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The map label for this gene is pyrG [H]

Identifier: 169629450

GI number: 169629450

Start: 2420100

End: 2421824

Strand: Direct

Name: pyrG [H]

Synonym: MAB_2364

Alternate gene names: 169629450

Gene position: 2420100-2421824 (Clockwise)

Preceding gene: 169629449

Following gene: 169629451

Centisome position: 47.76

GC content: 64.35

Gene sequence:

>1725_bases
TTGCCCTGCGCAGTCGTCACGGGAGCCAACTTGGCAGGTCTACGTAAGCATCCGCAAACCGCTACCAAGCATCTTTTTGT
GAGCGGTGGAGTTGCCTCCTCGCTGGGTAAGGGTTTGACCGCGTCCAGCCTTGGGCAACTTCTCACCTCACGCGGCCTGC
AAGTGACCATGCAGAAGCTCGACCCGTATCTCAACGTGGACCCGGGCACCATGAACCCGTTCCAGCACGGCGAGGTCTTC
GTCACCGAGGACGGCGCGGAGACCGATCTGGACGTCGGGCACTACGAGCGCTTCTTGGACCGTGATCTGTCTGGGTCGGC
GAATGTGACTACCGGGCAGGTGTATTCGTCGGTCATCGCCAAGGAACGGCGTGGCGAGTACCTGGGTGACACCGTGCAGG
TGATTCCGCATATCACCGACGAGATCAAGAGCCGCATCCTGGCGATGGCCGAGCCTAACGAAAACGGGCAGCGGCCCGAC
ATCGTCATCACCGAGATCGGCGGCACCGTCGGCGACATCGAATCGCAGCCGTTCCTGGAGGCCGCGCGGCAGATCCGCCA
TGACGTCGGCCGTGACAACGTCTTCTTCCTGCACGTCTCGCTGGTGCCGTACCTGAAGCCGTCCGGCGAGCTCAAGACCA
AGCCGACGCAGCACTCCGTCGCCGCGCTGCGCAGCATCGGTATCACTCCGGATGCACTGATCCTGCGCTGTGACCGGGAT
GTGCCCGAGCCGCTCAAGAACAAGATCGCCCTCATGTGTGACGTGGACGTCGACGGTGTCATCTCCACGCCCGACGCGCC
ATCCATCTACGACATCCCCAAGGTGTTGCATCGTGAGGAACTCGACGCATACGTGGTGCGCCGGCTCAACCTGCCCTTCC
GCGACGTGGACTGGACCGAGTGGGGCGATCTGCTGCAGCGGGTCCACGAGCCCAGTGAATCGGTACGAATCGCCTTGGTG
GGCAAGTATATTGACCTACCCGATGCCTATCTGTCGGTCACCGAGGCGCTGCGCGCTGGCGGATTCCGGCACCATACGAA
GGTTGACATCAAGTGGGTGCCGTCGGATGACTGCGAAACCGAGAGTGGGGCGCAGGCGGCACTCGGAGATGTCGACGGTG
TGCTGATTCCCGGCGGCTTCGGCATCCGGGGTATCGAGGGCAAACTCGGCGCCATCCGCTATGCCCGCAAGCGGCGGGTG
CCGATACTCGGGCTGTGTCTTGGCTTGCAGTGCATGGTTATCGAGGCGGCGCGGTCGGCGGGGCTTGCCGACGCCAACTC
CGCCGAGTTCGATCCCGACACCCCGAGCCCGGTGATCGCCACCATGGCGGACCAGGTGCGGGCTGTCGCCGGTGAGGCCG
ACCTGGGCGGAACGATGCGCCTGGGCGCCTATCCCGCTGTCCTGGAGCCTGATTCCATCGTCGCCGAGGCGTACGGCACC
ACCGAGGTGTCCGAACGGCACCGGCATCGTTACGAGGTGAACAACCCCTACCGCGACAAGATCGCCGAGAGCGGCCTGCG
GTTCTCTGGGACGTCGCCCGACGGGCATCTGGTGGAATTCGTGGAGTACCCGCGGGAGGTTCACCCGTTCGCGGTGGCCA
CTCAGGCGCACCCTGAGCTCAAGAGCCGTCCCACCCGTCCGCATCCGCTGTTCAGCGCGTTCATTCGCGCTGCCATGGAG
TACAAAGCGGCCGAGCGTCTTCCGCTGGACCCCGACAGTGAGTGA

Upstream 100 bases:

>100_bases
GGGGATCTAGCCCACATCCCGCGGCGTGTTCGGCGCCGGTTGTCGGCGTATTTGTTAGGGTGAGGTTCCGTGGGTCAGCA
GGGCCCCGAGCTTTGAAGAA

Downstream 100 bases:

>100_bases
CGGGACTTCGGGAGAGCGCGAACGGCACGAGTTCGTCACCCTGGAGTCCGAGCCCGTCTACATGGGCGGCATCCTGGCGC
TGCGCCGCGATCGGGTGGCG

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase [H]

Number of amino acids: Translated: 574; Mature: 573

Protein sequence:

>574_residues
MPCAVVTGANLAGLRKHPQTATKHLFVSGGVASSLGKGLTASSLGQLLTSRGLQVTMQKLDPYLNVDPGTMNPFQHGEVF
VTEDGAETDLDVGHYERFLDRDLSGSANVTTGQVYSSVIAKERRGEYLGDTVQVIPHITDEIKSRILAMAEPNENGQRPD
IVITEIGGTVGDIESQPFLEAARQIRHDVGRDNVFFLHVSLVPYLKPSGELKTKPTQHSVAALRSIGITPDALILRCDRD
VPEPLKNKIALMCDVDVDGVISTPDAPSIYDIPKVLHREELDAYVVRRLNLPFRDVDWTEWGDLLQRVHEPSESVRIALV
GKYIDLPDAYLSVTEALRAGGFRHHTKVDIKWVPSDDCETESGAQAALGDVDGVLIPGGFGIRGIEGKLGAIRYARKRRV
PILGLCLGLQCMVIEAARSAGLADANSAEFDPDTPSPVIATMADQVRAVAGEADLGGTMRLGAYPAVLEPDSIVAEAYGT
TEVSERHRHRYEVNNPYRDKIAESGLRFSGTSPDGHLVEFVEYPREVHPFAVATQAHPELKSRPTRPHPLFSAFIRAAME
YKAAERLPLDPDSE

Sequences:

>Translated_574_residues
MPCAVVTGANLAGLRKHPQTATKHLFVSGGVASSLGKGLTASSLGQLLTSRGLQVTMQKLDPYLNVDPGTMNPFQHGEVF
VTEDGAETDLDVGHYERFLDRDLSGSANVTTGQVYSSVIAKERRGEYLGDTVQVIPHITDEIKSRILAMAEPNENGQRPD
IVITEIGGTVGDIESQPFLEAARQIRHDVGRDNVFFLHVSLVPYLKPSGELKTKPTQHSVAALRSIGITPDALILRCDRD
VPEPLKNKIALMCDVDVDGVISTPDAPSIYDIPKVLHREELDAYVVRRLNLPFRDVDWTEWGDLLQRVHEPSESVRIALV
GKYIDLPDAYLSVTEALRAGGFRHHTKVDIKWVPSDDCETESGAQAALGDVDGVLIPGGFGIRGIEGKLGAIRYARKRRV
PILGLCLGLQCMVIEAARSAGLADANSAEFDPDTPSPVIATMADQVRAVAGEADLGGTMRLGAYPAVLEPDSIVAEAYGT
TEVSERHRHRYEVNNPYRDKIAESGLRFSGTSPDGHLVEFVEYPREVHPFAVATQAHPELKSRPTRPHPLFSAFIRAAME
YKAAERLPLDPDSE
>Mature_573_residues
PCAVVTGANLAGLRKHPQTATKHLFVSGGVASSLGKGLTASSLGQLLTSRGLQVTMQKLDPYLNVDPGTMNPFQHGEVFV
TEDGAETDLDVGHYERFLDRDLSGSANVTTGQVYSSVIAKERRGEYLGDTVQVIPHITDEIKSRILAMAEPNENGQRPDI
VITEIGGTVGDIESQPFLEAARQIRHDVGRDNVFFLHVSLVPYLKPSGELKTKPTQHSVAALRSIGITPDALILRCDRDV
PEPLKNKIALMCDVDVDGVISTPDAPSIYDIPKVLHREELDAYVVRRLNLPFRDVDWTEWGDLLQRVHEPSESVRIALVG
KYIDLPDAYLSVTEALRAGGFRHHTKVDIKWVPSDDCETESGAQAALGDVDGVLIPGGFGIRGIEGKLGAIRYARKRRVP
ILGLCLGLQCMVIEAARSAGLADANSAEFDPDTPSPVIATMADQVRAVAGEADLGGTMRLGAYPAVLEPDSIVAEAYGTT
EVSERHRHRYEVNNPYRDKIAESGLRFSGTSPDGHLVEFVEYPREVHPFAVATQAHPELKSRPTRPHPLFSAFIRAAMEY
KAAERLPLDPDSE

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen [H]

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Homo sapiens, GI148491070, Length=557, Percent_Identity=44.165170556553, Blast_Score=465, Evalue=1e-131,
Organism=Homo sapiens, GI28559085, Length=553, Percent_Identity=43.5804701627486, Blast_Score=452, Evalue=1e-127,
Organism=Homo sapiens, GI28559083, Length=553, Percent_Identity=43.5804701627486, Blast_Score=452, Evalue=1e-127,
Organism=Homo sapiens, GI221316689, Length=553, Percent_Identity=43.5804701627486, Blast_Score=452, Evalue=1e-127,
Organism=Escherichia coli, GI1789142, Length=549, Percent_Identity=52.0947176684882, Blast_Score=550, Evalue=1e-158,
Organism=Caenorhabditis elegans, GI25148299, Length=602, Percent_Identity=37.375415282392, Blast_Score=365, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6319432, Length=566, Percent_Identity=43.1095406360424, Blast_Score=446, Evalue=1e-126,
Organism=Saccharomyces cerevisiae, GI6322563, Length=565, Percent_Identity=42.4778761061947, Blast_Score=433, Evalue=1e-122,
Organism=Drosophila melanogaster, GI24664469, Length=555, Percent_Identity=44.5045045045045, Blast_Score=449, Evalue=1e-126,
Organism=Drosophila melanogaster, GI21357815, Length=500, Percent_Identity=43.2, Blast_Score=383, Evalue=1e-106,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991 [H]

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase [H]

EC number: =6.3.4.2 [H]

Molecular weight: Translated: 62577; Mature: 62445

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPCAVVTGANLAGLRKHPQTATKHLFVSGGVASSLGKGLTASSLGQLLTSRGLQVTMQKL
CCCEEEECCCCHHHHCCCCHHHHEEEEECCHHHHHCCCCCHHHHHHHHHHCCCEEEHHHC
DPYLNVDPGTMNPFQHGEVFVTEDGAETDLDVGHYERFLDRDLSGSANVTTGQVYSSVIA
CCCEECCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
KERRGEYLGDTVQVIPHITDEIKSRILAMAEPNENGQRPDIVITEIGGTVGDIESQPFLE
HHHCCCCCCCHHHHHHHHHHHHHHHEEEEECCCCCCCCCCEEEEECCCCCCCCCCCHHHH
AARQIRHDVGRDNVFFLHVSLVPYLKPSGELKTKPTQHSVAALRSIGITPDALILRCDRD
HHHHHHHHCCCCCEEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCCEEEEECCC
VPEPLKNKIALMCDVDVDGVISTPDAPSIYDIPKVLHREELDAYVVRRLNLPFRDVDWTE
CCHHHHCCEEEEEECCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
WGDLLQRVHEPSESVRIALVGKYIDLPDAYLSVTEALRAGGFRHHTKVDIKWVPSDDCET
HHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCC
ESGAQAALGDVDGVLIPGGFGIRGIEGKLGAIRYARKRRVPILGLCLGLQCMVIEAARSA
CCCCHHHHCCCCCEEECCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHC
GLADANSAEFDPDTPSPVIATMADQVRAVAGEADLGGTMRLGAYPAVLEPDSIVAEAYGT
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCCEECCCHHHHHHCCC
TEVSERHRHRYEVNNPYRDKIAESGLRFSGTSPDGHLVEFVEYPREVHPFAVATQAHPEL
HHHHHHHHHCCCCCCCHHHHHHHCCCEECCCCCCCCHHHHHHCCCCCCCEEEEECCCCHH
KSRPTRPHPLFSAFIRAAMEYKAAERLPLDPDSE
HCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
PCAVVTGANLAGLRKHPQTATKHLFVSGGVASSLGKGLTASSLGQLLTSRGLQVTMQKL
CCEEEECCCCHHHHCCCCHHHHEEEEECCHHHHHCCCCCHHHHHHHHHHCCCEEEHHHC
DPYLNVDPGTMNPFQHGEVFVTEDGAETDLDVGHYERFLDRDLSGSANVTTGQVYSSVIA
CCCEECCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
KERRGEYLGDTVQVIPHITDEIKSRILAMAEPNENGQRPDIVITEIGGTVGDIESQPFLE
HHHCCCCCCCHHHHHHHHHHHHHHHEEEEECCCCCCCCCCEEEEECCCCCCCCCCCHHHH
AARQIRHDVGRDNVFFLHVSLVPYLKPSGELKTKPTQHSVAALRSIGITPDALILRCDRD
HHHHHHHHCCCCCEEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCCEEEEECCC
VPEPLKNKIALMCDVDVDGVISTPDAPSIYDIPKVLHREELDAYVVRRLNLPFRDVDWTE
CCHHHHCCEEEEEECCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
WGDLLQRVHEPSESVRIALVGKYIDLPDAYLSVTEALRAGGFRHHTKVDIKWVPSDDCET
HHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCC
ESGAQAALGDVDGVLIPGGFGIRGIEGKLGAIRYARKRRVPILGLCLGLQCMVIEAARSA
CCCCHHHHCCCCCEEECCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHC
GLADANSAEFDPDTPSPVIATMADQVRAVAGEADLGGTMRLGAYPAVLEPDSIVAEAYGT
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCCEECCCHHHHHHCCC
TEVSERHRHRYEVNNPYRDKIAESGLRFSGTSPDGHLVEFVEYPREVHPFAVATQAHPEL
HHHHHHHHHCCCCCCCHHHHHHHCCCEECCCCCCCCHHHHHHCCCCCCCEEEEECCCCHH
KSRPTRPHPLFSAFIRAAMEYKAAERLPLDPDSE
HCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA