTCGACAGGCGATCTTGGCGATGGCCGCGGTGGGTTGCGTCGGCGCCGTCGGCAC
GGCAGCACTGTCCCTCACCGAGAAGATCGTTCCCGCCATGGTGCCGACATCGTTGATCGGCGTGGCATCCGGCGTGCTCG
CCTCATCGCTGAGCGCTGCCGCGATGCATGTCAGTCCGCATACCGTCTCCGGGGTGGGGTCCGCGGTACTCAACACCAGC
CGGCAGAGCGGGATGGTTATCGCGATCGCGCTGCTGGGCGGTTTGTCGTTCGATCATCAACTGCTGGTGCCCATGCTCCT
CGTTGCATCGGCGTTCGCCATGGTGCTCGTGACGACCGCCCTCGCCTTTCGCCCAAACCTGTTCAAACAGAGTTCGGCCC
AACGCCTTCAATCTTCAGCCTGCCAATTCCCGTCGCGTGGATAG

Upstream 100 bases:

>100_bases
ATGGTCGTGCCGTCGGAGTGACGACGCCCATCCATTGGTGTATCTACGCCTCCCAGTTGCCGGCAGAAATCGCTGCGCGC
AAACCCACGGAACACGCACC

Downstream 100 bases:

>100_bases
CATTTGGATATGGGTAACACTCTGACCGTTCAGACGGCGCTCCTGGACGTAGAAGTACGGCGACACGGCAACCCGGAGAA
CACGGACAAGCTGCCGGTTG

Product: major facilitator transporter

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: MMR peptide [H]

Number of amino acids: Translated: 467; Mature: 466

Protein sequence:

>467_residues
MTEQLRAQPLSMMGVVGASIGNFLVAFDASAINVALPTATEELHATVDVGQWFLDGYTIPLCVFLLVSGAIGDRYGAVKV
YRWSMLAFLAASVACAAADTAGTLIVARIAQGVGASFVVPMTLAILTKGIPDPRRRSTMIGAWGVVGGIGIASAPLLSGL
ITEYAGWRWLFLINVPICAFALRATRTIANIPADQPRRFNPISQLLLCVFLTCIASVLIEGRRLGWSSVSTLAMAGIAVL
SMAALWQVERRSAEPTIPPALARNRSYLLIVCAGSFYQFASYGSLLVLALFLQVRHGLRADHAGYIMSICCVAWLLGNVL
AVKVTPDNRRQAILAMAAVGCVGAVGTAALSLTEKIVPAMVPTSLIGVASGVLASSLSAAAMHVSPHTVSGVGSAVLNTS
RQSGMVIAIALLGGLSFDHQLLVPMLLVASAFAMVLVTTALAFRPNLFKQSSAQRLQSSACQFPSRG

Sequences:

>Translated_467_residues
MTEQLRAQPLSMMGVVGASIGNFLVAFDASAINVALPTATEELHATVDVGQWFLDGYTIPLCVFLLVSGAIGDRYGAVKV
YRWSMLAFLAASVACAAADTAGTLIVARIAQGVGASFVVPMTLAILTKGIPDPRRRSTMIGAWGVVGGIGIASAPLLSGL
ITEYAGWRWLFLINVPICAFALRATRTIANIPADQPRRFNPISQLLLCVFLTCIASVLIEGRRLGWSSVSTLAMAGIAVL
SMAALWQVERRSAEPTIPPALARNRSYLLIVCAGSFYQFASYGSLLVLALFLQVRHGLRADHAGYIMSICCVAWLLGNVL
AVKVTPDNRRQAILAMAAVGCVGAVGTAALSLTEKIVPAMVPTSLIGVASGVLASSLSAAAMHVSPHTVSGVGSAVLNTS
RQSGMVIAIALLGGLSFDHQLLVPMLLVASAFAMVLVTTALAFRPNLFKQSSAQRLQSSACQFPSRG
>Mature_466_residues
TEQLRAQPLSMMGVVGASIGNFLVAFDASAINVALPTATEELHATVDVGQWFLDGYTIPLCVFLLVSGAIGDRYGAVKVY
RWSMLAFLAASVACAAADTAGTLIVARIAQGVGASFVVPMTLAILTKGIPDPRRRSTMIGAWGVVGGIGIASAPLLSGLI
TEYAGWRWLFLINVPICAFALRATRTIANIPADQPRRFNPISQLLLCVFLTCIASVLIEGRRLGWSSVSTLAMAGIAVLS
MAALWQVERRSAEPTIPPALARNRSYLLIVCAGSFYQFASYGSLLVLALFLQVRHGLRADHAGYIMSICCVAWLLGNVLA
VKVTPDNRRQAILAMAAVGCVGAVGTAALSLTEKIVPAMVPTSLIGVASGVLASSLSAAAMHVSPHTVSGVGSAVLNTSR
QSGMVIAIALLGGLSFDHQLLVPMLLVASAFAMVLVTTALAFRPNLFKQSSAQRLQSSACQFPSRG

Specific function: Resistance to the epoxide antibiotic methylenomycin [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1789042, Length=292, Percent_Identity=26.7123287671233, Blast_Score=110, Evalue=3e-25,
Organism=Escherichia coli, GI1788710, Length=301, Percent_Identity=26.578073089701, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1790195, Length=408, Percent_Identity=25, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI87081983, Length=403, Percent_Identity=25.5583126550869, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1788392, Length=290, Percent_Identity=27.9310344827586, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6325455, Length=141, Percent_Identity=29.7872340425532, Blast_Score=67, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 48972; Mature: 48841

Theoretical pI: Translated: 9.70; Mature: 9.70

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEQLRAQPLSMMGVVGASIGNFLVAFDASAINVALPTATEELHATVDVGQWFLDGYTIP
CCCCHHHCCHHHHHHHHHHHHCEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHCCCHHH
LCVFLLVSGAIGDRYGAVKVYRWSMLAFLAASVACAAADTAGTLIVARIAQGVGASFVVP
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHH
MTLAILTKGIPDPRRRSTMIGAWGVVGGIGIASAPLLSGLITEYAGWRWLFLINVPICAF
HHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCEEEEEECHHHHHH
ALRATRTIANIPADQPRRFNPISQLLLCVFLTCIASVLIEGRRLGWSSVSTLAMAGIAVL
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
SMAALWQVERRSAEPTIPPALARNRSYLLIVCAGSFYQFASYGSLLVLALFLQVRHGLRA
HHHHHHHHHHHCCCCCCCHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCC
DHAGYIMSICCVAWLLGNVLAVKVTPDNRRQAILAMAAVGCVGAVGTAALSLTEKIVPAM
CCHHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VPTSLIGVASGVLASSLSAAAMHVSPHTVSGVGSAVLNTSRQSGMVIAIALLGGLSFDHQ
HHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHCCCCCCCEEEEHHHCCCCCCHH
LLVPMLLVASAFAMVLVTTALAFRPNLFKQSSAQRLQSSACQFPSRG
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TEQLRAQPLSMMGVVGASIGNFLVAFDASAINVALPTATEELHATVDVGQWFLDGYTIP
CCCHHHCCHHHHHHHHHHHHCEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHCCCHHH
LCVFLLVSGAIGDRYGAVKVYRWSMLAFLAASVACAAADTAGTLIVARIAQGVGASFVVP
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHH
MTLAILTKGIPDPRRRSTMIGAWGVVGGIGIASAPLLSGLITEYAGWRWLFLINVPICAF
HHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCEEEEEECHHHHHH
ALRATRTIANIPADQPRRFNPISQLLLCVFLTCIASVLIEGRRLGWSSVSTLAMAGIAVL
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
SMAALWQVERRSAEPTIPPALARNRSYLLIVCAGSFYQFASYGSLLVLALFLQVRHGLRA
HHHHHHHHHHHCCCCCCCHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCC
DHAGYIMSICCVAWLLGNVLAVKVTPDNRRQAILAMAAVGCVGAVGTAALSLTEKIVPAM
CCHHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VPTSLIGVASGVLASSLSAAAMHVSPHTVSGVGSAVLNTSRQSGMVIAIALLGGLSFDHQ
HHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHCCCCCCCEEEEHHHCCCCCCHH
LLVPMLLVASAFAMVLVTTALAFRPNLFKQSSAQRLQSSACQFPSRG
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1379177; 9384377 [H]