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The map label for this gene is sthA [H]

Identifier: 169630115

GI number: 169630115

Start: 3083926

End: 3085377

Strand: Direct

Name: sthA [H]

Synonym: MAB_3032

Alternate gene names: 169630115

Gene position: 3083926-3085377 (Clockwise)

Preceding gene: 169630112

Following gene: 169630116

Centisome position: 60.86

GC content: 64.12

Gene sequence:

>1452_bases
ATGACCAACGGTCTTCGCCCGAGCGGCTCATCCCCGACAGCTGATACTCCTTCCTACGATCTCGTCGTCATCGGGTCCGG
CCCCGGAGGCCAGAAGGCCGCCATCGCCGCGGCCAAGCTCGGCAAGTCGGTGGCGGTCGTCGAACGCGACAACATGCTCG
GTGGCGTCTGCACCAATACCGGGACCATTCCGTCCAAGACACTGCGCGAGGCGGTGCTCTATCTGACGGGCATGAACCAG
CGCGAGCTGTACGGCGCCAGCTACCGCGTGAAGGCCAACATCACCCCGGAGGATCTGCTGGCGCGCACCGAGCACGTCAT
CCGCAAGGAGATCGAGGTGGTGCGTGCCCAGCTGCAGCGCAACCGGATCGATCTGATCAGCGGCATCGGCCGCTTCGCCG
ACGAACACACCGTCGTCGTGGAAGAACCTTCGCGCGGAGAGCGCACCACGCTGCATGCCGACTACGTCGTCATCGCCACC
GGAACCAATCCCGCCCGCCCCGATGGAGTGGCCTTCGACGAGAAGCGTGTCCTGGACTCGGACGGCATCTTGAATCTGCG
TTTCATCCCGGGATCGATGGTCGTCGTGGGCGCCGGTGTCATCGGCATCGAGTACGCGTCCATGTTCGCCGCCCTGGGCA
CCAAGGTGACCGTGGTGGAAAAGCGTGACACCATGCTGGATTTCTGCGACCCGGAAGTGGTTGAGGCCCTTCGTTTTCAC
CTGCGGGACCTGGCGGTGACGTTCCGGTTCGGCGAAGAGGTGACCACCGTGGAGGTCAATGACACCGGCACCATGACCAC
CCTGGCCAGCGGCAAGCAAATTCCCGCCGACACCGTCATGTACTCCGCAGGACGGCAGGGACAGACCGACCAGCTCGACC
TCCCCAAGGCGGGCCTGGAGGCCGATCGCCGCGGCCGCATCTGGGTCGACGCAAACTTCCAGACCAAGGTCGACCACATC
TACGCGGTGGGCGACGTGATCGGGTTCCCGGCGCTAGCGGCCACCTCGATGGATCAGGGGCGTCTGGCGGCCTATCACGC
GTTCGGAGAGCCGTCGAAAGGCATGACGGACCTGCAGCCGATCGGCATCTACTCCATCCCCGAGGTGTCCTATGTGGGCG
CCACCGAGGTTGAACTCACCAAGAACGCGATTCCCTACGAGGTGGGCGTCTCGCGCTACCGCGAGCTGGCGCGTGGCCAG
ATCGCCGGGGATTCGTACGGAATGCTCAAGTTGCTGGTGTCGACCGAGGACCTGCGACTGCTCGGGATACACATCTTCGG
ATCCGACGCCACCGATCTGGTGCACATCGGCCAGGCGGTGATGGGCTGCGGCGGCACCGTCGAATACCTGGTAGACGCGG
TTTTCAACTACCCGACGTTCTCGGAGGCGTACAAGGTGGCCGCACTCGACGTGATGAACAAGATTCGCGCGCTGAATCAG
TTCAAGGCCTGA

Upstream 100 bases:

>100_bases
GCCCCAGGAGGCGCGCGCGAGATTCAGGCGGGACAACTGTTCATATCGCCGTGACGCGCAGGGCATGCACGATTCGGCGA
ATCGGCGTATGAGTACACCC

Downstream 100 bases:

>100_bases
GGCATTTCGCGCTGGGCGAATAGCGGCCGGGCGCGGAATTCGCATCCCGCCCGGGCCGTTGACCCGATAGGTACATTCGC
CGTTTGCCTGCCGGTAAGGG

Product: soluble pyridine nucleotide transhydrogenase

Products: NA

Alternate protein names: STH; NAD(P)(+) transhydrogenase [B-specific] [H]

Number of amino acids: Translated: 483; Mature: 482

Protein sequence:

>483_residues
MTNGLRPSGSSPTADTPSYDLVVIGSGPGGQKAAIAAAKLGKSVAVVERDNMLGGVCTNTGTIPSKTLREAVLYLTGMNQ
RELYGASYRVKANITPEDLLARTEHVIRKEIEVVRAQLQRNRIDLISGIGRFADEHTVVVEEPSRGERTTLHADYVVIAT
GTNPARPDGVAFDEKRVLDSDGILNLRFIPGSMVVVGAGVIGIEYASMFAALGTKVTVVEKRDTMLDFCDPEVVEALRFH
LRDLAVTFRFGEEVTTVEVNDTGTMTTLASGKQIPADTVMYSAGRQGQTDQLDLPKAGLEADRRGRIWVDANFQTKVDHI
YAVGDVIGFPALAATSMDQGRLAAYHAFGEPSKGMTDLQPIGIYSIPEVSYVGATEVELTKNAIPYEVGVSRYRELARGQ
IAGDSYGMLKLLVSTEDLRLLGIHIFGSDATDLVHIGQAVMGCGGTVEYLVDAVFNYPTFSEAYKVAALDVMNKIRALNQ
FKA

Sequences:

>Translated_483_residues
MTNGLRPSGSSPTADTPSYDLVVIGSGPGGQKAAIAAAKLGKSVAVVERDNMLGGVCTNTGTIPSKTLREAVLYLTGMNQ
RELYGASYRVKANITPEDLLARTEHVIRKEIEVVRAQLQRNRIDLISGIGRFADEHTVVVEEPSRGERTTLHADYVVIAT
GTNPARPDGVAFDEKRVLDSDGILNLRFIPGSMVVVGAGVIGIEYASMFAALGTKVTVVEKRDTMLDFCDPEVVEALRFH
LRDLAVTFRFGEEVTTVEVNDTGTMTTLASGKQIPADTVMYSAGRQGQTDQLDLPKAGLEADRRGRIWVDANFQTKVDHI
YAVGDVIGFPALAATSMDQGRLAAYHAFGEPSKGMTDLQPIGIYSIPEVSYVGATEVELTKNAIPYEVGVSRYRELARGQ
IAGDSYGMLKLLVSTEDLRLLGIHIFGSDATDLVHIGQAVMGCGGTVEYLVDAVFNYPTFSEAYKVAALDVMNKIRALNQ
FKA
>Mature_482_residues
TNGLRPSGSSPTADTPSYDLVVIGSGPGGQKAAIAAAKLGKSVAVVERDNMLGGVCTNTGTIPSKTLREAVLYLTGMNQR
ELYGASYRVKANITPEDLLARTEHVIRKEIEVVRAQLQRNRIDLISGIGRFADEHTVVVEEPSRGERTTLHADYVVIATG
TNPARPDGVAFDEKRVLDSDGILNLRFIPGSMVVVGAGVIGIEYASMFAALGTKVTVVEKRDTMLDFCDPEVVEALRFHL
RDLAVTFRFGEEVTTVEVNDTGTMTTLASGKQIPADTVMYSAGRQGQTDQLDLPKAGLEADRRGRIWVDANFQTKVDHIY
AVGDVIGFPALAATSMDQGRLAAYHAFGEPSKGMTDLQPIGIYSIPEVSYVGATEVELTKNAIPYEVGVSRYRELARGQI
AGDSYGMLKLLVSTEDLRLLGIHIFGSDATDLVHIGQAVMGCGGTVEYLVDAVFNYPTFSEAYKVAALDVMNKIRALNQF
KA

Specific function: Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=481, Percent_Identity=30.5613305613306, Blast_Score=213, Evalue=4e-55,
Organism=Homo sapiens, GI50301238, Length=462, Percent_Identity=27.7056277056277, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI291045266, Length=474, Percent_Identity=26.7932489451477, Blast_Score=132, Evalue=7e-31,
Organism=Homo sapiens, GI22035672, Length=467, Percent_Identity=28.9079229122056, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI291045268, Length=468, Percent_Identity=26.0683760683761, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI148277071, Length=452, Percent_Identity=24.5575221238938, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI148277065, Length=452, Percent_Identity=24.5575221238938, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI33519430, Length=452, Percent_Identity=24.5575221238938, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI33519428, Length=452, Percent_Identity=24.5575221238938, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI33519426, Length=452, Percent_Identity=24.5575221238938, Blast_Score=108, Evalue=9e-24,
Organism=Escherichia coli, GI87082354, Length=461, Percent_Identity=44.2516268980477, Blast_Score=393, Evalue=1e-110,
Organism=Escherichia coli, GI1786307, Length=456, Percent_Identity=31.359649122807, Blast_Score=207, Evalue=1e-54,
Organism=Escherichia coli, GI87081717, Length=460, Percent_Identity=29.1304347826087, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI1789915, Length=439, Percent_Identity=27.7904328018223, Blast_Score=137, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI32565766, Length=463, Percent_Identity=31.7494600431965, Blast_Score=226, Evalue=3e-59,
Organism=Caenorhabditis elegans, GI17557007, Length=482, Percent_Identity=25.103734439834, Blast_Score=132, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI71983429, Length=365, Percent_Identity=26.5753424657534, Blast_Score=102, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI71983419, Length=365, Percent_Identity=26.5753424657534, Blast_Score=102, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI71982272, Length=460, Percent_Identity=23.9130434782609, Blast_Score=97, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17559934, Length=219, Percent_Identity=28.310502283105, Blast_Score=70, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6321091, Length=473, Percent_Identity=30.4439746300211, Blast_Score=204, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6325240, Length=467, Percent_Identity=29.9785867237687, Blast_Score=183, Evalue=4e-47,
Organism=Saccharomyces cerevisiae, GI6325166, Length=467, Percent_Identity=26.5524625267666, Blast_Score=120, Evalue=4e-28,
Organism=Drosophila melanogaster, GI21358499, Length=461, Percent_Identity=31.4533622559653, Blast_Score=218, Evalue=1e-56,
Organism=Drosophila melanogaster, GI24640553, Length=490, Percent_Identity=29.7959183673469, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24640549, Length=483, Percent_Identity=29.6066252587992, Blast_Score=158, Evalue=8e-39,
Organism=Drosophila melanogaster, GI24640551, Length=475, Percent_Identity=29.8947368421053, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI17737741, Length=485, Percent_Identity=28.8659793814433, Blast_Score=139, Evalue=3e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327
- InterPro:   IPR022962 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.6.1.1 [H]

Molecular weight: Translated: 52102; Mature: 51971

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNGLRPSGSSPTADTPSYDLVVIGSGPGGQKAAIAAAKLGKSVAVVERDNMLGGVCTNT
CCCCCCCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHCCCEEEEEECCCCCCEEECCC
GTIPSKTLREAVLYLTGMNQRELYGASYRVKANITPEDLLARTEHVIRKEIEVVRAQLQR
CCCCHHHHHHHHHHHCCCCHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
NRIDLISGIGRFADEHTVVVEEPSRGERTTLHADYVVIATGTNPARPDGVAFDEKRVLDS
CHHHHHHHHHHHCCCCEEEEECCCCCCCEEEEEEEEEEEECCCCCCCCCCCCCHHHEECC
DGILNLRFIPGSMVVVGAGVIGIEYASMFAALGTKVTVVEKRDTMLDFCDPEVVEALRFH
CCEEEEEECCCCEEEEECCCHHHHHHHHHHHHCCEEEEEECCCCCHHCCCHHHHHHHHHH
LRDLAVTFRFGEEVTTVEVNDTGTMTTLASGKQIPADTVMYSAGRQGQTDQLDLPKAGLE
HHHHEEEEEECCEEEEEEECCCCCEEEECCCCCCCHHHHEECCCCCCCCCCCCCCCCCCC
ADRRGRIWVDANFQTKVDHIYAVGDVIGFPALAATSMDQGRLAAYHAFGEPSKGMTDLQP
CCCCCEEEEECCCCCCHHHEEEHHHHHCCCHHHHCCCCCCCEEEEEECCCCCCCCCCCCC
IGIYSIPEVSYVGATEVELTKNAIPYEVGVSRYRELARGQIAGDSYGMLKLLVSTEDLRL
CCEEECCCEEECCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCEEE
LGIHIFGSDATDLVHIGQAVMGCGGTVEYLVDAVFNYPTFSEAYKVAALDVMNKIRALNQ
EEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
FKA
HCC
>Mature Secondary Structure 
TNGLRPSGSSPTADTPSYDLVVIGSGPGGQKAAIAAAKLGKSVAVVERDNMLGGVCTNT
CCCCCCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHCCCEEEEEECCCCCCEEECCC
GTIPSKTLREAVLYLTGMNQRELYGASYRVKANITPEDLLARTEHVIRKEIEVVRAQLQR
CCCCHHHHHHHHHHHCCCCHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
NRIDLISGIGRFADEHTVVVEEPSRGERTTLHADYVVIATGTNPARPDGVAFDEKRVLDS
CHHHHHHHHHHHCCCCEEEEECCCCCCCEEEEEEEEEEEECCCCCCCCCCCCCHHHEECC
DGILNLRFIPGSMVVVGAGVIGIEYASMFAALGTKVTVVEKRDTMLDFCDPEVVEALRFH
CCEEEEEECCCCEEEEECCCHHHHHHHHHHHHCCEEEEEECCCCCHHCCCHHHHHHHHHH
LRDLAVTFRFGEEVTTVEVNDTGTMTTLASGKQIPADTVMYSAGRQGQTDQLDLPKAGLE
HHHHEEEEEECCEEEEEEECCCCCEEEECCCCCCCHHHHEECCCCCCCCCCCCCCCCCCC
ADRRGRIWVDANFQTKVDHIYAVGDVIGFPALAATSMDQGRLAAYHAFGEPSKGMTDLQP
CCCCCEEEEECCCCCCHHHEEEHHHHHCCCHHHHCCCCCCCEEEEEECCCCCCCCCCCCC
IGIYSIPEVSYVGATEVELTKNAIPYEVGVSRYRELARGQIAGDSYGMLKLLVSTEDLRL
CCEEECCCEEECCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCEEE
LGIHIFGSDATDLVHIGQAVMGCGGTVEYLVDAVFNYPTFSEAYKVAALDVMNKIRALNQ
EEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
FKA
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]