Click here to switch to the map view.

The map label for this gene is nudF [H]

Identifier: 169629451

GI number: 169629451

Start: 2421817

End: 2422461

Strand: Direct

Name: nudF [H]

Synonym: MAB_2365

Alternate gene names: 169629451

Gene position: 2421817-2422461 (Clockwise)

Preceding gene: 169629450

Following gene: 169629452

Centisome position: 47.79

GC content: 70.23

Gene sequence:

>645_bases
GTGAGTGACGGGACTTCGGGAGAGCGCGAACGGCACGAGTTCGTCACCCTGGAGTCCGAGCCCGTCTACATGGGCGGCAT
CCTGGCGCTGCGCCGCGATCGGGTGGCGATGCCCGGAGGCGGGAGCGCCACCCGTGAGGTTGTCGAACACTATGGCGCGG
TGGCGGTGGCGGCCGTGGATGAGGCTGGCCGGGTTGCGCTGGTGTACCAGTATCGGCACCCGCTGGGGCACCGCCTGTGG
GAGCTGCCCGCCGGGCTACTCGATATCGCGGGGGAGGACAGCCAGCGGGCCGCGGCACGCGAGCTGCTGGAGGAAGCGGG
TATCGAGGCCGGGACCTGGCGGGTGCTGGTGGATGCCGCTGCCTCGCCCGGATTCACCGATGAGGTGGTCCGGGTATTCC
TGGCCACCGGGCTGTCACACCCGGGCCGGGGAGAGAGCCACGACGAAGAGGCCGATATGACGGTGCACTGGGTGCCGCTA
TCCGAAGCGGTGTCGATGGTGATGGCCGGCGAGGTGGTCAATGCCATTGCGGTGGCGGGCATTCTGGCCACGCATATCGC
ACTCGGGGGTCACCACACCCGGCCGGTGGACGCGCCCTGGCCGGACCGGCCCACGGCCTTCGCGGAACGCAAGGCCGCAA
CGTGA

Upstream 100 bases:

>100_bases
CTCAAGAGCCGTCCCACCCGTCCGCATCCGCTGTTCAGCGCGTTCATTCGCGCTGCCATGGAGTACAAAGCGGCCGAGCG
TCTTCCGCTGGACCCCGACA

Downstream 100 bases:

>100_bases
CGGCCGCGGTCGGGCTCCTTGACGGCGAGATCCAGTCCTACCTGGATCATCTCGACGTGGAACGCGGCGTCGCCGCCAAT
ACGCTGAGCTCCTACCGTCG

Product: MutT/nudix family protein

Products: NA

Alternate protein names: ADP-ribose diphosphatase; ADP-ribose phosphohydrolase; ASPPase; Adenosine diphosphoribose pyrophosphatase; ADPR-PPase [H]

Number of amino acids: Translated: 214; Mature: 213

Protein sequence:

>214_residues
MSDGTSGERERHEFVTLESEPVYMGGILALRRDRVAMPGGGSATREVVEHYGAVAVAAVDEAGRVALVYQYRHPLGHRLW
ELPAGLLDIAGEDSQRAAARELLEEAGIEAGTWRVLVDAAASPGFTDEVVRVFLATGLSHPGRGESHDEEADMTVHWVPL
SEAVSMVMAGEVVNAIAVAGILATHIALGGHHTRPVDAPWPDRPTAFAERKAAT

Sequences:

>Translated_214_residues
MSDGTSGERERHEFVTLESEPVYMGGILALRRDRVAMPGGGSATREVVEHYGAVAVAAVDEAGRVALVYQYRHPLGHRLW
ELPAGLLDIAGEDSQRAAARELLEEAGIEAGTWRVLVDAAASPGFTDEVVRVFLATGLSHPGRGESHDEEADMTVHWVPL
SEAVSMVMAGEVVNAIAVAGILATHIALGGHHTRPVDAPWPDRPTAFAERKAAT
>Mature_213_residues
SDGTSGERERHEFVTLESEPVYMGGILALRRDRVAMPGGGSATREVVEHYGAVAVAAVDEAGRVALVYQYRHPLGHRLWE
LPAGLLDIAGEDSQRAAARELLEEAGIEAGTWRVLVDAAASPGFTDEVVRVFLATGLSHPGRGESHDEEADMTVHWVPLS
EAVSMVMAGEVVNAIAVAGILATHIALGGHHTRPVDAPWPDRPTAFAERKAAT

Specific function: Acts on ADP-mannose and ADP-glucose as well as ADP- ribose. Prevents glycogen biosynthesis. The reaction catalyzed by this enzyme is a limiting step of the gluconeogenic process [H]

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004385
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: =3.6.1.13 [H]

Molecular weight: Translated: 22829; Mature: 22698

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDGTSGERERHEFVTLESEPVYMGGILALRRDRVAMPGGGSATREVVEHYGAVAVAAVD
CCCCCCCCCCHHEEEEECCCCEEEHHHHHHHCCCCCCCCCCHHHHHHHHHHCCEEEEEEC
EAGRVALVYQYRHPLGHRLWELPAGLLDIAGEDSQRAAARELLEEAGIEAGTWRVLVDAA
CCCCEEEEEECCCCHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHCCCCCCCEEEEEECC
ASPGFTDEVVRVFLATGLSHPGRGESHDEEADMTVHWVPLSEAVSMVMAGEVVNAIAVAG
CCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHH
ILATHIALGGHHTRPVDAPWPDRPTAFAERKAAT
HHHHHHHHCCCCCCCCCCCCCCCCCHHHHHCCCC
>Mature Secondary Structure 
SDGTSGERERHEFVTLESEPVYMGGILALRRDRVAMPGGGSATREVVEHYGAVAVAAVD
CCCCCCCCCHHEEEEECCCCEEEHHHHHHHCCCCCCCCCCHHHHHHHHHHCCEEEEEEC
EAGRVALVYQYRHPLGHRLWELPAGLLDIAGEDSQRAAARELLEEAGIEAGTWRVLVDAA
CCCCEEEEEECCCCHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHCCCCCCCEEEEEECC
ASPGFTDEVVRVFLATGLSHPGRGESHDEEADMTVHWVPLSEAVSMVMAGEVVNAIAVAG
CCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHH
ILATHIALGGHHTRPVDAPWPDRPTAFAERKAAT
HHHHHHHHCCCCCCCCCCCCCCCCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377; 10542272 [H]