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The map label for this gene is hisB [H]

Identifier: 169629753

GI number: 169629753

Start: 2709635

End: 2710258

Strand: Reverse

Name: hisB [H]

Synonym: MAB_2668c

Alternate gene names: 169629753

Gene position: 2710258-2709635 (Counterclockwise)

Preceding gene: 169629754

Following gene: 169629752

Centisome position: 53.49

GC content: 65.71

Gene sequence:

>624_bases
ATGACGGTTCCAACTCAGGCGCGGACAGCGCGCGTGGCGCGGGCCACCCGTGAGTCGGACATCGTGGTGGAACTGAACCT
GGACGGGTCCGGCCAGGTACAGATCGACACCGGAGTGCCGTTCTACGACCACATGCTCACCGCGCTGGGCACGCATGCCA
GCTTTGATCTCACGATAACCGCCAAGGGCGACACCGAAATCGAGGCCCATCACACGGTGGAAGACACCGCCATCACCCTG
GGGCAGGCGCTGGCCGAGGCTCTCGGGGACAAGAAGGGCATCCGGCGGTTCGGCGATGCCTTCATCCCGATGGACGAGAC
TTTGGCGCATGCCGTGGTGGATGTGTCCGGTCGTCCCTACTGTGTGCACACCGGTGAGCCGGACCATCTGCTGCACACCA
CGATTGCTGGCTCTTCGGTGCCCTACCATACCGTGATCAACGCGCATGTATTCGAGTCGCTGGCGCTCAACGCCCGGATC
GCGCTGCACGTGCGCACTCTCTACGGCCGCGACCCGCACCACATCACCGAGGCGCAATACAAGGCGGTGGCCCGGGCGCT
GCGCCAGGCCGTCGAGCCCGATCCCCGGGTCACCGGTGTGCCGTCGACCAAGGGCAGCCTGTGA

Upstream 100 bases:

>100_bases
CGGGTTATCTGCGTGTGACTGTCGGACTGGCGAGCGAGAATGACGTGTTCTTGAAGGTCAGCGACAGTCTGGCTGCGACG
GACCTAGAAGTGGAGGCATC

Downstream 100 bases:

>100_bases
CCGGTGCTGGGCCGAAAGTTGTTGTCCTCGACTACGGCTCAGGCAATCTGAGGTCCGCACAGCGTGCACTGGAACGGGTT
GGCGCCGATGTTACGGTGAC

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD [H]

Number of amino acids: Translated: 207; Mature: 206

Protein sequence:

>207_residues
MTVPTQARTARVARATRESDIVVELNLDGSGQVQIDTGVPFYDHMLTALGTHASFDLTITAKGDTEIEAHHTVEDTAITL
GQALAEALGDKKGIRRFGDAFIPMDETLAHAVVDVSGRPYCVHTGEPDHLLHTTIAGSSVPYHTVINAHVFESLALNARI
ALHVRTLYGRDPHHITEAQYKAVARALRQAVEPDPRVTGVPSTKGSL

Sequences:

>Translated_207_residues
MTVPTQARTARVARATRESDIVVELNLDGSGQVQIDTGVPFYDHMLTALGTHASFDLTITAKGDTEIEAHHTVEDTAITL
GQALAEALGDKKGIRRFGDAFIPMDETLAHAVVDVSGRPYCVHTGEPDHLLHTTIAGSSVPYHTVINAHVFESLALNARI
ALHVRTLYGRDPHHITEAQYKAVARALRQAVEPDPRVTGVPSTKGSL
>Mature_206_residues
TVPTQARTARVARATRESDIVVELNLDGSGQVQIDTGVPFYDHMLTALGTHASFDLTITAKGDTEIEAHHTVEDTAITLG
QALAEALGDKKGIRRFGDAFIPMDETLAHAVVDVSGRPYCVHTGEPDHLLHTTIAGSSVPYHTVINAHVFESLALNARIA
LHVRTLYGRDPHHITEAQYKAVARALRQAVEPDPRVTGVPSTKGSL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI87082027, Length=202, Percent_Identity=44.0594059405941, Blast_Score=154, Evalue=6e-39,
Organism=Saccharomyces cerevisiae, GI6324776, Length=224, Percent_Identity=37.0535714285714, Blast_Score=139, Evalue=3e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00475 IGPD [H]

EC number: =4.2.1.19 [H]

Molecular weight: Translated: 22327; Mature: 22196

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00954 IGP_DEHYDRATASE_1 ; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVPTQARTARVARATRESDIVVELNLDGSGQVQIDTGVPFYDHMLTALGTHASFDLTIT
CCCCCCHHHHHHHHHCCCCCEEEEEECCCCCEEEECCCCCHHHHHHHHHCCCCEEEEEEE
AKGDTEIEAHHTVEDTAITLGQALAEALGDKKGIRRFGDAFIPMDETLAHAVVDVSGRPY
ECCCCCEEECCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHEECCCCCE
CVHTGEPDHLLHTTIAGSSVPYHTVINAHVFESLALNARIALHVRTLYGRDPHHITEAQY
EEECCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCEEEEEEEEEECCCCCCHHHHHHH
KAVARALRQAVEPDPRVTGVPSTKGSL
HHHHHHHHHHCCCCCCEECCCCCCCCC
>Mature Secondary Structure 
TVPTQARTARVARATRESDIVVELNLDGSGQVQIDTGVPFYDHMLTALGTHASFDLTIT
CCCCCHHHHHHHHHCCCCCEEEEEECCCCCEEEECCCCCHHHHHHHHHCCCCEEEEEEE
AKGDTEIEAHHTVEDTAITLGQALAEALGDKKGIRRFGDAFIPMDETLAHAVVDVSGRPY
ECCCCCEEECCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHEECCCCCE
CVHTGEPDHLLHTTIAGSSVPYHTVINAHVFESLALNARIALHVRTLYGRDPHHITEAQY
EEECCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCEEEEEEEEEECCCCCCHHHHHHH
KAVARALRQAVEPDPRVTGVPSTKGSL
HHHHHHHHHHCCCCCCEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]