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The map label for this gene is gltC [H]

Identifier: 169629765

GI number: 169629765

Start: 2722637

End: 2723557

Strand: Reverse

Name: gltC [H]

Synonym: MAB_2680c

Alternate gene names: 169629765

Gene position: 2723557-2722637 (Counterclockwise)

Preceding gene: 169629767

Following gene: 169629762

Centisome position: 53.75

GC content: 66.78

Gene sequence:

>921_bases
ATGGATCAGTGGACATCGCAGCTCGCGCCACAGCTGCGAGCCCTGGTGGAGCTCGCCGCCCACGACGGGCACATGACCCA
GGCGGCGCTCACATTGGGTATTCCGCAGTCGTCGATGAGCCGGCGTATTCACGCATTGCAGGCGGCGCTGGGAGTGCCGC
TGCTCATTCACGACGGCAGAACGGTGCGCCTTACCCCGGAGGCTCGTCTGCTTGCGGCCCGGACTCGCGAGCCGCTGGCC
GAACTCGATCACACACTCTCGGAGGTGACGGGGGACGCCGACCCAGAGCGCGGCACCGTCCGCTTCGGATTCCCGCTGAC
GATGGGGTCAGGTCACATCCCCGATCTGCTGGCTGCCTTCCGGCATCGGCACCCCGGCATCCGCGTGCTGCTCAAGCAGG
CCCACGGCAGCGAACTCGGTGCGCAGCTGCTCACCGGCGACCTGGACCTTGCCGTCGTGATACCGGCGCCAGAACGATTG
CACCACATCACGATAGGTGCCCAGCACATACACATCGCCGTTCCCGAAGACCATCGATTGGCCGGCGCCGCGCAGGTGCG
GCTCCGCGAATTGTCCGGTGAGACCTTCATCGCCAATCCGCCCAGCTACAACCTGCGCCAGCTCACCGAGCGGTGGTGCC
GCGAAGCGGGATATGCCCCCAATGTCACGATCGAGGTAACGGAGTTCAGCACCATCCGCGAGCTCATCGGCCGGGGGCTC
GGCGTGGCGCTGCTCCCGCACGATGATCGCGCACTCCCCGGAATACGCGAGATACCGCTCGCGGGGGACGGTTACCACCG
CGCCATTGCCCTGGCCTGGGGCACAGCCACCCGTGCGGCACCCACGAGGCGCCTCAATGACTTCCTGCTCCAACACTTCT
CGCAAGCCGAAGTCAACAGCGCCGCGATCCGGAAGGGCTAG

Upstream 100 bases:

>100_bases
GGTGCGCTTGGGATGCTCGCGGGATTCTGCTCATACCCATCACAATCCGCCGATGCCATCCGTTCCGTCCAATGAATGAT
TGAAGCAGTACCATCCGATA

Downstream 100 bases:

>100_bases
CGGTGGCTGCCGCTGCTTGATTTCGACCCTTCGCCACCGGATTTGGCCGCACTGCTCGCCGAAGCCGAGGGCTTGTTCGC
CGAGTCGTGCGCGGTGGTGC

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MDQWTSQLAPQLRALVELAAHDGHMTQAALTLGIPQSSMSRRIHALQAALGVPLLIHDGRTVRLTPEARLLAARTREPLA
ELDHTLSEVTGDADPERGTVRFGFPLTMGSGHIPDLLAAFRHRHPGIRVLLKQAHGSELGAQLLTGDLDLAVVIPAPERL
HHITIGAQHIHIAVPEDHRLAGAAQVRLRELSGETFIANPPSYNLRQLTERWCREAGYAPNVTIEVTEFSTIRELIGRGL
GVALLPHDDRALPGIREIPLAGDGYHRAIALAWGTATRAAPTRRLNDFLLQHFSQAEVNSAAIRKG

Sequences:

>Translated_306_residues
MDQWTSQLAPQLRALVELAAHDGHMTQAALTLGIPQSSMSRRIHALQAALGVPLLIHDGRTVRLTPEARLLAARTREPLA
ELDHTLSEVTGDADPERGTVRFGFPLTMGSGHIPDLLAAFRHRHPGIRVLLKQAHGSELGAQLLTGDLDLAVVIPAPERL
HHITIGAQHIHIAVPEDHRLAGAAQVRLRELSGETFIANPPSYNLRQLTERWCREAGYAPNVTIEVTEFSTIRELIGRGL
GVALLPHDDRALPGIREIPLAGDGYHRAIALAWGTATRAAPTRRLNDFLLQHFSQAEVNSAAIRKG
>Mature_306_residues
MDQWTSQLAPQLRALVELAAHDGHMTQAALTLGIPQSSMSRRIHALQAALGVPLLIHDGRTVRLTPEARLLAARTREPLA
ELDHTLSEVTGDADPERGTVRFGFPLTMGSGHIPDLLAAFRHRHPGIRVLLKQAHGSELGAQLLTGDLDLAVVIPAPERL
HHITIGAQHIHIAVPEDHRLAGAAQVRLRELSGETFIANPPSYNLRQLTERWCREAGYAPNVTIEVTEFSTIRELIGRGL
GVALLPHDDRALPGIREIPLAGDGYHRAIALAWGTATRAAPTRRLNDFLLQHFSQAEVNSAAIRKG

Specific function: Positive regulator of glutamate biosynthesis (gltAB genes). Negatively regulates its own expression [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI157672245, Length=275, Percent_Identity=30.1818181818182, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1787879, Length=283, Percent_Identity=29.3286219081272, Blast_Score=91, Evalue=7e-20,
Organism=Escherichia coli, GI2367136, Length=247, Percent_Identity=25.9109311740891, Blast_Score=88, Evalue=6e-19,
Organism=Escherichia coli, GI1790399, Length=268, Percent_Identity=26.4925373134328, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788887, Length=257, Percent_Identity=24.9027237354086, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1787806, Length=284, Percent_Identity=26.4084507042254, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1787530, Length=242, Percent_Identity=23.1404958677686, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI87082132, Length=241, Percent_Identity=25.7261410788382, Blast_Score=65, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33373; Mature: 33373

Theoretical pI: Translated: 7.61; Mature: 7.61

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDQWTSQLAPQLRALVELAAHDGHMTQAALTLGIPQSSMSRRIHALQAALGVPLLIHDGR
CCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHHCCCEEEECCC
TVRLTPEARLLAARTREPLAELDHTLSEVTGDADPERGTVRFGFPLTMGSGHIPDLLAAF
EEEECCCHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCEEEEECEEECCCCCCHHHHHHH
RHRHPGIRVLLKQAHGSELGAQLLTGDLDLAVVIPAPERLHHITIGAQHIHIAVPEDHRL
HHCCCCCEEHEEHHCCHHHHHHHHCCCCCEEEEECCCHHEEEEEEECEEEEEECCCCCCC
AGAAQVRLRELSGETFIANPPSYNLRQLTERWCREAGYAPNVTIEVTEFSTIRELIGRGL
CHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHCCCCCCEEEEEECHHHHHHHHHCCC
GVALLPHDDRALPGIREIPLAGDGYHRAIALAWGTATRAAPTRRLNDFLLQHFSQAEVNS
CEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCC
AAIRKG
HHHCCC
>Mature Secondary Structure
MDQWTSQLAPQLRALVELAAHDGHMTQAALTLGIPQSSMSRRIHALQAALGVPLLIHDGR
CCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHHCCCEEEECCC
TVRLTPEARLLAARTREPLAELDHTLSEVTGDADPERGTVRFGFPLTMGSGHIPDLLAAF
EEEECCCHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCEEEEECEEECCCCCCHHHHHHH
RHRHPGIRVLLKQAHGSELGAQLLTGDLDLAVVIPAPERLHHITIGAQHIHIAVPEDHRL
HHCCCCCEEHEEHHCCHHHHHHHHCCCCCEEEEECCCHHEEEEEEECEEEEEECCCCCCC
AGAAQVRLRELSGETFIANPPSYNLRQLTERWCREAGYAPNVTIEVTEFSTIRELIGRGL
CHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHCCCCCCEEEEEECHHHHHHHHHCCC
GVALLPHDDRALPGIREIPLAGDGYHRAIALAWGTATRAAPTRRLNDFLLQHFSQAEVNS
CEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCC
AAIRKG
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2548995; 9384377 [H]