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The map label for this gene is acdA [H]

Identifier: 169630205

GI number: 169630205

Start: 3163698

End: 3164900

Strand: Direct

Name: acdA [H]

Synonym: MAB_3123

Alternate gene names: 169630205

Gene position: 3163698-3164900 (Clockwise)

Preceding gene: 169630204

Following gene: 169630206

Centisome position: 62.44

GC content: 65.25

Gene sequence:

>1203_bases
ATGAGCGCCAGCGAAGACCATCAAACCCGGATGAGCGCCAGCGAAGACAATCAAACCCGGATGAGCGCCAGCGAAGACAA
TCAGGCCCAGATCAATGAATTCGAGTTCACCGAAGAACACGGCGACCTGCGCTCGCTGGTACGCAGCTGGTGTGAACGGG
TCTGGACACCCAAGCACGTGCGCCAGATTGCCGAGGCTGGATCAGTGGATCTGGATGCCTGGCGCGCCCTCGGCTCCGAA
CTGGGTGTGGTGGGCCTAAGTCTGCCCGAACAGCATGGCGGCGGTGGGTTGGGTGTCATCGAATTGTCCATCGTGGCCGA
GGAATTGGGGCGGGCTCTGGCGTGCCTGCCGTGGATATCCAGTGCTGCCCTGGGCGCCACCGCCCTGGTGTCCAGCGGCG
ACGACAGCGCCTTGGCCGAGTGGGTACCGGCGCTGGCCGCCGGCGAGAAGACGATCACGCTGGCGGGCGGCCGTACCCGT
TTAGCGGACGCGATCACCGTGTCTGCCGAATCCGATACCGACGGCTGGAAGCTCACCGGCGACACCGAGCATGTTCCCGA
CGGCGCGACCGCCGACGTGATCCTGGTGCTCGCCGATACCGATTCGGGACCAAGCCTTTTCGCGGTCGACGGCGATGCGC
CAGGTGTCGACCGACACTCGCTGGCGACCCTTGATATGACCCGGCGGCAGGCCAACATCCACTTCAACTCCGCCCCCGCA
CGCCTGATCGGTGCACAGGGGCGGGGTGCGGAGGCCGTCGCCACGGCACTCGACGTCGCAGCCACCGTACTGGCGGCCGA
GCAGGCCGGTATCGCCGCCCACATGCTGGATGTGACAACCGAATACGCGAAGTCCCGGATCCAGTTCGGGCGCATCATCG
GGTCATTCCAGGCCGTCAAACACCGCCTTGCCGATATGGCCGCGGCGACCGGGAATGTGCGTGGCGCCGCGTATCACGCG
GCCTGGTCACATGATCACCCGAGCCTTGACGATCCGGCGCTGGCCACCAGTATTGCTCAACAGGTGGCGTCGGCAGGAGC
TGTGGAGGTAACCGCCAAGGCCATCCAGAGCCATGGCGGCATCGGTTTCACCTGGGAGCACCCGGCCCATCTGTATTACA
AACGCGCCGTGAGTAACTCGGCCCTCTTCGGGGGGCGCGCCGTCCACGCCGAACGTATTGCCAAGGAGGTAATCGACGCA
TGA

Upstream 100 bases:

>100_bases
CCTCCGACGTGATGCGCAACATCATCGGAGAACGCGTACTCGGATTGCCCGGCGATATTCGGGTCGACACCGACAAAGCC
TGGAAGGACGTGCCCCGCGG

Downstream 100 bases:

>100_bases
CCGAACCAATTTTGTTGACCCACACCGAAGACCGCATCTGCACCATCACCCTGAACCGGCCGCAAGCACGTAACGCCTTG
AGCACCGCCCTGGGCGAGGA

Product: putative acyl-CoA dehydrogenase

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 400; Mature: 399

Protein sequence:

>400_residues
MSASEDHQTRMSASEDNQTRMSASEDNQAQINEFEFTEEHGDLRSLVRSWCERVWTPKHVRQIAEAGSVDLDAWRALGSE
LGVVGLSLPEQHGGGGLGVIELSIVAEELGRALACLPWISSAALGATALVSSGDDSALAEWVPALAAGEKTITLAGGRTR
LADAITVSAESDTDGWKLTGDTEHVPDGATADVILVLADTDSGPSLFAVDGDAPGVDRHSLATLDMTRRQANIHFNSAPA
RLIGAQGRGAEAVATALDVAATVLAAEQAGIAAHMLDVTTEYAKSRIQFGRIIGSFQAVKHRLADMAAATGNVRGAAYHA
AWSHDHPSLDDPALATSIAQQVASAGAVEVTAKAIQSHGGIGFTWEHPAHLYYKRAVSNSALFGGRAVHAERIAKEVIDA

Sequences:

>Translated_400_residues
MSASEDHQTRMSASEDNQTRMSASEDNQAQINEFEFTEEHGDLRSLVRSWCERVWTPKHVRQIAEAGSVDLDAWRALGSE
LGVVGLSLPEQHGGGGLGVIELSIVAEELGRALACLPWISSAALGATALVSSGDDSALAEWVPALAAGEKTITLAGGRTR
LADAITVSAESDTDGWKLTGDTEHVPDGATADVILVLADTDSGPSLFAVDGDAPGVDRHSLATLDMTRRQANIHFNSAPA
RLIGAQGRGAEAVATALDVAATVLAAEQAGIAAHMLDVTTEYAKSRIQFGRIIGSFQAVKHRLADMAAATGNVRGAAYHA
AWSHDHPSLDDPALATSIAQQVASAGAVEVTAKAIQSHGGIGFTWEHPAHLYYKRAVSNSALFGGRAVHAERIAKEVIDA
>Mature_399_residues
SASEDHQTRMSASEDNQTRMSASEDNQAQINEFEFTEEHGDLRSLVRSWCERVWTPKHVRQIAEAGSVDLDAWRALGSEL
GVVGLSLPEQHGGGGLGVIELSIVAEELGRALACLPWISSAALGATALVSSGDDSALAEWVPALAAGEKTITLAGGRTRL
ADAITVSAESDTDGWKLTGDTEHVPDGATADVILVLADTDSGPSLFAVDGDAPGVDRHSLATLDMTRRQANIHFNSAPAR
LIGAQGRGAEAVATALDVAATVLAAEQAGIAAHMLDVTTEYAKSRIQFGRIIGSFQAVKHRLADMAAATGNVRGAAYHAA
WSHDHPSLDDPALATSIAQQVASAGAVEVTAKAIQSHGGIGFTWEHPAHLYYKRAVSNSALFGGRAVHAERIAKEVIDA

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI226958412, Length=362, Percent_Identity=27.0718232044199, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI226958414, Length=324, Percent_Identity=28.0864197530864, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI4501857, Length=380, Percent_Identity=25, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI4501859, Length=384, Percent_Identity=24.21875, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI4557231, Length=390, Percent_Identity=27.1794871794872, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI187960098, Length=390, Percent_Identity=27.1794871794872, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI4557233, Length=363, Percent_Identity=26.9972451790634, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI21361497, Length=390, Percent_Identity=23.0769230769231, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI7656849, Length=345, Percent_Identity=24.0579710144928, Blast_Score=76, Evalue=5e-14,
Organism=Escherichia coli, GI1786223, Length=309, Percent_Identity=23.6245954692557, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI87081958, Length=356, Percent_Identity=24.1573033707865, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17538396, Length=356, Percent_Identity=26.4044943820225, Blast_Score=118, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI17506239, Length=338, Percent_Identity=25.1479289940828, Blast_Score=102, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17508101, Length=388, Percent_Identity=24.2268041237113, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17569725, Length=362, Percent_Identity=26.2430939226519, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17534899, Length=360, Percent_Identity=26.6666666666667, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17570075, Length=366, Percent_Identity=25.6830601092896, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17533517, Length=365, Percent_Identity=23.5616438356164, Blast_Score=75, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI71985184, Length=310, Percent_Identity=25.8064516129032, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71990804, Length=277, Percent_Identity=22.3826714801444, Blast_Score=71, Evalue=9e-13,
Organism=Drosophila melanogaster, GI21356377, Length=366, Percent_Identity=25.4098360655738, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24646207, Length=367, Percent_Identity=25.0681198910082, Blast_Score=92, Evalue=8e-19,
Organism=Drosophila melanogaster, GI21355753, Length=354, Percent_Identity=25.9887005649718, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24660351, Length=364, Percent_Identity=27.7472527472527, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24666513, Length=330, Percent_Identity=26.6666666666667, Blast_Score=89, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 41886; Mature: 41755

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSASEDHQTRMSASEDNQTRMSASEDNQAQINEFEFTEEHGDLRSLVRSWCERVWTPKHV
CCCCCCHHHHCCCCCCCCHHCCCCCCCCCCCCCEECCHHHHHHHHHHHHHHHHCCCHHHH
RQIAEAGSVDLDAWRALGSELGVVGLSLPEQHGGGGLGVIELSIVAEELGRALACLPWIS
HHHHHCCCCCHHHHHHHHHHCCEEEECCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHH
SAALGATALVSSGDDSALAEWVPALAAGEKTITLAGGRTRLADAITVSAESDTDGWKLTG
HHHHCHHHEECCCCCHHHHHHHHHHHCCCEEEEEECCCEECCCEEEEECCCCCCCEEECC
DTEHVPDGATADVILVLADTDSGPSLFAVDGDAPGVDRHSLATLDMTRRQANIHFNSAPA
CCCCCCCCCCCEEEEEEEECCCCCEEEEECCCCCCCCCHHEEHHHHHHHHCCEEECCCCC
RLIGAQGRGAEAVATALDVAATVLAAEQAGIAAHMLDVTTEYAKSRIQFGRIIGSFQAVK
EEEECCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HRLADMAAATGNVRGAAYHAAWSHDHPSLDDPALATSIAQQVASAGAVEVTAKAIQSHGG
HHHHHHHHHCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCC
IGFTWEHPAHLYYKRAVSNSALFGGRAVHAERIAKEVIDA
CCEEECCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
SASEDHQTRMSASEDNQTRMSASEDNQAQINEFEFTEEHGDLRSLVRSWCERVWTPKHV
CCCCCHHHHCCCCCCCCHHCCCCCCCCCCCCCEECCHHHHHHHHHHHHHHHHCCCHHHH
RQIAEAGSVDLDAWRALGSELGVVGLSLPEQHGGGGLGVIELSIVAEELGRALACLPWIS
HHHHHCCCCCHHHHHHHHHHCCEEEECCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHH
SAALGATALVSSGDDSALAEWVPALAAGEKTITLAGGRTRLADAITVSAESDTDGWKLTG
HHHHCHHHEECCCCCHHHHHHHHHHHCCCEEEEEECCCEECCCEEEEECCCCCCCEEECC
DTEHVPDGATADVILVLADTDSGPSLFAVDGDAPGVDRHSLATLDMTRRQANIHFNSAPA
CCCCCCCCCCCEEEEEEEECCCCCEEEEECCCCCCCCCHHEEHHHHHHHHCCEEECCCCC
RLIGAQGRGAEAVATALDVAATVLAAEQAGIAAHMLDVTTEYAKSRIQFGRIIGSFQAVK
EEEECCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HRLADMAAATGNVRGAAYHAAWSHDHPSLDDPALATSIAQQVASAGAVEVTAKAIQSHGG
HHHHHHHHHCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCC
IGFTWEHPAHLYYKRAVSNSALFGGRAVHAERIAKEVIDA
CCEEECCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]